Search Results - "Roxburgh, C"

Cancer and systemic inflammation: treat the tumour and treat the host by Roxburgh, C S D, McMillan, D C

“…Determinants of cancer progression and survival are multifactorial and host responses are increasingly appreciated to have a major role. Indeed, the…”
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Organ preservation in rectal cancer: towards the norm rather than the exception by Roxburgh, C S

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The relationship between tumour stroma percentage, the tumour microenvironment and survival in patients with primary operable colorectal cancer by Park, J.H., Richards, C.H., McMillan, D.C., Horgan, P.G., Roxburgh, C.S.D.

“…Tumour stroma percentage (TSP) has previously been reported to predict survival in patients with colorectal cancer (CRC); however, whether this is independent…”
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Comparison of the prognostic value of longitudinal measurements of systemic inflammation in patients undergoing curative resection of colorectal cancer by Guthrie, G J K, Roxburgh, C S D, Farhan-Alanie, O M, Horgan, P G, McMillan, D C

“…Background: The systemic inflammation-based prognostic scores, modified Glasgow Prognostic Score (mGPS) and the neutrophil-lymphocyte ratio (NLR) are now…”
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The role of the in situ local inflammatory response in predicting recurrence and survival in patients with primary operable colorectal cancer by Roxburgh, C.S.D, McMillan, D.C

“…Abstract Colorectal cancer progression and survival is dependent on complex interactions between the tumour and the host. The pronounced local inflammatory…”
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Tumour invasiveness, the local and systemic environment and the basis of staging systems in colorectal cancer by Park, J H, van Wyk, H, Roxburgh, C S D, Horgan, P G, Edwards, J, McMillan, D C

“…Background: The present study aimed to examine the relationship between tumour invasiveness (T stage), the local and systemic environment and cancer-specific…”
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Circulating IL-6 concentrations link tumour necrosis and systemic and local inflammatory responses in patients undergoing resection for colorectal cancer by Guthrie, G J K, Roxburgh, C S D, Richards, C H, Horgan, P G, McMillan, D C

“…Background: Cancer-associated inflammation, in the form of local and systemic inflammatory responses, appear to be linked to tumour necrosis and have…”
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The Glasgow Microenvironment Score and risk and site of recurrence in TNM I–III colorectal cancer by Alexander, P. G., van Wyk, H. C., Pennel, K. A. F., Hay, J., McMillan, D. C., Horgan, P. G., Roxburgh, C. S. D., Edwards, J., Park, J. H.

“…Background Glasgow Microenvironment Score (GMS) stratifies long-term survival into three groups based on tumour phenotype: peritumoural inflammation…”
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The role of dietary polyphenols in the moderation of the inflammatory response in early stage colorectal cancer by Little, C. H., Combet, E., McMillan, D. C., Horgan, P. G., Roxburgh, C. S. D.

“…Current focus in colorectal cancer (CRC) management is on reducing overall mortality by increasing the number of early-stage cancers diagnosed and treated with…”
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The relationship between pre-operative psoas and skeletal muscle parameters and survival following endovascular aneurysm repair: a systematic review and meta-analysis by Bradley, N. A., Roxburgh, C. S. D., McMillan, D. C., Guthrie, G. J. K.

“…Sarcopenia is characterised by chronically reduced skeletal muscle volume and function, and is determined radiologically by psoas and skeletal muscle…”
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Prognostic value of tumour necrosis and host inflammatory responses in colorectal cancer by Richards, C. H., Roxburgh, C. S. D., Anderson, J. H., McKee, R. F., Foulis, A. K., Horgan, P. G., McMillan, D. C.

“…Background: Tumour necrosis is a marker of poor prognosis in some tumours but the mechanism is unclear. This study examined the prognostic value of tumour…”
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The relationships between cellular components of the peritumoural inflammatory response, clinicopathological characteristics and survival in patients with primary operable colorectal cancer by Richards, C H, Flegg, K M, SD Roxburgh, C, Going, J J, Mohammed, Z, Horgan, P G, McMillan, D C

“…Background: The host inflammatory response is an important determinant of cancer outcome. We examined different methods of assessing the local inflammatory…”
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The impact of anti-inflammatory agents on the outcome of patients with colorectal cancer by Park, J.H, McMillan, D.C, Horgan, P.G, Roxburgh, C.S

“…Summary Although there is increasing appreciation of the role of the host inflammatory response in determining outcome in patients in colorectal cancer, there…”
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Surgical outcome in patients undergoing reversal of Hartmann's procedures: a multicentre study by Richards, C. H., Roxburgh, C. S. D.

“…Aim Recent evidence has suggested that a laparoscopic rather than an open approach to reversal of Hartmann's procedure (ROH) may be associated with fewer…”
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Relationship Between Preoperative Comorbidity, Systemic Inflammatory Response, and Survival in Patients Undergoing Curative Resection for Colorectal Cancer by Roxburgh, C. S. D., Platt, J. J., Leitch, E. F., Kinsella, J., Horgan, P. G., McMillan, D. C.

“…Background Besides tumor characteristics, colorectal cancer (CRC) outcomes are also determined by host factors, in particular the systemic inflammatory…”
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The impact of aspirin, statins and ACE-inhibitors on the presentation of colorectal neoplasia in a colorectal cancer screening programme by Mansouri, D, McMillan, D C, Roxburgh, C S D, Crighton, E M, Horgan, P G

“…Background: There is increasing evidence that aspirin, statins and ACE-inhibitors can reduce the incidence of colorectal cancer. The aim of the present study…”
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Route to diagnosis of colorectal cancer and association with survival within the context of a bowel screening programme by Golder, A.M., Mshihadani, A., McMillan, D.C., Horgan, P.G., Roxburgh, C.S., Mansouri, D.

“…Bowel cancer screening has been introduced to improve colorectal cancer outcomes; however, a significant proportion of cases continue to present with TNM Stage…”
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Trends in pneumonia and empyema in Scottish children in the past 25 years by Roxburgh, C S D, Youngson, G G, Townend, J A, Turner, S W

“…Background:The incidence of childhood empyema, a complication of pneumonia, is increasing, and the underlying mechanisms are not understood. Whether a rise in…”
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The relationship between aortic calcification and anastomotic leak following gastrointestinal resection: A systematic review by Knight, K.A., Horgan, P.G., McMillan, D.C., Roxburgh, C.S.D., Park, J.H.

“…Anastomotic leak (AL) is a significant complication of gastrointestinal (GI) surgery. Impaired perfusion of the anastomosis is thought to play an important…”
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Comment on ‘Tumour-infiltrating inflammation and prognosis in colorectal cancer: systematic review and meta-analysis’ by Park, J H, Roxburgh, C S D, McMillan, D C

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