Search Results - "Roxana, O."

Vascular, glial, and lymphatic immune gateways of the central nervous system by Engelhardt, Britta, Carare, Roxana O., Bechmann, Ingo, Flügel, Alexander, Laman, Jon D., Weller, Roy O.

“…Immune privilege of the central nervous system (CNS) has been ascribed to the presence of a blood–brain barrier and the lack of lymphatic vessels within the…”
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The meninges as barriers and facilitators for the movement of fluid, cells and pathogens related to the rodent and human CNS by Weller, Roy O., Sharp, Matthew M., Christodoulides, Myron, Carare, Roxana O., Møllgård, Kjeld

“…Meninges that surround the CNS consist of an outer fibrous sheet of dura mater (pachymeninx) that is also the inner periosteum of the skull. Underlying the…”
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Physiology and Clinical Relevance of Enlarged Perivascular Spaces in the Aging Brain by Bown, Corey W., Carare, Roxana O., Schrag, Matthew S., Jefferson, Angela L.

“…Perivascular spaces (PVS) are fluid-filled compartments that are part of the cerebral blood vessel wall and represent the conduit for fluid transport in and…”
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Cerebrovascular Smooth Muscle Cells as the Drivers of Intramural Periarterial Drainage of the Brain by Aldea, Roxana, Weller, Roy O, Wilcock, Donna M, Carare, Roxana O, Richardson, Giles

“…The human brain is the organ with the highest metabolic activity but it lacks a traditional lymphatic system responsible for clearing waste products. We have…”
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Neurofilaments: neurobiological foundations for biomarker applications by Gafson, Arie R, Barthélemy, Nicolas R, Bomont, Pascale, Carare, Roxana O, Durham, Heather D, Julien, Jean-Pierre, Kuhle, Jens, Leppert, David, Nixon, Ralph A, Weller, Roy O, Zetterberg, Henrik, Matthews, Paul M

“…Interest in neurofilaments has risen sharply in recent years with recognition of their potential as biomarkers of brain injury or neurodegeneration in CSF and…”
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Convective influx/glymphatic system: tracers injected into the CSF enter and leave the brain along separate periarterial basement membrane pathways by Albargothy, Nazira J., Johnston, David A., MacGregor-Sharp, Matthew, Weller, Roy O., Verma, Ajay, Hawkes, Cheryl A., Carare, Roxana O.

“…Tracers injected into CSF pass into the brain alongside arteries and out again. This has been recently termed the “glymphatic system” that proposes tracers…”
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Lymphatic Clearance of the Brain: Perivascular, Paravascular and Significance for Neurodegenerative Diseases by Bakker, Erik N. T. P., Bacskai, Brian J., Arbel-Ornath, Michal, Aldea, Roxana, Bedussi, Beatrice, Morris, Alan W. J., Weller, Roy O., Carare, Roxana O.

“…The lymphatic clearance pathways of the brain are different compared to the other organs of the body and have been the subject of heated debates. Drainage of…”
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Clearance systems in the brain—implications for Alzheimer disease by Tarasoff-Conway, Jenna M., Carare, Roxana O., Osorio, Ricardo S., Glodzik, Lidia, Butler, Tracy, Fieremans, Els, Axel, Leon, Rusinek, Henry, Nicholson, Charles, Zlokovic, Berislav V., Frangione, Blas, Blennow, Kaj, Ménard, Joël, Zetterberg, Henrik, Wisniewski, Thomas, de Leon, Mony J.

“…Key Points Accumulation of neurotoxic forms of amyloid-β (Aβ) and tau proteins is the pathological hallmark of Alzheimer disease (AD) Excess deposition of Aβ…”
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Lymphatic drainage of the brain and the pathophysiology of neurological disease by Weller, Roy O., Djuanda, Effie, Yow, Hong-Yeen, Carare, Roxana O.

“…There are no conventional lymphatics in the brain but physiological studies have revealed a substantial and immunologically significant lymphatic drainage from…”
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Brain intra- and extracellular sodium concentration in multiple sclerosis: a 7 T MRI study by Petracca, Maria, Vancea, Roxana O, Fleysher, Lazar, Jonkman, Laura E, Oesingmann, Niels, Inglese, Matilde

“…Intra-axonal accumulation of sodium ions is one of the key mechanisms of delayed neuro-axonal degeneration that contributes to disability accrual in multiple…”
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White Matter Changes in Dementia: Role of Impaired Drainage of Interstitial Fluid by Weller, Roy O., Hawkes, Cheryl A., Kalaria, Raj N., Werring, David J., Carare, Roxana O.

