Search Results - "Roudko, Vladimir"

Computational Prediction and Validation of Tumor-Associated Neoantigens by Roudko, Vladimir, Greenbaum, Benjamin, Bhardwaj, Nina

“…Tumor progression is typically accompanied by an accumulation of driver and passenger somatic mutations. A handful of those mutations occur in protein coding…”
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Architecture of the Nuclease Module of the Yeast Ccr4-Not Complex: the Not1-Caf1-Ccr4 Interaction by Basquin, Jérôme, Roudko, Vladimir V., Rode, Michaela, Basquin, Claire, Séraphin, Bertrand, Conti, Elena

“…Shortening eukaryotic poly(A) tails represses mRNA translation and induces mRNA turnover. The major cytoplasmic deadenylase, the Ccr4-Not complex, is a…”
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Towards superior dendritic-cell vaccines for cancer therapy by Saxena, Mansi, Balan, Sreekumar, Roudko, Vladimir, Bhardwaj, Nina

“…Potent dendritic-cell cancer vaccines could be used to induce functional antitumour immunity without off-target toxicity…”
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Monocytes re-enter the bone marrow during fasting and alter the host response to infection by Janssen, Henrike, Kahles, Florian, Liu, Dan, Downey, Jeffrey, Koekkoek, Laura L., Roudko, Vladimir, D’Souza, Darwin, McAlpine, Cameron S., Halle, Lennard, Poller, Wolfram C., Chan, Christopher T., He, Shun, Mindur, John E., Kiss, Máté G., Singh, Sumnima, Anzai, Atsushi, Iwamoto, Yoshiko, Kohler, Rainer H., Chetal, Kashish, Sadreyev, Ruslan I., Weissleder, Ralph, Kim-Schulze, Seunghee, Merad, Miriam, Nahrendorf, Matthias, Swirski, Filip K.

“…Diet profoundly influences physiology. Whereas over-nutrition elevates risk for disease via its influence on immunity and metabolism, caloric restriction and…”
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Lynch Syndrome and MSI-H Cancers: From Mechanisms to "Off-The-Shelf" Cancer Vaccines by Roudko, Vladimir, Cimen Bozkus, Cansu, Greenbaum, Benjamin, Lucas, Aimee, Samstein, Robert, Bhardwaj, Nina

“…Defective DNA mismatch repair (dMMR) is associated with many cancer types including colon, gastric, endometrial, ovarian, hepatobiliary tract, urinary tract,…”
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HNRNPM controls circRNA biogenesis and splicing fidelity to sustain cancer cell fitness by Ho, Jessica Sy, Di Tullio, Federico, Schwarz, Megan, Low, Diana, Incarnato, Danny, Gay, Florence, Tabaglio, Tommaso, Zhang, JingXian, Wollmann, Heike, Chen, Leilei, An, Omer, Chan, Tim Hon Man, Hall Hickman, Alexander, Zheng, Simin, Roudko, Vladimir, Chen, Sujun, Karz, Alcida, Ahmed, Musaddeque, He, Housheng Hansen, Greenbaum, Benjamin D, Oliviero, Salvatore, Serresi, Michela, Gargiulo, Gaetano, Mann, Karen M, Hernando, Eva, Mulholland, David, Marazzi, Ivan, Wee, Dave Keng Boon, Guccione, Ernesto

“…High spliceosome activity is a dependency for cancer cells, making them more vulnerable to perturbation of the splicing machinery compared to normal cells. To…”
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Pyrimidine biosynthesis links mitochondrial respiration to the p53 pathway by Khutornenko, Anastasia A., Roudko, Vladimir V., Chernyak, Boris V., Vartapetian, Andrey B., Chumakov, Peter M., Evstafieva, Alexandra G., Stark, George R.

“…While many functions of the p53 tumor suppressor affect mitochondrial processes, the role of altered mitochondrial physiology in a modulation of p53 response…”
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500 Quantification of the HIV reservoir in the gut-associated lymphoid tissue by Cossarini, Francesca, D’Souza, Darwin, Roudko, Vladimir, Aberg, Judith, Mehandru, Saurabh

