Search Results - "Routledge, Matthew"

Superspreaders drive the largest outbreaks of hospital onset COVID-19 infections by Illingworth, Christopher Jr, Hamilton, William L, Warne, Ben, Routledge, Matthew, Popay, Ashley, Jackson, Chris, Fieldman, Tom, Meredith, Luke W, Houldcroft, Charlotte J, Hosmillo, Myra, Jahun, Aminu S, Caller, Laura G, Caddy, Sarah L, Yakovleva, Anna, Hall, Grant, Khokhar, Fahad A, Feltwell, Theresa, Pinckert, Malte L, Georgana, Iliana, Chaudhry, Yasmin, Curran, Martin D, Parmar, Surendra, Sparkes, Dominic, Rivett, Lucy, Jones, Nick K, Sridhar, Sushmita, Forrest, Sally, Dymond, Tom, Grainger, Kayleigh, Workman, Chris, Ferris, Mark, Gkrania-Klotsas, Effrossyni, Brown, Nicholas M, Weekes, Michael P, Baker, Stephen, Peacock, Sharon J, Goodfellow, Ian G, Gouliouris, Theodore, de Angelis, Daniela, Török, M Estée

“…SARS-CoV-2 is notable both for its rapid spread, and for the heterogeneity of its patterns of transmission, with multiple published incidences of…”
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Effective control of SARS-CoV-2 transmission between healthcare workers during a period of diminished community prevalence of COVID-19 by Jones, Nick K, Rivett, Lucy, Sparkes, Dominic, Forrest, Sally, Sridhar, Sushmita, Young, Jamie, Pereira-Dias, Joana, Cormie, Claire, Gill, Harmeet, Reynolds, Nicola, Wantoch, Michelle, Routledge, Matthew, Warne, Ben, Levy, Jack, Córdova Jiménez, William David, Samad, Fathima Nisha Begum, McNicholas, Chris, Ferris, Mark, Gray, Jane, Gill, Michael, Curran, Martin D, Fuller, Stewart, Chaudhry, Afzal, Shaw, Ashley, Bradley, John R, Hannon, Gregory J, Goodfellow, Ian G, Dougan, Gordon, Smith, Kenneth Gc, Lehner, Paul J, Wright, Giles, Matheson, Nicholas J, Baker, Stephen, Weekes, Michael P

“…Previously, we showed that 3% (31/1032)of asymptomatic healthcare workers (HCWs) from a large teaching hospital in Cambridge, UK, tested positive for…”
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A Guillain-Barré syndrome-associated SIGLEC10 rare variant impairs its recognition of gangliosides by Alborzian Deh Sheikh, Amin, Gomaa, Soha, Li, Xuexin, Routledge, Matthew, Saigoh, Kazumasa, Numoto, Nobutaka, Angata, Takashi, Hitomi, Yuki, Takematsu, Hiromu, Tsuiji, Makoto, Ito, Nobutoshi, Kusunoki, Susumu, Tsubata, Takeshi

“…Guillain-Barré syndrome (GBS), including its variant Miller Fisher syndrome (MFS), is an acute peripheral neuropathy that involves autoimmune mechanisms…”
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Point of Care Nucleic Acid Testing for SARS-CoV-2 in Hospitalized Patients: A Clinical Validation Trial and Implementation Study by Collier, Dami A., Assennato, Sonny M., Warne, Ben, Sithole, Nyarie, Sharrocks, Katherine, Ritchie, Allyson, Ravji, Pooja, Routledge, Matthew, Sparkes, Dominic, Skittrall, Jordan, Smielewska, Anna, Ramsey, Isobel, Goel, Neha, Curran, Martin, Enoch, David, Tassell, Rhys, Lineham, Michelle, Vaghela, Devan, Leong, Clare, Mok, Hoi Ping, Bradley, John, Smith, Kenneth G.C., Mendoza, Vivienne, Demiris, Nikos, Besser, Martin, Dougan, Gordon, Lehner, Paul J., Siedner, Mark J., Zhang, Hongyi, Waddington, Claire S., Lee, Helen, Gupta, Ravindra K., Baker, Stephen, Bradley, John, Dougan, Gordon, Goodfellow, Ian, Gupta, Ravindra K., Lehner, Paul J., Lyons, Paul, Matheson, Nicholas J., Smith, Kenneth G.C., Toshner, Mark, Weekes, Michael P., Brown, Nick, Curran, Martin, Palmar, Surendra, Zhang, Hongyi, Enoch, David, Chapman, Daniel, Shaw, Ashley, Mendoza, Vivien, Jose, Sherly, Bermperi, Areti, Zerrudo, Julie Ann, Kourampa, Evgenia, Saunders, Caroline, de Jesus, Ranalie, Domingo, Jason, Pasquale, Ciro, Vergese, Bensi, Vargas, Phoebe, Fabiculana, Marivic, Perales, Marlyn, Skells, Richard, Mynott, Lee, Blake, Elizabeth, Bates, Amy, Vallier, Anne-laure, Williams, Alexandra, Phillips, David, Chiu, Edmund, Overhill, Alex, Ramenante, Nicola, Sipple, Jamal, Frost, Steven, Knock, Helena, Hardy, Richard, Foster, Emily, Davidson, Fiona, Rundell, Viona, Bundi, Purity, Abeseabe, Richmond, Clark, Sarah, Vicente, Isabel

