Search Results - "Roy, Kevin R"

Histone deacetylase Hos2 regulates protein expression noise by potentially modulating the protein translation machinery by Lin, Wei-Han, Opoc, Florica J G, Liao, Chia-Wei, Roy, Kevin R, Steinmetz, Lars M, Leu, Jun-Yi

“…Abstract Non-genetic variations derived from expression noise at transcript or protein levels can result in cell-to-cell heterogeneity within an isogenic…”
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The interplay of additivity, dominance, and epistasis on fitness in a diploid yeast cross by Matsui, Takeshi, Mullis, Martin N., Roy, Kevin R., Hale, Joseph J., Schell, Rachel, Levy, Sasha F., Ehrenreich, Ian M.

“…In diploid species, genetic loci can show additive, dominance, and epistatic effects. To characterize the contributions of these different types of genetic…”
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Genome-scale analysis of interactions between genetic perturbations and natural variation by Hale, Joseph J., Matsui, Takeshi, Goldstein, Ilan, Mullis, Martin N., Roy, Kevin R., Ville, Christopher Ne, Miller, Darach, Wang, Charley, Reynolds, Trevor, Steinmetz, Lars M., Levy, Sasha F., Ehrenreich, Ian M.

“…Interactions between genetic perturbations and segregating loci can cause perturbations to show different phenotypic effects across genetically distinct…”
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Protein Methylation and Translation: Role of Lysine Modification on the Function of Yeast Elongation Factor 1A by White, Jonelle T, Cato, Tieranee, Deramchi, Neil, Gabunilas, Jason, Roy, Kevin R, Wang, Charles, Chanfreau, Guillaume F, Clarke, Steven G

“…To date, 12 protein lysine methyltransferases that modify translational elongation factors and ribosomal proteins (Efm1–7 and Rkm 1–5) have been identified in…”
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A scalable and cGMP-compatible autologous organotypic cell therapy for Dystrophic Epidermolysis Bullosa by Neumayer, Gernot, Torkelson, Jessica L., Li, Shengdi, McCarthy, Kelly, Zhen, Hanson H., Vangipuram, Madhuri, Mader, Marius M., Gebeyehu, Gulilat, Jaouni, Taysir M., Jacków-Malinowska, Joanna, Rami, Avina, Hansen, Corey, Guo, Zongyou, Gaddam, Sadhana, Tate, Keri M., Pappalardo, Alberto, Li, Lingjie, Chow, Grace M., Roy, Kevin R., Nguyen, Thuylinh Michelle, Tanabe, Koji, McGrath, Patrick S., Cramer, Amber, Bruckner, Anna, Bilousova, Ganna, Roop, Dennis, Tang, Jean Y., Christiano, Angela, Steinmetz, Lars M., Wernig, Marius, Oro, Anthony E.

“…We present Dystrophic Epidermolysis Bullosa Cell Therapy (DEBCT), a scalable platform producing autologous organotypic iPS cell-derived induced skin composite…”
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CRISPR-Cas9 Gene Editing in Yeast: A Molecular Biology and Bioinformatics Laboratory Module for Undergraduate and High School Students by Sankaran, Saumya M, Smith, Justin D, Roy, Kevin R

“…CRISPR-Cas9 genome editing technology is widely used in scientific research and biotechnology. As this technology becomes a staple tool in life sciences…”
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Engineered Graphene Oxide Nanocomposite Capable of Preventing the Evolution of Antimicrobial Resistance by Zheng, Huizhen, Ji, Zhaoxia, Roy, Kevin R, Gao, Meng, Pan, Yanxia, Cai, Xiaoming, Wang, Liming, Li, Wei, Chang, Chong Hyun, Kaweeteerawat, Chitrada, Chen, Chunying, Xia, Tian, Zhao, Yuliang, Li, Ruibin

“…Antimicrobial resistance (AMR) is spreading worldwide and keeps evolving to adapt to antibiotics, causing increasing threats in clinics, which necessitates the…”
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Robust mapping of polyadenylated and non-polyadenylated RNA 3′ ends at nucleotide resolution by 3′-end sequencing by Roy, Kevin R., Chanfreau, Guillaume F.