“…White matter abnormalities on magnetic resonance imaging (MRI) are associated with dementia and include white matter hyperintensities (WMH; also termed…”
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A control mechanism for intra-mural peri-arterial drainage via astrocytes: How neuronal activity could improve waste clearance from the brain by Diem, Alexandra K, Carare, Roxana O, Weller, Roy O, Bressloff, Neil W

“…The mechanisms behind the clearance of soluble waste from deep within the parenchyma of the brain remain unclear. Experimental evidence reveals that one…”
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Monomeric C‐reactive protein: A novel biomarker predicting neurodegenerative disease and vascular dysfunction by Pastorello, Ylenia, Carare, Roxana O., Banescu, Claudia, Potempa, Lawrence, Di Napoli, Mario, Slevin, Mark

“…Circulating C‐reactive protein (pCRP) concentrations rise dramatically during both acute (e.g., following stroke) or chronic infection and disease (e.g.,…”
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Loss of clusterin shifts amyloid deposition to the cerebrovasculature via disruption of perivascular drainage pathways by Wojtas, Aleksandra M., Kang, Silvia S., Olley, Benjamin M., Gatherer, Maureen, Shinohara, Mitsuru, Lozano, Patricia A., Liu, Chia-Chen, Kurti, Aishe, Baker, Kelsey E., Dickson, Dennis W., Yue, Mei, Petrucelli, Leonard, Bu, Guojun, Carare, Roxana O., Fryer, John D.

“…Alzheimer’s disease (AD) is characterized by amyloid-β (Aβ) peptide deposition in brain parenchyma as plaques and in cerebral blood vessels as cerebral amyloid…”
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Cerebrospinal Fluid Clearance in Alzheimer Disease Measured with Dynamic PET by de Leon, Mony J, Li, Yi, Okamura, Nobuyuki, Tsui, Wai H, Saint-Louis, Les A, Glodzik, Lidia, Osorio, Ricardo S, Fortea, Juan, Butler, Tracy, Pirraglia, Elizabeth, Fossati, Silvia, Kim, Hee-Jin, Carare, Roxana O, Nedergaard, Maiken, Benveniste, Helene, Rusinek, Henry

“…Evidence supporting the hypothesis that reduced cerebrospinal fluid (CSF) clearance is involved in the pathophysiology of Alzheimer disease (AD) comes…”
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Vascular basement membranes as pathways for the passage of fluid into and out of the brain by Morris, Alan W. J., Sharp, Matthew MacGregor, Albargothy, Nazira J., Fernandes, Rute, Hawkes, Cheryl A., Verma, Ajay, Weller, Roy O., Carare, Roxana O.

“…In the absence of conventional lymphatics, drainage of interstitial fluid and solutes from the brain parenchyma to cervical lymph nodes is along basement…”
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In memoriam, Roy Weller (1938–2022) by Carare, Roxana O., Engelhardt, Britta, Perry, Victor Hugh, Kalaria, Raj

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The association between hypertensive arteriopathy and cerebral amyloid angiopathy in spontaneously hypertensive stroke‐prone rats by Jandke, Solveig, Garz, Cornelia, Schwanke, Daniel, Sendtner, Michael, Heinze, Hans‐Jochen, Carare, Roxana O., Schreiber, Stefanie

“…We aimed to test the hypothesis that in spontaneously hypertensive stroke‐prone rats (SHRSP), non‐amyloid cerebral small vessel disease/hypertensive…”
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Failure of Perivascular Drainage of β-amyloid in Cerebral Amyloid Angiopathy by Hawkes, Cheryl A., Jayakody, Nimeshi, Johnston, David A., Bechmann, Ingo, Carare, Roxana O.

“…In Alzheimer's disease, amyloid‐β (Aβ) accumulates as insoluble plaques in the brain and deposits in blood vessel walls as cerebral amyloid angiopathy (CAA)…”
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Disruption of arterial perivascular drainage of amyloid-β from the brains of mice expressing the human APOE ε4 allele by Hawkes, Cheryl A, Sullivan, Patrick M, Hands, Sarah, Weller, Roy O, Nicoll, James A R, Carare, Roxana O

“…Failure of elimination of amyloid-β (Aβ) from the brain and vasculature appears to be a key factor in the etiology of sporadic Alzheimer's disease (AD) and…”
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