Search Results - "Rotter, Jerome"

Predictors of mortality in hospitalized COVID‐19 patients: A systematic review and meta‐analysis by Tian, Wenjie, Jiang, Wanlin, Yao, Jie, Nicholson, Christopher J., Li, Rebecca H., Sigurslid, Haakon H., Wooster, Luke, Rotter, Jerome I., Guo, Xiuqing, Malhotra, Rajeev

“…Mortality rates of coronavirus disease‐2019 (COVID‐19) continue to rise across the world. Information regarding the predictors of mortality in patients with…”
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Predictive Accuracy of a Polygenic Risk Score Compared With a Clinical Risk Score for Incident Coronary Heart Disease by Mosley, Jonathan D, Gupta, Deepak K, Tan, Jingyi, Yao, Jie, Wells, Quinn S, Shaffer, Christian M, Kundu, Suman, Robinson-Cohen, Cassianne, Psaty, Bruce M, Rich, Stephen S, Post, Wendy S, Guo, Xiuqing, Rotter, Jerome I, Roden, Dan M, Gerszten, Robert E, Wang, Thomas J

“…IMPORTANCE: Polygenic risk scores comprising millions of single-nucleotide polymorphisms (SNPs) could be useful for population-wide coronary heart disease…”
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Pangenomics enables genotyping of known structural variants in 5202 diverse genomes by Sirén, Jouni, Monlong, Jean, Chang, Xian, Novak, Adam M, Eizenga, Jordan M, Markello, Charles, Sibbesen, Jonas A, Hickey, Glenn, Chang, Pi-Chuan, Carroll, Andrew, Gupta, Namrata, Gabriel, Stacey, Blackwell, Thomas W, Ratan, Aakrosh, Taylor, Kent D, Rich, Stephen S, Rotter, Jerome I, Haussler, David, Garrison, Erik, Paten, Benedict

“…We introduce Giraffe, a pangenome short-read mapper that can efficiently map to a collection of haplotypes threaded through a sequence graph. Giraffe maps…”
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Genetic architecture of gene expression traits across diverse populations by Mogil, Lauren S, Andaleon, Angela, Badalamenti, Alexa, Dickinson, Scott P, Guo, Xiuqing, Rotter, Jerome I, Johnson, W Craig, Im, Hae Kyung, Liu, Yongmei, Wheeler, Heather E

“…For many complex traits, gene regulation is likely to play a crucial mechanistic role. How the genetic architectures of complex traits vary between populations…”
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Genetics Insights in the Relationship Between Type 2 Diabetes and Coronary Heart Disease by Goodarzi, Mark O., Rotter, Jerome I.

“…Diabetes mellitus is a major risk factor for coronary heart disease (CHD). The major form of diabetes mellitus is type 2 diabetes mellitus (T2D), which is thus…”
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Evaluation of mitochondrial DNA copy number estimation techniques by Longchamps, Ryan J, Castellani, Christina A, Yang, Stephanie Y, Newcomb, Charles E, Sumpter, Jason A, Lane, John, Grove, Megan L, Guallar, Eliseo, Pankratz, Nathan, Taylor, Kent D, Rotter, Jerome I, Boerwinkle, Eric, Arking, Dan E

“…Mitochondrial DNA copy number (mtDNA-CN), a measure of the number of mitochondrial genomes per cell, is a minimally invasive proxy measure for mitochondrial…”
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Whole-Genome Sequencing to Characterize Monogenic and Polygenic Contributions in Patients Hospitalized With Early-Onset Myocardial Infarction by Khera, Amit V., Chaffin, Mark, Zekavat, Seyedeh M., Collins, Ryan L., Roselli, Carolina, Natarajan, Pradeep, Lichtman, Judith H., D’Onofrio, Gail, Mattera, Jennifer, Dreyer, Rachel, Spertus, John A., Taylor, Kent D., Psaty, Bruce M., Rich, Stephen S., Post, Wendy, Gupta, Namrata, Gabriel, Stacey, Lander, Eric, Ida Chen, Yii-Der, Talkowski, Michael E., Rotter, Jerome I., Krumholz, Harlan M., Kathiresan, Sekar

“…BACKGROUND:The relative prevalence and clinical importance of monogenic mutations related to familial hypercholesterolemia and of high polygenic score…”
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Genome-Wide Association Studies by Guo, Xiuqing, Rotter, Jerome I

“…This JAMA Guide to Statistics and Methods reviews the use of whole genome association studies to quantify the association between single-nucleotide…”
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Genome-Wide Analysis of Left Ventricular Image-Derived Phenotypes Identifies Fourteen Loci Associated With Cardiac Morphogenesis and Heart Failure Development by Aung, Nay, Vargas, Jose D, Yang, Chaojie, Cabrera, Claudia P, Warren, Helen R, Fung, Kenneth, Tzanis, Evan, Barnes, Michael R, Rotter, Jerome I, Taylor, Kent D, Manichaikul, Ani W, Lima, Joao A.C, Bluemke, David A, Piechnik, Stefan K, Neubauer, Stefan, Munroe, Patricia B, Petersen, Steffen E