“…There is an urgent need for rapid SARS-CoV-2 testing in hospitals to limit nosocomial spread. We report an evaluation of point of care (POC) nucleic acid…”
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26 The Join Well Study: Chronic Strongyloides stercoralis infection in Fijian migrants to the United Kingdom serving in the Armed Forces by Nevin, William, Melhuish, Jake, Toriro, Romeo, Routledge, Matthew, Swithenbank, Luke, Troth, Tom, Jones, Jayne, Woolley, Stephen, Nicol, Edward, Dermont, Mark, Beeching, Nicholas, Lamb, Lucy, O'Shea, Matthew, Fletcher, Thomas

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A blueprint for the implementation of a validated approach for the detection of SARS-Cov2 in clinical samples in academic facilities by Sridhar, Sushmita, Forrest, Sally, Kean, Iain, Young, Jamie, Bartholdson Scott, Josefin, Maes, Mailis, Pereira-Dias, Joana, Parmar, Surendra, Routledge, Matthew, Sparkes, Dominic, Rivett, Lucy, Dougan, Gordon, Weekes, Michael, Curran, Martin, Goodfellow, Ian, Baker, Stephen

“…The COVID-19 pandemic is expanding at an unprecedented rate. As a result, diagnostic services are stretched to their limit, and there is a clear need for the…”
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Development and implementation of a customised rapid syndromic diagnostic test for severe pneumonia by Navapurkar, Vilas, Bartholdson Scott, Josefin, Maes, Mailis, Hellyer, Thomas P, Higginson, Ellen, Forrest, Sally, Pereira-Dias, Joana, Parmar, Surendra, Heasman-Hunt, Emma, Polgarova, Petra, Brown, Joanne, Titti, Lissamma, Smith, William PW, Scott, Jonathan, Rostron, Anthony, Routledge, Matthew, Sapsford, David, Török, M. Estée, McMullan, Ronan, Enoch, David A, Wong, Vanessa, Curran, Martin D, Brown, Nicholas M, Simpson, A John, Herre, Jurgen, Dougan, Gordon, Conway Morris, Andrew

“…Background: The diagnosis of pneumonia has been hampered by a reliance on bacterial cultures which take several days to return a result, and are frequently…”
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Antimicrobial-associated harm in critical care: a narrative review by Arulkumaran, Nishkantha, Routledge, Matthew, Schlebusch, Sanmarié, Lipman, Jeffrey, Conway Morris, Andrew

“…The belief that, for the individual patient, the benefit of prompt and continued use of antimicrobials outweighs any potential harm is a significant barrier to…”
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Screening of healthcare workers for SARS-CoV-2 highlights the role of asymptomatic carriage in COVID-19 transmission by Rivett, Lucy, Sridhar, Sushmita, Sparkes, Dominic, Routledge, Matthew, Jones, Nick K, Forrest, Sally, Young, Jamie, Pereira-Dias, Joana, Hamilton, William L, Ferris, Mark, Torok, M Estee, Meredith, Luke, Curran, Martin D, Fuller, Stewart, Chaudhry, Afzal, Shaw, Ashley, Samworth, Richard J, Bradley, John R, Dougan, Gordon, Smith, Kenneth Gc, Lehner, Paul J, Matheson, Nicholas J, Wright, Giles, Goodfellow, Ian G, Baker, Stephen, Weekes, Michael P

