Search Results - "Rouge, Jessica L."

Towards Self-Transfecting Nucleic Acid Nanostructures for Gene Regulation by Gudipati, Saketh, Zhang, Ke, Rouge, Jessica L.

“…Nanoscale structures of therapeutic nucleic acids have shown enormous potential to help clinicians realize the promise of personaliz ed medicine using…”
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Spherical Nucleic Acids as a Divergent Platform for Synthesizing RNA–Nanoparticle Conjugates through Enzymatic Ligation by Rouge, Jessica L, Hao, Liangliang, Wu, Xiaochen A, Briley, William E, Mirkin, Chad A

“…Herein, we describe a rapid, divergent method for using spherical nucleic acids (SNAs) as a universal platform for attaching RNA to DNA-modified nanoparticles…”
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Viral Mimicry as a Design Template for Nucleic Acid Nanocarriers by de la Fuente, Ina F, Sawant, Shraddha S, Tolentino, Mark Q, Corrigan, Patrick M, Rouge, Jessica L

“…Therapeutic nucleic acids hold immense potential in combating undruggable, gene-based diseases owing to their high programmability and relative ease of…”
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Controlled Release of a Dual Zinc‐Sensing and Gene Regulating Small Molecule from DNA Micelles by Sawant, Shraddha S., Gudipati, Saketh, Veczko, Samantha R., Rouge, Jessica L.

“…Intracellular zinc ions are essential for various biological cell processes and are often dysregulated in many diseases de‐pending on their location, protein…”
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Nucleic Acid Nanocapsules for Enzyme-Triggered Drug Release by Awino, Joseph K, Gudipati, Saketh, Hartmann, Alyssa K, Santiana, Joshua J, Cairns-Gibson, Dominic F, Gomez, Nicole, Rouge, Jessica L

“…Herein we describe a nucleic acid functionalized nanocapsule in which nucleic acid ligands are assembled and disassembled in the presence of enzymes. The…”
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Chimeric siRNA-DNA Surfactants for the Enhanced Delivery and Sustained Cytotoxicity of a Gold(III) Metallodrug by Hartmann, Alyssa K, Gudipati, Saketh, Pettenuzzo, Andrea, Ronconi, Luca, Rouge, Jessica L

“…Using a recently developed nucleic acid delivery platform, we demonstrate the effective delivery of metallodrug [AuIIIBr2(SSC-Inp-OEt)] (AP228; Inp =…”
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Programmable Peptide-Cross-Linked Nucleic Acid Nanocapsules as a Modular Platform for Enzyme Specific Cargo Release by Santiana, Joshua J, Sui, Binglin, Gomez, Nicole, Rouge, Jessica L

“…Herein we describe a modular assembly strategy for photo-cross-linking peptides into nucleic acid functionalized nanocapsules. The peptides embedded within the…”
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Tracking nucleic acid nanocapsule assembly, cellular uptake and disassembly using a novel fluorescently labeled surfactant by Arifuzzaman, Md, Hartmann, Alyssa K, Rouge, Jessica L

“…Intracellular trafficking and delivery of nucleic acids is an area of growing interest, particularly as it relates to therapeutic applications. Spectroscopic…”
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Cellular Uptake Mechanism of Nucleic Acid Nanocapsules and Their DNA-Surfactant Building Blocks by Pal, Suman, de la Fuente, Ina F., Sawant, Shraddha S., Cannata, Jenna N., He, Wu, Rouge, Jessica L.

“…Nucleic acid nanocapsules (NANs) are enzyme-responsive DNA-functionalized micelles built for the controlled release of DNA-surfactant conjugates (DSCs) that…”
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A GATA3 Targeting Nucleic Acid Nanocapsule for In Vivo Gene Regulation in Asthma by Gavitt, Tyler D., Hartmann, Alyssa K., Sawant, Shraddha S., Mara, Arlind B., Szczepanek, Steven M., Rouge, Jessica L.

