Search Results - "Rowley, Kirk"

Structure-Guided Design of an Anti-dengue Antibody Directed to a Non-immunodominant Epitope by Robinson, Luke N., Tharakaraman, Kannan, Rowley, Kirk J., Costa, Vivian V., Chan, Kuan Rong, Wong, Yee Hwa, Ong, Li Ching, Tan, Hwee Cheng, Koch, Tyree, Cain, David, Kirloskar, Rama, Viswanathan, Karthik, Liew, Chong Wai, Tissire, Hamid, Ramakrishnan, Boopathy, Myette, James R., Babcock, Gregory J., Sasisekharan, V., Alonso, Sylvie, Chen, Jianzhu, Lescar, Julien, Shriver, Zachary, Ooi, Eng Eong, Sasisekharan, Ram

“…Dengue is the most common vector-borne viral disease, causing nearly 400 million infections yearly. Currently there are no approved therapies. Antibody…”
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Neutralization of antibody-enhanced dengue infection by VIS513, a pan serotype reactive monoclonal antibody targeting domain III of the dengue E protein by Budigi, Yadunanda, Ong, Eugenia Z, Robinson, Luke N, Ong, Li Ching, Rowley, Kirk J, Winnett, Alexander, Tan, Hwee Cheng, Hobbie, Sven, Shriver, Zachary, Babcock, Gregory J, Alonso, Sylvie, Ooi, Eng Eong

“…Dengue virus (DENV) infection imposes enormous health and economic burden worldwide with no approved treatment. Several small molecules, including lovastatin,…”
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Human monoclonal antibody HCV1 effectively prevents and treats HCV infection in chimpanzees by Morin, Trevor J, Broering, Teresa J, Leav, Brett A, Blair, Barbra M, Rowley, Kirk J, Boucher, Elisabeth N, Wang, Yang, Cheslock, Peter S, Knauber, Michael, Olsen, David B, Ludmerer, Steve W, Szabo, Gyongyi, Finberg, Robert W, Purcell, Robert H, Lanford, Robert E, Ambrosino, Donna M, Molrine, Deborah C, Babcock, Gregory J

“…Hepatitis C virus (HCV) infection is a leading cause of liver transplantation and there is an urgent need to develop therapies to reduce rates of HCV infection…”
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Preclinical evaluation of VIS513, a therapeutic antibody against dengue virus, in non-human primates by Ong, Eugenia Z., Budigi, Yadunanda, Tan, Hwee Cheng, Robinson, Luke N., Rowley, Kirk J., Winnett, Alexander, Hobbie, Sven, Shriver, Zachary, Babcock, Gregory J., Ooi, Eng Eong

“…Despite useful in vivo activity, no therapeutic against dengue virus (DENV) has demonstrated efficacy in clinical trials. Herein, we explored dosing and…”
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Identification of a Human Monoclonal Antibody To Replace Equine Diphtheria Antitoxin for Treatment of Diphtheria Intoxication by Sevigny, Leila M, Booth, Brian J, Rowley, Kirk J, Leav, Brett A, Cheslock, Peter S, Garrity, Kerry A, Sloan, Susan E, Thomas, Jr, William, Babcock, Gregory J, Wang, Yang

“…Classifications Services IAI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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High-throughput sequencing analysis of post-liver transplantation HCV E2 glycoprotein evolution in the presence and absence of neutralizing monoclonal antibody by Babcock, Gregory J, Iyer, Sowmya, Smith, Heidi L, Wang, Yang, Rowley, Kirk, Ambrosino, Donna M, Zamore, Phillip D, Pierce, Brian G, Molrine, Deborah C, Weng, Zhiping

“…Chronic hepatitis C virus (HCV) infection is the most common cause of end-stage liver disease, often leading to liver transplantation, in which case…”
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Identification and characterization of a human monoclonal antibody that potently neutralizes a broad panel of rabies virus isolates by Sloan, Susan E, Hanlon, Cathleen, Weldon, William, Niezgoda, Michael, Blanton, Jesse, Self, Josh, Rowley, Kirk J, Mandell, Robert B, Babcock, Gregory J, Thomas, William D, Rupprecht, Charles E, Ambrosino, Donna M

“…Abstract Rabies is a zoonosis that results in millions of human exposures worldwide each year. Human monoclonal antibodies (HuMAbs) that neutralize rabies…”
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G glycoprotein amino acid residues required for human monoclonal antibody RAB1 neutralization are conserved in rabies virus street isolates by Wang, Yang, Rowley, Kirk J., Booth, Brian J., Sloan, Susan E., Ambrosino, Donna M., Babcock, Gregory J.

“…Replacement of polyclonal anti-rabies immunoglobulin (RIG) used in rabies post-exposure prophylaxis (PEP) with a monoclonal antibody will eliminate cost and…”
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