“…Significant differences exist in the availability of healthcare worker (HCW) SARS-CoV-2 testing between countries, and existing programmes focus on screening…”
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The formation and function of the neutrophil phagosome by Naish, Emily, Wood, Alexander JT, Stewart, Andrew P, Routledge, Matthew, Morris, Andrew Conway, Chilvers, Edwin R, Lodge, Katharine M

“…Summary Neutrophils are the most abundant circulating leukocyte and are crucial to the initial innate immune response to infection. One of their key…”
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Epidemiology and outcomes of hospital-acquired bloodstream infections in intensive care unit patients: the EUROBACT-2 international cohort study by Tabah, Alexis, Buetti, Niccolò, Staiquly, Quentin, Ruckly, Stéphane, Akova, Murat, Aslan, Abdullah Tarik, Leone, Marc, Conway Morris, Andrew, Bassetti, Matteo, Arvaniti, Kostoula, Lipman, Jeffrey, Ferrer, Ricard, Qiu, Haibo, Paiva, José-Artur, Povoa, Pedro, De Bus, Liesbet, De Waele, Jan, Zand, Farid, Gurjar, Mohan, Alsisi, Adel, Abidi, Khalid, Bracht, Hendrik, Hayashi, Yoshiro, Jeon, Kyeongman, Elhadi, Muhammed, Barbier, François, Timsit, Jean-François

“…Purpose In the critically ill, hospital-acquired bloodstream infections (HA-BSI) are associated with significant mortality. Granular data are required for…”
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"All Models Are Wrong, Some Are Useful": George Box by Routledge, Matthew, Conway Morris, Andrew

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Drug-induced liver injury from antituberculous treatment: a retrospective study from a large TB centre in the UK by Abbara, Aula, Chitty, Sarah, Roe, Jennifer K, Ghani, Rohma, Collin, Simon M, Ritchie, Andrew, Kon, Onn Min, Dzvova, John, Davidson, Harriet, Edwards, Thomas E, Hateley, Charlotte, Routledge, Matthew, Buckley, Jim, Davidson, Robert N, John, Laurence

“…We describe drug-induced liver injury (DILI) secondary to antituberculous treatment (ATT) in a large tuberculosis (TB) centre in London; we identify the…”
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Neutrophil extracellular traps protect the kidney from ascending infection and are required for a positive leukocyte dipstick test by Stewart, Andrew P, Loudon, Kevin W, Routledge, Matthew, Lee, Colin Y C, Trotter, Patrick, Richoz, Nathan, Gillman, Eleanor, Antrobus, Robin, Mccaffrey, James, Posner, David, Conway Morris, Andrew, Karet Frankl, Fiona E, Clatworthy, Menna R

“…Lower urinary tract infection (UTI) is common but only rarely complicated by pyelonephritis. However, the mechanisms preventing extension to the kidney are…”
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Single-dose BNT162b2 vaccine protects against asymptomatic SARS-CoV-2 infection by Jones, Nick K, Rivett, Lucy, Seaman, Shaun, Samworth, Richard J, Warne, Ben, Workman, Chris, Ferris, Mark, Wright, Jo, Quinnell, Natalie, Shaw, Ashley, Goodfellow, Ian G, Lehner, Paul J, Howes, Rob, Wright, Giles, Matheson, Nicholas J, Weekes, Michael P

“…The BNT162b2 mRNA COVID-19 vaccine (Pfizer-BioNTech) is being utilised internationally for mass COVID-19 vaccination. Evidence of single-dose protection…”
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The role of centre and country factors on process and outcome indicators in critically ill patients with hospital-acquired bloodstream infections by Buetti, Niccolò, Tabah, Alexis, Setti, Nour, Ruckly, Stéphane, Barbier, François, Akova, Murat, Aslan, Abdullah Tarik, Leone, Marc, Bassetti, Matteo, Morris, Andrew Conway, Arvaniti, Kostoula, Paiva, José-Artur, Ferrer, Ricard, Qiu, Haibo, Montrucchio, Giorgia, Cortegiani, Andrea, Kayaaslan, Bircan, De Bus, Liesbet, De Waele, Jan J., Timsit, Jean-François

