Search Results - "Roxburgh, Campbell S"

Epithelial NOTCH Signaling Rewires the Tumor Microenvironment of Colorectal Cancer to Drive Poor-Prognosis Subtypes and Metastasis by Jackstadt, Rene, van Hooff, Sander R., Leach, Joshua D., Cortes-Lavaud, Xabier, Lohuis, Jeroen O., Ridgway, Rachel A., Wouters, Valérie M., Roper, Jatin, Kendall, Timothy J., Roxburgh, Campbell S., Horgan, Paul G., Nixon, Colin, Nourse, Craig, Gunzer, Matthias, Clark, William, Hedley, Ann, Yilmaz, Omer H., Rashid, Mamunur, Bailey, Peter, Biankin, Andrew V., Campbell, Andrew D., Adams, David J., Barry, Simon T., Steele, Colin W., Medema, Jan Paul, Sansom, Owen J.

“…The metastatic process of colorectal cancer (CRC) is not fully understood and effective therapies are lacking. We show that activation of NOTCH1 signaling in…”
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The prognostic value of systemic inflammation in patients undergoing surgery for colon cancer: comparison of composite ratios and cumulative scores by Dolan, Ross D, McSorley, Stephen T, Park, James H, Watt, David G, Roxburgh, Campbell S, Horgan, Paul G, McMillan, Donald C

“…Introduction The systemic inflammatory response has been proven to have a prognostic value. There are two methods of assessing the systemic inflammatory…”
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Mismatch Repair-Deficient Rectal Cancer and Resistance to Neoadjuvant Chemotherapy by Cercek, Andrea, Dos Santos Fernandes, Gustavo, Roxburgh, Campbell S, Ganesh, Karuna, Ng, Shu, Sanchez-Vega, Francisco, Yaeger, Rona, Segal, Neil H, Reidy-Lagunes, Diane L, Varghese, Anna M, Markowitz, Arnold, Wu, Chao, Szeglin, Bryan, Sauvé, Charles-Etienne Gabriel, Salo-Mullen, Erin, Tran, Christina, Patel, Zalak, Krishnan, Asha, Tkachuk, Kaitlyn, Nash, Garrett M, Guillem, Jose, Paty, Philip B, Shia, Jinru, Schultz, Nikolaus, Garcia-Aguilar, Julio, Diaz, Luis A, Goodman, Karyn, Saltz, Leonard B, Weiser, Martin R, Smith, J Joshua, Stadler, Zsofia K

“…Evaluate response of mismatch repair-deficient (dMMR) rectal cancer to neoadjuvant chemotherapy. dMMR rectal tumors at Memorial Sloan Kettering Cancer Center…”
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Determinants of emergency presentation in patients with colorectal cancer: a systematic review and meta-analysis by Golder, Allan M., McMillan, Donald C., Horgan, Paul G., Roxburgh, Campbell S. D.

“…Colorectal cancer remains a significant cause of morbidity and mortality, even despite curative treatment. A significant proportion of patients present…”
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CT-derived body composition: Differential association with disease, age and inflammation in a retrospective cohort study by Bradley, Nicholas A, McGovern, Josh, Dolan, Ross D, Golder, Allan M, Roxburgh, Campbell S D, Guthrie, Graeme J K, McMillan, Donald C

“…Low skeletal muscle mass and density, as assessed by CT-body composition (CT-BC), are recognised to have prognostic value in non-cancer and cancer patients…”
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Role of systemic inflammatory response in predicting survival in patients with primary operable cancer by Roxburgh, Campbell S D, McMillan, Donald C

“…Disease progression in cancer is dependent on the complex interaction between the tumor and the host inflammatory response. There is substantial evidence in…”
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The relationships between body composition and the systemic inflammatory response in patients with primary operable colorectal cancer by Richards, Colin H, Roxburgh, Campbell S D, MacMillan, Mark T, Isswiasi, Sanad, Robertson, Ewen G, Guthrie, Graeme K, Horgan, Paul G, McMillan, Donald C

“…Weight loss is recognised as a marker of poor prognosis in patients with cancer but the aetiology of cancer cachexia remains unclear. The aim of the present…”
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Signal Transduction and Activator of Transcription-3 (STAT3) in Patients with Colorectal Cancer: Associations with the Phenotypic Features of the Tumor and Host by Park, James H, van Wyk, Hester, McMillan, Donald C, Quinn, Jean, Clark, Jennifer, Roxburgh, Campbell S D, Horgan, Paul G, Edwards, Joanne

“…In patients with colorectal cancer, a high-density local inflammatory infiltrate response is associated with improved survival, whereas elevated systemic…”
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Robotic-assisted surgery for left-sided colon and rectal resections is associated with reduction in the postoperative surgical stress response and improved short-term outcomes: a cohort study by Ingham, Abigail R., Kong, Chia Yew, Wong, Tin-Ning, McSorley, Stephen T., McMillan, Donald C., Nicholson, Gary A., Alani, Ahmed, Mansouri, David, Chong, David, MacKay, Graham J., Roxburgh, Campbell S. D.