“…BACKGROUND:The genetic basis of left ventricular (LV) image-derived phenotypes, which play a vital role in the diagnosis, management, and risk stratification…”
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Clonal Hematopoiesis Is Associated With Higher Risk of Stroke by Bhattacharya, Romit, Zekavat, Seyedeh M., Haessler, Jeffrey, Fornage, Myriam, Raffield, Laura, Uddin, Md Mesbah, Bick, Alexander G., Niroula, Abhishek, Yu, Bing, Gibson, Christopher, Griffin, Gabriel, Morrison, Alanna C., Psaty, Bruce M., Longstreth, William T., Bis, Joshua C., Rich, Stephen S., Rotter, Jerome I., Tracy, Russell P., Correa, Adolfo, Seshadri, Sudha, Johnson, Andrew, Collins, Jason M., Hayden, Kathleen M., Madsen, Tracy E., Ballantyne, Christie M., Jaiswal, Siddhartha, Ebert, Benjamin L., Kooperberg, Charles, Manson, JoAnn E., Whitsel, Eric A., Natarajan, Pradeep, Reiner, Alexander P.

“…Clonal hematopoiesis of indeterminate potential (CHIP) is a novel age-related risk factor for cardiovascular disease-related morbidity and mortality. The…”
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Racial and Ethnic Differences in All-Cause and Cardiovascular Disease Mortality: The MESA Study by Post, Wendy S., Watson, Karol E., Hansen, Spencer, Folsom, Aaron R., Szklo, Moyses, Shea, Steven, Barr, R. Graham, Burke, Gregory, Bertoni, Alain G., Allen, Norrina, Pankow, James S., Lima, Joao A.C., Rotter, Jerome I., Kaufman, Joel D., Johnson, W. Craig, Kronmal, Richard A., Diez-Roux, Ana V., McClelland, Robyn L.

“…Despite improvements in population health, marked racial and ethnic disparities in longevity and cardiovascular disease (CVD) mortality persist. This study…”
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Comparison of Proteomic Assessment Methods in Multiple Cohort Studies by Raffield, Laura M., Dang, Hong, Pratte, Katherine A., Jacobson, Sean, Gillenwater, Lucas A., Ampleford, Elizabeth, Barjaktarevic, Igor, Basta, Patricia, Clish, Clary B., Comellas, Alejandro P., Cornell, Elaine, Curtis, Jeffrey L., Doerschuk, Claire, Durda, Peter, Emson, Claire, Freeman, Christine M., Guo, Xiuqing, Hastie, Annette T., Hawkins, Gregory A., Herrera, Julio, Johnson, W. Craig, Labaki, Wassim W., Liu, Yongmei, Masters, Brett, Miller, Michael, Ortega, Victor E., Papanicolaou, George, Peters, Stephen, Taylor, Kent D., Rich, Stephen S., Rotter, Jerome I., Auer, Paul, Reiner, Alex P., Tracy, Russell P., Ngo, Debby, Gerszten, Robert E., O'Neal, Wanda K., Bowler, Russell P.

“…Novel proteomics platforms, such as the aptamer‐based SOMAscan platform, can quantify large numbers of proteins efficiently and cost‐effectively and are…”
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Analysis of cardiac magnetic resonance imaging in 36,000 individuals yields genetic insights into dilated cardiomyopathy by Pirruccello, James P., Bick, Alexander, Wang, Minxian, Chaffin, Mark, Friedman, Samuel, Yao, Jie, Guo, Xiuqing, Venkatesh, Bharath Ambale, Taylor, Kent D., Post, Wendy S., Rich, Stephen, Lima, Joao A. C., Rotter, Jerome I., Philippakis, Anthony, Lubitz, Steven A., Ellinor, Patrick T., Khera, Amit V., Kathiresan, Sekar, Aragam, Krishna G.

“…Dilated cardiomyopathy (DCM) is an important cause of heart failure and the leading indication for heart transplantation. Many rare genetic variants have been…”
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A combined polygenic score of 21,293 rare and 22 common variants improves diabetes diagnosis based on hemoglobin A1C levels by Dornbos, Peter, Koesterer, Ryan, Ruttenburg, Andrew, Nguyen, Trang, Cole, Joanne B., Leong, Aaron, Meigs, James B., Florez, Jose C., Rotter, Jerome I., Udler, Miriam S., Flannick, Jason