“…Purpose The primary objective of this study was to evaluate the associations between centre/country-based factors and two important process and outcome…”
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Correction: The role of centre and country factors on process and outcome indicators in critically ill patients with hospital-acquired bloodstream infections by Buetti, Niccolò, Tabah, Alexis, Setti, Nour, Ruckly, Stéphane, Barbier, François, Akova, Murat, Aslan, Abdullah Tarik, Leone, Marc, Bassetti, Matteo, Morris, Andrew Conway, Arvaniti, Kostoula, Paiva, José-Artur, Ferrer, Ricard, Qiu, Haibo, Montrucchio, Giorgia, Cortegiani, Andrea, Kayaaslan, Bircan, De Bus, Liesbet, De Waele, Jan J., Timsit, Jean-François

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A2B-COVID: A Tool for Rapidly Evaluating Potential SARS-CoV-2 Transmission Events by Illingworth, Christopher J R, Hamilton, William L, Jackson, Christopher, Warne, Ben, Popay, Ashley, Meredith, Luke, Hosmillo, Myra, Jahun, Aminu, Fieldman, Tom, Routledge, Matthew, Houldcroft, Charlotte J, Caller, Laura, Caddy, Sarah, Yakovleva, Anna, Hall, Grant, Khokhar, Fahad A, Feltwell, Theresa, Pinckert, Malte L, Georgana, Iliana, Chaudhry, Yasmin, Curran, Martin, Parmar, Surendra, Sparkes, Dominic, Rivett, Lucy, Jones, Nick K, Sridhar, Sushmita, Forrest, Sally, Dymond, Tom, Grainger, Kayleigh, Workman, Chris, Gkrania-Klotsas, Effrossyni, Brown, Nicholas M, Weekes, Michael P, Baker, Stephen, Peacock, Sharon J, Gouliouris, Theodore, Goodfellow, Ian, Angelis, Daniela De, Török, M Estée

“…Abstract Identifying linked cases of infection is a critical component of the public health response to viral infectious diseases. In a clinical context, there…”
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CD47 plays a critical role in T-cell recruitment by regulation of LFA-1 and VLA-4 integrin adhesive functions by Azcutia, Veronica, Routledge, Matthew, Williams, Marcie R, Newton, Gail, Frazier, William A, Manica, Andrè, Croce, Kevin J, Parkos, Charles A, Schmider, Angela B, Turman, Melissa V, Soberman, Roy J, Luscinskas, Francis W

“…CD47 plays an important but incompletely understood role in the innate and adaptive immune responses. CD47, also called integrin-associated protein, has been…”
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A prospective study of risk factors associated with seroprevalence of SARS-CoV-2 antibodies in healthcare workers at a large UK teaching hospital by Cooper, Daniel J, Lear, Sara, Watson, Laura, Shaw, Ashley, Ferris, Mark, Doffinger, Rainer, Bousfield, Rachel, Sharrocks, Katherine, Weekes, Michael P., Warne, Ben, Sparkes, Dominic, Jones, Nick K, Rivett, Lucy, Routledge, Matthew, Chaudhry, Afzal, Dempsey, Katherine, Matson, Montgomery, Lakha, Adil, Gathercole, George, O'Connor, Olivia, Wilson, Emily, Shahzad, Orthi, Toms, Kieran, Thompson, Rachel, Halsall, Ian, Halsall, David, Houghton, Sally, Papadia, Sofia, Kingston, Nathalie, Stirrups, Kathleen E, Graves, Barbara, Townsend, Paul, Walker, Neil, Stark, Hannah, De Angelis, Daniela, Seaman, Shaun, Dougan, Gordon, Bradley, John R, Török, M. Estée, Goodfellow, Ian, Baker, Stephen

“…•The risk of SARS-CoV-2 infection in healthcare workers is highly heterogeneous•The risk of SARS-CoV-2 is significantly higher in BAME healthcare…”
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