Search Results - "Rougier, Jean‐Sébastien"

Ion Channel Macromolecular Complexes in Cardiomyocytes: Roles in Sudden Cardiac Death by Abriel, Hugues, Rougier, Jean-Sébastien, Jalife, José

“…The movement of ions across specific channels embedded on the membrane of individual cardiomyocytes is crucial for the generation and propagation of the…”
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A detailed analysis of single‐channel Nav1.5 recordings does not reveal any cooperative gating by Selimi, Zoja, Rougier, Jean‐Sébastien, Abriel, Hugues, Kucera, Jan P.

“…Cardiac voltage‐gated sodium (Na+) channels (Nav1.5) are crucial for myocardial electrical excitation. Recent studies based on single‐channel recordings have…”
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Deletion of Trpm4 Alters the Function of the Nav1.5 Channel in Murine Cardiac Myocytes by Ozhathil, Lijo Cherian, Rougier, Jean-Sébastien, Arullampalam, Prakash, Essers, Maria C., Ross-Kaschitza, Daniela, Abriel, Hugues

“…Transient receptor potential melastatin member 4 (TRPM4) encodes a Ca2+-activated, non-selective cation channel that is functionally expressed in several…”
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The dispensability of 14-3-3 proteins for the regulation of human cardiac sodium channel Nav1.5 by Iamshanova, Oksana, Hämmerli, Anne-Flore, Ramaye, Elise, Seljmani, Arbresh, Ross-Kaschitza, Daniela, Schärz, Noëlia, Essers, Maria, Guichard, Sabrina, Rougier, Jean-Sébastien, Abriel, Hugues

“…14-3-3 proteins are ubiquitous proteins that play a role in cardiac physiology (e.g., metabolism, development, and cell cycle). Furthermore, 14-3-3 proteins…”
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Cardiac voltage-gated calcium channel macromolecular complexes by Rougier, Jean-Sébastien, Abriel, Hugues

“…Over the past 20years, a new field of research, called channelopathies, investigating diseases caused by ion channel dysfunction has emerged. Cardiac ion…”
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Multiomics uncover the proinflammatory role of Trpm4 deletion after myocardial infarction in mice by Boukenna, Mey, Rougier, Jean-Sébastien, Aghagolzadeh, Parisa, Pradervand, Sylvain, Guichard, Sabrina, Hämmerli, Anne-Flore, Pedrazzini, Thierry, Abriel, Hugues

“…Upon myocardial infarction (MI), ischemia-induced cell death triggers an inflammatory response responsible for removing necrotic material and inducing tissue…”
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Species-Specific Effects of Cation Channel TRPM4 Small-Molecule Inhibitors by Arullampalam, Prakash, Preti, Barbara, Ross-Kaschitza, Daniela, Lochner, Martin, Rougier, Jean-Sébastien, Abriel, Hugues

“…Background: The Transient Receptor Potential Melastatin member 4 ( TRPM4 ) gene encodes a calcium-activated non-selective cation channel expressed in several…”
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TRPM4 channels in the cardiovascular system: Physiology, pathophysiology, and pharmacology by Abriel, Hugues, Syam, Ninda, Sottas, Valentin, Amarouch, Mohamed Yassine, Rougier, Jean-Sébastien

“…The transient receptor potential channel (TRP) family comprises at least 28 genes in the human genome. These channels are widely expressed in many different…”
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Knockdown of the TRPM4 channel alters cardiac electrophysiology and hemodynamics in a sex‐ and age‐dependent manner in mice by Arullampalam, Prakash, Essers, Maria C., Boukenna, Mey, Guichard, Sabrina, Rougier, Jean‐Sébastien, Abriel, Hugues

“…TRPM4 is a calcium‐activated, voltage‐modulated, nonselective ion channel widely expressed in various cells and tissues. TRPM4 regulates the influx of sodium…”
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Single-Molecule Localization of the Cardiac Voltage-Gated Sodium Channel Reveals Different Modes of Reorganization at Cardiomyocyte Membrane Domains by Vermij, Sarah H., Rougier, Jean-Sébastien, Agulló-Pascual, Esperanza, Rothenberg, Eli, Delmar, Mario, Abriel, Hugues

“…BACKGROUNDMutations in the gene encoding the cardiac voltage-gated sodium channel Nav1.5 cause various cardiac arrhythmias. This variety may arise from…”
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Bioorthogonal site-selective conjugation of fluorescent dyes to antibodies: method and potential applications by Grossenbacher, Philipp, Essers, Maria C, Moser, Joël, Singer, Simon A, Häusler, Stephanie, Stieger, Bruno, Rougier, Jean-Sébastien, Lochner, Martin

“…Antibodies are immensely useful tools for biochemical research and have found application in numerous protein detection and purification methods. Moreover,…”
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Dystrophin and calcium current are decreased in cardiomyocytes expressing Cre enzyme driven by αMHC but not TNT promoter by Gillet, Ludovic, Guichard, Sabrina, Essers, Maria C., Rougier, Jean-Sébastien, Abriel, Hugues

