Search Results - "Roumier, T"

Cyclin-dependent kinase-1: linking apoptosis to cell cycle and mitotic catastrophe by Castedo, M, Perfettini, J-L, Roumier, T, Kroemer, G

“…The cyclin-dependent kinase 1 (Cdk1), formerly called Cdc2 (or p34(Cdc2)), interacts with cyclin B1 to form an active heterodimer. The activity of Cdk1 is…”
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Mechanisms of apoptosis induction by the HIV-1 envelope by Perfettini, J-L, Castedo, M, Roumier, T, Andreau, K, Nardacci, R, Piacentini, M, Kroemer, G

“…The envelope glycoprotein complex (Env) of human immunodeficiency virus-1 (HIV-1) can induce apoptosis by a cornucopia of distinct mechanisms. A soluble Env…”
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Human immunodeficiency virus 1 envelope glycoprotein complex-induced apoptosis involves mammalian target of rapamycin/FKBP12-rapamycin-associated protein-mediated p53 phosphorylation by Castedo, M, Ferri, K F, Blanco, J, Roumier, T, Larochette, N, Barretina, J, Amendola, A, Nardacci, R, Métivier, D, Este, J A, Piacentini, M, Kroemer, G

“…Syncytia arising from the fusion of cells expressing a lymphotropic human immunodeficiency virus (HIV)-1-encoded envelope glycoprotein complex (Env) gene with…”
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The C-terminal moiety of HIV-1 Vpr induces cell death via a caspase-independent mitochondrial pathway by Roumier, T, Vieira, H L A, Castedo, M, Ferri, K F, Boya, P, Andreau, K, Druillennec, S, Joza, N, Penninger, J M, Roques, B, Kroemer, G

“…Previous biochemical studies suggested that HIV-1-encoded Vpr may kill cells through an effect on the adenine nucleotide translocase (ANT), thereby causing…”
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HIV-1 protease inhibitors and cytomegalovirus vMIA induce mitochondrial fragmentation without triggering apoptosis by Roumier, T, Szabadkai, G, Simoni, A-M, Perfettini, J-L, Paulau, A-L, Castedo, M, Métivier, D, Badley, A, Rizzuto, R, Kroemer, G

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A cellular machine generating apoptosis-prone aneuploid cells by Roumier, T, Valent, A, Perfettini, J-L, Métivier, D, Castedo, M, Kroemer, G

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Mitochondria, the killer organelles and their weapons by Ravagnan, Luigi, Roumier, Thomas, Kroemer, Guido

“…Apoptosis is a cell‐autonomous mode of death that is activated to eradicate superfluous, damaged, mutated, or aged cells. In addition to their role as the…”
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Cell death by mitotic catastrophe: a molecular definition by Castedo, Maria, Perfettini, Jean-Luc, Roumier, Thomas, Andreau, Karine, Medema, Rene, Kroemer, Guido

“…The current literature is devoid of a clearcut definition of mitotic catastrophe, a type of cell death that occurs during mitosis. Here, we propose that…”
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Mitochondrial fusion and fission in the control of apoptosis by Perfettini, Jean-Luc, Roumier, Thomas, Kroemer, Guido

“…Mitochondrial outer membrane permeabilization (MOMP) determines the point-of-no-return of most if not all signal-transduction cascades leading to cell death…”
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Quantitation of mitochondrial alterations associated with apoptosis by Castedo, Maria, Ferri, Karine, Roumier, Thomas, Métivier, Didier, Zamzami, Naoufal, Kroemer, Guido

“…Mitochondria undergo two major changes during early apoptosis. On the one hand, the outer mitochondrial membrane becomes permeable to proteins, resulting in…”
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Mitochondrial membrane permeabilization is a critical step of lysosome-initiated apoptosis induced by hydroxychloroquine by BOYA, Patricia, GONZALEZ-POLO, Rosa-Ana, PONCET, Delphine, ANDREAU, Karine, LA VIEIRA, Helena, ROUMIER, Thomas, PERFETTINI, Jean-Luc, KROEMER, Guido

“…Hydroxychloroquine (HCQ) is a lysosomotropic amine with cytotoxic properties. Here, we show that HCQ induces signs of lysosomal membrane permeabilization…”
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Mitotic catastrophe constitutes a special case of apoptosis whose suppression entails aneuploidy by CASTEDO, Maria, PERFETTINI, Jean-Luc, VAINCHENKER, William, KROEMER, Guido, ROUMIER, Thomas, VALENT, Alexander, RASLOVA, Hana, YAKUSHIJIN, Kenichi, HORNE, David, FEUNTEUN, Jean, LENOIR, Gilbert, MEDEMA, René

