Search Results - "Rowland, Robert T."

Potential gene therapy strategies in the treatment of cardiovascular disease by Rowland, Robert T., Cleveland, Joseph C., Meng, Xianzhong, Harken, Alden H., Brown, James M.

“…Gene therapy is the introduction of new genetic material into somatic cells to synthesize missing or defective proteins. Efficient methods for the introduction…”
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Preconditioning and Hypothermic Cardioplegia Protect Human Heart Equally Against Ischemia by Cleveland, MD, Joseph C, Meldrum, MD, Daniel R, Rowland, MD, Robert T, Banerjee, PhD, Anirban, Harken, MD, Alden H

“…Background. The purpose of this study was to determine whether transient ischemic preconditioning protects human myocardium against normothermic ischemic…”
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Early and delayed preconditioning: differential mechanisms and additive protection by Meldrum, D R, Cleveland, Jr, J C, Rowland, R T, Banerjee, A, Harken, A H, Meng, X

“…The purposes of this study were to determine whether 1) 24-h endotoxin (ETX) pretreatment induces delayed ("second window") myocardial protection against…”
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Cardiac preconditioning with calcium: Clinically accessible myocardial protection by Meldrum, Daniel R., Cleveland, Joseph C., Sheridan, Brett C., Rowland, Robert T., Banerjee, Anirban, Harken, Alden H.

“…Cardiac preconditioning is mediated by protein kinase C. Although endogenous calcium is a potent stimulus of protein kinase C, it remains unknown whether…”
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Myocardial gene reprogramming associated with a cardiac cross-resistant state induced by LPS preconditioning by Meng, X, Brown, J M, Ao, L, Rowland, R T, Nordeen, S K, Banerjee, A, Harken, A H

“…Lipopolysaccharide (LPS) preconditioning induces cardiac resistance to subsequent LPS or ischemia. This study tested the hypothesis that resistance to LPS and…”
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Cardiac surgical implications of calcium dyshomeostasis in the heart by Meldrum, Daniel R., Cleveland, Joseph C., Sheridan, Brett C., Rowland, Robert T., Banerjee, Anirban, Harken, Alden H.

“…The prevalence of coronary artery disease renders myocardial ischemia a leading cause of morbidity and mortality. Both cardiac bypass operations and cardiac…”
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LPS-induced delayed myocardial adaptation enhances acute preconditioning to optimize postischemic cardiac function by Rowland, R T, Meng, X, Cleveland, Jr, J C, Meldrum, D R, Harken, A H, Brown, J M

“…Myocardial tolerance to ischemia and reperfusion (I/R) injury can be achieved by either acute or delayed cardioprotective mechanisms. Ischemic preconditioning…”
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Optimal myocardial preservation: Cooling, cardioplegia, and conditioning by Cleveland, Joseph C., Meldrum, Daniel R., Rowland, Robert T., Banerjee, Anirban, Harken, Alden H.

“…Myocardial preservation techniques have evolved in conjunction with cardiac surgery and currently offer substantial protection against myocardial injury. We…”
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Cardioadaptation Induced by Cyclic Ischemic Preconditioning Is Mediated by Translational Regulation ofde NovoProtein Synthesis by Rowland, Robert T., Meng, Xianzhong, Cleveland, Joseph C., Meldrum, Daniel R., Harken, Alden H., Brown, James M.

“…Repetitive episodes of brief ischemia induce myocardial adaptation to prolonged ischemia. To investigate whether this myocardial adaptive response involves…”
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Adenosine Preconditioning of Human Myocardium is Dependent upon the ATP-sensitive K+Channel by Cleveland, Jr, Joseph C., Meldrum, Daniel R., Rowland, Robert T., Banerjee, Anirban, Harken, Alden H.

