Search Results - "Roughley, P"

The structure and function of cartilage proteoglycans by Roughley, P J

“…Cartilage contains a variety of proteoglycans that are essential for its normal function. These include aggrecan, decorin, biglycan, fibromodulin and lumican…”
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A role for TNFα in intervertebral disc degeneration: A non-recoverable catabolic shift by Purmessur, D., Walter, B.A., Roughley, P.J., Laudier, D.M., Hecht, A.C., Iatridis, James

“…[Display omitted] ► TNFα induced catabolic changes similar to human intervertebral disc degeneration. ► The metabolic shift induced by TNFα was sustained…”
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Acute mechanical injury of the human intervertebral disc: link to degeneration and pain by Alkhatib, B, Rosenzweig, D H, Krock, E, Roughley, P J, Beckman, L, Steffen, T, Weber, M H, Ouellet, J A, Haglund, L

“…Excessive mechanical loading or acute trauma to intervertebral discs (IVDs) is thought to contribute to degeneration and pain. However, the exact mechanisms by…”
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Human cartilaginous endplate degeneration is induced by calcium and the extracellular calcium-sensing receptor in the intervertebral disc by Grant, M P, Epure, L M, Bokhari, R, Roughley, P, Antoniou, J, Mwale, F

“…The cartilaginous endplates (CEPs) are thin layers of hyaline cartilage found adjacent to intervertebral discs (IVDs). In addition to providing structural…”
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Complex loading affects intervertebral disc mechanics and biology by Walter, B.A, Korecki, C.L, Purmessur, D, Roughley, P.J, Michalek, A.J, Iatridis, J.C

“…Summary Background Complex loading develops in multiple spinal motions and in the case of hyperflexion is known to cause intervertebral disc (IVD) injury. Few…”
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A vision on the future of articular cartilage repair by Cucchiarini, M, Madry, H, Guilak, F, Saris, D B, Stoddart, M J, Koon Wong, M, Roughley, P

“…An AO Foundation (Davos, Switzerland) sponsored workshop "Cell Therapy in Cartilage Repair" from the Symposium "Where Science meets Clinics" (September 5-7,…”
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Distinction between the extracellular matrix of the nucleus pulposus and hyaline cartilage: a requisite for tissue engineering of intervertebral disc by Mwale, F, Roughley, P, Antoniou, J

“…Tissue engineering of intervertebral discs (IVD) using mesenchymal stem cells (MSCs) induced to differentiate into a disc-cell phenotype has been considered as…”
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Short link N acts as a disease modifying osteoarthritis drug by Antoniou, J, Epure, L M, Grant, M P, Richard, H, Sampalis, J, Roughley, P J, Laverty, S, Mwale, F

“…Osteoarthritis (OA) is a degenerative joint disease characterised by a progressive degradation of articular cartilage and underlaying bone and is associated…”
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Dynamic loading, matrix maintenance and cell injection therapy of human intervertebral discs cultured in a bioreactor by Rosenzweig, D H, Gawri, R, Moir, J, Beckman, L, Eglin, D, Steffen, T, Roughley, P J, Ouellet, J A, Haglund, L

“…Low back pain originating from intervertebral disc (IVD) degeneration affects the quality of life for millions of people, and it is a major contributor to…”
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Spine degeneration in a murine model of chronic human tobacco smokers by Wang, D, Nasto, L.A, Roughley, P, Leme, A.S, Houghton, A.M, Usas, A, Sowa, G, Lee, J, Niedernhofer, L, Shapiro, S, Kang, J, Vo, N

“…Summary Objective To investigate the mechanisms by which chronic tobacco smoking promotes intervertebral disc degeneration (IDD) and vertebral degeneration in…”
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The role of proteoglycans in aging, degeneration and repair of the intervertebral disc by Roughley, P J, Alini, M, Antoniou, J

“…The ability of the nucleus pulposus of the intervertebral disc to resist compressive loads is due to its high content of the proteoglycan aggrecan…”
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The non-aggregated aggrecan in the human intervertebral disc can arise by a non-proteolytic mechanism by Roughley, P J, Geng, Y, Mort, J S

“…Analysis of both the aggregated and non-aggregated fractions of aggrecan isolated from adult human intervertebral disc using immunoblotting with antibodies…”
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A biological approach to treating disc degeneration: not for today, but maybe for tomorrow by Alini, M, Roughley, P J, Antoniou, J, Stoll, T, Aebi, M

“…The intervertebral disc unites the vertebrae in the spine, providing the flexibility required for bending and twisting and resisting the compression inflicted…”
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The involvement of aggrecan polymorphism in degeneration of human intervertebral disc and articular cartilage by Roughley, P, Martens, D, Rantakokko, J, Alini, M, Mwale, F, Antoniou, J

“…The functions of the intervertebral disc and of articular cartilage are intimately related to their aggrecan content. Aggrecan is a proteoglycan that interacts…”
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Link protein can retard the degradation of hyaluronan in proteoglycan aggregates by Rodriguez, E., Roughley, P.

“…Loss of articular cartilage and intervertebral disc function in arthritis or disc degeneration is associated with degradation of the proteoglycan (PG)…”
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Best paper NASS 2013: link-N can stimulate proteoglycan synthesis in the degenerated human intervertebral discs by Gawri, Rahul, Antoniou, John, Ouellet, Jean, Awwad, Waleed, Steffen, Thomas, Roughley, Peter, Haglund, Lisbet, Mwale, Fackson

“…Intervertebral disc (IVD) degeneration is the most common cause of back pain. Presently there is no medical treatment, leaving surgery as the only offered…”
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Short- and Long-Term Outcome of Patients with Pseudo-Vitamin D Deficiency Rickets Treated with Calcitriol by Edouard, T, Alos, N, Chabot, G, Roughley, P, Glorieux, F. H, Rauch, F

“…Background: Pseudo-vitamin D deficiency rickets (PDDR; OMIM 264700) is a rare autosomal recessive disorder caused by mutations in the CYP27B1 gene, leading to…”
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Identification of opticin, a member of the small leucine-rich repeat proteoglycan family, in human articular tissues: a novel target for MMP-13 in osteoarthritis by Monfort, J., M.D, Tardif, G., Ph.D, Roughley, P., M.D, Reboul, P., Ph.D, Boileau, C., Ph.D, Bishop, P.N., Ph.D., F.R.C.Ophth, Pelletier, J.-P., M.D, Martel-Pelletier, J., Ph.D

“…Summary Objective One of the proteoglycan families is the small leucine-rich proteoglycans (SLRPs) that are characterized by their association with collagen…”
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Mechanism of proteoglycan aggregate degradation in cartilage stimulated with oncostatin M by Durigova, M., M.Sc, Roughley, P.J., Ph.D, Mort, J.S., Ph.D

“…Summary Objective To investigate the potential synergistic and differential effects of cytokine combinations on proteoglycan aggregate catabolism in cartilage…”
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The cleavage of biglycan by aggrecanases by Melching, L.I., Fisher, W.D., Lee, E.R., Mort, J.S., Roughley, P.J.

“…Aggrecanase-1 [a disintegrin and metalloproteinase with thrombospondin motifs (ADAMTS)-4] and aggrecanase-2 (ADAMTS-5) have been named for their ability to…”
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