Search Results - "Rouhani, Foad J."

Mutational History of a Human Cell Lineage from Somatic to Induced Pluripotent Stem Cells by Rouhani, Foad J, Nik-Zainal, Serena, Wuster, Arthur, Li, Yilong, Conte, Nathalie, Koike-Yusa, Hiroko, Kumasaka, Natsuhiko, Vallier, Ludovic, Yusa, Kosuke, Bradley, Allan

“…The accuracy of replicating the genetic code is fundamental. DNA repair mechanisms protect the fidelity of the genome ensuring a low error rate between…”
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Targeted gene correction of α1-antitrypsin deficiency in induced pluripotent stem cells by Yusa, Kosuke, Rashid, S. Tamir, Strick-Marchand, Helene, Varela, Ignacio, Liu, Pei-Qi, Paschon, David E., Miranda, Elena, Ordóñez, Adriana, Hannan, Nicholas R. F., Rouhani, Foad J., Darche, Sylvie, Alexander, Graeme, Marciniak, Stefan J., Fusaki, Noemi, Hasegawa, Mamoru, Holmes, Michael C., Di Santo, James P., Lomas, David A., Bradley, Allan, Vallier, Ludovic

“…Fixing the genes in iPS cells Before human induced pluripotent stem (iPS) cells can be used to treat genetically inherited human disease, it will be necessary…”
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Novel stem cell technologies are powerful tools to understand the impact of human factors on Plasmodium falciparum malaria by Pance, Alena, Ng, Bee L, Mwikali, Kioko, Koutsourakis, Manousos, Agu, Chukwuma, Rouhani, Foad J, Montandon, Ruddy, Law, Frances, Ponstingl, Hannes, Rayner, Julian C

“…parasites have a complex life cycle, but the most clinically relevant stage of the disease is the invasion of erythrocytes and the proliferation of the…”
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The future of liver transplantation by Feng, Sandy, Roll, Garrett R, Rouhani, Foad J, Sanchez Fueyo, Alberto

“…Over the last 50 years, liver transplantation has evolved into a procedure routinely performed in many countries worldwide. Those able to access this therapy…”
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Substantial somatic genomic variation and selection for BCOR mutations in human induced pluripotent stem cells by Rouhani, Foad J., Zou, Xueqing, Danecek, Petr, Badja, Cherif, Amarante, Tauanne Dias, Koh, Gene, Wu, Qianxin, Memari, Yasin, Durbin, Richard, Martincorena, Inigo, Bassett, Andrew R., Gaffney, Daniel, Nik-Zainal, Serena

“…We explored human induced pluripotent stem cells (hiPSCs) derived from different tissues to gain insights into genomic integrity at single-nucleotide…”
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Convergent somatic mutations in metabolism genes in chronic liver disease by Ng, Stanley W. K., Rouhani, Foad J., Brunner, Simon F., Brzozowska, Natalia, Aitken, Sarah J., Yang, Ming, Abascal, Federico, Moore, Luiza, Nikitopoulou, Efterpi, Chappell, Lia, Leongamornlert, Daniel, Ivovic, Aleksandra, Robinson, Philip, Butler, Timothy, Sanders, Mathijs A., Williams, Nicholas, Coorens, Tim H. H., Teague, Jon, Raine, Keiran, Butler, Adam P., Hooks, Yvette, Wilson, Beverley, Birtchnell, Natalie, Naylor, Huw, Davies, Susan E., Stratton, Michael R., Martincorena, Iñigo, Rahbari, Raheleh, Frezza, Christian, Hoare, Matthew, Campbell, Peter J.

“…The progression of chronic liver disease to hepatocellular carcinoma is caused by the acquisition of somatic mutations that affect 20–30 cancer genes 1 – 8 …”
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Bouveret Syndrome: A Systematic Review of Endoscopic Therapy and a Novel Predictive Tool to Aid in Management by Ong, John, Swift, Carla, Stokell, Benjamin G., Ong, Sharon, Lucarelli, Pierino, Shankar, Arun, Rouhani, Foad J., Al-Naeeb, Yasseen

“…BACKGROUND AND GOALS:Bouveret syndrome is characterized by gastroduodenal obstruction caused by an impacted gallstone. Current literature recommends endoscopic…”
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Acquisition of epithelial plasticity in human chronic liver disease by Gribben, Christopher, Galanakis, Vasileios, Calderwood, Alexander, Williams, Eleanor C., Chazarra-Gil, Ruben, Larraz, Miguel, Frau, Carla, Puengel, Tobias, Guillot, Adrien, Rouhani, Foad J., Mahbubani, Krishnaa, Godfrey, Edmund, Davies, Susan E., Athanasiadis, Emmanouil, Saeb-Parsy, Kourosh, Tacke, Frank, Allison, Michael, Mohorianu, Irina, Vallier, Ludovic