“…OBJECTIVES/GOALS: The major obstacle to an effective cure or remission for HIV infection is the integration of HIV into the genome of long-lived resting cells…”
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Systemic chemokine-modulatory regimen combined with neoadjuvant chemotherapy in patients with triple-negative breast cancer by Gandhi, Shipra, Slomba, Ronald T, Janes, Cayla, Fitzpatrick, Victoria, Miller, Janine, Attwood, Kristopher, Ioannou, Giorgio, Ozbey, Sinem, De Souza, Igor, Roudko, Vladimir, Kumar, Prasanna, Kalathil, Suresh, Kokolus, Kathleen M, Wang, Jianming, Cortes Gomez, Eduardo, Takabe, Kazuaki, Edge, Stephen, Young, Jessica, Cappuccino, Helen, Opyrchal, Mateusz, O’Connor, Tracey, Levine, Ellis G, Gnjatic, Sacha, Kalinski, Pawel

“…Background Higher cytotoxic T lymphocyte (CTL) numbers in the tumor microenvironment (TME) predict pathologic complete response (pCR) to neoadjuvant…”
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Shared Immunogenic Poly-Epitope Frameshift Mutations in Microsatellite Unstable Tumors by Roudko, Vladimir, Bozkus, Cansu Cimen, Orfanelli, Theofano, McClain, Christopher B., Carr, Caitlin, O’Donnell, Timothy, Chakraborty, Lauren, Samstein, Robert, Huang, Kuan-lin, Blank, Stephanie V., Greenbaum, Benjamin, Bhardwaj, Nina

“…Microsatellite instability-high (MSI-H) tumors are characterized by high tumor mutation burden and responsiveness to checkpoint blockade. We identified…”
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Therapeutic Immune Modulation against Solid Cancers with Intratumoral Poly-ICLC: A Pilot Trial by Kyi, Chrisann, Roudko, Vladimir, Sabado, Rachel, Saenger, Yvonne, Loging, William, Mandeli, John, Thin, Tin Htwe, Lehrer, Deborah, Donovan, Michael, Posner, Marshall, Misiukiewicz, Krzysztof, Greenbaum, Benjamin, Salazar, Andres, Friedlander, Philip, Bhardwaj, Nina

“…Polyinosinic-polycytidylic acid-poly-l-lysine carboxymethylcellulose (poly-ICLC), a synthetic double-stranded RNA complex, is a ligand for toll-like receptor-3…”
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Immune Checkpoint Blockade Enhances Shared Neoantigen-Induced T-cell Immunity Directed against Mutated Calreticulin in Myeloproliferative Neoplasms by Cimen Bozkus, Cansu, Roudko, Vladimir, Finnigan, John P, Mascarenhas, John, Hoffman, Ronald, Iancu-Rubin, Camelia, Bhardwaj, Nina

“…Somatic frameshift mutations in the calreticulin ( ) gene are key drivers of cellular transformation in myeloproliferative neoplasms (MPN). All patients…”
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Spatial CRISPR genomics identifies regulators of the tumor microenvironment by Dhainaut, Maxime, Rose, Samuel A., Akturk, Guray, Wroblewska, Aleksandra, Nielsen, Sebastian R., Park, Eun Sook, Buckup, Mark, Roudko, Vladimir, Pia, Luisanna, Sweeney, Robert, Le Berichel, Jessica, Wilk, C. Matthias, Bektesevic, Anela, Lee, Brian H., Bhardwaj, Nina, Rahman, Adeeb H., Baccarini, Alessia, Gnjatic, Sacha, Pe’er, Dana, Merad, Miriam, Brown, Brian D.

“…While CRISPR screens are helping uncover genes regulating many cell-intrinsic processes, existing approaches are suboptimal for identifying extracellular gene…”
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Abstract 5587: Characterization of shared immunogenic frameshift mutations in microsatellite unstable cancers to guide the design of off-the-shelf immunotherapies by Bozkus, Cansu Cimen, Roudko, Vladimir, Orfanelli, Theofani, Blank, Stephanie, Greenbaum, Benjamin, Bhardwaj, Nina

“…Abstract Microsatellite instability-high (MSI-H) cancers are an important model for evaluating neoantigen-based immunotherapies, given their high loads of…”
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An IL-4 signalling axis in bone marrow drives pro-tumorigenic myelopoiesis by LaMarche, Nelson M., Hegde, Samarth, Park, Matthew D., Maier, Barbara B., Troncoso, Leanna, Le Berichel, Jessica, Hamon, Pauline, Belabed, Meriem, Mattiuz, Raphaël, Hennequin, Clotilde, Chin, Theodore, Reid, Amanda M., Reyes-Torres, Iván, Nemeth, Erika, Zhang, Ruiyuan, Olson, Oakley C., Doroshow, Deborah B., Rohs, Nicholas C., Gomez, Jorge E., Veluswamy, Rajwanth, Hall, Nicole, Venturini, Nicholas, Ginhoux, Florent, Liu, Zhaoyuan, Buckup, Mark, Figueiredo, Igor, Roudko, Vladimir, Miyake, Kensuke, Karasuyama, Hajime, Gonzalez-Kozlova, Edgar, Gnjatic, Sacha, Passegué, Emmanuelle, Kim-Schulze, Seunghee, Brown, Brian D., Hirsch, Fred R., Kim, Brian S., Marron, Thomas U., Merad, Miriam

