Search Results - "Rouzina, Ioulia"

Mechanisms of small molecule-DNA interactions probed by single-molecule force spectroscopy by Almaqwashi, Ali A, Paramanathan, Thayaparan, Rouzina, Ioulia, Williams, Mark C

“…There is a wide range of applications for non-covalent DNA binding ligands, and optimization of such interactions requires detailed understanding of the…”
Get full text

T4 gp32 forms dynamic, compacting filaments on ssDNA that reorganize through interprotein interactions by Cashen, Benjamin, Morse, Michael, Rouzina, Ioulia F., Karpel, Richard L., Williams, Mark C.

Get full text

Binding and wrapping of E. coli single stranded binding protein (SSB) C-terminal tail variants measured using force spectroscopy by Moller, Gudfridur B., Morse, Michael, McIsaac, James, Rouzina, Ioulia F., Beuning, Penny, Williams, Mark C.

Get full text

Structure and function of SARS-CoV-2 nucleocapsid protein measured using optical tweezers, confocal fluorescence, and AFM by Morse, Michael, Sefcikova, Jana, McCauley, Micah J., Rouzina, Ioulia F., Beuning, Penny J., Williams, Mark C.

Get full text

Revealing the competition between peeled ssDNA, melting bubbles, and S-DNA during DNA overstretching by single-molecule calorimetry by Zhang, Xinghua, Chen, Hu, Le, Shimin, Rouzina, Ioulia, Doyle, Patrick S., Yan, Jie

“…Double-stranded DNA (dsDNA) unconstrained by torsion undergoes an overstretching transition at about 65 pN, elongating the DNA to about 1.7-fold. Three…”
Get full text

Nucleosome chaperone activity of LEDGF and HDGF2 characterized with single molecule force spectroscopy by Joshi, Joha, McCauley, Micah J., Becker, Nicole A., Morse, Michael, Rouzina, Ioulia F., Maher, Louis J., Lyumkis, Dmitry, Williams, Mark C.

Get full text

Thermodynamics and kinetics of the B-S transition in base-modified DNA by Sundar Rajan, Vinoth Edal, Levin, Sune, McCauley, Micah J., Williams, Mark C., Rouzina, Ioulia F., Wilhelmsson, Marcus, Westerlund, Fredrik

“…Understanding changes in the mechanical properties of nucleic acids is important to understand many biological processes. DNA exhibits a conformational change…”
Get full text

HIV-1 nucleocapsid protein binds double-stranded DNA in multiple modes to regulate compaction and capsid uncoating by Gien, Helena, Morse, Michael, McCauley, Micah J., Rouzina, Ioulia F., Kitzrow, Jonathan, Musier-Forsyth, Karin, Gorelick, Robert, Williams, Mark C.

Get full text

Dimerization regulates both deaminase-dependent and deaminase-independent HIV-1 restriction by APOBEC3G by Morse, Michael, Huo, Ran, Feng, Yuqing, Rouzina, Ioulia, Chelico, Linda, Williams, Mark C.

“…APOBEC3G (A3G) is a human enzyme that inhibits human immunodeficiency virus type 1 (HIV-1) infectivity, in the absence of the viral infectivity factor Vif,…”
Get full text

HIV restriction factor APOBEC3G binds in multiple steps and conformations to search and deaminate single-stranded DNA by Morse, Michael, Naufer, M Nabuan, Feng, Yuqing, Chelico, Linda, Rouzina, Ioulia, Williams, Mark C

“…APOBEC3G (A3G), an enzyme expressed in primates with the potential to inhibit human immunodeficiency virus type 1 (HIV-1) infectivity, is a single-stranded DNA…”
Get full text

Visualizing both nucleosome disassembly and reassembly during FACT chaperone activity by McCauley, Micah J., Morse, Michael, Becker, Nicole A., Hu, Qi, Botuyan, Maria V., Navarrete, Emily, Huo, Ran, Muthurajan, Uma, Rouzina, Ioulia F., Luger, Karolin, Mer, Georges, Maher, L. James, Williams, Mark C.

