Search Results - "Rouru, J."

Safety and efficacy of ORM-12741 on cognitive and behavioral symptoms in patients with Alzheimer's disease: A randomized, double-blind, proof-of-concept study by Rinne, J.O, Wesnes, K, Hänninen, J, Murphy, M, Riordan, H, Rouru, J, ALPO Study Group

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Involvement of thyroid hormones in the effect of intracerebroventricular leptin infusion on uncoupling protein-3 expression in rat muscle by CUSIN, I, ROURU, J, VISSER, T, BURGER, A. G, ROHNER-JEANRENAUD, F

“…Involvement of thyroid hormones in the effect of intracerebroventricular leptin infusion on uncoupling protein-3 expression in rat muscle. I Cusin , J Rouru ,…”
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Pharmacokinetics of deramciclane and N-desmethylderamciclane after single and repeated oral doses in healthy volunteers by Huupponen, R, Anttila, M, Rouru, J, Kanerva, H, Miettinen, T, Scheinin, M

“…To study the pharmacokinetics and accumulation of deramciclane and its metabolite N-desmethylderamciclane after 60 mg twice daily doses for 4 weeks. Sixteen…”
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Pharmacokinetics of oral entacapone after frequent multiple dosing and effects on levodopa disposition by ROURU, J, GORDIN, A, HUUPPONEN, R, HUHTALA, S, SAVONTAUS, E, KORPELA, K, REINIKAINEN, K, SCHEININ, M

“…Entacapone is a peripherally acting catechol O-methyltransferase (COMT) inhibitor used as an adjunct to each daily levodopa/dopa decarboxylase (DDC) inhibitor…”
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2-[18F]fluoro-2-deoxy-d-glucose combined with microdialysis can be used for the comparison of tissue glucose metabolism in obese and lean rats by Virtanen, K. A., Haaparanta, M., Grönroos, T., Bergman, J., Solin, O., Rouru, J., Nuutila, P., Huupponen, R.

“…Aims: Direct assessment of tissue metabolism in vivo is important to understand the pathogenesis of obesity. Labelled glucose analogues are potential…”
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Normal serum uric acid concentrations in women with polycystic ovary syndrome by ANTTILA, L, ROURU, J, PENTTILÄ, T, IRJALA, K

“…Recently, an inverse correlation between serum uric acid concentrations and insulin sensitivity has been described in subjects with varying degrees of…”
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Effects of estrous cycle and steroid replacement on the expression of leptin and uncoupling proteins in adipose tissue in the rat by Luukkaa, V., Savontaus, E., Rouru, J., Virtanen, K. A., Boss, O., Huhtaniemi, I., Koulu, M., Pesonen, U., Huupponen, R.

“…Among other actions ,leptin has been suggested to increase energy expenditure and to modulate the menstrual cycle. In fact ,the main effect of leptin seems to…”
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Pharmacokinetics and safety of deramciclane during multiple oral dosing by Kanerva, H, Kilkku, O, Helminen, A, Rouru, J, Scheinin, M, Huupponen, R, Klebovich, I, Drabant, S, Urtti, A

“…Deramciclane is a new putative non-benzodiazepine-type anxiolytic compound. It is a selective serotonin 5-HT(2A) and 5-HT(2C) receptor antagonist and has also…”
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Effects of estrous cycle and steroid replacement on the expression of leptin and uncoupling proteins in adipose tissue in the rat by LUUKKAA, V, SAVONTAUS, E, ROURU, J, VIRTANEN, K. A, BOSS, O, HUHTANIEMI, I, KOULU, M, PESONEN, U, HUUPPONEN, R

“…Among other actions, leptin has been suggested to increase energy expenditure and to modulate the menstrual cycle. In fact, the main effect of leptin seems to…”
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Effects of metformin treatment on glucose transporter proteins in subcellular fractions of skeletal muscle in (fa/fa) Zucker rats by Rouru, J., Peltonen, J., Hänninen, V., Pesonen, U., Huupponen, R., Koulu, M., Santti, E.

“…1 The present study was designed to clarify the cellular mechanism through which the antihyperglycaemic drug, metformin, exerts its effects. For this purpose…”
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A double-blind, randomized, placebo-controlled crossover trial of the  2C-adrenoceptor antagonist ORM-12741 for prevention of cold-induced vasospasm in patients with systemic sclerosis by Herrick, A. L., Murray, A. K., Ruck, A., Rouru, J., Moore, T. L., Whiteside, J., Hakulinen, P., Wigley, F., Snapir, A.

