Search Results - "Rowe, Jared H"

Foxp3(+) regulatory T cell expansion required for sustaining pregnancy compromises host defense against prenatal bacterial pathogens by Rowe, Jared H, Ertelt, James M, Aguilera, Marijo N, Farrar, Michael A, Way, Sing Sing

“…Although pregnancy confers unique susceptibility to infection, the pregnancy-associated immune defects that erode host defense remain largely undefined…”
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Regulatory T cell suppressive potency dictates the balance between bacterial proliferation and clearance during persistent Salmonella infection by Johanns, Tanner M, Ertelt, James M, Rowe, Jared H, Way, Sing Sing

“…The pathogenesis of persistent infection is dictated by the balance between opposing immune activation and suppression signals. Herein, virulent Salmonella was…”
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Listeria monocytogenes cytoplasmic entry induces fetal wastage by disrupting maternal Foxp3+ regulatory T cell-sustained fetal tolerance by Rowe, Jared H, Ertelt, James M, Xin, Lijun, Way, Sing Sing

“…Although the intracellular bacterium Listeria monocytogenes has an established predilection for disseminated infection during pregnancy that often results in…”
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Severe congenital neutropenia due to jagunal homolog 1 ( JAGN1 ) mutation: a case report and literature review by Thomas, Sanya, Guenther, Geoffrey, Rowe, Jared H, Platt, Craig D, Shimamura, Akiko, Levy, Ofer, Ganapathi, Lakshmi

“…Severe congenital neutropenia caused by jagunal homolog 1 ( ) mutation is a rare condition resulting from maturation arrest secondary to endoplasmic reticulum…”
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Commensal microbes drive intestinal inflammation by IL-17–producing CD4⁺ T cells through ICOSL and OX40L costimulation in the absence of B7-1 and B7-2 by Xin, Lijun, Jiang, Tony T., Chaturvedi, Vandana, Kinder, Jeremy M., Ertelt, James M., Rowe, Jared H., Steinbrecher, Kris A., Way, Sing Sing

“…The costimulatory B7-1 (CD80)/B7-2 (CD86) molecules, along with T-cell receptor stimulation, together facilitate T-cell activation. This explains why in vivo…”
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The aging lung: Physiology, disease, and immunity by Schneider, Jaime L., Rowe, Jared H., Garcia-de-Alba, Carolina, Kim, Carla F., Sharpe, Arlene H., Haigis, Marcia C.

“…The population is aging at a rate never seen before in human history. As the number of elderly adults grows, it is imperative we expand our understanding of…”
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Low frequency of treatable pediatric disease alleles in gnomAD: An opportunity for future genomic screening of newborns by Gold, Nina B., Harrison, Steven M., Rowe, Jared H., Gold, Jessica, Furutani, Elissa, Biffi, Alessandra, Duncan, Christine N., Shimamura, Akiko, Lehmann, Leslie E., Green, Robert C.

“…Hematopoietic stem cell transplant (HSCT) can prevent progression of several genetic disorders. Although a subset of these disorders are identified on newborn…”
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Tumor cells dictate anti-tumor immune responses by altering pyruvate utilization and succinate signaling in CD8+ T cells by Elia, Ilaria, Rowe, Jared H., Johnson, Sheila, Joshi, Shakchhi, Notarangelo, Giulia, Kurmi, Kiran, Weiss, Sarah, Freeman, Gordon J., Sharpe, Arlene H., Haigis, Marcia C.

“…The tumor microenvironment (TME) is a unique metabolic niche that can inhibit T cell metabolism and cytotoxicity. To dissect the metabolic interplay between…”
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Pregnancy imprints regulatory memory that sustains anergy to fetal antigen by Rowe, Jared H., Ertelt, James M., Xin, Lijun, Way, Sing Sing

“…Successful pregnancy requires immune tolerance against paternal antigens expressed by the fetus; here pregnancy is shown to stimulate the selective…”
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Defining a new immune deficiency syndrome: MAN2B2-CDG by Verheijen, Jan, Wong, Sunnie Y., Rowe, Jared H., Raymond, Kimiyo, Stoddard, Jennifer, Delmonte, Ottavia M., Bosticardo, Marita, Dobbs, Kerry, Niemela, Julie, Calzoni, Enrica, Pai, Sung-Yun, Choi, Uimook, Yamazaki, Yasuhiro, Comeau, Anne Marie, Janssen, Erin, Henderson, Lauren, Hazen, Melissa, Berry, Gerard, Rosenzweig, Sergio D., Aldhekri, Hasan Hamdan, He, Miao, Notarangelo, Luigi D., Morava, Eva

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B7-1/B7-2 blockade overrides the activation of protective CD8 T cells stimulated in the absence of Foxp3+ regulatory T cells by Ertelt, James M., Buyukbasaran, Esra Z., Jiang, Tony T., Rowe, Jared H., Xin, Lijun, Way, Sing Sing

“…The activation of protective CD8 T cells requires B7‐1/B7‐2 costimulation, even when suppression by Tregs, and in particular, Treg intrinsic CTLA‐4, is…”
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Foxp3+ regulatory T cells, immune stimulation and host defence against infection by Rowe, Jared H., Ertelt, James M., Way, Sing Sing

