Search Results - "Rovsnik, Urska"
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Discovery of lipid binding sites in a ligand-gated ion channel by integrating simulations and cryo-EM
Published in eLife (30-01-2024)“…Ligand-gated ion channels transduce electrochemical signals in neurons and other excitable cells. Aside from canonical ligands, phospholipids are thought to…”
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Automated simulation-based membrane protein refinement into cryo-EM data
Published in Biophysical journal (11-07-2023)“…The resolution revolution has increasingly enabled single-particle cryogenic electron microscopy (cryo-EM) reconstructions of previously inaccessible systems,…”
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3
Biophysical characterization of calcium-binding and modulatory-domain dynamics in a pentameric ligand-gated ion channel
Published in Proceedings of the National Academy of Sciences - PNAS (13-12-2022)“…Pentameric ligand-gated ion channels (pLGICs) perform electrochemical signal transduction in organisms ranging from bacteria to humans. Among the prokaryotic…”
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Probing solution structure of the pentameric ligand-gated ion channel GLIC by small-angle neutron scattering
Published in Proceedings of the National Academy of Sciences - PNAS (14-09-2021)“…Pentameric ligand-gated ion channels undergo subtle conformational cycling to control electrochemical signal transduction in many kingdoms of life. Several…”
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5
Allosteric Modulation via Transmembrane Interfaces in a Pentameric Ligand-Gated Ion Channel
Published in Biophysical journal (15-02-2019)Get full text
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Dynamic closed states of a ligand-gated ion channel captured by cryo-EM and simulations
Published in Life science alliance (01-08-2021)“…Ligand-gated ion channels are critical mediators of electrochemical signal transduction across evolution. Biophysical and pharmacological characterization of…”
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Integrating simulations and cryo-EM reveal lipid binding sites in a ligand-gated ion channel
Published in European biophysics journal (2023)Get full text
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cryo-EM and small-angle scattering of a pentameric ligand-gated ion channel reveals a dynamic regulatory domain
Published in Biophysical journal (11-02-2022)Get full text
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9
Functional and structural characterization of a novel pH-modulated open state of a pentameric ligand-gated ion channel
Published in Biophysical journal (11-02-2022)Get full text
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10
Phospholipid interaction sites in a ligand-gated ion channel from simulations and cryo-electron microscopy
Published in Biophysical journal (11-02-2022)Get full text
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11
Characterizing Functional States of a Model Ligand-Gated Ion Channel by Cryo-Electron Microscopy
Published in Biophysical journal (15-02-2019)Get full text
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12
Discovery of lipid binding sites in the ligand-gated ion channel GLIC through simulations and Cryo-EM
Published in Biophysical journal (10-02-2023)Get full text
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13
Structural characterization of pH- and calcium-modulated open and closed states of the pentameric ligand-gated ion channel DeCLIC
Published in Biophysical journal (10-02-2023)Get full text
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14
Cryo-EM Structure Determination and Model Fitting of the Proton-Gated Ligand-Gated Ion Channel glic at Multiple pH States
Published in Biophysical journal (07-02-2020)Get full text
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15
Balancing Stereochemistry and Goodness-of-Fit for Automated Simulation-Based Refinement into Cryo-EM Maps
Published in Biophysical journal (12-02-2021)Get full text
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16
Heterogeneous Populations of Ligand-Gated Ion Channel, GLIC, Revealed by Cryo-Electron Microscopy and Simulations
Published in Biophysical journal (12-02-2021)Get full text
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17
Structural Studies of the Gating Mechanism in a Pentameric Ligand-Gated Ion Channel Containing Two Additional N-Terminal Periplasmic Domains
Published in Biophysical journal (15-02-2019)Get full text
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18
Allosteric Gating Determinants in the Transmembrane Domain of Pentameric Ligand-Gated Ion Channels
Published in Biophysical journal (07-02-2020)Get full text
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19
Solution Structure of the Gloeobacter Violaceus Ligand-Gated Ion Channel Probed by Small-Angle Neutron Scattering
Published in Biophysical journal (12-02-2021)Get full text
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20
Direct detection of SARS-CoV-2 using non-commercial RT-LAMP reagents on heat-inactivated samples
Published in Scientific reports (19-01-2021)“…RT-LAMP detection of SARS-CoV-2 has been shown to be a valuable approach to scale up COVID-19 diagnostics and thus contribute to limiting the spread of the…”
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