Search Results - "Rouhana, Labib"

Dynein assembly factor with WD repeat domains 1 (DAW1) is required for the function of motile cilia in the planarian Schmidtea mediterranea by Lesko, Sydney Lynn, Rouhana, Labib

“…Motile cilia propel directed cell movements and sweep fluids across the surface of tissues. Orthologs of Dynein Assembly Factor with WD Repeat Domains 1 (DAW1)…”
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Tau tubulin kinase is required for spermatogenesis and development of motile cilia in planarian flatworms by Magley, Robert Alan, Rouhana, Labib

“…Cilia are microtubule-based structures that protrude from the apical surface of cells to mediate motility, transport, intracellular signaling, and…”
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RNA interference by feeding in vitro–synthesized double‐stranded RNA to planarians: Methodology and dynamics by Rouhana, Labib, Weiss, Jennifer A., Forsthoefel, David J., Lee, Hayoung, King, Ryan S., Inoue, Takeshi, Shibata, Norito, Agata, Kiyokazu, Newmark, Phillip A.

“…Background The ability to assess gene function is essential for understanding biological processes. Currently, RNA interference (RNAi) is the only technique…”
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Genetic dissection of the planarian reproductive system through characterization of Schmidtea mediterranea CPEB homologs by Rouhana, Labib, Tasaki, Junichi, Saberi, Amir, Newmark, Phillip A.

“…Cytoplasmic polyadenylation is a mechanism of mRNA regulation prevalent in metazoan germ cells; it is largely dependent on Cytoplasmic Polyadenylation Element…”
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Cellular and molecular dissection of pluripotent adult somatic stem cells in planarians by Shibata, Norito, Rouhana, Labib, Agata, Kiyokazu

“…Freshwater planarians, Plathelminthes, have been an intriguing model animal of regeneration studies for more than 100 years. Their robust regenerative ability…”
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Germline Defects Caused by Smed-boule RNA-Interference Reveal That Egg Capsule Deposition Occurs Independently of Fertilization, Ovulation, Mating, or the Presence of Gametes in Planarian Flatworms by Steiner, Jessica Kathryne, Tasaki, Junichi, Rouhana, Labib

“…Few animals are known to lay eggs in the absence of ovulation or copulation, as it is presumably energetically wasteful and subjected to negative selection…”
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Inheritance of a Nuclear PIWI from Pluripotent Stem Cells by Somatic Descendants Ensures Differentiation by Silencing Transposons in Planarian by Shibata, Norito, Kashima, Makoto, Ishiko, Taisuke, Nishimura, Osamu, Rouhana, Labib, Misaki, Kazuyo, Yonemura, Shigenobu, Saito, Kuniaki, Siomi, Haruhiko, Siomi, Mikiko C., Agata, Kiyokazu

“…Differentiation of pluripotent stem cells (PSCs) requires transposon silencing throughout the process. PIWIs, best known as key factors in germline transposon…”
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PRMT5 and the role of symmetrical dimethylarginine in chromatoid bodies of planarian stem cells by Rouhana, Labib, Vieira, Ana P, Roberts-Galbraith, Rachel H, Newmark, Phillip A

“…Planarian flatworms contain a population of adult stem cells (neoblasts) that proliferate and generate cells of all tissues during growth, regeneration and…”
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Genetic expansion of chaperonin‐containing TCP‐1 (CCT/TRiC) complex subunits yields testis‐specific isoforms required for spermatogenesis in planarian flatworms by Counts, Jenna T., Hester, Tasha M., Rouhana, Labib

“…Chaperonin‐containing Tail‐less complex polypeptide 1 (CCT) is a highly conserved, hetero‐oligomeric complex that ensures proper folding of actin, tubulin, and…”
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Girardia dorotocephala transcriptome sequence, assembly, and validation through characterization of piwi homologs and stem cell progeny markers by Almazan, Eugene Matthew P., Lesko, Sydney L., Markey, Michael P., Rouhana, Labib

“…Planarian flatworms are popular models for the study of regeneration and stem cell biology in vivo. Technical advances and increased availability of genetic…”
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PIWI homologs mediate histone H4 mRNA localization to planarian chromatoid bodies by Rouhana, Labib, Weiss, Jennifer A, King, Ryan S, Newmark, Phillip A

“…The well-known regenerative abilities of planarian flatworms are attributed to a population of adult stem cells called neoblasts that proliferate and…”
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Epigenetics and Shared Molecular Processes in the Regeneration of Complex Structures by Rouhana, Labib, Tasaki, Junichi

“…The ability to regenerate complex structures is broadly represented in both plant and animal kingdoms. Although regenerative abilities vary significantly…”
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Regeneration of Planarian Auricles and Reestablishment of Chemotactic Ability by Almazan, Eugene Matthew P, Ryan, Joseph F, Rouhana, Labib

“…Detection of chemical stimuli is crucial for living systems and also contributes to quality of life in humans. Since loss of olfaction becomes more prevalent…”
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Time of day regulates subcellular trafficking, tripartite synaptic localization, and polyadenylation of the astrocytic Fabp7 mRNA by Gerstner, Jason R, Vanderheyden, William M, LaVaute, Timothy, Westmark, Cara J, Rouhana, Labib, Pack, Allan I, Wickens, Marv, Landry, Charles F

“…The astrocyte brain fatty acid binding protein (Fabp7) has previously been shown to have a coordinated diurnal regulation of mRNA and protein throughout mouse…”
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Vertebrate GLD2 poly(A) polymerases in the germline and the brain by Rouhana, Labib, Wang, Liaoteng, Buter, Natascha, Kwak, Jae Eun, Schiltz, Craig A, Gonzalez, Tania, Kelley, Ann E, Landry, Charles F, Wickens, Marvin

“…Cytoplasmic polyadenylation is important in the control of mRNA stability and translation, and for early animal development and synaptic plasticity. Here, we…”
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Analysis of Morphogenesis and Flagellar Assembly During Spermatogenesis in Planarian Flatworms by Rouhana, Labib, Chong, Tracy, Newmark, Phillip A

“…Spermatogenesis is one of the most dramatic cellular differentiation events observed in animals. In particular, spermiogenesis (the final stage of…”
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Different requirements for conserved post-transcriptional regulators in planarian regeneration and stem cell maintenance by Rouhana, Labib, Shibata, Norito, Nishimura, Osamu, Agata, Kiyokazu

“…Planarian regeneration depends on the presence and precise regulation of pluripotent adult somatic stem cells named neoblasts, which differentiate to replace…”
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Heterotrimeric Kinesin II is required for flagellar assembly and elongation of nuclear morphology during spermiogenesis in Schmidtea mediterranea by Christman, Donovan A., Curry, Haley N., Rouhana, Labib

“…Development of sperm requires microtubule-based movements that drive assembly of a compact head and flagellated tails. Much is known about how flagella are…”
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Analysis of Stem Cell Motility In Vivo Based on Immunodetection of Planarian Neoblasts and Tracing of BrdU-Labeled Cells After Partial Irradiation by Tasaki, Junichi, Uchiyama-Tasaki, Chihiro, Rouhana, Labib

“…Planarian flatworms have become an important system for the study of stem cell behavior and regulation in vivo. These organisms are able to regenerate any part…”
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Cytoplasmic Polyadenylation Is an Ancestral Hallmark of Early Development in Animals by Rouhana, Labib, Edgar, Allison, Hugosson, Fredrik, Dountcheva, Valeria, Martindale, Mark Q, Ryan, Joseph F

“…Differential regulation of gene expression has produced the astonishing diversity of life on Earth. Understanding the origin and evolution of mechanistic…”
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