Search Results - "Rouzina, I"

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    DNA confinement drives uncoating of the HIV Virus by Rouzina, I., Bruinsma, R.

    “…The enzyme reverse transcriptase converts single-stranded RNA molecules into double-stranded DNA molecules inside mature HIV viral capsids. We present a model…”
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    Journal Article
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    The HIV-1 nucleocapsid chaperone protein forms locally compacted globules on long double-stranded DNA by Jiang, Kai, Humbert, Nicolas, K.K., Sriram, Rouzina, Ioulia, Mely, Yves, Westerlund, Fredrik

    Published in Nucleic acids research (07-05-2021)
    “…Abstract The nucleocapsid (NC) protein plays key roles in Human Immunodeficiency Virus 1 (HIV-1) replication, notably by condensing and protecting the viral…”
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    Journal Article
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    Left versus right: Exploring the effects of chiral threading intercalators using optical tweezers by Jabak, Adam A., Bryden, Nicholas, Westerlund, Fredrik, Lincoln, Per, McCauley, Micah J., Rouzina, Ioulia, Williams, Mark C., Paramanathan, Thayaparan

    Published in Biophysical journal (04-10-2022)
    “…Small-molecule DNA-binding drugs have shown promising results in clinical use against many types of cancer. Understanding the molecular mechanisms of DNA…”
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    Journal Article
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    Thermodynamics and kinetics of the B-S transition in base-modified DNA by Sundar Rajan, Vinoth Edal, Levin, Sune, McCauley, Micah J., Williams, Mark C., Rouzina, Ioulia F., Wilhelmsson, Marcus, Westerlund, Fredrik

    Published in Biophysical journal (10-02-2023)
    “…Understanding changes in the mechanical properties of nucleic acids is important to understand many biological processes. DNA exhibits a conformational change…”
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    Journal Article
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    Distinct binding interactions of HIV-1 Gag to Psi and non-Psi RNAs: implications for viral genomic RNA packaging by Webb, Joseph A, Jones, Christopher P, Parent, Leslie J, Rouzina, Ioulia, Musier-Forsyth, Karin

    Published in RNA (Cambridge) (01-08-2013)
    “…Despite the vast excess of cellular RNAs, precisely two copies of viral genomic RNA (gRNA) are selectively packaged into new human immunodeficiency type 1…”
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    Journal Article
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    DNA intercalation optimized by two-step molecular lock mechanism by Almaqwashi, Ali A., Andersson, Johanna, Lincoln, Per, Rouzina, Ioulia, Westerlund, Fredrik, Williams, Mark C.

    Published in Scientific reports (05-12-2016)
    “…The diverse properties of DNA intercalators, varying in affinity and kinetics over several orders of magnitude, provide a wide range of applications for…”
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    Journal Article
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    Reshaping the Energy Landscape Transforms the Mechanism and Binding Kinetics of DNA Threading Intercalation by Clark, Andrew G, Naufer, M. Nabuan, Westerlund, Fredrik, Lincoln, Per, Rouzina, Ioulia, Paramanathan, Thayaparan, Williams, Mark C

    Published in Biochemistry (Easton) (06-02-2018)
    “…Molecules that bind DNA via threading intercalation show high binding affinity as well as slow dissociation kinetics, properties ideal for the development of…”
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    Journal Article
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    Strong DNA deformation required for extremely slow DNA threading intercalation by a binuclear ruthenium complex by Almaqwashi, Ali A, Paramanathan, Thayaparan, Lincoln, Per, Rouzina, Ioulia, Westerlund, Fredrik, Williams, Mark C

    Published in Nucleic acids research (13-10-2014)
    “…DNA intercalation by threading is expected to yield high affinity and slow dissociation, properties desirable for DNA-targeted therapeutics. To measure these…”
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    Journal Article
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    Force-Induced Melting of the DNA Double Helix 1. Thermodynamic Analysis by Rouzina, Ioulia, Bloomfield, Victor A.

    Published in Biophysical journal (01-02-2001)
    “…The highly cooperative elongation of a single B-DNA molecule to almost twice its contour length upon application of a stretching force is interpreted as…”
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    Journal Article
  10. 10

    Dissecting the Dynamic Pathways of Stereoselective DNA Threading Intercalation by Almaqwashi, Ali A., Andersson, Johanna, Lincoln, Per, Rouzina, Ioulia, Westerlund, Fredrik, Williams, Mark C.

    Published in Biophysical journal (29-03-2016)
    “…DNA intercalators that have high affinity and slow kinetics are developed for potential DNA-targeted therapeutics. Although many natural intercalators contain…”
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    Journal Article
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    A ruthenium dimer complex with a flexible linker slowly threads between DNA bases in two distinct steps by Bahira, Meriem, McCauley, Micah J, Almaqwashi, Ali A, Lincoln, Per, Westerlund, Fredrik, Rouzina, Ioulia, Williams, Mark C

    Published in Nucleic acids research (15-10-2015)
    “…Several multi-component DNA intercalating small molecules have been designed around ruthenium-based intercalating monomers to optimize DNA binding properties…”
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    Journal Article
  12. 12

    Distinct nucleic acid interaction properties of HIV-1 nucleocapsid protein precursor NCp15 explain reduced viral infectivity by Wang, Wei, Naiyer, Nada, Mitra, Mithun, Li, Jialin, Williams, Mark C, Rouzina, Ioulia, Gorelick, Robert J, Wu, Zhengrong, Musier-Forsyth, Karin

    Published in Nucleic acids research (17-06-2014)
    “…During human immunodeficiency virus type 1 (HIV-1) maturation, three different forms of nucleocapsid (NC) protein-NCp15 (p9 + p6), NCp9 (p7 + SP2) and…”
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    Journal Article
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    Thermodynamics of DNA binding and condensation: isothermal titration calorimetry and electrostatic mechanism by Matulis, D, Rouzina, I, Bloomfield, V A

    Published in Journal of molecular biology (03-03-2000)
    “…The thermodynamics of binding of the trivalent cations cobalt hexammine and spermidine to plasmid DNA was studied by isothermal titration calorimetry. Two…”
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    Journal Article
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    Force spectroscopy of single DNA and RNA molecules by Williams, Mark C, Rouzina, Ioulia

    Published in Current Opinion in Structural Biology (01-06-2002)
    “…Experiments in which single molecules of RNA and DNA are stretched, and the resulting force as a function of extension is measured have yielded new information…”
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    Book Review Journal Article
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    Force-Induced Melting of the DNA Double Helix. 2. Effect of Solution Conditions by Rouzina, Ioulia, Bloomfield, Victor A.

    Published in Biophysical journal (01-02-2001)
    “…In this paper, we consider the implications of the general theory developed in the accompanying paper, to interpret experiments on DNA overstretching that…”
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    Journal Article
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    HIV-1 Nucleocapsid Protein Switches the Pathway of Transactivation Response Element RNA/DNA Annealing from Loop–Loop “Kissing” to “Zipper” by Vo, My-Nuong, Barany, George, Rouzina, Ioulia, Musier-Forsyth, Karin

    Published in Journal of molecular biology (27-02-2009)
    “…The chaperone activity of HIV-1 (human immunodeficiency virus type 1) nucleocapsid protein (NC) facilitates multiple nucleic acid rearrangements that are…”
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    Journal Article
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