“…The Cre/lox system is a potent technology to control gene expression in mouse tissues. However, cardiac-specific Cre recombinase expression alone can lead to…”
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Functional characterization of a novel SCN5A variant associated with long QT syndrome and sudden cardiac death by Neubauer, Jacqueline, Wang, Zizun, Rougier, Jean-Sébastien, Abriel, Hugues, Rieubland, Claudine, Bartholdi, Deborah, Haas, Cordula, Medeiros-Domingo, Argelia

“…Sudden arrhythmic death syndrome (SADS) in young individuals is a devastating and tragic event often caused by an undiagnosed inherited cardiac disease…”
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Biochemical re-programming of human dermal stem cells to neurons by increasing mitochondrial membrane potential by Liu, He, He, Zhaoyue, April, Simon Leonhard, Trefny, Marcel Philipp, Rougier, Jean-Sébastien, Salemi, Souzan, Olariu, Radu, Widmer, Hans Rudolf, Simon, Hans-Uwe

“…Stem cells are generally believed to contain a small number of mitochondria, thus accounting for their glycolytic phenotype. We demonstrate here, however, that…”
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Annotation of functional impact of voltage‐gated sodium channel mutations by Hinard, Valérie, Britan, Aurore, Schaeffer, Mathieu, Zahn‐Zabal, Monique, Thomet, Urs, Rougier, Jean‐Sébastien, Bairoch, Amos, Abriel, Hugues, Gaudet, Pascale

“…Voltage‐gated sodium channels are pore‐forming transmembrane proteins that selectively allow sodium ions to flow across the plasma membrane according to the…”
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Variants of Transient Receptor Potential Melastatin Member 4 in Childhood Atrioventricular Block by Syam, Ninda, Chatel, Stéphanie, Ozhathil, Lijo Cherian, Sottas, Valentin, Rougier, Jean‐Sébastien, Baruteau, Alban, Baron, Estelle, Amarouch, Mohamed‐Yassine, Daumy, Xavier, Probst, Vincent, Schott, Jean‐Jacques, Abriel, Hugues

“…Background Transient receptor potential melastatin member 4 (TRPM4) is a nonselective cation channel. TRPM4 mutations have been linked to cardiac conduction…”
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Identification of a novel loss-of-function calcium channel gene mutation in short QT syndrome (SQTS6) by Templin, Christian, Ghadri, Jelena-Rima, Rougier, Jean-Sébastien, Baumer, Alessandra, Kaplan, Vladimir, Albesa, Maxime, Sticht, Heinrich, Rauch, Anita, Puleo, Colleen, Hu, Dan, Barajas-Martinez, Héctor, Antzelevitch, Charles, Lüscher, Thomas F, Abriel, Hugues, Duru, Firat

“…Short QT syndrome (SQTS) is a genetically determined ion-channel disorder, which may cause malignant tachyarrhythmias and sudden cardiac death. Thus far,…”
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Lateral Membrane-Specific MAGUK CASK Down-Regulates NaV1.5 Channel in Cardiac Myocytes by Eichel, Catherine A, Beuriot, Adeline, Chevalier, Morgan Y.E, Rougier, Jean-Sébastien, Louault, Florent, Dilanian, Gilles, Amour, Julien, Coulombe, Alain, Abriel, Hugues, Hatem, Stéphane N, Balse, Elise

“…RATIONALE:Mechanisms underlying membrane protein localization are crucial in the proper function of cardiac myocytes. The main cardiac sodium channel, NaV1.5,…”
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PDZ Domain-Binding Motif Regulates Cardiomyocyte Compartment-Specific Nav1.5 Channel Expression and Function by SHY, Diana, GILLET, Ludovic, MARSMAN, Roos F, VAN MIL, Anneke M, ROTMAN, Samuel, REDON, Richard, BEZZINA, Connie R, REMME, Carol Ann, ABRIEL, Hugues, OGRODNIK, Jakob, ALBESA, Maxime, VERKERK, Arie O, WOLSWINKEL, Rianne, ROUGIER, Jean-Sébastien, BARC, Julien, ESSERS, Maria C, SYAM, Ninda

“…Sodium channel NaV1.5 underlies cardiac excitability and conduction. The last 3 residues of NaV1.5 (Ser-Ile-Val) constitute a PDZ domain-binding motif that…”
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Cardiac Sodium Channel Nav1.5 Is Regulated by a Multiprotein Complex Composed of Syntrophins and Dystrophin by Gavillet, Bruno, Rougier, Jean-Sébastien, Domenighetti, Andrea A, Behar, Romina, Boixel, Christophe, Ruchat, Patrick, Lehr, Hans-Anton, Pedrazzini, Thierry, Abriel, Hugues

“…The cardiac sodium channel Nav1.5 plays a key role in cardiac excitability and conduction. The purpose of this study was to elucidate the role of the PDZ…”
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