Get full text

Mechanism of DNA Intercalation by Chloroquine Provides Insights into Toxicity by Joshi, Joha, McCauley, Micah J, Morse, Michael, Muccio, Michael R, Kanlong, Joseph G, Rocha, Márcio S, Rouzina, Ioulia, Musier-Forsyth, Karin, Williams, Mark C

“…Chloroquine has been used as a potent antimalarial, anticancer drug, and prophylactic. While chloroquine is known to interact with DNA, the details of…”
Get full text

Cationic Residues of the HIV-1 Nucleocapsid Protein Enable DNA Condensation to Maintain Viral Core Particle Stability during Reverse Transcription by Gien, Helena, Morse, Michael, McCauley, Micah J, Rouzina, Ioulia, Gorelick, Robert J, Williams, Mark C

“…The HIV-1 nucleocapsid protein (NC) is a multifunctional viral protein necessary for HIV-1 replication. Recent studies have demonstrated that reverse…”
Get full text

Single‐molecule mechanochemical characterization of E. coli pol III core catalytic activity by Naufer, M. Nabuan, Murison, David A., Rouzina, Ioulia, Beuning, Penny J., Williams, Mark C.

“…Pol III core is the three‐subunit subassembly of the E. coli replicative DNA polymerase III holoenzyme. It contains the catalytic polymerase subunit α, the 3′…”
Get full text

Deaminase-independent inhibition of HIV-1 reverse transcription by APOBEC3G by Iwatani, Yasumasa, Chan, Denise S.B., Wang, F., Maynard, Kristen Stewart, Sugiura, Wataru, Gronenborn, Angela M., Rouzina, Ioulia, Williams, Mark C., Musier-Forsyth, Karin, Levin, Judith G.

“…APOBEC3G (A3G), a host protein that inhibits HIV-1 reverse transcription and replication in the absence of Vif, displays cytidine deaminase and single-stranded…”
Get full text

Distinct binding interactions of HIV-1 Gag to Psi and non-Psi RNAs: implications for viral genomic RNA packaging by Webb, Joseph A, Jones, Christopher P, Parent, Leslie J, Rouzina, Ioulia, Musier-Forsyth, Karin

“…Despite the vast excess of cellular RNAs, precisely two copies of viral genomic RNA (gRNA) are selectively packaged into new human immunodeficiency type 1…”
Get full text

Targeted binding of nucleocapsid protein transforms the folding landscape of HIV-1 TAR RNA by McCauley, Micah J., Rouzina, Ioulia, Manthei, Kelly A., Gorelick, Robert J., Musier-Forsyth, Karin, Williams, Mark C.

“…Retroviral nucleocapsid (NC) proteins are nucleic acid chaperones that play a key role in the viral life cycle. During reverse transcription, HIV-1 NC…”
Get full text

HIV-1 Nucleocapsid Protein Binds Double-Stranded DNA in Multiple Modes to Regulate Compaction and Capsid Uncoating by Gien, Helena, Morse, Michael, McCauley, Micah J, Kitzrow, Jonathan P, Musier-Forsyth, Karin, Gorelick, Robert J, Rouzina, Ioulia, Williams, Mark C

“…The HIV-1 nucleocapsid protein (NC) is a multi-functional protein necessary for viral replication. Recent studies have demonstrated reverse transcription…”
Get full text

Specific inter-domain interactions stabilize a compact HIV-1 Gag conformation by Lin, Chen, Mendoza-Espinosa, Paola, Rouzina, Ioulia, Guzmán, Orlando, Moreno-Razo, José Antonio, Francisco, Joseph S, Bruinsma, Robijn

“…HIV-1 Gag is a large multidomain poly-protein with flexible unstructured linkers connecting its globular subdomains. It is compact when in solution but assumes…”
Get full text

Oligomerization transforms human APOBEC3G from an efficient enzyme to a slowly dissociating nucleic acid-binding protein by Chaurasiya, Kathy R., McCauley, Micah J., Wang, Wei, Qualley, Dominic F., Wu, Tiyun, Kitamura, Shingo, Geertsema, Hylkje, Chan, Denise S. B., Hertz, Amber, Iwatani, Yasumasa, Levin, Judith G., Musier-Forsyth, Karin, Rouzina, Ioulia, Williams, Mark C.

“…The human APOBEC3 proteins are a family of DNA-editing enzymes that play an important role in the innate immune response against retroviruses and…”
Get full text