Search Results - "Rowland, Leslie A."

The role of skeletal-muscle-based thermogenic mechanisms in vertebrate endothermy by Rowland, Leslie A., Bal, Naresh C., Periasamy, Muthu

“…ABSTRACT Thermogenesis is one of the most important homeostatic mechanisms that evolved during vertebrate evolution. Despite its importance for the survival of…”
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Both brown adipose tissue and skeletal muscle thermogenesis processes are activated during mild to severe cold adaptation in mice by Bal, Naresh C., Singh, Sushant, Reis, Felipe C.G., Maurya, Santosh K., Pani, Sunil, Rowland, Leslie A., Periasamy, Muthu

“…Thermogenesis is an important homeostatic mechanism essential for survival and normal physiological functions in mammals. Both brown adipose tissue (BAT) (i.e…”
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Sarcolipin is a newly identified regulator of muscle-based thermogenesis in mammals by Bal, Naresh C, Maurya, Santosh K, Sopariwala, Danesh H, Sahoo, Sanjaya K, Gupta, Subash C, Shaikh, Sana A, Pant, Meghna, Rowland, Leslie A, Bombardier, Eric, Goonasekera, Sanjeewa A, Tupling, A Russell, Molkentin, Jeffery D, Periasamy, Muthu

“…Animals use their muscles to shiver to generate heat when exposed to the cold. But this is a short-term adaptation. Long term, it is believed the body relies…”
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Sarcolipin Is a Key Determinant of the Basal Metabolic Rate, and Its Overexpression Enhances Energy Expenditure and Resistance against Diet-induced Obesity by Maurya, Santosh K., Bal, Naresh C., Sopariwala, Danesh H., Pant, Meghna, Rowland, Leslie A., Shaikh, Sana A., Periasamy, Muthu

“…Sarcolipin (SLN) is a novel regulator of sarcoplasmic reticulum Ca2+ ATPase (SERCA) in muscle. SLN binding to SERCA uncouples Ca2+ transport from ATP…”
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Paternal Exercise Improves Glucose Metabolism in Adult Offspring by Stanford, Kristin I, Rasmussen, Morten, Baer, Lisa A, Lehnig, Adam C, Rowland, Leslie A, White, Joseph D, So, Kawai, De Sousa-Coelho, Ana Luisa, Hirshman, Michael F, Patti, Mary-Elizabeth, Rando, Oliver J, Goodyear, Laurie J

“…Poor paternal diet has emerged as a risk factor for metabolic disease in offspring, and alterations in sperm may be a major mechanism mediating these…”
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De novo lipogenesis fuels adipocyte autophagosome and lysosome membrane dynamics by Rowland, Leslie A., Guilherme, Adilson, Henriques, Felipe, DiMarzio, Chloe, Munroe, Sean, Wetoska, Nicole, Kelly, Mark, Reddig, Keith, Hendricks, Gregory, Pan, Meixia, Han, Xianlin, Ilkayeva, Olga R., Newgard, Christopher B., Czech, Michael P.

“…Adipocytes robustly synthesize fatty acids (FA) from carbohydrate through the de novo lipogenesis (DNL) pathway, yet surprisingly DNL contributes little to…”
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Single-Cell RNA Profiling Reveals Adipocyte to Macrophage Signaling Sufficient to Enhance Thermogenesis by Henriques, Felipe, Bedard, Alexander H., Guilherme, Adilson, Kelly, Mark, Chi, Jingyi, Zhang, Peng, Lifshitz, Lawrence M., Bellvé, Karl, Rowland, Leslie A., Yenilmez, Batuhan, Kumar, Shreya, Wang, Yetao, Luban, Jeremy, Weinstein, Lee S., Lin, Jiandie D., Cohen, Paul, Czech, Michael P.

“…Adipocytes deficient in fatty acid synthase (iAdFASNKO) emit signals that mimic cold exposure to enhance the appearance of thermogenic beige adipocytes in…”
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Acetyl-CoA carboxylase 1 is a suppressor of the adipocyte thermogenic program by Guilherme, Adilson, Rowland, Leslie A., Wetoska, Nicole, Tsagkaraki, Emmanouela, Santos, Kaltinaitis B., Bedard, Alexander H., Henriques, Felipe, Kelly, Mark, Munroe, Sean, Pedersen, David J., Ilkayeva, Olga R., Koves, Timothy R., Tauer, Lauren, Pan, Meixia, Han, Xianlin, Kim, Jason K., Newgard, Christopher B., Muoio, Deborah M., Czech, Michael P.

“…Disruption of adipocyte de novo lipogenesis (DNL) by deletion of fatty acid synthase (FASN) in mice induces browning in inguinal white adipose tissue (iWAT)…”
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Crosstalk between corepressor NRIP1 and cAMP signaling on adipocyte thermogenic programming by Tsagkaraki, Emmanouela, Guilherme, Adilson, Nicoloro, Sarah M., Kelly, Mark, Lifshitz, Lawrence M., Wang, Hui, Min, Kyounghee, Rowland, Leslie A., Santos, Kaltinaitis B., Wetoska, Nicole, Friedline, Randall H., Maitland, Stacy A., Chen, Min, Weinstein, Lee S., Wolfe, Scot A., Kim, Jason K., Czech, Michael P.

