Search Results - "Rowlinson, S.W."

Initial cohort expansion results of sustained arginine depletion with pegzilarginase in melanoma patients in a phase I advanced solid tumor trial by Chmielowski, B., Gordon, M., Buchbinder, E.I., Sullivan, R.J., Cohen, J.V., Curti, B.D., Davar, D., Homsi, J., Komatsubara, K.M., Lara-Guerra, H., Alters, S.E., Ferrati, S., Eckert, S., Rowlinson, S.W., Wooldridge, J.E., Ribas, A., Carvajal, R.D.

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A growth hormone agonist produced by targeted mutagenesis at binding site 1: evidence that site 1 regulates bioactivity by Rowlinson, S.W. (University of Queensland, Brisbane, Queensland, Australia.), Barnard, R, Bastiras, S, Robins, A.J, Brinkworth, R, Waters, M.J

“…Growth hormone (GH) is believed to signal by dimerizing its receptor through two binding sites on the hormone. Previous attempts to increase the biopotency of…”
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Large-scale preparation and characterization of recombinant ovine placental lactogen by Sakal, E, Bignon, C, Grosclaude, J, Kantor, A, Shapira, R, Leibovitch, H, Helman, D, Nespoulous, C, Shamay, A, Rowlinson, S W, Djiane, J, Gertler, A

“…To clone ovine placental lactogen (oPL) cDNA, total RNA from sheep placental cotyledon was reverse transcribed and the single-stranded cDNA was PCR-amplified…”
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Signal transduction by the growth hormone receptor by Waters, M J, Rowlinson, S W, Clarkson, R W, Chen, C M, Lobie, P E, Norstedt, G, Mertani, H, Morel, G, Brinkworth, R, Wells, C A

“…It has been proposed that dimerization of identical receptor subunits by growth hormone (GH) is the mechanism of signal transduction across the cell membrane…”
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Evidence for Involvement of the Carboxy Terminus of Helix 1 of Growth Hormone in Receptor Binding: Use of Charge Reversal Mutagenesis to Account for Calcium Dependence of Binding and for Design of Higher Affinity Analogs by Rowlinson, Scott W, Barnard, Ross, Bastiras, Stan, Robins, Allan J, Senn, Carol, Wells, Julian R. E, Brinkworth, Ross, Waters, Michael J

“…In this study we have demonstrated that the C-terminus of helix 1 of porcine GH (pGH) is a receptor-interactive region, thus extending the current binding site…”
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An electrostatic model for the interaction between growth hormone and its receptor involving chelation of Ca2+ to the human growth hormone molecule by Barnard, R, Rowlinson, S W, Waters, M J

“…We previously postulated the local involvement of cations in the complex between human growth hormone and its receptors in the liver. The original…”
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