Search Results - "Rouschop, Kasper M. A."

Hypoxia leads to significant changes in alternative splicing and elevated expression of CLK splice factor kinases in PC3 prostate cancer cells by Bowler, Elizabeth, Porazinski, Sean, Uzor, Simon, Thibault, Philippe, Durand, Mathieu, Lapointe, Elvy, Rouschop, Kasper M A, Hancock, John, Wilson, Ian, Ladomery, Michael

“…Mounting evidence suggests that one of the ways that cells adapt to hypoxia is through alternative splicing. The aim of this study was firstly to examine the…”
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Optimal selection of natural killer cells to kill myeloma: the role of HLA-E and NKG2A by Sarkar, Subhashis, van Gelder, Michel, Noort, Willy, Xu, Yunping, Rouschop, Kasper M. A., Groen, Richard, Schouten, Harry C., Tilanus, Marcel G. J., Germeraad, Wilfred T. V., Martens, Anton C. M., Bos, Gerard M. J., Wieten, Lotte

“…Immunotherapy with allogeneic natural killer (NK) cells offers therapeutic perspectives for multiple myeloma patients. Here, we aimed to refine NK cell therapy…”
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Distinct radiation responses after in vitro mtDNA depletion are potentially related to oxidative stress by van Gisbergen, Marike W, Voets, An M, Biemans, Rianne, Hoffmann, Roland F, Drittij-Reijnders, Marie-José, Haenen, Guido R M M, Heijink, Irene H, Rouschop, Kasper M A, Dubois, Ludwig J, Lambin, Philippe

“…Several clinically used drugs are mitotoxic causing mitochondrial DNA (mtDNA) variations, and thereby influence cancer treatment response. We hypothesized that…”
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Sertraline/chloroquine combination therapy to target hypoxic and immunosuppressive serine/glycine synthesis-dependent glioblastomas by Sánchez-Castillo, Anaís, Savelkouls, Kim G., Baldini, Alessandra, Hounjet, Judith, Sonveaux, Pierre, Verstraete, Paulien, De Keersmaecker, Kim, Dewaele, Barbara, Björkblom, Benny, Melin, Beatrice, Wu, Wendy Y., Sjöberg, Rickard L., Rouschop, Kasper M. A., Broen, Martijn P. G., Vooijs, Marc, Kampen, Kim R.

“…The serine/glycine (ser/gly) synthesis pathway branches from glycolysis and is hyperactivated in approximately 30% of cancers. In ~13% of glioblastoma cases,…”
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Physiological Oxygen Levels Differentially Regulate Adipokine Production in Abdominal and Femoral Adipocytes from Individuals with Obesity Versus Normal Weight by Lempesis, Ioannis G, Hoebers, Nicole, Essers, Yvonne, Jocken, Johan W E, Rouschop, Kasper M A, Blaak, Ellen E, Manolopoulos, Konstantinos N, Goossens, Gijs H

“…Adipose tissue (AT) inflammation may increase obesity-related cardiometabolic complications. Altered AT oxygen partial pressure (pO ) may impact the adipocyte…”
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LC3/GABARAP family proteins: autophagy‐(un)related functions by Schaaf, Marco B. E., Keulers, Tom G., Vooijs, Marc A., Rouschop, Kasper M. A.

“…ABSTRACT From yeast to mammals, autophagy is an important mechanism for sustaining cellular homeostasis through facilitating the degradation and recycling of…”
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Protection against renal ischemia reperfusion injury by CD44 disruption by ROUSCHOP, Kasper M. A, ROELOFS, Joris J. T. H, CLAESSEN, Nike, DA COSTA MARTINS, Paula, ZWAGINGA, Jaap-Jan, PALS, Steven T, WEENING, Jan J, FLORQUIN, Sandrine

“…Inflammation contributes to renal ischemia reperfusion (I/R) injury, potentially causing renal dysfunction. The inflammatory infiltrate mainly consists of…”
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EGFR signaling and autophagy dependence for growth, survival, and therapy resistance by Jutten, Barry, rouschop, Kasper

“…The epidermal growth factor receptor (EGFR) is amplified or mutated in various human epithelial tumors. Its expression and activation leads to cell…”
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Hypoxic Activation of the PERK/eIF2α Arm of the Unfolded Protein Response Promotes Metastasis through Induction of LAMP3 by MUJCIC, Hilda, NAGELKERKE, Anika, KORITZINSKY, Marianne, WOUTERS, Bradly G, ROUSCHOP, Kasper M. A, CHUNG, Stephen, CHAUDARY, Naz, SPAN, Paul N, CLARKE, Blaise, MILOSEVIC, Michael, SYKES, Jenna, HILL, Richard P

“…Conditions of poor oxygenation (hypoxia) are present in many human tumors, including cervix cancer, and are associated with increased risk of metastasis and…”
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Iron deficiency‐induced loss of skeletal muscle mitochondrial proteins and respiratory capacity; the role of mitophagy and secretion of mitochondria‐containing vesicles by Leermakers, Pieter A., Remels, Alexander H. V., Zonneveld, Marijke I., Rouschop, Kasper M. A., Schols, Annemie M. W. J., Gosker, Harry R.

