Search Results - "Rowbotham, D.J."

Simultaneous targeting of multiple opioid receptors: a strategy to improve side-effect profile by Dietis, N., Guerrini, R., Calo, G., Salvadori, S., Rowbotham, D.J., Lambert, D.G.

“…Opioid receptors are currently classified as µ (mu: mOP), δ (delta: dOP), κ (kappa: kOP) with a fourth related non-classical opioid receptor for…”
Get full text

Cebranopadol: a first in-class example of a nociceptin/orphanin FQ receptor and opioid receptor agonist by Lambert, D.G., Bird, M.F., Rowbotham, D.J.

Get full text

Pharmacological characterization of the bifunctional opioid ligand H-Dmt-Tic-Gly-NH-Bzl (UFP-505) by Dietis, N., McDonald, J., Molinari, S., Calo, G., Guerrini, R., Rowbotham, D.J., Lambert, D.G.

“…While producing good-quality analgesia, µ-opioid (MOP) receptor activation produces a number of side-effects including tolerance. Simultaneous blockade of…”
Get full text

Controlling cancer pain: Is morphine the best we can do? by Dietis, N, Rowbotham, D.J, Lambert, D.G

“…Summary Despite the existence of a family of 3 classical and one non-classical opioid receptor, morphine, acting at the MOP (μ) receptor remains the gold…”
Get full text

Comparison of effects of remifentanil and alfentanil on cardiovascular response to tracheal intubation in hypertensive patients by Maguire, A.M., Kumar, N., Parker, J.L., Rowbotham, D.J., Thompson, J.P.

“…In a randomized double-blind study, we compared the effect of remifentanil and alfentanil on the cardiovascular response to laryngoscopy and tracheal…”
Get full text

Temperature-dependent activation of recombinant rat vanilloid VR1 receptors expressed in HEK293 cells by capsaicin and anandamide by Sprague, J, Harrison, C, Rowbotham, D.J, Smart, D, Lambert, D.G

“…Capsaicin activates vanilloid (VR1) receptors found on sensory neurons. These ligand-gated ion channels are also sensitive to low pH, elevated temperature and…”
Get full text

Persistent postoperative pain: where are we now? by Niraj, G., Rowbotham, D.J.

“…There has been considerable interest and controversy around persistent postoperative pain for several years. Most of the available data arise from studies with…”
Get full text

Opioid receptor subtypes: fact or artifact? by Dietis, N., Rowbotham, D.J., Lambert, D.G.

“…There is a vast amount of pharmacological evidence favouring the existence of multiple subtypes of opioid receptors. In addition to the primary classification…”
Get full text

Editorial II: Gabapentin: a new drug for postoperative pain? by Rowbotham, D.J.

Get full text

I. Managing pain: recent advances and new challenges by Colvin, L.A., Rowbotham, D.J.

Get full text

Evaluation of primary opioid receptor antibodies for use in western blotting by Niwa, H., Rowbotham, D.J., Lambert, D.G.

Get full text

National Institute of Academic Anaesthesia research priority setting exercise by Howell, S.J., Pandit, J.J., Rowbotham, D.J.

“…Formal research priority setting is a recognized way of identifying important clinical research questions and promoting these as topics for commissioned…”
Get full text

Neurokinin-1 antagonists: a step change in prevention of postoperative nausea and vomiting? by Rowbotham, D.J.

Get full text

Development and characterisation of novel fentanyl-delta opioid receptor antagonist based bivalent ligands by Bird, M.F., Vardanyan, R.S., Hruby, V.J., Calò, G., Guerrini, R., Salvadori, S., Trapella, C., McDonald, J., Rowbotham, D.J., Lambert, D.G.

“…Opioid tolerance is a limiting factor in chronic pain. Delta opioid peptide (DOP)(δ) receptor antagonism has been shown to reduce tolerance. Here, the common…”
Get full text

Editorial by Rowbotham, D.J.

Get full text

Editorial by Rowbotham, D.J.

Get full text

Recent advances in the non-pharmacological management of postoperative nausea and vomiting by Rowbotham, D.J.

Get full text

Effect of single doses of cisapride and ranitidine administered simultaneously on plasma concentrations of cisapride and ranitidine by Rowbotham, D J, Milligan, K, McHugh, P

“…We have studied in 12 volunteers the effect of single doses of cisapride and ranitidine, administered simultaneously, on plasma concentrations of cisapride and…”
Get more information

Nociceptin and urotensin-II concentrations in critically ill patients with sepsis by Williams, J. P., Thompson, J. P., Young, S. P., Gold, S. J., McDonald, J., Rowbotham, D. J., Lambert, D. G.

“…Background The systemic inflammatory response to infection (sepsis) involves widespread organ dysfunction, including changes in immune modulation,…”
Get full text

Effect of pulsed magnetic field therapy on pain reported by human volunteers in a laboratory model of acute pain by Fernandez, M.I., Watson, P.J., Rowbotham, D.J.

“…Pulsed magnetic field therapy (PMFT) is a non-invasive, simple technique used extensively for the treatment of muscle pain. However, evidence to support its…”
Get full text