“…Polygenic scores (PGSs) combine the effects of common genetic variants 1 , 2 to predict risk or treatment strategies for complex diseases 3 – 7 . Adding rare…”
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HDAC9 is implicated in atherosclerotic aortic calcification and affects vascular smooth muscle cell phenotype by Malhotra, Rajeev, Mauer, Andreas C., Lino Cardenas, Christian L., Guo, Xiuqing, Yao, Jie, Zhang, Xiaoling, Wunderer, Florian, Smith, Albert V., Wong, Quenna, Pechlivanis, Sonali, Hwang, Shih-Jen, Wang, Judy, Lu, Lingyi, Nicholson, Christopher J., Shelton, Georgia, Buswell, Mary D., Barnes, Hanna J., Sigurslid, Haakon H., Slocum, Charles, Rourke, Caitlin O’, Rhee, David K., Bagchi, Aranya, Nigwekar, Sagar U., Buys, Emmanuel S., Campbell, Catherine Y., Harris, Tamara, Budoff, Matthew, Criqui, Michael H., Rotter, Jerome I., Johnson, Andrew D., Song, Ci, Franceschini, Nora, Debette, Stephanie, Hoffmann, Udo, Kälsch, Hagen, Nöthen, Markus M., Sigurdsson, Sigurdur, Freedman, Barry I., Bowden, Donald W., Jöckel, Karl-Heinz, Moebus, Susanne, Erbel, Raimund, Feitosa, Mary F., Gudnason, Vilmundur, Thanassoulis, George, Zapol, Warren M., Lindsay, Mark E., Bloch, Donald B., Post, Wendy S., O’Donnell, Christopher J.

“…Aortic calcification is an important independent predictor of future cardiovascular events. We performed a genome-wide association meta-analysis to determine…”
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AtheroSpectrum Reveals Novel Macrophage Foam Cell Gene Signatures Associated With Atherosclerotic Cardiovascular Disease Risk by Li, Chuan, Qu, Lili, Matz, Alyssa J., Murphy, Patrick A., Liu, Yongmei, Manichaikul, Ani W., Aguiar, Derek, Rich, Stephen S., Herrington, David M., Vu, David, Johnson, W. Craig, Rotter, Jerome I., Post, Wendy S., Vella, Anthony T., Rodriguez-Oquendo, Annabelle, Zhou, Beiyan

“…Whereas several interventions can effectively lower lipid levels in people at risk for atherosclerotic cardiovascular disease (ASCVD), cardiovascular event…”
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Serum metabolic signatures of coronary and carotid atherosclerosis and subsequent cardiovascular disease by Tzoulaki, Ioanna, Castagné, Raphaële, Boulangé, Claire L, Karaman, Ibrahim, Chekmeneva, Elena, Evangelou, Evangelos, Ebbels, Timothy M D, Kaluarachchi, Manuja R, Chadeau-Hyam, Marc, Mosen, David, Dehghan, Abbas, Moayyeri, Alireza, Ferreira, Diana L Santos, Guo, Xiuqing, Rotter, Jerome I, Taylor, Kent D, Kavousi, Maryam, de Vries, Paul S, Lehne, Benjamin, Loh, Marie, Hofman, Albert, Nicholson, Jeremy K, Chambers, John, Gieger, Christian, Holmes, Elaine, Tracy, Russell, Kooner, Jaspal, Greenland, Philip, Franco, Oscar H, Herrington, David, Lindon, John C, Elliott, Paul

“…Abstract Aims To characterize serum metabolic signatures associated with atherosclerosis in the coronary or carotid arteries and subsequently their association…”
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Clonal hematopoiesis associated with epigenetic aging and clinical outcomes by Nachun, Daniel, Lu, Ake T., Bick, Alexander G., Natarajan, Pradeep, Weinstock, Joshua, Szeto, Mindy D., Kathiresan, Sekar, Abecasis, Goncalo, Taylor, Kent D., Guo, Xiuqing, Tracy, Russ, Durda, Peter, Liu, Yongmei, Johnson, Craig, Rich, Stephen S., Van Den Berg, David, Laurie, Cecilia, Blackwell, Tom, Papanicolaou, George J., Correa, Adolfo, Raffield, Laura M., Johnson, Andrew D., Murabito, Joanne, Manson, JoAnn E., Desai, Pinkal, Kooperberg, Charles, Assimes, Themistocles L., Levy, Daniel, Rotter, Jerome I., Reiner, Alex P., Whitsel, Eric A., Wilson, James G., Horvath, Steve, Jaiswal, Siddhartha

“…Clonal hematopoiesis of indeterminate potential (CHIP) is a common precursor state for blood cancers that most frequently occurs due to mutations in the…”
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Interactions Between Commensal Fungi and the C-Type Lectin Receptor Dectin-1 Influence Colitis by Iliev, Iliyan D., Funari, Vincent A., Taylor, Kent D., Nguyen, Quoclinh, Reyes, Christopher N., Strom, Samuel P., Brown, Jordan, Becker, Courtney A., Fleshner, Phillip R., Dubinsky, Marla, Rotter, Jerome I., Wang, Hanlin L., McGovern, Dermot P. B., Brown, Gordon D., Underhill, David M.

“…The intestinal microflora, typically equated with bacteria, influences diseases such as obesity and inflammatory bowel disease. Here, we show that the…”
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Leptin-Mediated Increases in Catecholamine Signaling Reduce Adipose Tissue Inflammation via Activation of Macrophage HDAC4 by Luan, Bing, Goodarzi, Mark O., Phillips, Naomi G., Guo, Xiuqing, Chen, Yii-Der I., Yao, Jie, Allison, Matthew, Rotter, Jerome I., Shaw, Reuben, Montminy, Marc

“…Obesity promotes systemic insulin resistance through inflammatory changes that lead to the release of cytokines from activated macrophages. Although the…”
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