“…Iron homeostasis is essential for mitochondrial function, and iron deficiency has been associated with skeletal muscle weakness and decreased exercise capacity…”
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Hypoxia induced impairment of NK cell cytotoxicity against multiple myeloma can be overcome by IL-2 activation of the NK cells by Sarkar, Subhashis, Germeraad, Wilfred T V, Rouschop, Kasper M A, Steeghs, Elisabeth M P, van Gelder, Michel, Bos, Gerard M J, Wieten, Lotte

“…Multiple Myeloma (MM) is an incurable plasma cell malignancy residing within the bone marrow (BM). We aim to develop allogeneic Natural Killer (NK) cell…”
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The Immunomodulatory Role of Hypoxic Tumor-Derived Extracellular Vesicles by Beaumont, Joel E J, Beelen, Nicky A, Wieten, Lotte, Rouschop, Kasper M A

“…Tumor-associated immune cells frequently display tumor-supportive phenotypes. These phenotypes, induced by the tumor microenvironment (TME), are described for…”
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Urothelial CD44 Facilitates Escherichia coli Infection of the Murine Urinary Tract by Rouschop, Kasper M. A, Sylva, Marc, Teske, Gwendoline J. D, Hoedemaeker, Inge, Pals, Steven T, Weening, Jan J, van der Poll, Tom, Florquin, Sandrine

“…Escherichia coli is the most common pathogen found in urinary tract infections (UTIs), mainly affecting children and women. We report that CD44, a hyaluronic…”
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Cancer EV stimulate endothelial glycolysis to fuel protein synthesis via mTOR and AMPKα activation by Beaumont, Joël E. J., Barbeau, Lydie M. O., Ju, Jinzhe, Savelkouls, Kim G., Bouwman, Freek G., Zonneveld, Marijke I., Bronckaers, Annelies, Kampen, Kim R., Keulers, Tom G. H., Rouschop, Kasper M. A.

“…Hypoxia is a common feature of solid tumours and activates adaptation mechanisms in cancer cells that induce therapy resistance and has profound effects on…”
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Tumors Responsive to Autophagy-Inhibition: Identification and Biomarkers by Barbeau, Lydie M.O., Keulers, Tom G.H., Rouschop, Kasper M.A.

“…Recent advances in cancer treatment modalities reveal the limitations of the prevalent “one-size-fits-all” therapies and emphasize the necessity to develop…”
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Hypoxia-induced Expression of Carbonic Anhydrase 9 Is Dependent on the Unfolded Protein Response by van den Beucken, Twan, Koritzinsky, Marianne, Niessen, Hanneke, Dubois, Ludwig, Savelkouls, Kim, Mujcic, Hilda, Jutten, Barry, Kopacek, Juraj, Pastorekova, Sylvia, van der Kogel, Albert J., Lambin, Philippe, Voncken, Willem, Rouschop, Kasper M.A., Wouters, Bradly G.

“…Adaptation to tumor hypoxia is mediated in large part by changes in protein expression. These are driven by multiple pathways, including activation of the…”
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Endogenous tissue-type plasminogen activator is protective during ascending urinary tract infection by Roelofs, Joris J. T. H., Rouschop, Kasper M. A., Teske, Gwendoline J. D., Wagenaar, Gerry T. M., Claessen, Nike, Weening, Jan J., van der Poll, Tom, Florquin, Sandrine

“…Background. Acute pyelonephritis is one of the most common bacterial infections. Tissue-type plasminogen activator (tPA) is a potent fibrinolytic agent, but…”
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Tissue-type plasminogen activator modulates inflammatory responses and renal function in ischemia reperfusion injury by ROELOFS, Joris J. T. H, ROUSCHOP, Kasper M. A, LEEMANS, Jaklien C, CLAESSEN, Nike, DE BOER, Anita M, FREDERIKS, Wilma M, LIJNEN, H. Roger, WEENING, Jan J, FLORQUIN, Sandrine

“…Acute renal failure is often the result of ischemia-reperfusion (I/R) injury. Neutrophil influx is an important damaging event in I/R. Tissue-type plasminogen…”
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Chloroquine combined with concurrent radiotherapy and temozolomide for newly diagnosed glioblastoma: a phase IB trial by Compter, Inge, Eekers, Danielle B. P., Hoeben, Ann, Rouschop, Kasper M. A., Reymen, Bart, Ackermans, Linda, Beckervordersantforth, Jan, Bauer, Noel J. C., Anten, Monique M., Wesseling, Pieter, Postma, Alida A., De Ruysscher, Dirk, Lambin, Philippe

“…Treatment of glioblastoma xenografts with chloroquine results in macroautophagy/autophagy inhibition, resulting in a reduction of tumor hypoxia and…”
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Pre-transplant plasma and cellular levels of CD44 correlate with acute renal allograft rejection by Rouschop, Kasper M. A., Roelofs, Joris J. T. H., Rowshani, Ajda T., Leemans, Jaklien C., van der Poll, Tom, ten Berge, Ineke J. M., Weening, Jan J., Florquin, Sandrine

“…Background. Since CD44 is involved in activation, proliferation, rolling and extravasation of lymphocytes, we hypothesized that it could be involved in the…”
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