“…•3′-end poly(A)+ sequencing enables poly(A) site mapping at nucleotide resolution.•Mis-priming of RT primer results in a variety of poly(A) site mapping…”
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Splicing factor Prp18p promotes genome-wide fidelity of consensus 3′-splice sites by Roy, Kevin R, Gabunilas, Jason, Neutel, Dean, Ai, Michelle, Yeh, Zoe, Samson, Joyce, Lyu, Guochang, Chanfreau, Guillaume F

“…Abstract The fidelity of splice site selection is critical for proper gene expression. In particular, proper recognition of 3′-splice site (3′SS) sequences by…”
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Multiplexed precision genome editing with trackable genomic barcodes in yeast by Roy, Kevin R, Smith, Justin D, Vonesch, Sibylle C, Lin, Gen, Tu, Chelsea Szu, Lederer, Alex R, Chu, Angela, Suresh, Sundari, Nguyen, Michelle, Horecka, Joe, Tripathi, Ashutosh, Burnett, Wallace T, Morgan, Maddison A, Schulz, Julia, Orsley, Kevin M, Wei, Wu, Aiyar, Raeka S, Davis, Ronald W, Bankaitis, Vytas A, Haber, James E, Salit, Marc L, St.Onge, Robert P, Steinmetz, Lars M

“…A method to introduce defined mutations into the yeast genome enables saturation mutagenesis of a gene and genome-scale introduction of genetic variants. Our…”
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Cu Nanoparticles Have Different Impacts in Escherichia coli and Lactobacillus brevis than Their Microsized and Ionic Analogues by Kaweeteerawat, Chitrada, Chang, Chong Hyun, Roy, Kevin R, Liu, Rong, Li, Ruibin, Toso, Daniel, Fischer, Heidi, Ivask, Angela, Ji, Zhaoxia, Zink, Jeffrey I, Zhou, Z. Hong, Chanfreau, Guillaume Francois, Telesca, Donatello, Cohen, Yoram, Holden, Patricia Ann, Nel, Andre E, Godwin, Hilary A

“…Copper formulations have been used for decades for antimicrobial and antifouling applications. With the development of nanoformulations of copper that are more…”
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Large scale microfluidic CRISPR screening for increased amylase secretion in yeast by Johansson, S Andreas, Dulermo, Thierry, Jann, Cosimo, Smith, Justin D, Pryszlak, Anna, Pignede, Georges, Schraivogel, Daniel, Colavizza, Didier, Desfougères, Thomas, Rave, Christophe, Farwick, Alexander, Merten, Christoph A, Roy, Kevin R, Wei, Wu, Steinmetz, Lars M

“…Key to our ability to increase recombinant protein production through secretion is a better understanding of the pathways that interact to translate, process…”
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Cu Nanoparticles Have Different Impacts in E. coli and L. brevis than Their Micron-Sized and Ionic Analogs by Kaweeteerawat, Chitrada, Chang, Chong Hyun, Roy, Kevin R., Liu, Rong, Li, Ruibin, Toso, Daniel, Fischer, Heidi, Ivask, Angela, Ji, Zhaoxia, Zink, Jeffrey I., Zhou, Z. Hong, Chanfreau, Guillaume Francois, Telesca, Donatello, Cohen, Yoram, Ann Holden, Patricia, Nel, Andre E., Godwin, Hilary A.

“…Copper formulations have been used for decades for antimicrobial and antifouling applications. With the development of nano-formulations of copper that are…”
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Schedule optimization with flexible durations by Roy, Kevin R

“…Cost, quality, and time are the pillars of a popular and well known business model. What is also well known about this model is that it is very difficult to be…”
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