Search Results - "Rouhani, Sherin"

Structural and functional features of central nervous system lymphatic vessels by Louveau, Antoine, Smirnov, Igor, Keyes, Timothy J., Eccles, Jacob D., Rouhani, Sherin J., Peske, J. David, Derecki, Noel C., Castle, David, Mandell, James W., Lee, Kevin S., Harris, Tajie H., Kipnis, Jonathan

“…The central nervous system undergoes constant immune surveillance, but the route that immune cells take to exit the brain has been unclear as it had been…”
Get full text

Effects of immune-related adverse events (irAEs) and their treatment on antitumor immune responses by Blum, Steven M, Rouhani, Sherin J, Sullivan, Ryan J

“…Immune checkpoint inhibitors (ICIs) are potentially life-saving cancer therapies that can trigger immune-related adverse events (irAEs). irAEs can impact any…”
Get full text

Immunotherapy partners after progression: Right place, right time? by Rouhani, Sherin J., Bestvina, Christine M.

“…This editorial aims to place the trial of pembrolizumab plus next line chemotherapy by Salous et al. in the context of other clinical trials evaluating…”
Get full text

Tolerogenic properties of lymphatic endothelial cells are controlled by the lymph node microenvironment by Cohen, Jarish N, Tewalt, Eric F, Rouhani, Sherin J, Buonomo, Erica L, Bruce, Amber N, Xu, Xiaojiang, Bekiranov, Stefan, Fu, Yang-Xin, Engelhard, Victor H

“…Peripheral self-tolerance eliminates lymphocytes specific for tissue-specific antigens not encountered in the thymus. Recently, we demonstrated that lymphatic…”
Get full text

CDKN2A loss-of-function predicts immunotherapy resistance in non-small cell lung cancer by Gutiontov, Stanley I., Turchan, William Tyler, Spurr, Liam F., Rouhani, Sherin J., Chervin, Carolina Soto, Steinhardt, George, Lager, Angela M., Wanjari, Pankhuri, Malik, Renuka, Connell, Philip P., Chmura, Steven J., Juloori, Aditya, Hoffman, Philip C., Ferguson, Mark K., Donington, Jessica S., Patel, Jyoti D., Vokes, Everett E., Weichselbaum, Ralph R., Bestvina, Christine M., Segal, Jeremy P., Pitroda, Sean P.

“…Immune checkpoint blockade (ICB) improves outcomes in non-small cell lung cancer (NSCLC) though most patients progress. There are limited data regarding…”
Get full text

Lymph node-resident lymphatic endothelial cells mediate peripheral tolerance via Aire-independent direct antigen presentation by Cohen, Jarish N, Guidi, Cynthia J, Tewalt, Eric F, Qiao, Hui, Rouhani, Sherin J, Ruddell, Alanna, Farr, Andrew G, Tung, Kenneth S, Engelhard, Victor H

“…Peripheral immune tolerance is generally thought to result from cross-presentation of tissue-derived proteins by quiescent tissue-resident dendritic cells to…”
Get full text

Checkpoint Blockade-Induced Dermatitis and Colitis Are Dominated by Tissue-Resident Memory T Cells and Th1/Tc1 Cytokines by Reschke, Robin, Shapiro, Jason W, Yu, Jovian, Rouhani, Sherin J, Olson, Daniel J, Zha, Yuanyuan, Gajewski, Thomas F

“…Immune checkpoint blockade is therapeutically successful for many patients across multiple cancer types. However, immune-related adverse events (irAE)…”
Get more information

Association Between Rheumatic Autoantibodies and Immune-Related Adverse Events by Mathias, Kristen, Rouhani, Sherin, Olson, Daniel, Bass, Anne R, Gajewski, Thomas F, Reid, Pankti

“…Abstract Background Side effects of immune checkpoint inhibitors (ICIs), called immune-related adverse events (irAEs), closely resemble primary autoimmune or…”
Get full text

Roles of lymphatic endothelial cells expressing peripheral tissue antigens in CD4 T-cell tolerance induction by Rouhani, Sherin J., Eccles, Jacob D., Riccardi, Priscila, Peske, J. David, Tewalt, Eric F., Cohen, Jarish N., Liblau, Roland, Mäkinen, Taija, Engelhard, Victor H.

“…Lymphatic endothelial cells (LECs) directly express peripheral tissue antigens and induce CD8 T-cell deletional tolerance. LECs express MHC-II molecules,…”
Get full text

Lymphatic endothelial cells induce tolerance via PD-L1 and lack of costimulation leading to high-level PD-1 expression on CD8 T cells by Tewalt, Eric F., Cohen, Jarish N., Rouhani, Sherin J., Guidi, Cynthia J., Qiao, Hui, Fahl, Shawn P., Conaway, Mark R., Bender, Timothy P., Tung, Kenneth S., Vella, Anthony T., Adler, Adam J., Chen, Lieping, Engelhard, Victor H.

“…Lymphatic endothelial cells (LECs) induce peripheral tolerance by direct presentation to CD8 T cells (TCD8). We demonstrate that LECs mediate deletion only via…”
Get full text

COVIDOSE: A Phase II Clinical Trial of Low‐Dose Tocilizumab in the Treatment of Noncritical COVID‐19 Pneumonia by Strohbehn, Garth W., Heiss, Brian L., Rouhani, Sherin J., Trujillo, Jonathan A., Yu, Jovian, Kacew, Alec J., Higgs, Emily F., Bloodworth, Jeffrey C., Cabanov, Alexandra, Wright, Rachel C., Koziol, Adriana K., Weiss, Alexandra, Danahey, Keith, Karrison, Theodore G., Edens, Cuoghi C., Bauer Ventura, Iazsmin, Pettit, Natasha N., Patel, Bhakti K., Pisano, Jennifer, Strek, Mary E., Gajewski, Thomas F., Ratain, Mark J., Reid, Pankti D.