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Validation of [11C]ORM-13070 as a PET tracer for alpha2c-adrenoceptors in the human brain by Lehto, Jussi, Hirvonen, Mika M., Johansson, Jarkko, Kemppainen, Jukka, Luoto, Pauliina, Naukkarinen, Tarja, Oikonen, Vesa, Arponen, Eveliina, Rouru, Juha, Sallinen, Jukka, Scheinin, Harry, Vuorilehto, Lauri, Finnema, Sjoerd J., Halldin, Christer, Rinne, Juha O., Scheinin, Mika

“…ABSTRACT This study explored the use of the α2C‐adrenoceptor PET tracer [11C]ORM‐13070 to monitor α2C‐AR occupancy in the human brain. The subtype‐nonselective…”
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Validation of [ 11 C]ORM‐13070 as a PET tracer for alpha 2c ‐adrenoceptors in the human brain by Lehto, Jussi, Hirvonen, Mika M., Johansson, Jarkko, Kemppainen, Jukka, Luoto, Pauliina, Naukkarinen, Tarja, Oikonen, Vesa, Arponen, Eveliina, Rouru, Juha, Sallinen, Jukka, Scheinin, Harry, Vuorilehto, Lauri, Finnema, Sjoerd J., Halldin, Christer, Rinne, Juha O., Scheinin, Mika

“…ABSTRACT This study explored the use of the α 2C ‐adrenoceptor PET tracer [ 11 C]ORM‐13070 to monitor α 2C ‐AR occupancy in the human brain. The…”
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Biomarker and Clinical Trial Design Support for Disease-Modifying Therapies: Report of a Survey of the EU/US: Alzheimer’s Disease Task Force by Cummings, Jeffrey, Fox, N., Vellas, B., Aisen, P., Shan, G.

“…Background Disease-modifying therapies are urgently needed for the treatment of Alzheimer’s disease (AD). The European Union/United States (EU/US) Task Force…”
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Serum leptin concentrations in women with polycystic ovary syndrome by ROURU, J, ANTTILA, L, KOSKINEN, P, PENTTILÄ, T.-A, IRJALA, K, HUUPPONEN, R, KOULU, M

“…The role of gonadotropins, androgens, and insulin in the regulation of circulating leptin levels is obscure. In order to clarify the relationships of these…”
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Intracerebroventricular Glucocorticoid Infusion in Normal Rats: Induction of Parasympathetic-Mediated Obesity and Insulin Resistance by Cusin, Isabelle, Rouru, Juha, Rohner‐Jeanrenaud, Françoise

“…Objective: The aims of the present study were to determine whether increased body weight resulting from intracerebroventricular (ICV) glucocorticoid…”
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Determination of metformin in plasma by high-performance liquid chromatography by Huupponen, R, Ojala-Karlsson, P, Rouru, J, Koulu, M

“…A high-performance liquid chromatographic method for the determination of metformin, an oral antidiabetic agent, in plasma is described. Plasma samples…”
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Selective dependence of intracerebroventricular neuropeptide Y-elicited effects on central glucocorticoids by Zakrzewska, K E, Sainsbury, A, Cusin, I, Rouru, J, Jeanrenaud, B, Rohner-Jeanrenaud, F

“…It has been reported that hyperphagia and excessive body weight gain of genetically obese rodents were abolished by adrenalectomy. High hypothalamic levels of…”
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Correlation between circulating leptin and luteinizing hormone during the menstrual cycle in normal-weight women by TEIRMAA, T, LUUKKAA, V, ROURU, J, KOULU, M, HUUPPONEN, R

“…Leptin is the hormonal product of the ob gene. It is expressed in adipocytes and participates in the regulation of food intake and metabolism. Since leptin…”
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Effects of Intravenously Infused Leptin on Insulin Sensitivity and on the Expression of Uncoupling Proteins in Brown Adipose Tissue by Rouru, Juha, Cusin, Isabelle, Zakrzewska, Katerina E., Jeanrenaud, Bernard, Rohner-Jeanrenaud, Françoise

“…Abstract Centrally administered leptin has been shown to increase insulin-stimulated glucose utilization and to favor the expression of uncoupling proteins…”
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