Search Results - "Rowan, A. D."

Interleukin 17 induces cartilage collagen breakdown: novel synergistic effects in combination with proinflammatory cytokines by Koshy, P J, Henderson, N, Logan, C, Life, P F, Cawston, T E, Rowan, A D

“…Objective: To investigate whether interleukin 17 (IL17), derived specifically from T cells, can promote type II collagen release from cartilage. The ability of…”
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Differential Toll-like receptor-dependent collagenase expression in chondrocytes by Zhang, Q, Hui, W, Litherland, G J, Barter, M J, Davidson, R, Darrah, C, Donell, S T, Clark, I M, Cawston, T E, Robinson, J H, Rowan, A D, Young, D A

“…To characterise the catabolic response of osteoarthritic chondrocytes to Toll-like receptor (TLR) ligands. Induction of the collagenases, matrix…”
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Development of a novel 2D proteomics approach for the identification of proteins secreted by primary chondrocytes after stimulation by IL-1 and oncostatin M by CATTERALL, J. B, ROWAN, A. D, SARSFIELD, S, SAKLATVALA, J, WAIT, R, CAWSTON, T. E

“…To develop a proteomics approach to study changes in the secreted protein levels of primary human chondrocytes after stimulation by the pro-inflammatory…”
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A Computer Simulation Approach to Assessing Therapeutic Intervention Points for the Prevention of Cytokine‐Induced Cartilage Breakdown by Proctor, C. J., Macdonald, C., Milner, J. M., Rowan, A. D., Cawston, T. E.

“…Objective To use a novel computational approach to examine the molecular pathways involved in cartilage breakdown and to use computer simulation to test…”
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Levels of matrix metalloproteinase (MMP)-1 in paired sera and synovial fluids of juvenile idiopathic arthritis patients: relationship to inflammatory activity, MMP-3 and tissue inhibitor of metalloproteinases-1 in a longitudinal study by Peake, N. J., Khawaja, K., Myers, A., Jones, D., Cawston, T. E., Rowan, A. D., Foster, H. E.

“…Objectives. To measure levels of the collagenases matrix metalloproteinase (MMP)-1 and -13 in the synovial fluid (SF) and serum of patients with juvenile…”
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An association between the CTLA4 exon 1 polymorphism and early rheumatoid arthritis with autoimmune endocrinopathies by Vaidya, B., Pearce, S. H. S., Charlton, S., Marshall, N., Rowan, A. D., Griffiths, I. D., Kendall‐Taylor, P., Cawston, T. E., Young‐Min, S.

“…Objective. To examine the allelic association of the single nucleotide polymorphism (CTLA4A/G) in exon 1 of the cytotoxic T lymphocyte antigen‐4 (CTLA4) gene…”
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Insulin-like growth factor 1 blocks collagen release and down regulates matrix metalloproteinase-1, -3, -8, and -13 mRNA expression in bovine nasal cartilage stimulated with oncostatin M in combination with interleukin 1α by Hui, W, Rowan, A D, Cawston, T

“…OBJECTIVE To investigate the effect of insulin-like growth factor 1 (IGF1) on the release of collagen, and the production and expression of matrix…”
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Oncostatin M in combination with tumour necrosis factor α induces a chondrocyte membrane associated aggrecanase that is distinct from ADAMTS aggrecanase-1 or -2 by Hui, W, Barksby, H E, Young, D A, Cawston, T E, McKie, N, Rowan, A D

“…Objective: To determine whether oncostatin M (OSM) + tumour necrosis factor α (TNFα) induces aggrecanase activity in chondrocyte membranes, to determine the…”
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Assessment of the clinical significance of gelatinase activity in patients with juvenile idiopathic arthritis using quantitative protein substrate zymography by Peake, N J, Foster, H E, Khawaja, K, Cawston, T E, Rowan, A D

“…Objective: To measure gelatinase activities in paired synovial fluid (SF) and serum of patients with juvenile idiopathic arthritis (JIA), and to assess how…”
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Interleukin-6 signalling in juvenile idiopathic arthritis is limited by proteolytically cleaved soluble interleukin-6 receptor by PEAKE, N. J, KHAWAJA, K, MYERS, A, NOWELL, M. A, JONES, S. A, ROWAN, A. D, CAWSTON, T. E, FOSTER, H. E

