Baldness and other correlates of sex hormones in relation to testicular cancer

Baldness and other correlates of sex hormones in relation to testicular cancer

There is evidence that sex hormones and intrauterine factors are involved in the etiology of testicular cancer. We evaluated the importance of perinatal and adult life correlates of sex hormones as risk factors for testicular cancer in a case control study of 97 incident, histologically confirmed ca...

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Published in:International journal of cancer Vol. 71; no. 6; pp. 982 - 985
Main Authors: Petridou, Eleni, Roukas, Kriton I., Dessypris, Nick, Aravantinos, Gerassimos, Bafaloukos, Dimitrios, Efraimidis, Anna, Papacharalambous, Antigoni, Pektasidis, Dimitrios, Rigatos, Gerassimos, Trichopoulos, Dimitrios
Format: Journal Article
Language:English
Published: New York Wiley Subscription Services, Inc., A Wiley Company 11-06-1997
Wiley-Liss
Subjects:
Adult
Alopecia - complications
Biological and medical sciences
Case-Control Studies
Confidence Intervals
Gonadal Steroid Hormones - physiology
Greece - epidemiology
Gynecology. Andrology. Obstetrics
Humans
Male
Male genital diseases
Medical sciences
Odds Ratio
Testicular Neoplasms - complications
Testicular Neoplasms - epidemiology
Tumors
Greece
Human
Androgen
Estrogen
Male
Exposure
Malignant tumor
Testicle
Carcinogenesis
Statistical study
In utero
Pregnancy
Alopecia
Risk factor
Adult
Hormonal investigation
Sex steroid hormone
Male genital diseases
Testicular diseases
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Summary:There is evidence that sex hormones and intrauterine factors are involved in the etiology of testicular cancer. We evaluated the importance of perinatal and adult life correlates of sex hormones as risk factors for testicular cancer in a case control study of 97 incident, histologically confirmed cases, residents of the Greater Athens area and environs, who were diagnosed in the 3 specialized cancer hospitals and the major General Hospital in Athens during the 2 year period 1993‐94. Cases were age‐matched to 2 healthy controls from the same study base. Both cases and controls as well as their mothers were interviewed by the same investigator and the data were analyzed through conditional logistic regression. The odds ratio for testicular cancer was elevated among persons born after a pregnancy characterized by severe nausea. Among the adult life factors, higher body mass was associated with reduced risk, as was evidence of baldness. To the extent that nausea during pregnancy reflects higher levels of pregnancy estrogens on the one hand, and baldness is linked to androgens on the other, our data suggest that estrogens in the intrauterine life and androgens at later stages may have sequential opposing effects for the development of testicular cancer. I J. Cancer 71: 982‐985, 1997. © 1997 Wiley‐Liss Inc.
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ISSN:0020-7136
1097-0215
DOI:10.1002/(SICI)1097-0215(19970611)71:6<982::AID-IJC13>3.0.CO;2-8