Search Results - "Roy, Didier Le"

TH17 cells promote microbial killing and innate immune sensing of DNA via interleukin 26 by Meller, Stephan, Di Domizio, Jeremy, Voo, Kui S, Friedrich, Heike C, Chamilos, Georgios, Ganguly, Dipyaman, Conrad, Curdin, Gregorio, Josh, Le Roy, Didier, Roger, Thierry, Ladbury, John E, Homey, Bernhard, Watowich, Stanley, Modlin, Robert L, Kontoyiannis, Dimitrios P, Liu, Yong-Jun, Arold, Stefan T, Gilliet, Michel

“…T H 17 cells have important roles at mucosal surfaces in both health and disease. Gilliet and colleagues show that IL-26 is preferentially produced by human T…”
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High expression levels of macrophage migration inhibitory factor sustain the innate immune responses of neonates by Roger, Thierry, Schneider, Anina, Weier, Manuela, Sweep, Fred C. G. J., Le Roy, Didier, Bernhagen, Jürgen, Calandra, Thierry, Giannoni, Eric

“…The vulnerability to infection of newborns is associated with a limited ability to mount efficient immune responses. High concentrations of adenosine and…”
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Sirtuin 2 Deficiency Increases Bacterial Phagocytosis by Macrophages and Protects from Chronic Staphylococcal Infection by Ciarlo, Eleonora, Heinonen, Tytti, Théroude, Charlotte, Herderschee, Jacobus, Mombelli, Matteo, Lugrin, Jérôme, Pfefferlé, Marc, Tyrrell, Beatrice, Lensch, Sarah, Acha-Orbea, Hans, Le Roy, Didier, Auwerx, Johan, Roger, Thierry

“…Sirtuin 2 (SIRT2) is one of the seven members of the family of NAD -dependent histone deacetylases. Sirtuins target histones and non-histone proteins according…”
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Sirtuin 5 Deficiency Does Not Compromise Innate Immune Responses to Bacterial Infections by Heinonen, Tytti, Ciarlo, Eleonora, Théroude, Charlotte, Pelekanou, Aimilia, Herderschee, Jacobus, Le Roy, Didier, Roger, Thierry

“…Sirtuin 5 (SIRT5) is a member of the family of NAD -dependent lysine/histone deacetylases. SIRT5 resides mainly in the mitochondria where it catalyzes…”
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Protection from septic shock by neutralization of macrophage migration inhibitory factor by Calandra, Thierry, Echtenacher, Bernd, Roy, Didier Le, Pugin, Jérôme, Metz, Christine N, Hültner, Lothar, Heumann, Didier, Männel, Daniela, Bucala, Richard, Glauser, Michel P

“…Identification of new therapeutic targets for the management of septic shock remains imperative as all investigational therapies, including anti-tumor necrosis…”
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A New Class of Isothiocyanate-Based Irreversible Inhibitors of Macrophage Migration Inhibitory Factor by Ouertatani-Sakouhi, Hajer, El-Turk, Farah, Fauvet, Bruno, Roger, Thierry, Le Roy, Didier, Karpinar, Damla Pinar, Leng, Lin, Bucala, Richard, Zweckstetter, Markus, Calandra, Thierry, Lashuel, Hilal A

“…Macrophage migration inhibitory factor (MIF) is a homotrimeric multifunctional proinflammatory cytokine that has been implicated in the pathogenesis of several…”
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Trained Immunity Confers Broad-Spectrum Protection Against Bacterial Infections by Ciarlo, Eleonora, Heinonen, Tytti, Théroude, Charlotte, Asgari, Fatemeh, Le Roy, Didier, Netea, Mihai G, Roger, Thierry

“…Abstract Background The innate immune system recalls a challenge to adapt to a secondary challenge, a phenomenon called trained immunity. Training involves…”
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Role of MyD88 and Toll-Like Receptors 2 and 4 in the Sensing of Parachlamydia acanthamoebae by Roger, Thierry, Casson, Nicola, Croxatto, Antony, Entenza, José Manuel, Pusztaszeri, Marc, Akira, Shizuo, Reymond, Marlies Knaup, Le Roy, Didier, Calandra, Thierry, Greub, Gilbert

“…Parachlamydia acanthamoebae is a Chlamydia-related organism whose pathogenic role in pneumonia is supported by serological and molecular clinical studies and…”
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Author Correction: Using weight loss to predict outcome and define a humane endpoint in preclinical sepsis studies by Brochut, Maëlick, Heinonen, Tytti, Snäkä, Tiia, Gilbert, Charly, Le Roy, Didier, Roger, Thierry

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Caspase-8-dependent gasdermin D cleavage promotes antimicrobial defense but confers susceptibility to TNF-induced lethality by Demarco, Benjamin, Grayczyk, James P, Bjanes, Elisabet, Le Roy, Didier, Tonnus, Wulf, Assenmacher, Charles-Antoine, Radaelli, Enrico, Fettrelet, Timothée, Mack, Vanessa, Linkermann, Andreas, Roger, Thierry, Brodsky, Igor E, Chen, Kaiwen W, Broz, Petr

“…Gasdermin D (GSDMD) is a pore-forming protein that promotes pyroptosis and release of proinflammatory cytokines. Recent studies revealed that apoptotic…”
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Seasonal migration, site fidelity, and population structure of European seabass (Dicentrarchus labrax) by de Pontual, Helene, Heerah, Karine, Goossens, Jolien, Garren, François, Martin, Stephane, Le Ru, Loic, Le Roy, Didier, Woillez, Mathieu

