Search Results - "Rouyer‐Fessard, Christiane"

Aberrant Expression of OX1 Receptors for Orexins in Colon Cancers and Liver Metastases: an Openable Gate to Apoptosis by VOISIN, Thierry, EI FIRAR, Aadil, LABURTHE, Marc, FASSEU, Magali, ROUYER-FESSARD, Christiane, DESCATOIRE, Véronique, WALKER, Francine, PARADIS, Valerie, BEDOSSA, Pierre, HENIN, Dominique, LEHY, Thérèse

“…Resistance to apoptosis is a recurrent theme in colon cancer. We have shown previously that the 7-transmembrane spanning receptor OX1R for orexins promotes…”
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hallmark of immunoreceptor, the tyrosine-based inhibitory motif ITIM, is present in the G protein-coupled receptor OX1R for orexins and drives apoptosis: a novel mechanism by Voisin, Thierry, El Firar, Aadil, Rouyer-Fessard, Christiane, Gratio, Valérie, Laburthe, Marc

“…Orexins acting at the G protein-coupled receptor (GPCR) OX1R have recently been shown to promote dramatic apoptosis in cancer cells. We report here that…”
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Discovery of a functional immunoreceptor tyrosine-based switch motif in a 7-transmembrane-spanning receptor: role in the orexin receptor OX1R-driven apoptosis by El Firar, Aadil, Voisin, Thierry, Rouyer-Fessard, Christiane, Ostuni, Mariano A, Couvineau, Alain, Laburthe, Marc

“…The orexin neuropeptides promote robust apoptosis in cancer cells. We have recently shown that the 7-transmembrane-spanning orexin receptor OX1R mediates…”
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Spatial proximity between the VPAC1 receptor and the amino terminus of agonist and antagonist peptides reveals distinct sites of interaction by Ceraudo, Emilie, Hierso, Régine, Tan, Yossan‐Var, Murail, Samuel, Rouyer‐Fessard, Christiane, Nicole, Pascal, Robert, Jean‐Claude, Jamin, Nadège, Neumann, Jean‐Michel, Robberecht, Patrick, Laburthe, Marc, Couvineau, Alain

“…Vasoactive intestinal peptide (VIP) plays a major role in pathophysiology. Our previous studies demonstrated that the VIP sequence 6‐28 interacts with the…”
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Orexins Acting at Native OX1 Receptor in Colon Cancer and Neuroblastoma Cells or at Recombinant OX1 Receptor Suppress Cell Growth by Inducing Apoptosis by Patricia Rouet-Benzineb, Christiane Rouyer-Fessard, Anne Jarry, Virgile Avondo, Cécile Pouzet, Masashi Yanagisawa, Christian Laboisse, Marc Laburthe, Thierry Voisin

“…Screening of 26 gut peptides for their ability to inhibit growth of human colon cancer HT29-D4 cells grown in 10% fetal calf serum identified orexin-A and…”
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Neurotensin and a non‐peptide neurotensin receptor antagonist control human colon cancer cell growth in cell culture and in cells xenografted into nude mice by Maoret, Jean‐José, Anini, Younes, Rouyer‐Fessard, Christiane, Gully, Danielle, Laburthe, Marc

“…The intestine is a large endocrine organ, but the dependence of colon cancer on hormones remains unknown. We show here that neurotensin, a paracrine/endocrine…”
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Serine 447 in the carboxyl tail of human VPAC1 receptor is crucial for agonist-induced desensitization but not internalization of the receptor by Marie, Jean-Claude, Rouyer-Fessard, Christiane, Couvineau, Alain, Nicole, Pascal, Devaud, Hélène, El Benna, Jamel, Laburthe, Marc

“…The VPAC1 receptor for vasoactive intestinal peptide (VIP) belongs to the class II family of G protein-coupled receptors and is coupled to Gs protein/adenylyl…”
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Enterocytic differentiation and glucose utilization in the human colon tumor cell line Caco-2: modulation by forskolin by Rousset, M, Laburthe, M, Pinto, M, Chevalier, G, Rouyer-Fessard, C, Dussaulx, E, Trugnan, G, Boige, N, Brun, J L, Zweibaum, A

“…The human colon cancer line Caco-2 exhibits after confluency a concomitant increase of glycogen accumulation and an enterocytic differentiation. The purpose of…”
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Constitutive Activation of the Human Vasoactive Intestinal Peptide 1 Receptor, a Member of the New Class II Family of G Protein-coupled Receptors by Gaudin, P, Maoret, J J, Couvineau, A, Rouyer-Fessard, C, Laburthe, M

“…The human vasoactive intestinal peptide (VIP) 1 receptor belongs to the new class II subfamily of G protein-coupled receptors. Specific change by mutagenesis…”
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Human VPAC1 Receptor Selectivity Filter by Du, Kai, Couvineau, Alain, Rouyer-Fessard, Christiane, Nicole, Pascal, Laburthe, Marc

