Search Results - "Royal, Joshua M"

Cholera toxin B: one subunit with many pharmaceutical applications by Baldauf, Keegan J, Royal, Joshua M, Hamorsky, Krystal Teasley, Matoba, Nobuyuki

“…Cholera, a waterborne acute diarrheal disease caused by Vibrio cholerae, remains prevalent in underdeveloped countries and is a serious health threat to those…”
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Therapeutic Potential of Cholera Toxin B Subunit for the Treatment of Inflammatory Diseases of the Mucosa by Royal, Joshua M, Matoba, Nobuyuki

“…Cholera toxin B subunit (CTB) is a mucosal immunomodulatory protein that induces robust mucosal and systemic antibody responses. This well-known biological…”
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Isolation and detection of a KDEL-tagged recombinant cholera toxin B subunit from Nicotiana benthamiana by Morris, David A., Reeves, Micaela A., Royal, Joshua M., Hamorsky, Krystal T., Matoba, Nobuyuki

“…[Display omitted] •A novel mucosal wound-healing protein (CTBSEKDEL) was produced in plants.•C-terminally truncated byproducts were removed by ceramic…”
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A modified cholera toxin B subunit containing an ER retention motif enhances colon epithelial repair via an unfolded protein response by Royal, Joshua M., Oh, Young Jun, Grey, Michael J., Lencer, Wayne I., Ronquillo, Nemencio, Galandiuk, Susan, Matoba, Nobuyuki

“…Cholera toxin B subunit (CTB) exhibits broad‐spectrum biologic activity upon mucosal administration. Here, we found that a recombinant CTB containing an…”
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Repeated Oral Administration of a KDEL-tagged Recombinant Cholera Toxin B Subunit Effectively Mitigates DSS Colitis Despite a Robust Immunogenic Response by Royal, Joshua M, Reeves, Micaela A, Matoba, Nobuyuki

“…Cholera toxin B subunit (CTB), a non-toxic homopentameric component of holotoxin, is an oral cholera vaccine antigen that induces an anti-toxin antibody…”
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Development of a SARS-CoV-2 Vaccine Candidate Using Plant-Based Manufacturing and a Tobacco Mosaic Virus-like Nano-Particle by Royal, Joshua M., Simpson, Carrie A., McCormick, Alison A., Phillips, Amanda, Hume, Steve, Morton, Josh, Shepherd, John, Oh, Youngjun, Swope, Kelsi, DeBeauchamp, Jennifer L., Webby, Richard J., Cross, Robert W., Borisevich, Viktoriya, Geisbert, Thomas W., Demarco, Jennifer K., Bratcher, Barry, Haydon, Hugh, Pogue, Gregory P.

“…Stable, effective, easy-to-manufacture vaccines are critical to stopping the COVID-19 pandemic resulting from the coronavirus SARS-CoV-2. We constructed a…”
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Spray-Dried Formulation of Epicertin, a Recombinant Cholera Toxin B Subunit Variant That Induces Mucosal Healing by Reeves, Micaela A, Royal, Joshua M, Morris, David A, Jurkiewicz, Jessica M, Matoba, Nobuyuki, Hamorsky, Krystal T

“…Epicertin (EPT) is a recombinant variant of the cholera toxin B subunit, modified with a C-terminal KDEL endoplasmic reticulum retention motif. EPT has…”
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CoV-RBD121-NP Vaccine Candidate Protects against Symptomatic Disease following SARS-CoV-2 Challenge in K18-hACE2 Mice and Induces Protective Responses That Prevent COVID-19-Associated Immunopathology by DeMarco, Jennifer K, Royal, Joshua M, Severson, William E, Gabbard, Jon D, Hume, Steve, Morton, Josh, Swope, Kelsi, Simpson, Carrie A, Shepherd, John W, Bratcher, Barry, Palmer, Kenneth E, Pogue, Gregory P

“…We developed a SARS-CoV-2 vaccine candidate (CoV-RBD121-NP) comprised of a tobacco mosaic virus-like nanoparticle conjugated to the receptor-binding domain of…”
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Oral Administration of a Cholera Vaccine Antigen Facilitates Colonic Mucosal Healing in a Murine Model of Colitis by Royal, Joshua M, Baldauf, Keegan, Yaddanapudi, Kavitha, Dryden, Gerald W, Matoba, Nobuyuki

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983 - Epicertin, a Cholera Toxin B Subunit Variant, Enhances Intestinal Wound Healing in a Mouse Acute Colitis Model and Human Ulcerative Colitis Colon Explants via an Unfolded Protein Response by Royal, Joshua M., Oh, Youngjun, Galandiuk, Susan, Matoba, Nobuyuki

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P032 EPICERTIN ENHANCES INTESTINAL WOUND HEALING IN A MOUSE COLITIS MODEL AND HUMAN ULCERATIVE COLITIS COLON EXPLANTS by Royal, Joshua M., Oh, Youngjun, Galandiuk, Susan, Matoba, Nobuyuki

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P032 EPICERTIN ENHANCES INTESTINAL WOUND HEALING IN A MOUSE COLITIS MODEL AND HUMAN ULCERATIVE COLITIS COLON EXPLANTS by Royal, Joshua M, Oh, Youngjun, Galandiuk, Susan, Matoba, Nobuyuki

“…Abstract Epicertin (EPT) is a new ulcerative colitis (UC) drug candidate derived from the nontoxic component of Vibrio cholerae cholera toxin. We have recently…”
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Su1856 - Oral Administration of a Cholera Vaccine Antigen Facilitates Colonic Mucosal Healing in a Murine Model of Colitis by Royal, Joshua M., Baldauf, Keegan, Yaddanapudi, Kavitha, Dryden, Gerald W., Matoba, Nobuyuki

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