“…Myeloid cells are known to suppress antitumour immunity 1 . However, the molecular drivers of immunosuppressive myeloid cell states are not well defined. Here…”
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Establishing a Pathogenic Role for NK Cells As Drivers of Bone Marrow Failure in the Myelodysplastic Syndromes (MDS) by Rai, Richa, Feld, Jonathan, Okulate, Iyinyeloluwa, Melana, Stella, Sheppard, Richard, Demakos, Erin, Hussein, Shafinaz, Chen, Rachel, Lee, Rachel, de Real, Ronaldo, Kelly, Geoffrey, Lee, Brian, Dawson, Travis, Chen, Zhihong, Roudko, Vladimir, kim-Schulze, Seunghee, Silverman, Lewis R R., Horowitz, Amir

“…Background: Myelodysplastic syndromes (MDS) are characterized by aberrant bone-marrow (BM) morphology leading to a clonal impairment of hematopoiesis…”
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Natural Adjuvants for in situ Vaccination Lymphoma Immunotherapy by Aleynick, Mark, Peng, Paul, Upadhyay, Ranjan, Hammerich, Linda, Roudko, Vladimir, Yellin, Michael, Brody, Joshua

“…Abstract BACKGROUND In situ vaccination (ISV) against lymphoma can be achieved with Flt3-ligand treatment to recruit dendritic cells (DC), radiotherapy to load…”
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Molecular states during acute COVID-19 reveal distinct etiologies of long-term sequelae by Thompson, Ryan C., Simons, Nicole W., Wilkins, Lillian, Cheng, Esther, Del Valle, Diane Marie, Hoffman, Gabriel E., Cervia, Carlo, Fennessy, Brian, Mouskas, Konstantinos, Francoeur, Nancy J., Johnson, Jessica S., Lepow, Lauren, Le Berichel, Jessica, Chang, Christie, Beckmann, Aviva G., Wang, Ying-chih, Nie, Kai, Zaki, Nicholas, Tuballes, Kevin, Barcessat, Vanessa, Cedillo, Mario A., Yuan, Dan, Huckins, Laura, Roussos, Panos, Marron, Thomas U., Glicksberg, Benjamin S., Nadkarni, Girish, Heath, James R., Gonzalez-Kozlova, Edgar, Boyman, Onur, Kim-Schulze, Seunghee, Sebra, Robert, Merad, Miriam, Gnjatic, Sacha, Schadt, Eric E., Charney, Alexander W., Beckmann, Noam D.

“…Post-acute sequelae of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection are debilitating, clinically heterogeneous and of unknown…”
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Structure and RNA-binding properties of the Not1–Not2–Not5 module of the yeast Ccr4–Not complex by Bhaskar, Varun, Roudko, Vladimir, Basquin, Jérôme, Sharma, Kundan, Urlaub, Henning, Séraphin, Bertrand, Conti, Elena

“…The Ccr4–Not complex is involved in several aspects of gene expression, including mRNA decay, translational repression and transcription. Structural,…”
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Interleukin-3 coordinates glial-peripheral immune crosstalk to incite multiple sclerosis by Kiss, Máté G., Mindur, John E., Yates, Abi G., Lee, Donghoon, Fullard, John F., Anzai, Atsushi, Poller, Wolfram C., Christie, Kathleen A., Iwamoto, Yoshiko, Roudko, Vladimir, Downey, Jeffrey, Chan, Christopher T., Huynh, Pacific, Janssen, Henrike, Ntranos, Achilles, Hoffmann, Jan D., Jacob, Walter, Goswami, Sukanya, Singh, Sumnima, Leppert, David, Kuhle, Jens, Kim-Schulze, Seunghee, Nahrendorf, Matthias, Kleinstiver, Benjamin P., Probert, Fay, Roussos, Panos, Swirski, Filip K., McAlpine, Cameron S.

“…Glial cells and central nervous system (CNS)-infiltrating leukocytes contribute to multiple sclerosis (MS). However, the networks that govern crosstalk among…”
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