Search Results - "Rouzina, I"
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DNA confinement drives uncoating of the HIV Virus
Published in The European physical journal. ST, Special topics (01-09-2014)“…The enzyme reverse transcriptase converts single-stranded RNA molecules into double-stranded DNA molecules inside mature HIV viral capsids. We present a model…”
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The HIV-1 nucleocapsid chaperone protein forms locally compacted globules on long double-stranded DNA
Published in Nucleic acids research (07-05-2021)“…Abstract The nucleocapsid (NC) protein plays key roles in Human Immunodeficiency Virus 1 (HIV-1) replication, notably by condensing and protecting the viral…”
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Left versus right: Exploring the effects of chiral threading intercalators using optical tweezers
Published in Biophysical journal (04-10-2022)“…Small-molecule DNA-binding drugs have shown promising results in clinical use against many types of cancer. Understanding the molecular mechanisms of DNA…”
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Thermodynamics and kinetics of the B-S transition in base-modified DNA
Published in Biophysical journal (10-02-2023)“…Understanding changes in the mechanical properties of nucleic acids is important to understand many biological processes. DNA exhibits a conformational change…”
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Distinct binding interactions of HIV-1 Gag to Psi and non-Psi RNAs: implications for viral genomic RNA packaging
Published in RNA (Cambridge) (01-08-2013)“…Despite the vast excess of cellular RNAs, precisely two copies of viral genomic RNA (gRNA) are selectively packaged into new human immunodeficiency type 1…”
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DNA intercalation optimized by two-step molecular lock mechanism
Published in Scientific reports (05-12-2016)“…The diverse properties of DNA intercalators, varying in affinity and kinetics over several orders of magnitude, provide a wide range of applications for…”
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Reshaping the Energy Landscape Transforms the Mechanism and Binding Kinetics of DNA Threading Intercalation
Published in Biochemistry (Easton) (06-02-2018)“…Molecules that bind DNA via threading intercalation show high binding affinity as well as slow dissociation kinetics, properties ideal for the development of…”
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Strong DNA deformation required for extremely slow DNA threading intercalation by a binuclear ruthenium complex
Published in Nucleic acids research (13-10-2014)“…DNA intercalation by threading is expected to yield high affinity and slow dissociation, properties desirable for DNA-targeted therapeutics. To measure these…”
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Force-Induced Melting of the DNA Double Helix 1. Thermodynamic Analysis
Published in Biophysical journal (01-02-2001)“…The highly cooperative elongation of a single B-DNA molecule to almost twice its contour length upon application of a stretching force is interpreted as…”
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Dissecting the Dynamic Pathways of Stereoselective DNA Threading Intercalation
Published in Biophysical journal (29-03-2016)“…DNA intercalators that have high affinity and slow kinetics are developed for potential DNA-targeted therapeutics. Although many natural intercalators contain…”
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A ruthenium dimer complex with a flexible linker slowly threads between DNA bases in two distinct steps
Published in Nucleic acids research (15-10-2015)“…Several multi-component DNA intercalating small molecules have been designed around ruthenium-based intercalating monomers to optimize DNA binding properties…”
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Distinct nucleic acid interaction properties of HIV-1 nucleocapsid protein precursor NCp15 explain reduced viral infectivity
Published in Nucleic acids research (17-06-2014)“…During human immunodeficiency virus type 1 (HIV-1) maturation, three different forms of nucleocapsid (NC) protein-NCp15 (p9 + p6), NCp9 (p7 + SP2) and…”
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Role of the Moiety Chirality in Determining the DNA Binding Characteristics of Threading Intercalators
Published in Biophysical journal (16-02-2016)Get full text
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Significance of Steric Bulk in DNA Threading Intercalation Revelaed through Force-Dependent Kinetics
Published in Biophysical journal (16-02-2016)Get full text
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Thermodynamics of DNA binding and condensation: isothermal titration calorimetry and electrostatic mechanism
Published in Journal of molecular biology (03-03-2000)“…The thermodynamics of binding of the trivalent cations cobalt hexammine and spermidine to plasmid DNA was studied by isothermal titration calorimetry. Two…”
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Force spectroscopy of single DNA and RNA molecules
Published in Current Opinion in Structural Biology (01-06-2002)“…Experiments in which single molecules of RNA and DNA are stretched, and the resulting force as a function of extension is measured have yielded new information…”
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Force-Induced Melting of the DNA Double Helix. 2. Effect of Solution Conditions
Published in Biophysical journal (01-02-2001)“…In this paper, we consider the implications of the general theory developed in the accompanying paper, to interpret experiments on DNA overstretching that…”
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HIV-1 Nucleocapsid Protein Switches the Pathway of Transactivation Response Element RNA/DNA Annealing from Loop–Loop “Kissing” to “Zipper”
Published in Journal of molecular biology (27-02-2009)“…The chaperone activity of HIV-1 (human immunodeficiency virus type 1) nucleocapsid protein (NC) facilitates multiple nucleic acid rearrangements that are…”
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Two-Step DNA Intercalation by Threading of the Flexible Ruthenium Dimer Studied by the Single Molecule DNA Stretching
Published in Biophysical journal (01-01-2015)Get full text
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20
Resolving the DNA Binding Mode of a Rotationally Flexible Binuclear Ruthenium Complex
Published in Biophysical journal (2015)Get full text
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