“…Interleukin-6 (IL-6) exerts multiple effects on chondrocytes and fibroblasts within the joint and is associated with disease activity in juvenile idiopathic…”
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Transforming growth factor β1 and insulin-like growth factor 1 block collagen degradation induced by oncostatin M in combination with tumour necrosis factor α from bovine cartilage by Hui, W, Cawston, T, Rowan, A D

“…Oncostatin M (OSM) in combination with tumour necrosis factor α (TNFα) promotes marked collagen breakdown from bovine cartilage in explant culture. This…”
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Human nasal cartilage responds to oncostatin M in combination with interleukin 1 or tumour necrosis factor α by the release of collagen fragments via collagenases by Morgan, T G, Rowan, A D, Dickinson, S C, Jones, D, Hollander, A P, Deehan, D, Cawston, T E

“…Background: The synergistic degradation of cartilage by oncostatin M (OSM) in combination with either interleukin 1 (IL1) or tumour necrosis factor α (TNFα)…”
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Retinoic acid and oncostatin M combine to promote cartilage degradation via matrix metalloproteinase-13 expression in bovine but not human chondrocytes by Shingleton, W. D., Jones, D., Xu, X., Cawston, T. E., Rowan, A. D.

“…Objectives. Retinoic acid (RetA) and oncostatin M (OSM) have both been shown to mediate potent effects with respect to extracellular matrix integrity. This…”
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Identification of the pathogenic pathways in osteoarthritic hip cartilage: commonality and discord between hip and knee OA by Xu, Y, Barter, M.J, Swan, D.C, Rankin, K.S, Rowan, A.D, Santibanez-Koref, M, Loughlin, J, Young, D.A

“…Summary Objective To define for the first time the transcriptomes of normal and end-stage osteoarthritis (OA) hip cartilage. Materials and methods RNA was…”
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Rat procathepsin B. Proteolytic processing to the mature form in vitro by ROWAN, A. D, MASON, P, MACH, L, MORT, J. S

“…Expression of rat procathepsin B in yeast led to the secretion of both the latent and mature forms of the enzyme. Culture in the presence of a cysteine…”
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Interleukin 13 blocks the release of collagen from bovine nasal cartilage treated with proinflammatory cytokines by Cleaver, C S, Rowan, A D, Cawston, T E

“…OBJECTIVE To investigate whether interleukin 13 (IL13) could act in a chondroprotective manner and protect cartilage stimulated to resorb with a combination of…”
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Process and controller performance monitoring: overview with industrial applications by Hoo, K. A., Piovoso, M. J., Schnelle, P. D., Rowan, D. A.

“…Complex processes depend on regulatory control systems to operate. Changes made to the sensor system and the process itself as well as the natural degradation…”
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Differential changes in the association and dissociation rate constants for binding of cystatins to target proteinases occurring on N-terminal truncation of the inhibitors indicate that the interaction mechanism varies with different enzymes by Bjork, I, Pol, E, Raub-Segall, E, Abrahamson, M, Rowan, A.D, Mort, J.S

“…The importance of the N-terminal region of human cystatin C or chicken cystatin for the kinetics of interactions of the inhibitors with four cysteine…”
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Esculetin inhibits cartilage resorption induced by interleukin 1α in combination with oncostatin M by Elliott, S, Rowan, A D, Carrère, S, Koshy, P, Catterall, J B, Cawston, T E

“…OBJECTIVE To determine if a new inhibitor, esculetin (EST), can block resorption of cartilage. METHODS Interleukin 1α (IL1α, 0.04–5 ng/ml) and oncostatin M…”
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Activation of procathepsin B in human hepatoma cells : the conversion into the mature enzyme relies on the action of cathepsin B itself by MACH, L, SCHWIHLA, H, STÜWE, K, ROWAN, A. D, MORT, J. S, GLÖSSL, J

“…In order to elucidate the processing mechanism of the lysosomal cysteine proteinase, cathepsin B, in mammalian cells, recombinant rat and human cathepsin B…”
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