Search Results - "Rougier, J‐S"

Stereoselective Block of hERG Channel by ( )-Methadone and QT Interval Prolongation in CYP2B6 Slow Metabolizers by Eap, C B, Crettol, S, Rougier, J‐S, Schläpfer, J, Sintra Grilo, L, Déglon, J‐J, Besson, J, Croquette‐Krokar, M, Carrupt, P‐A, Abriel, H

“…Methadone inhibits the cardiac potassium channel hERG and can cause a prolonged QT interval. Methadone is chiral but its therapeutic activity is mainly due to…”
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Selective inhibition of persistent sodium current by F 15845 prevents ischaemia‐induced arrhythmias by Pignier, C, Rougier, J‐S, Vié, B, Culié, C, Verscheure, Y, Vacher, B, Abriel, H, Le Grand, B

“…BACKGROUND AND PURPOSE Myocardial ischaemia is associated with perturbations of electrophysiological profile of cardiac myocytes. The persistent sodium current…”
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Identification of a novel loss-of-function calcium channel gene mutation in short QT syndrome (SQTS6) by Templin, Christian, Ghadri, Jelena-Rima, Rougier, Jean-Sébastien, Baumer, Alessandra, Kaplan, Vladimir, Albesa, Maxime, Sticht, Heinrich, Rauch, Anita, Puleo, Colleen, Hu, Dan, Barajas-Martinez, Héctor, Antzelevitch, Charles, Lüscher, Thomas F, Abriel, Hugues, Duru, Firat

“…Short QT syndrome (SQTS) is a genetically determined ion-channel disorder, which may cause malignant tachyarrhythmias and sudden cardiac death. Thus far,…”
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ICEPO: the ion channel electrophysiology ontology by Hinard, V, Britan, A, Rougier, J S, Bairoch, A, Abriel, H, Gaudet, P

“…Ion channels are transmembrane proteins that selectively allow ions to flow across the plasma membrane and play key roles in diverse biological processes. A…”
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G010 Regulation of voltage-dependent calcium channels by Nedd4-1 by Albesa, M, Rougier, J.-S, Abriel, H, Viard, P

“…Calcium entry into excitable cells can be regulated by controlling both the activity of calcium channels and the amount of channels available at the plasma…”
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P265Functional characterization of a LQT3 mutation located in the PY motif of the cardiac sodium channel associated with altered channel ubiquitylation by Casini, S, Portero, V, Rougier, J S, Albesa, M, Marchal, G A, Chung, W K, Bezzina, C R, Abriel, H, Remme, C A

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Unexpected dominance: Brugada syndrome SCN5A variants exert negative dominance via  -subunit interaction by Rougier, J.-S., Abriel, H.

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Variable Na(v)1.5 protein expression from the wild-type allele correlates with the penetrance of cardiac conduction disease in the Scn5a(+/-) mouse model by Leoni, Anne-Laure, Gavillet, Bruno, Rougier, Jean-Sébastien, Marionneau, Céline, Probst, Vincent, Le Scouarnec, Solena, Schott, Jean-Jacques, Demolombe, Sophie, Bruneval, Patrick, Huang, Christopher L H, Colledge, William H, Grace, Andrew A, Le Marec, Hervé, Wilde, Arthur A, Mohler, Peter J, Escande, Denis, Abriel, Hugues, Charpentier, Flavien

“…Loss-of-function mutations in SCN5A, the gene encoding Na(v)1.5 Na+ channel, are associated with inherited cardiac conduction defects and Brugada syndrome,…”
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Brugada syndrome and fever : Genetic and molecular characterization of patients carrying SCN5A mutations by KELLER, Dagmar I, ROUGIER, Jean-Sébastien, KUCERA, Jan P, BENAMMAR, Nawal, FRESSART, Véronique, GUICHENEY, Pascale, MADLE, Alois, FROMER, Martin, SCHLÄPFER, Jürg, ABRIEL, Hugues

“…Brugada syndrome (BrS) is characterized by ventricular tachyarrhythmias leading to sudden cardiac death and is caused, in part, by mutations in the SCN5A gene…”
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Molecular determinants of voltage-gated sodium channel regulation by the Nedd4/Nedd4-like proteins by Rougier, Jean-Sébastien, van Bemmelen, Miguel X, Bruce, M Christine, Jespersen, Thomas, Gavillet, Bruno, Apothéloz, Florine, Cordonier, Sophie, Staub, Olivier, Rotin, Daniela, Abriel, Hugues

“…The voltage-gated Na(+) channels (Na(v)) form a family composed of 10 genes. The COOH termini of Na(v) contain a cluster of amino acids that are nearly…”
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Modulation of Na[subscript v]1.5 Channel Function by an Alternatively Spliced Sequence in the DII/DIII Linker Region by Camacho, Juan A, Hensellek, Sabine, Rougier, Jean-Sébastien, Blechschmidt, Steve, Abriel, Hugues, Benndorf, Klaus, Zimmer, Thomas

“…In the present study, we identified a novel splice variant of the human cardiac Na⁺ channel Na[subscript v]1.5 (Na[subscript v]1.5d), in which a 40-amino acid…”
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Molecular characterization of two founder mutations causing long QT syndrome and identification of compound heterozygous patients by Fodstad, Heidi, Bendahhou, Saïd, Rougier, Jean-Sébastien, Laitinen-Forsblom, Päivi J, Barhanin, Jacques, Abriel, Hugues, Schild, Laurent, Kontula, Kimmo, Swan, Heikki

“…Mutations of at least six different genes have been found to cause long QT syndrome (LQTS), an inherited arrhythmic disorder characterized by a prolonged QT…”
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