“…Introduction There is growing evidence that the use of robotic-assisted surgery (RAS) in colorectal cancer resections is associated with improved short-term…”
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CT-derived body composition and differential association with age, TNM stage and systemic inflammation in patients with colon cancer by Golder, Allan M., Ferguson, Michael, McMillan, Paul, Mansouri, David, Horgan, Paul G., Roxburgh, Campbell S., Dolan, Ross D., McGovern, Josh, McMillan, Donald C.

“…Low skeletal muscle index/density (SMI/SMD) is prevalent in cancer, adversely prognostic and associated with tumour stage and the systemic inflammatory…”
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The Impact of Preoperative Dexamethasone on the Magnitude of the Postoperative Systemic Inflammatory Response and Complications Following Surgery for Colorectal Cancer by McSorley, Stephen T., Roxburgh, Campbell S. D., Horgan, Paul G., McMillan, Donald C.

“…Background The magnitude of the postoperative systemic inflammatory response (SIR), as evidenced by C-reactive protein (CRP), is associated with both short-…”
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The role of faecal calprotectin in diagnosis and staging of colorectal neoplasia: a systematic review and meta-analysis by Ross, Fiona A, Park, James H, Mansouri, David, Combet, Emilie, Horgan, Paul G, McMillan, Donald C, Roxburgh, Campbell S D

“…The presence of inflammation is a key hallmark of cancer and, plays an important role in disease progression and survival in colorectal cancer (CRC)…”
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Comparison of the Prognostic Value of Inflammation-Based Pathologic and Biochemical Criteria in Patients Undergoing Potentially Curative Resection for Colorectal Cancer by ROXBURGH, Campbell S. D, SALMOND, Jonathan M, HORGAN, Paul G, OIEN, Karin A, MCMILLAN, Donald C

“…To examine interrelationships between the local inflammatory response (Klintrup and Jass scores) and the systemic inflammatory response (Glasgow prognostic…”
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Systemic Inflammation and Outcome in 2295 Patients with Stage I–III Colorectal Cancer from Scotland and Norway: First Results from the ScotScan Colorectal Cancer Group by Park, James H., Fuglestad, Anniken J., Køstner, Anne H., Oliwa, Agata, Graham, Janet, Horgan, Paul G., Roxburgh, Campbell S. D., Kersten, Christian, McMillan, Donald C.

“…Background Systemic inflammatory response (SIR) is an adverse prognostic marker in colorectal cancer (CRC) patients. The ScotScan Colorectal Cancer Group was…”
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The clinical utility of the local inflammatory response in colorectal cancer by Richards, Colin H, Roxburgh, Campbell S.D, Powell, Arfon G, Foulis, Alan K, Horgan, Paul G, McMillan, Donald C

“…Abstract Background The host immune response is important in the prevention of tumour progression in solid organ cancers. The aim was to evaluate the clinical…”
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The relationship between anaesthetic technique, clinicopathological characteristics and the magnitude of the postoperative systemic inflammatory response in patients undergoing elective surgery for colon cancer by Alhayyan, Aliah M, McSorley, Stephen T, Kearns, Rachel J, Horgan, Paul G, Roxburgh, Campbell S D, McMillan, Donald C

“…The magnitude of the postoperative systemic inflammatory response (SIR) is now recognised to be associated with both short and long-term outcomes in patients…”
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The Glasgow Microenvironment Score associates with prognosis and adjuvant chemotherapy response in colorectal cancer by Alexander, Peter G., Roseweir, Antonia K., Pennel, Kathryn A. F., van Wyk, Hester C., Powell, Arfon G. M. T., McMillan, Donald C., Horgan, Paul G., Kelly, Caroline, Hay, Jennifer, Sansom, Owen, Harkin, Andrea, Roxburgh, Campbell S. D., Graham, Janet, Church, David N., Tomlinson, Ian, Saunders, Mark, Iveson, Tim J., Edwards, Joanne, Park, James H.

“…Background The Glasgow Microenvironment Score (GMS) combines peritumoural inflammation and tumour stroma percentage to assess interactions between tumour and…”
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Does interleukin-6 link explain the link between tumour necrosis, local and systemic inflammatory responses and outcome in patients with colorectal cancer? by Guthrie, Graeme J.K, Roxburgh, Campbell S.D, Horgan, Paul G, McMillan, Donald C

“…Abstract Cancer-associated inflammation has been identified as a key determinant of disease progression and survival in colorectal cancer. In particular, it…”
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Aortic calcification is associated with non-infective rather than infective postoperative complications following colorectal cancer resection: an observational cohort study by Knight, Katrina A., Fei, Chui Hon, Boland, Kate F., Dolan, Daniel R., Golder, Allan M., McMillan, Donald C., Horgan, Paul G., Black, Douglas H., Park, James H., Roxburgh, Campbell S. D.

“…Objectives Complications following colorectal cancer resection are common. The degree of aortic calcification (AC) on CT has been proposed as a predictor of…”
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The relationship between the mode of presentation, CT‐derived body composition, systemic inflammatory grade and survival in colon cancer by Golder, Allan M., Sin, Ling Kwan Ernest, Alani, Fatima, Alasadi, Ala, Dolan, Ross, Mansouri, David, Horgan, Paul G., McMillan, Donald C., Roxburgh, Campbell S.

“…Background Within colorectal cancer, the systemic inflammatory response (SIR) and CT‐derived body composition, particularly the loss of lean muscle mass, are…”
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