“…For many adult human organs, tissue regeneration during chronic disease remains a controversial subject. Regenerative processes are easily observed in animal…”
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Inflammatory Gene Expression in Livers Undergoing Ex Situ Normothermic Perfusion Is Attenuated by Leukocyte Removal From the Perfusate by Bahadori, Kasra, Lee, Colin Y C, Ferdinand, John R, Cabantous, Mia, Butler, Andrew J, Rouhani, Foad J, Watson, Christopher J E, Clatworthy, Menna R

“…Ex situ normothermic perfusion (ESNP) is a method to evaluate and potentially recondition organs before transplantation. However, increased expression of…”
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Abrogation of Antibody-Mediated Allograft Rejection by Regulatory CD4 T Cells with Indirect Allospecificity by Callaghan, Chris J, Rouhani, Foad J, Negus, Margaret C, Curry, Allison J, Bolton, Eleanor M, Bradley, J. Andrew, Pettigrew, Gavin J

“…Alloantibody is an important effector mechanism for allograft rejection. In this study, we tested the hypothesis that regulatory T cells with indirect…”
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Large-scale genomic analysis of human iPSCs identifies recurrent somatic driver mutations

“…The genetic landscape of human induced pluripotent stem cells (iPSCs) is strongly influenced by the somatic cells of origin, and mutational signatures directly…”
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Large-scale genomic analysis of human iPSCs identifies recurrent somatic driver mutations by Rouhani, Foad J, Nik-Zainal, Serena

“…Large-scale studies on this topic have been limited, with previous research reporting on small numbers of iPSC lines, predominantly from one tissue type (for…”
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Investigation of red blood cells from α1,3-galactosyltransferase-knockout pigs for human blood transfusion by Rouhani, Foad J., Dor, Frank J.M.F., Cooper, David K.C.

“…BACKGROUND:  Pigs are a potential source of red blood cells (RBCs) for transfusion into humans, but the pre‐sence of galactose‐α1,3‐galactose (Gal) epitopes on…”
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Targeted gene correction of [alpha]1-antitrypsin deficiency in induced pluripotent stem cells by Yusa, Kosuke, Rashid, S Tamir, Strick-Marchand, Helene, Varela, Ignacio, Liu, Pei-Qi, Paschon, David E, Miranda, Elena, Ordóñez, Adriana, Hannan, Nicholas R F, Rouhani, Foad J, Darche, Sylvie, Alexander, Graeme, Marciniak, Stefan J, Fusaki, Noemi, Hasegawa, Mamoru, Holmes, Michael C, Di Santo, James P, Lomas, David A, Bradley, Allan, Vallier, Ludovic

“…Human induced pluripotent stem cells (iPSCs) represent a unique opportunity for regenerative medicine because they offer the prospect of generating unlimited…”
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Targeted gene correction of [alpha].sub.1-antitrypsin deficiency in induced pluripotent stem cells by Yusa, Kosuke, Rashid, S. Tamir, Strick-Marchand, Helene, Varela, Ignacio, Liu, Pei-Qi, Paschon, David E, Miranda, Elena, Ordonez, Adriana, Hannan, Nicholas R.F, Rouhani, Foad J, Darche, Sylvie, Alexander, Graeme, Marciniak, Stefan J, Fusaki, Noemi, Hasegawa, Mamoru, Holmes, Michael C, Di Santo, James P

“…Fixing the genes in iPS cells…”
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Targeted gene correction of [α.sub.1]-antitrypsin deficiency in induced pluripotent stem cells by Yusa, Kosuke, Rashid, S. Tamir, Strick-Marchand, Helene, Varela, Ignacio, Liu, Pei-Qi, Paschon, David E, Miranda, Elena, Ordonez, Adriana, Hannan, Nicholas R.F, Rouhani, Foad J, Darche, Sylvie, Alexander, Graeme, Marciniak, Stefan J, Fusaki, Noemi, Hasegawa, Mamoru, Holmes, Michael C, Di Santo, James P, Lomas, David A, Bradley, Allan, Vallier, Ludovic

“…Human induced pluripotent stem cells (iPSCs) represent a unique opportunity for regenerative medicine because they offer the prospect of generating unlimited…”
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Targeted gene correction of alpha sub(1)-antitrypsin deficiency in induced pluripotent stem cells by Yusa, Kosuke, Rashid, STamir, Strick-Marchand, Helene, Varela, Ignacio, Liu, Pei-Qi, Paschon, David E, Miranda, Elena, Ordonez, Adriana, Hannan, Nicholas RF, Rouhani, Foad J, Darche, Sylvie, Alexander, Graeme, Marciniak, Stefan J, Fusaki, Noemi, Hasegawa, Mamoru, Holmes, Michael C, Di Santo, James P, Lomas, David A, Bradley, Allan, Vallier, Ludovic

“…Human induced pluripotent stem cells (iPSCs) represent a unique opportunity for regenerative medicine because they offer the prospect of generating unlimited…”
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Investigation of red blood cells from alpha1,3-galactosyltransferase-knockout pigs for human blood transfusion by Rouhani, Foad J, Dor, Frank J M F, Cooper, David K C

“…Pigs are a potential source of red blood cells (RBCs) for transfusion into humans, but the presence of galactose-alpha1,3-galactose (Gal) epitopes on their…”
Get full text