“…Abstract Large-scale electronic tagging is a very powerful tool to study how fish movements and migrations shape the internal dynamics of populations. This…”
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Impact of the Dual Deletion of the Mitochondrial Sirtuins SIRT3 and SIRT5 on Anti-microbial Host Defenses by Heinonen, Tytti, Ciarlo, Eleonora, Le Roy, Didier, Roger, Thierry

“…The sirtuins SIRT3 and SIRT5 are the main mitochondrial lysine deacetylase and desuccinylase, respectively. SIRT3 and SIRT5 regulate metabolism and redox…”
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Using weight loss to predict outcome and define a humane endpoint in preclinical sepsis studies by Brochut, Maëlick, Heinonen, Tytti, Snäkä, Tiia, Gilbert, Charly, Le Roy, Didier, Roger, Thierry

“…Preclinical mouse models are critical for understanding the pathophysiological response to infections and developing treatment strategies for sepsis. In…”
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Histone deacetylase inhibitors impair innate immune responses to Toll-like receptor agonists and to infection by Roger, Thierry, Lugrin, Jérôme, Le Roy, Didier, Goy, Geneviève, Mombelli, Matteo, Koessler, Thibaud, Ding, Xavier C., Chanson, Anne-Laure, Reymond, Marlies Knaup, Miconnet, Isabelle, Schrenzel, Jacques, François, Patrice, Calandra, Thierry

“…Regulated by histone acetyltransferases and deacetylases (HDACs), histone acetylation is a key epigenetic mechanism controlling chromatin structure, DNA…”
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The fungal ligand chitin directly binds TLR2 and triggers inflammation dependent on oligomer size by Fuchs, Katharina, Cardona Gloria, Yamel, Wolz, Olaf‐Oliver, Herster, Franziska, Sharma, Lokesh, Dillen, Carly A, Täumer, Christoph, Dickhöfer, Sabine, Bittner, Zsofia, Dang, Truong‐Minh, Singh, Anurag, Haischer, Daniel, Schlöffel, Maria A, Koymans, Kirsten J, Sanmuganantham, Tharmila, Krach, Milena, Roger, Thierry, Le Roy, Didier, Schilling, Nadine A, Frauhammer, Felix, Miller, Lloyd S, Nürnberger, Thorsten, LeibundGut‐Landmann, Salomé, Gust, Andrea A, Macek, Boris, Frank, Martin, Gouttefangeas, Cécile, Dela Cruz, Charles S, Hartl, Dominik, Weber, Alexander NR

“…Chitin is the second most abundant polysaccharide in nature and linked to fungal infection and asthma. However, bona fide immune receptors directly binding…”
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COVID‐19 rapidly increases MDSCs and prolongs innate immune dysfunctions by Schrijver, Irene T., Théroude, Charlotte, Antonakos, Nikolaos, Regina, Jean, Le Roy, Didier, Bart, Pierre‐Alexandre, Chiche, Jean‐Daniel, Perreau, Matthieu, Pantaleo, Giuseppe, Calandra, Thierry, Roger, Thierry

“…We used unsupervised immunophenotyping of blood leukocytes and measured cytokine production by innate immune cell exposed to LPS and R848. We show that…”
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Dual Deletion of the Sirtuins SIRT2 and SIRT3 Impacts on Metabolism and Inflammatory Responses of Macrophages and Protects From Endotoxemia by Heinonen, Tytti, Ciarlo, Eleonora, Rigoni, Ersilia, Regina, Jean, Le Roy, Didier, Roger, Thierry

“…Sirtuin 2 (SIRT2) and SIRT3 are cytoplasmic and mitochondrial NAD-dependent deacetylases. SIRT2 and SIRT3 target proteins involved in metabolic, proliferation…”
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Protection from lethal Gram-negative bacterial sepsis by targeting Toll-like receptor 4 by Roger, Thierry, Froidevaux, Céline, Le Roy, Didier, Reymond, Marlies Knaup, Chanson, Anne-Laure, Mauri, Davide, Burns, Kim, Riederer, Beat Michel, Akira, Shizuo, Calandra, Thierry

“…Toll-like receptor 4 (TLR4), the signal-transducing molecule of the LPS receptor complex, plays a fundamental role in the sensing of LPS from Gram-negative…”
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Trained Immunity Confers Prolonged Protection From Listeriosis by Théroude, Charlotte, Reverte, Marta, Heinonen, Tytti, Ciarlo, Eleonora, Schrijver, Irene T, Antonakos, Nikolaos, Maillard, Nicolas, Pralong, Florian, Le Roy, Didier, Roger, Thierry

“…Trained immunity refers to the ability of the innate immune system exposed to a first challenge to provide an enhanced response to a secondary homologous or…”
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Expression and function of macrophage migration inhibitory factor (MIF) in melioidosis by Wiersinga, W Joost, Calandra, Thierry, Kager, Liesbeth M, van der Windt, Gerritje J W, Roger, Thierry, le Roy, Didier, Florquin, Sandrine, Peacock, Sharon J, Sweep, Fred C G J, van der Poll, Tom

“…Macrophage migration inhibitory factor (MIF) has emerged as a pivotal mediator of innate immunity and has been shown to be an important effector molecule in…”
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