“…Nuclear receptor interacting protein 1 (NRIP1) suppresses energy expenditure via repression of nuclear receptors, and its depletion markedly elevates uncoupled…”
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The adipocyte supersystem of insulin and cAMP signaling by Guilherme, Adilson, Rowland, Leslie A., Wang, Hui, Czech, Michael P.

“…Adipose tissue signals to brain, liver, and muscles to control whole body metabolism through secreted lipid and protein factors as well as neurotransmission,…”
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Uncoupling Protein 1 and Sarcolipin Are Required to Maintain Optimal Thermogenesis, and Loss of Both Systems Compromises Survival of Mice under Cold Stress by Rowland, Leslie A., Bal, Naresh C., Kozak, Leslie P., Periasamy, Muthu

“…The importance of brown adipose tissue as a site of nonshivering thermogenesis has been well documented. Emerging studies suggest that skeletal muscle is also…”
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Fatty acid availability controls autophagy and associated cell functions by Rowland, Leslie A., Czech, Michael P.

“…Macroautophagy/autophagy requires enormous membrane expansions during concerted actions of transient autophagic vesicles and lysosomes, yet the source of the…”
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Sarcolipin and uncoupling protein 1 play distinct roles in diet‐induced thermogenesis and do not compensate for one another by Rowland, Leslie A., Maurya, Santosh K., Bal, Naresh C., Kozak, Leslie, Periasamy, Muthu

“…Objective It is well known that uncoupling protein 1 (UCP1) in brown adipose tissue plays an important role in diet‐induced thermogenesis. In this study,…”
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Disruption of Dopamine Receptor 1 Localization to Primary Cilia Impairs Signaling in Striatal Neurons by Stubbs, Toneisha, Koemeter-Cox, Andrew, Bingman, James I, Zhao, Fangli, Kalyanasundaram, Anuradha, Rowland, Leslie A, Periasamy, Muthu, Carter, Calvin S, Sheffield, Val C, Askwith, Candice C, Mykytyn, Kirk

“…A rod-shaped appendage called a primary cilium projects from the soma of most central neurons in the mammalian brain. The importance of cilia within the…”
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Exercise Training Promotes Sex-Specific Adaptations in Mouse Inguinal White Adipose Tissue by Nigro, Pasquale, Middelbeek, Roeland J W, Alves, Christiano R R, Rovira-Llopis, Susana, Ramachandran, Krithika, Rowland, Leslie A, Møller, Andreas B, Takahashi, Hirokazu, Alves-Wagner, Ana B, Vamvini, Maria, Makarewicz, Nathan S, Albertson, Brent G, Hirshman, Michael F, Goodyear, Laurie J

“…Recent studies demonstrate that adaptations to white adipose tissue are important components of the beneficial effects of exercise training on metabolic…”
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720-P: Exercise Training Causes Vast Changes in the Circulating Factor Profile of Human Subjects by MIDDELBEEK, ROELAND, RICHARD, JEFFREY J., ROWLAND, LESLIE A., NIGRO, PASQUALE, PAN, HUI, DREYFUSS, JONATHAN, GOODYEAR, LAURIE J.

“…Exercise training induces adaptations to the body that improve metabolic health; however, the molecular mechanisms mediating these beneficial adaptations to…”
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Sarcolipin is a newly identified regulator of muscle-based thermogenesis in mammals by Bal, Naresh C, Maurya, Santosh K, Sopariwala, Danesh H, Sahoo, Sanjaya K, Gupta, Subash C, Shaikh, Sana A, Pant, Meghna, Rowland, Leslie A, Goonasekera, Sanjeewa A, Molkentin, Jeffery D, Periasamy, Muthu

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Sexual-Dimorphism in Exercise-Induced Beiging and Altered Mitochondrial Function in Inguinal White Adipose Tissue (iWAT) from the Mouse by NIGRO, PASQUALE, MIDDELBEEK, ROELAND, ALVES, CHRISTIANO R., ALBERTSON, BRENT G., ROWLAND, LESLIE A., WAGNER, ANA B., PRINCE, NOAH B., HIRSHMAN, MICHAEL F., GOODYEAR, LAURIE J.

“…Regular physical exercise has numerous benefits on metabolic health, likely involving adaptations to many tissues, including adipose tissue. There are…”
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Sarcolipin is a novel regulator of muscle based thermogenesis and metabolism in mammals by Bal, Naresh Chandra, Maurya, Santosh Kumar, Sopariwala, Danesh H, Sahoo, Sanjaya Kumar, Shaikh, Sana A, Pant, Meghna, Rowland, Leslie A, Periasamy, Muthu

“…Abstract only Sarcolipin (SLN) is a novel regulator of S arco/ E ndoplasmic R eticulum C a 2+ ‐ A TPase (SERCA) pump and it is expressed exclusively in…”
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Erratum: Corrigendum: Sarcolipin is a newly identified regulator of muscle-based thermogenesis in mammals by Bal, Naresh C, Maurya, Santosh K, Sopariwala, Danesh H, Sahoo, Sanjaya K, Gupta, Subash C, Shaikh, Sana A, Pant, Meghna, Rowland, Leslie A, Goonasekera, Sanjeewa A, Molkentin, Jeffery D, Periasamy, Muthu

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