“…A conflict in cell cycle progression or DNA damage can lead to mitotic catastrophe when the DNA structure checkpoints are inactivated, for instance when the…”
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The cell cycle checkpoint kinase Chk2 is a negative regulator of mitotic catastrophe by CASTEDO, Maria, PERFETTINI, Jean-Luc, ROUMIER, Thomas, YAKUSHIJIN, Kenichi, HORNE, David, MEDEMA, René, KROEMER, Guido

“…Fusion between nonsynchronized cells leads to the formation of heterokarya which transiently activate Cyclin-dependent kinase 1 (Cdk1)/cyclin B1 and enter the…”
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NF-κB and p53 Are the Dominant Apoptosis-inducing Transcription Factors Elicited by the HIV-1 Envelope by Perfettini, Jean-Luc, Roumier, Thomas, Castedo, Maria, Larochette, Nathanael, Boya, Patricia, Raynal, Brigitte, Lazar, Vladimir, Ciccosanti, Fabiola, Nardacci, Roberta, Penninger, Josef, Piacentini, Mauro, Kroemer, Guido

“…The coculture of cells expressing the HIV-1 envelope glycoprotein complex (Env) with cells expressing CD4 results into cell fusion, deregulated mitosis, and…”
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Sequential involvement of Cdk1, mTOR and p53 in apoptosis induced by the HIV-1 envelope by Castedo, Maria, Roumier, Thomas, Blanco, Julià, Ferri, Karine F., Barretina, Jordi, Tintignac, Lionel A., Andreau, Karine, Perfettini, Jean-Luc, Amendola, Alessandra, Nardacci, Roberta, Leduc, Philip, Ingber, Donald E., Druillennec, Sabine, Roques, Bernard, Leibovitch, Serge A., Vilella-Bach, Montserrat, Chen, Jie, Este, José A., Modjtahedi, Nazanine, Piacentini, Mauro, Kroemer, Guido

“…Syncytia arising from the fusion of cells expressing the HIV‐1‐encoded Env gene with cells expressing the CD4/CXCR4 complex undergo apoptosis following the…”
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Pathogen induced regulatory cell populations preventing allergy through the Th1/Th2 paradigm point of view by Roumier, Thomas, Capron, Monique, Dombrowicz, David, Faveeuw, Christelle

“…Epidemiological studies have demonstrated an inverse correlation between prevalence of helminth infections and allergic diseases both associated to Th2 immune…”
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Mitochondrion-targeted apoptosis regulators of viral origin by Boya, Patricia, Roumier, Thomas, Andreau, Karine, Gonzalez-Polo, Rosa-Ana, Zamzami, Naoufal, Castedo, Maria, Kroemer, Guido

“…During coevolution with their hosts, viruses have “learned” to intercept or to activate the principal signal transducing pathways leading to cell death. A…”
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Mitochondrial Apoptosis Induced by the HIV-1 Envelope by CASTEDO, MARIA, PERFETTINI, JEAN-LUC, ANDREAU, KARINE, ROUMIER, THOMAS, PIACENTINI, MAURO, KROEMER, GUIDO

“…: The envelope glycoprotein complex (Env), encoded by the human immunodeficiency virus (HIV‐1), kills uninfected cells expressing CD4 and/or the chemokine…”
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Mitochondrion-mediated apoptosis in HIV-1 infection by Badley, Andrew D., Roumier, Thomas, Lum, Julian J., Kroemer, Guido

“…Acquired immunodeficiency syndrome (AIDS), which is caused by human immunodeficiency virus (HIV-1), involves the apoptotic destruction of lymphocytes and, in…”
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Preapoptotic Chromatin Condensation Upstream of the Mitochondrial Checkpoint by Andreau, Karine, Castedo, Maria, Perfettini, Jean-Luc, Roumier, Thomas, Pichart, Evelyne, Souquere, Sylvie, Vivet, Sonia, Larochette, Nathanael, Kroemer, Guido

“…When added for a short period (2-4 h) to cells, the kinase inhibitor staurosporine (STS), can trigger double strand breaks, the formation of nuclear foci…”
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