“…Summary The immune system is intricately regulated allowing potent effectors to expand and become rapidly mobilized after infection, while simultaneously…”
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Patients with CD3G mutations reveal a role for human CD3γ in T reg diversity and suppressive function by Rowe, Jared H, Delmonte, Ottavia M, Keles, Sevgi, Stadinski, Brian D, Dobbs, Adam K, Henderson, Lauren A, Yamazaki, Yasuhiro, Allende, Luis M, Bonilla, Francisco A, Gonzalez-Granado, Luis I, Celikbilek Celik, Seyma, Guner, Sukru N, Kapakli, Hasan, Yee, Christina, Pai, Sung-Yun, Huseby, Eric S, Reisli, Ismail, Regueiro, Jose R, Notarangelo, Luigi D

“…Integrity of the T-cell receptor/CD3 complex is crucial for positive and negative selection of T cells in the thymus and for effector and regulatory functions…”
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Cysteine and hydrophobic residues in CDR3 serve as distinct T-cell self-reactivity indices by Daley, Stephen R., Koay, Hui-Fern, Dobbs, Kerry, Bosticardo, Marita, Wirasinha, Rushika C., Pala, Francesca, Castagnoli, Riccardo, Rowe, Jared H., Ott de Bruin, Lisa M., Keles, Sevgi, Lee, Yu Nee, Somech, Raz, Holland, Steven M., Delmonte, Ottavia M., Draper, Debbie, Maxwell, Sandra, Niemela, Julie, Stoddard, Jennifer, Rosenzweig, Sergio D., Poliani, Pietro Luigi, Capo, Valentina, Villa, Anna, Godfrey, Dale I., Notarangelo, Luigi D.

“…TCR-sequencing (for polymerase chain reaction primers, see Table E3 in this article's Online Repository at www.jacionline.org) revealed that, compared with…”
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Cutting edge: committed Th1 CD4+ T cell differentiation blocks pregnancy-induced Foxp3 expression with antigen-specific fetal loss by Xin, Lijun, Ertelt, James M, Rowe, Jared H, Jiang, Tony T, Kinder, Jeremy M, Chaturvedi, Vandana, Elahi, Shokrollah, Way, Sing Sing

“…Pregnancy stimulates induced Foxp3 expression among maternal CD4(+) T cells with fetal specificity. Although sustained maternal regulatory CD4(+) T cell (Treg)…”
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Epigenetic tuning of PD-1 expression improves exhausted T cell function and viral control by Weiss, Sarah A., Huang, Amy Y., Fung, Megan E., Martinez, Daniela, Chen, Alex C. Y., LaSalle, Thomas J., Miller, Brian C., Scharer, Christopher D., Hegde, Mudra, Nguyen, Thao H., Rowe, Jared H., Osborn, Jossef F., Patterson, Dillon G., Sifnugel, Natalia, Mei-An Nolan, C., Davidson, Richard A., Schwartz, Marc A., Bally, Alexander P. R., Neeld, Dennis K., LaFleur, Martin W., Boss, Jeremy M., Doench, John G., Nicholas Haining, W., Sharpe, Arlene H., Sen, Debattama R.

“…PD-1 is a key negative regulator of CD8 + T cell activation and is highly expressed by exhausted T cells in cancer and chronic viral infection. Although PD-1…”
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Regulatory T cells and the immune pathogenesis of prenatal infection by Rowe, Jared H, Ertelt, James M, Xin, Lijun, Way, Sing Sing

“…Pregnancy in placental mammals offers exceptional comprehensive benefits of in utero protection, nutrition, and metabolic waste elimination for the developing…”
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Complete Absence of CD3γ Protein Expression Is Responsible for Combined Immunodeficiency with Autoimmunity Rather than SCID by Delmonte, Ottavia M., Rowe, Jared H., Dobbs, Adam K., Palterer, Boaz, Castagnoli, Riccardo, Notarangelo, Luigi D.

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Abnormalities of T-cell receptor repertoire in CD4+ regulatory and conventional T cells in patients with RAG mutations: Implications for autoimmunity by Rowe, Jared H., Stadinski, Brian D., Henderson, Lauren A., Ott de Bruin, Lisa, Delmonte, Ottavia, Lee, Yu Nee, de la Morena, M. Teresa, Goyal, Rakesh K., Hayward, Anthony, Huang, Chiung-Hui, Kanariou, Maria, King, Alejandra, Kuijpers, Taco W., Soh, Jian Yi, Neven, Benedicte, Walter, Jolan E., Huseby, Eric S., Notarangelo, Luigi D.

“…In both patients, Treg cells displayed reduced suppressive activity compared with controls (Fig E3, B). Because genetic defects affecting Treg-cell development…”
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Modeling altered T-cell development with induced pluripotent stem cells from patients with RAG1-dependent immune deficiencies by Brauer, Patrick M., Pessach, Itai M., Clarke, Erik, Rowe, Jared H., Ott de Bruin, Lisa, Lee, Yu Nee, Dominguez-Brauer, Carmen, Comeau, Anne M., Awong, Geneve, Felgentreff, Kerstin, Zhang, Yuhang H., Bredemeyer, Andrea, Al-Herz, Waleed, Du, Likun, Ververs, Francesca, Kennedy, Marion, Giliani, Silvia, Keller, Gordon, Sleckman, Barry P., Schatz, David G., Bushman, Frederic D., Notarangelo, Luigi D., Zúñiga-Pflücker, Juan Carlos

“…Primary immunodeficiency diseases comprise a group of heterogeneous genetic defects that affect immune system development and/or function. Here we use in vitro…”
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