Search Results - "Rowley, Ellen R"

Structure−Activity Relationships of Selective Estrogen Receptor Modulators:  Modifications to the 2-Arylbenzothiophene Core of Raloxifene by Grese, Timothy A, Cho, Stephen, Finley, Don R, Godfrey, Alexander G, Jones, Charles D, Lugar, Charles W, Martin, Michael J, Matsumoto, Ken, Pennington, Lewis D, Winter, Mark A, Adrian, M. Dee, Cole, Harlan W, Magee, David E, Phillips, D. Lynn, Rowley, Ellen R, Short, Lorri L, Glasebrook, Andrew L, Bryant, Henry U

“…The 2-arylbenzothiophene raloxifene, 1, is a selective estrogen receptor modulator which is currently under clinical evaluation for the prevention and…”
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Effects of prolonged ethinyl estradiol treatment on calcium channel binding and in vivo calcium-mediated hemodynamic responses in ovariectomized rats by Bowling, N, Bloomquist, W E, Cohen, M L, Bryant, H U, Cole, H W, Magee, D E, Rowley, E R, Vlahos, C J

“…Ethinyl estradiol (EE2), administered orally to ovariectomized (ovex) rats, has been shown to prevent loss of bone mineral density and to decrease serum…”
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Synthesis and pharmacology of 2-alkyl raloxifene analogs by Grese, Timothy A., Cho, Stephen, Bryant, Henry U., Cole, Harlan W., Glasebrook, Andrew L., Magee, David E., Phillips, D.Lynn, Rowley, Ellen R., Short, Lorri L.

“…A series of 2-alkyl and 2-cycloalkyl raloxifene analogs have been prepared and evaluated in both in vitro and in vivo models of estrogen/antiestrogen activity…”
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Raloxifene (LY139481 HCl) prevents bone loss and reduces serum cholesterol without causing uterine hypertrophy in ovariectomized rats by BLACK, L. J, SATO, M, FROLIK, C. A, TERMINE, J. D, BRYANT, H. U, ROWLEY, E. R, MAGEE, D. E, BEKELE, A, WILLIAMS, D. C, CULLINAN, G. J, BENDELE, R, KAUFFMAN, R. F, BENSCH, W. R

“…There is a medical need for an agent with the positive effects of estrogen on bone and the cardiovascular system, but without the negative effects on…”
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Synthesis and Pharmacology of Conformationally Restricted Raloxifene Analogues:  Highly Potent Selective Estrogen Receptor Modulators by Grese, Timothy A., Pennington, Lewis D., Sluka, James P., Adrian, M. Dee, Cole, Harlan W., Fuson, Tina R., Magee, David E., Phillips, D. Lynn, Rowley, Ellen R., Shetler, Pamela K., Short, Lorri L., Venugopalan, Murali, Yang, Na N., Sato, Masahiko, Glasebrook, Andrew L., Bryant, Henry U.

“…The 2-arylbenzothiophene raloxifene, 1, is a selective estrogen receptor modulator (SERM) which is currently under clinical evaluation for the prevention and…”
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Benzopyran selective estrogen receptor modulators (SERMs): Pharmacological effects and structural correlation with raloxifene by Grese, Timothy A., Sluka, James P., Bryant, Henry U., Cole, Harlan W., Kim, John R., Magee, David E., Rowley, Ellen R., Sato, Masahiko

“…Several 2,3-diarylbenzopyrans have been evaluated in an ovariectomized rat model and found to exhibit tissue selective estrogen agonist activity on bone and…”
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