Search Results - "Roxburgh, C. S."

Cancer and systemic inflammation: treat the tumour and treat the host by Roxburgh, C S D, McMillan, D C

“…Determinants of cancer progression and survival are multifactorial and host responses are increasingly appreciated to have a major role. Indeed, the…”
Get full text

The relationship between tumour stroma percentage, the tumour microenvironment and survival in patients with primary operable colorectal cancer by Park, J.H., Richards, C.H., McMillan, D.C., Horgan, P.G., Roxburgh, C.S.D.

“…Tumour stroma percentage (TSP) has previously been reported to predict survival in patients with colorectal cancer (CRC); however, whether this is independent…”
Get full text

Comparison of the prognostic value of longitudinal measurements of systemic inflammation in patients undergoing curative resection of colorectal cancer by Guthrie, G J K, Roxburgh, C S D, Farhan-Alanie, O M, Horgan, P G, McMillan, D C

“…Background: The systemic inflammation-based prognostic scores, modified Glasgow Prognostic Score (mGPS) and the neutrophil-lymphocyte ratio (NLR) are now…”
Get full text

The relationship between pre-operative psoas and skeletal muscle parameters and survival following endovascular aneurysm repair: a systematic review and meta-analysis by Bradley, N. A., Roxburgh, C. S. D., McMillan, D. C., Guthrie, G. J. K.

“…Sarcopenia is characterised by chronically reduced skeletal muscle volume and function, and is determined radiologically by psoas and skeletal muscle…”
Get full text

Circulating IL-6 concentrations link tumour necrosis and systemic and local inflammatory responses in patients undergoing resection for colorectal cancer by Guthrie, G J K, Roxburgh, C S D, Richards, C H, Horgan, P G, McMillan, D C

“…Background: Cancer-associated inflammation, in the form of local and systemic inflammatory responses, appear to be linked to tumour necrosis and have…”
Get full text

The Glasgow Microenvironment Score and risk and site of recurrence in TNM I–III colorectal cancer by Alexander, P. G., van Wyk, H. C., Pennel, K. A. F., Hay, J., McMillan, D. C., Horgan, P. G., Roxburgh, C. S. D., Edwards, J., Park, J. H.

“…Background Glasgow Microenvironment Score (GMS) stratifies long-term survival into three groups based on tumour phenotype: peritumoural inflammation…”
Get full text

The role of dietary polyphenols in the moderation of the inflammatory response in early stage colorectal cancer by Little, C. H., Combet, E., McMillan, D. C., Horgan, P. G., Roxburgh, C. S. D.

“…Current focus in colorectal cancer (CRC) management is on reducing overall mortality by increasing the number of early-stage cancers diagnosed and treated with…”
Get full text

The impact of anti-inflammatory agents on the outcome of patients with colorectal cancer by Park, J.H, McMillan, D.C, Horgan, P.G, Roxburgh, C.S

“…Summary Although there is increasing appreciation of the role of the host inflammatory response in determining outcome in patients in colorectal cancer, there…”
Get full text

Prognostic value of tumour necrosis and host inflammatory responses in colorectal cancer by Richards, C. H., Roxburgh, C. S. D., Anderson, J. H., McKee, R. F., Foulis, A. K., Horgan, P. G., McMillan, D. C.

“…Background: Tumour necrosis is a marker of poor prognosis in some tumours but the mechanism is unclear. This study examined the prognostic value of tumour…”
Get full text

Relationship Between Preoperative Comorbidity, Systemic Inflammatory Response, and Survival in Patients Undergoing Curative Resection for Colorectal Cancer by Roxburgh, C. S. D., Platt, J. J., Leitch, E. F., Kinsella, J., Horgan, P. G., McMillan, D. C.

“…Background Besides tumor characteristics, colorectal cancer (CRC) outcomes are also determined by host factors, in particular the systemic inflammatory…”
Get full text

Organ preservation in rectal cancer: towards the norm rather than the exception by Roxburgh, C S

Get full text

The impact of aspirin, statins and ACE-inhibitors on the presentation of colorectal neoplasia in a colorectal cancer screening programme by Mansouri, D, McMillan, D C, Roxburgh, C S D, Crighton, E M, Horgan, P G

“…Background: There is increasing evidence that aspirin, statins and ACE-inhibitors can reduce the incidence of colorectal cancer. The aim of the present study…”
Get full text

The in situ local immune response, tumour senescence and proliferation in colorectal cancer by Roxburgh, C S, Richards, C H, MacDonald, A I, Powell, A G, McGlynn, L M, McMillan, D C, Horgan, P G, Edwards, J, Shiels, P G

“…Background: Immune cell infiltrates are important determinants of colorectal cancer (CRC) outcome. Their presence may be driven by tumour or host-specific…”
Get full text

The relationships between cellular components of the peritumoural inflammatory response, clinicopathological characteristics and survival in patients with primary operable colorectal cancer by Richards, C H, Flegg, K M, SD Roxburgh, C, Going, J J, Mohammed, Z, Horgan, P G, McMillan, D C

“…Background: The host inflammatory response is an important determinant of cancer outcome. We examined different methods of assessing the local inflammatory…”
Get full text

Trends in pneumonia and empyema in Scottish children in the past 25 years by Roxburgh, C S D, Youngson, G G, Townend, J A, Turner, S W

“…Background:The incidence of childhood empyema, a complication of pneumonia, is increasing, and the underlying mechanisms are not understood. Whether a rise in…”
Get full text

The role of S100 staining in the pathological assessment of perineural invasion in rectal cancer by White, M., Foulis, A. K., Smith, G., Horgan, P. G., Roxburgh, C. S.

Get full text

Comparison of visual and automated assessment of tumour inflammatory infiltrates in patients with colorectal cancer by Forrest, R, Guthrie, G.J.K, Orange, C, Horgan, P.G, McMillan, D.C, Roxburgh, C.S.D

“…Abstract Background Cancer-associated inflammation is increasingly recognised to be an important determinant of oncological outcome. In colorectal cancer, the…”
Get full text

Effect of preoperative oral antibiotics in combination with mechanical bowel preparation on inflammatory response and short‐term outcomes following left‐sided colonic and rectal resections by Golder, A. M., Steele, C. W., Conn, D., MacKay, G. J., McMillan, D. C., Horgan, P. G., Roxburgh, C. S., McSorley, S. T.

“…Background Preoperative oral antibiotics in addition to intravenous antibiotics and mechanical bowel preparation (MBP) may influence the gut microbiome and…”
Get full text

Determinants of short- and long-term outcome in patients undergoing simultaneous resection of colorectal cancer and synchronous colorectal liver metastases by Roxburgh, C. S. D., Richards, C. H., Moug, S. J., Foulis, A. K., McMillan, D. C., Horgan, P. G.

“…Purpose The optimal surgical strategy for patients presenting with colorectal liver metastases has yet to be determined. Short- and long-term outcomes must be…”
Get full text

Comparison of the prognostic value of tumour- and patient-related factors in patients undergoing potentially curative surgery for colon cancer by Roxburgh, C. S. D., Wallace, A. M., Guthrie, G. K., Horgan, P. G., McMillan, D. C.

“…Aim  To comprehensively compare the prognostic value of tumour‐ and patient‐related factors in patients undergoing curative surgery for colon cancer. Method …”
Get full text