“…Interleukin‐6 (IL‐6)–mediated hyperinflammation may contribute to the mortality of coronavirus disease 2019 (COVID‐19). The IL‐6 receptor–blocking monoclonal…”
Get full text

Sensitive detection and quantification of SARS-CoV-2 in saliva by Abasiyanik, Mustafa Fatih, Flood, Blake, Lin, Jing, Ozcan, Sefika, Rouhani, Sherin J., Pyzer, Athalia, Trujillo, Jonathan, Zhen, Chaojie, Wu, Ping, Jumic, Stephen, Wang, Andrew, Gajewski, Thomas F., Wang, Peng, Hartley, Madeline, Ameti, Bekim, Niemiec, Rachael, Fernando, Marian, Mishra, Vasudha, Savage, Peter, Aydogan, Bulent, Bethel, Cindy, Matushek, Scott, Beavis, Kathleen G., Agrawal, Nishant, Segal, Jeremy, Tay, Savaş, Izumchenko, Evgeny

“…Saliva has significant advantages as a test medium for detection of SARS-CoV-2 infection in patients, such as ease of collection, minimal requirement of…”
Get full text

Comparative Transcriptomic Analysis Identifies a Range of Immunologically Related Functional Elaborations of Lymph Node Associated Lymphatic and Blood Endothelial Cells by Berendam, Stella J, Koeppel, Alexander F, Godfrey, Nicole R, Rouhani, Sherin J, Woods, Amber N, Rodriguez, Anthony B, Peske, J David, Cummings, Kara L, Turner, Stephen D, Engelhard, Victor H

“…Lymphatic and blood vessels are formed by specialized lymphatic endothelial cells (LEC) and blood endothelial cells (BEC), respectively. These endothelial…”
Get full text

Brief Report: Discordance Between Liquid and Tissue Biopsy-Based Next-Generation Sequencing in Lung Adenocarcinoma at Disease Progression by Tran, Misha C., Strohbehn, Garth W., Karrison, Theodore G., Rouhani, Sherin J., Segal, Jeremy P., Shergill, Ardaman, Hoffman, Philip C., Patel, Jyoti D., Garassino, Marina C., Vokes, Everett E., Bestvina, Christine M.

“…•Liquid biopsy and next-generation sequencing of circulating tumor DNA is increasingly used at the time of diagnosis of non-small cell lung cancer. Its role at…”
Get full text

Neutrophil-to-Lymphocyte Ratio Is a Predictive Biomarker in Patients with Epidermal Growth Factor Receptor (EGFR) Mutated Advanced Non-Small Cell Lung Cancer (NSCLC) Treated with Tyrosine Kinase Inhibitor (TKI) Therapy by Yun, Nicole K, Rouhani, Sherin J, Bestvina, Christine M, Ritz, Ethan M, Gilmore, Brendan A, Tarhoni, Imad, Borgia, Jeffrey A, Batus, Marta, Bonomi, Philip D, Fidler, Mary Jo

“…First-line treatment for patients with non-small cell lung cancer (NSCLC) with a sensitizing epidermal growth factor receptor ( ) mutation is a tyrosine kinase…”
Get full text

Peripheral tissue homing receptors enable T cell entry into lymph nodes and affect the anatomical distribution of memory cells by Brinkman, C Colin, Rouhani, Sherin J, Srinivasan, Nithya, Engelhard, Victor H

“…Peripheral tissue homing receptors enable T cells to access inflamed nonlymphoid tissues. In this study, we show that two such molecules, E-selectin ligand and…”
Get full text

Insights from a Rapidly Implemented COVID-19 Biobank Using Electronic Consent and Informatics Tools by Higgs, Emily F, Flood, Blake A, Pyzer, Athalia R, Rouhani, Sherin J, Trujillo, Jonathan A, Gajewski, Thomas F

“…Biobanking during the COVID-19 pandemic presented unique challenges regarding patient enrollment, sample collection, and experimental analysis. This report…”
Get more information

Severe COVID-19 induces autoantibodies against angiotensin II that correlate with blood pressure dysregulation and disease severity by Briquez, Priscilla S, Rouhani, Sherin J, Yu, Jovian, Pyzer, Athalia R, Trujillo, Jonathan, Dugan, Haley L, Stamper, Christopher T, Changrob, Siriruk, Sperling, Anne I, Wilson, Patrick C, Gajewski, Thomas F, Hubbell, Jeffrey A, Swartz, Melody A

“…Patients infected with the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) can experience life-threatening respiratory distress, blood pressure…”
Get full text

Lymphatic endothelial cells - key players in regulation of tolerance and immunity by Tewalt, Eric F, Cohen, Jarish N, Rouhani, Sherin J, Engelhard, Victor H

“…The lymphatic vasculature provides routes for dendritic cell and lymphocyte migration into and out of lymph nodes. Lymphatic endothelial cells (LEC) control…”
Get full text

Correction: Peripheral Tissue Homing Receptors Enable T Cell Entry into Lymph Nodes and Affect the Anatomical Distribution of Memory Cells by Brinkman, C. Colin, Rouhani, Sherin J., Srinivasan, Nithya, Engelhard, Victor H.

Get full text