Clinical factors affecting short- and long-term mortality in older patients with COVID-19: a retrospective cohort study

The majority of fatal cases of SARS-CoV-2 was concentrated among older patients. We aimed at assessing risk factors contributing to mortality in this population. A retrospective study including 584 COVID-19 patients aged ≥80 years hospitalized between October 10th 2020 to May 4th 2021 at Ospedale di...

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Bibliographic Details
Published in:	Italian journal of medicine Vol. 18; no. 1
Main Authors:	Pennella, Benedetta, Rotunno, Francesca, Mercuri, Martina, Guerci, Marco, Molteni, Mauro, Biancucci, Marta, Berton, Clelia, Troian, Francesca, Tripodi, Paolo Maria, Gilio, Alessia, Milano, Antea, Dalla Gasperina, Daniela, Dentali, Francesco, Bonaventura, Aldo, Maresca, Andrea Maria
Format:	Journal Article
Language:	English
Published:	PAGEPress Publications 01-01-2024
Subjects:	COVID-19 frailty mortality older patients SARS-CoV-2
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Summary:	The majority of fatal cases of SARS-CoV-2 was concentrated among older patients. We aimed at assessing risk factors contributing to mortality in this population. A retrospective study including 584 COVID-19 patients aged ≥80 years hospitalized between October 10th 2020 to May 4th 2021 at Ospedale di Circolo (Varese, Italy) and Ospedale Galmarini (Tradate, Italy) was conducted. Evaluation of risk factors associated with in-hospital mortality was the primary endpoint. 509 patients were considered. Median age was 86 [82-89] years. Almost half of the patients (n=241) suffered from ≥3 comorbidities. Overall in-hospital mortality was 39.7% (n=202). Age, chronic kidney disease (CKD), peripheral oxygen saturation at admission, and high-flow oxygen during hospital stay independently predicted in-hospital mortality. Overall mortality at 6 months was 57.8% (n=294) and increased with increasing age and number of comorbidities (P<0.05). Age, CKD, and dementia independently predicted 6-month mortality. Age and comorbidities predicted short- and long-term mortality in older patients (≥80 years). Stratification of patients according to age and comorbidities might provide critical information for a better management of elderly patients.
ISSN:	1877-9344 1877-9352
DOI:	10.4081/itjm.2024.1707