“…Allergic asthma is one of the leading chronic lung diseases of both children and adults worldwide, resulting in significant morbidity and mortality in affected…”
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Ribozyme–Spherical Nucleic Acids by Rouge, Jessica L, Sita, Timothy L, Hao, Liangliang, Kouri, Fotini M, Briley, William E, Stegh, Alexander H, Mirkin, Chad A

“…Ribozymes are highly structured RNA sequences that can be tailored to recognize and cleave specific stretches of mRNA. Their current therapeutic efficacy…”
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Determining the Role of Surfactant on the Cytosolic Delivery of DNA Cross-Linked Micelles by Fuente, Ina F. de la, Sawant, Shraddha S., Kho, Kiang W., Sarangi, Nirod K., Canete, Rachelle C., Pal, Suman, Liang, Lisa H., Keyes, Tia E., Rouge, Jessica L.

“…Nucleic Acid Nanocapsules (NANs) are nucleic acid nanostructures that radially display oligonucleotides on the surface of cross-linked surfactant micelles…”
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Polymer stiffness governs template mediated self-assembly of liposome-like nanoparticles: simulation, theory and experiment by Shen, Zhiqiang, Loe, David T, Fisher, Alessandro, Kröger, Martin, Rouge, Jessica L, Li, Ying

“…This study suggests that the self-assembly of a template-mediated liposome (TML) can be utilized as a general method to produce liposomes with controlled…”
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Modulating the Bond Strength of DNA–Nanoparticle Superlattices by Seo, Soyoung E, Wang, Mary X, Shade, Chad M, Rouge, Jessica L, Brown, Keith A, Mirkin, Chad A

“…A method is introduced for modulating the bond strength in DNA–programmable nanoparticle (NP) superlattice crystals. This method utilizes noncovalent…”
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Self-assembly of core-polyethylene glycol-lipid shell (CPLS) nanoparticles and their potential as drug delivery vehicles by Shen, Zhiqiang, Loe, David T, Awino, Joseph K, Kröger, Martin, Rouge, Jessica L, Li, Ying

“…Herein a new multifunctional formulation, referred to as a core-polyethylene glycol-lipid shell (CPLS) nanoparticle, has been proposed and studied in silico…”
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Biocompatible Infinite-Coordination-Polymer Nanoparticle-Nucleic-Acid Conjugates for Antisense Gene Regulation by Calabrese, Colin M., Merkel, Timothy J., Briley, William E., Randeria, Pratik S., Narayan, Suguna P., Rouge, Jessica L., Walker, David A., Scott, Alexander W., Mirkin, Chad A.

“…Herein, we report the synthesis of DNA‐functionalized infinite‐coordination‐polymer (ICP) nanoparticles as biocompatible gene‐regulation agents. ICP…”
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Controlled release of small molecules and proteins from DNA-surfactant stabilized metal organic frameworks by Tolentino, Mark Q, Hartmann, Alyssa K, Loe, David T, Rouge, Jessica L

“…This work highlights a multifunctional nanoscale material which can effectively compartmentalize small molecules and biomolecules into a single, micellar…”
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Enzymatically Ligated DNA–Surfactants: Unmasking Hydrophobically Modified DNA for Intracellular Gene Regulation by Hartmann, Alyssa K., Cairns‐Gibson, Dominic F., Santiana, Joshua J., Tolentino, Mark Q., Barber, Halle M., Rouge, Jessica L.

“…Herein, we describe the characterization of a novel self‐assembling and intracellular disassembling nanomaterial for nucleic acid delivery and targeted gene…”
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A thermoresponsive crosslinker for reversible micelle stabilization by Tolentino, Mark Q, Rouge, Jessica L

“…Herein we report a thermoresponsive crosslinker that can be utilized to stabilize the surface of micelles through a "click" reaction and to trigger the…”
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Tunable DNA Cleavage by Intercalating Peptidoconjugates by Mahon, Kerry P. Jr, Roy, Marc D, Carreon, Jay R, Prestwich, Erin G, Rouge, Jessica L, Shin, Stephanie, Kelley, Shana O

“…The properties of a novel family of peptide-based DNA-cleavage agents are described. Examination of the DNA-cleavage activities of a systematic series of…”
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