“…The human VPAC1 receptor for vasoactive intestinal peptide (VIP) and pituitary adenylate cyclase activating peptide (PACAP) belongs to the class II family of G…”
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Identification of Cytoplasmic Domains of hVPAC1 Receptor Required for Activation of Adenylyl Cyclase by Alain Couvineau, Jean-Jacques Lacapère, Yossan-Var Tan, Christiane Rouyer-Fessard, Pascal Nicole, Marc Laburthe

“…The VPAC1 receptor mediates the action of two neuropeptides, vasoactive intestinal peptide (VIP) and pituitary adenylate cyclase-activating peptide. It is a…”
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The Human VPAC1 Receptor by Lins, Laurence, Couvineau, Alain, Rouyer-Fessard, Christiane, Nicole, Pascal, Maoret, Jean-José, Benhamed, Moussa, Brasseur, Robert, Thomas, Annick, Laburthe, Marc

“…The human VPAC1receptor for vasoactive intestinal peptide (VIP) and pituitary adenylate cyclase activating peptide belongs to the class II family of…”
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Cloning and Functional Characterization of the Human VIP1/PACAP Receptor Promoter by COUVINEAU, ALAIN, MAORET, JEAN JOSE, ROUYER-FESSARD, CHRISTIANE, CARRERO, ISABEL, LABURTHE, MARC

“…: The 5′‐flanking region (1.5 kb) of the gene coding for the human VIP1/PACAP receptor was isolated, sequenced, and characterized. Transient expression of…”
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Identification of Key Residues for Interaction of Vasoactive Intestinal Peptide with Human VPAC1 and VPAC2Receptors and Development of a Highly Selective VPAC1Receptor Agonist by Nicole, Pascal, Lins, Laurence, Rouyer-Fessard, Christiane, Drouot, Cyrille, Fulcrand, Pierre, Thomas, Annick, Couvineau, Alain, Martinez, Jean, Brasseur, Robert, Laburthe, Marc

“…The widespread neuropeptide vasoactive intestinal peptide (VIP) has two receptors VPAC1 and VPAC2. Solid-phase syntheses of VIP analogs in which each amino…”
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Constitutive Activation of the Human VIP1 Receptor by GAUDIN, PASCALE, ROUYER-FESSARD, CHRISTIANE, COUVINEAU, ALAIN, MAORET, JEAN-JOSE, LABURTHE, MARC

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Vasoactive Intestinal Peptide (VIP)1 Receptor by Couvineau, Alain, Rouyer-Fessard, Christiane, Maoret, Jean-José, Gaudin, Pascale, Nicole, Pascal, Laburthe, Marc

“…Vasoactive intestinal peptide (VIP) 1 receptors in rats and humans recognize peptide histidine isoleucineamide (PHI) with high and low affinity, respectively…”
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Identification of key residues for interaction of vasoactive intestinal peptide with human VPAC1 and VPAC2 receptors and development of a highly selective VPAC1 receptor agonist. Alanine scanning and molecular modeling of the peptide by Nicole, P, Lins, L, Rouyer-Fessard, C, Drouot, C, Fulcrand, P, Thomas, A, Couvineau, A, Martinez, J, Brasseur, R, Laburthe, M

“…The widespread neuropeptide vasoactive intestinal peptide (VIP) has two receptors VPAC(1) and VPAC(2). Solid-phase syntheses of VIP analogs in which each amino…”
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Presence of a N-terminal signal peptide in class II G protein-coupled receptors: crucial role for expression of the human VPAC1 receptor by Couvineau, Alain, Rouyer-Fessard, Christiane, Laburthe, Marc

“…The hVPAC1 receptor for vasoactive intestinal peptide (VIP) and pituitary adenylyl cyclase activating peptide (PACAP) has an N-terminal signal peptide like all…”
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Identification of cytoplasmic domains of hVPAC1 receptor required for activation of adenylyl cyclase. Crucial role of two charged amino acids strictly conserved in class II G protein-coupled receptors by Couvineau, Alain, Lacapere, Jean-Jacques, Tan, Yossan-Var, Rouyer-Fessard, Christiane, Nicole, Pascal, Laburthe, Marc

“…The VPAC1 receptor mediates the action of two neuropeptides, vasoactive intestinal peptide (VIP) and pituitary adenylate cyclase-activating peptide. It is a…”
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Production and Purification of Large Quantities of the Functional N-Terminal Ectodomain of Human VPAC1 Receptor by Couvineau, Alain, Robert, Jean-Claude, Ramdani, Tarik, Lacapère, Jean-Jacques, Rouyer-Fessard, Christiane, Laburthe, Marc

“…Vasoactive intestinal peptide (VIP) is implicated in many physiological and pathophysiological processes, and its receptors are promising targets for the…”
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