“…Evidence supports the involvement of adenosine receptor stimulation and activation of KATPchannels in ischemic preconditioning of human myocardium. It is…”
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Ischemic preconditioning in human and rat ventricle by Cleveland, Jr, J C, Wollmering, M M, Meldrum, D R, Rowland, R T, Rehring, T F, Sheridan, B C, Harken, A H, Banerjee, A

“…The signal transduction of ischemic preconditioning involves activation of endogenous receptor-based systems, including alpha 1-adrenoceptors and adenosine…”
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Norepinephrine-induced Sustained Myocardial Adaptation to Ischemia is Dependent on α1-Adrenoceptors and Protein Synthesis by Meng, Xianzhong, Cleveland, Joseph C., Rowland, Robert T., Mitchell, Max B., Brown, James M., Banerjee, Anirban, Harken, Alden H.

“…The authors have shown that stimulation of cardiac α 1-adrenoceptors confers immediate cardioprotection in the isolated rat heart against post-ischemic…”
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Cardioadaptation induced by cyclic ischemic preconditioning is mediated by translational regulation of de novo protein synthesis by ROWLAND, R. T, MENG, X, CLEVELAND, J. C, MELDRUM, D. R, HARKEN, A. H, BROWN, J. M

“…Repetitive episodes of brief ischemia induce myocardial adaptation to prolonged ischemia. To investigate whether this myocardial adaptive response involves…”
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Constructive priming of myocardium against ischemia-reperfusion injury by Meldrum, D R, Cleveland, Jr, J C, Mitchell, M B, Rowland, R T, Banerjee, A, Harken, A H

“…Ischemia and ischemic stress hormones induce endogenous cardiac protection against ischemia-reperfusion (I/R) injury. Although ischemia and ischemic stress…”
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The obligate role of protein kinase C in mediating clinically accessible cardiac preconditioning by Cleveland, Joseph C., Meldrum, Daniel R., Rowland, Robert T., Sheridan, Brett C., Banerjee, Anirban, Harken, Alden H.

“…Background Cardiac preconditioning is an adaptation of cardiomyocytes that promotes tolerance to a subsequent ischemic insult. Adenosine receptor signaling is…”
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Transportation or Noise Is Associated with Tolerance to Myocardial Ischemia and Reperfusion Injury by Rowland, Robert T., Cleveland, Joseph C., Upadhya, Prakash, Harken, Alden H., Brown, James M.

“…Myocardial stress can result in myocellular phenotypic changes including enhanced activity of antioxidant enzyme systems. Accordingly, endogenous tissue…”
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α-Adrenergic Activation of Myocardial NFκB during Hemorrhage by Meldrum, Daniel R., Cleveland, Joseph C., Sheridan, Brett C., Rowland, Robert T., Selzman, Craig H., Banerjee, Anirban, Harken, Alden H.

“…Hemorrhage and resuscitation has been recognized as an exclusively destructive process which results in multiple organ dysfunction. Although it is well…”
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A Single Endotoxin Challenge Induces Delayed Myocardial Protection against Infarction by Rowland, Robert T., Cleveland, Jr, Joseph C., Meng, Xianzhong, Ao, Lihua, Harken, Alden H., Brown, James M.

“…Sublethal endotoxemia attenuates cardiac functional injury from global ischemia but it is unknown whether endotoxemia can protect myocardium against…”
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Calcium-Induced Inotropy Is in Part Mediated by Protein Kinase C by Meldrum, Daniel R., Cleveland, Jr, Joseph C., Rowland, Robert T., Banerjee, Anirban, Harken, Alden H.

“…Protein kinase C (PKC) is an ubiquitous regulatory enzyme with dense myocardial distribution and activity; however, its physiologic relevance to myocardial…”
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Differential Effects of Adenosine Preconditioning on the Postischemic Rat Myocardium by Meldrum, Daniel R., Cleveland, Jr, Joseph C., Sheridan, Brett C., Rowland, Robert T., Banerjee, Anirban, Harken, Alden H.

“…Ischemic preconditioning describes the phenomenon of endogenous myocardial protection against sustained ischemia-reperfusion injury (I/R). Although the complex…”
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