Search Results - "Rots, M."

Continuous EEG Monitoring for Early Detection of Delayed Cerebral Ischemia in Subarachnoid Hemorrhage: A Pilot Study by Rots, M. L., van Putten, M. J. A. M., Hoedemaekers, C. W. E., Horn, J.

“…Introduction Early identification of delayed cerebral ischemia (DCI) in patients with aneurysmal subarachnoid hemorrhage (aSAH) is a major challenge. The aim…”
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The past and presence of gene targeting: from chemicals and DNA via proteins to RNA by Geel, T. M., Ruiters, M. H. J., Cool, R. H., Halby, L., Voshart, D. C., Andrade Ruiz, L., Niezen-Koning, K. E., Arimondo, P. B., Rots, M. G.

“…The ability to target DNA specifically at any given position within the genome allows many intriguing possibilities and has inspired scientists for decades…”
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Effect of bilateral carotid occlusion on cerebral hemodynamics and perivascular innervation: An experimental rat model by Rots, M. L., de Borst, G. J., van der Toorn, A., Moll, F. L., Pennekamp, C. W. A., Dijkhuizen, R. M., Bleys, R. L. A. W.

“…We aimed to investigate the effect of chronic cerebral hypoperfusion on cerebral hemodynamics and perivascular nerve density in a rat model. Bilateral common…”
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The role of neutrophil gelatinase associated lipocalin (NGAL) as biological constituent linking depression and cardiovascular disease by Gouweleeuw, L, Naudé, P.J.W, Rots, M, DeJongste, M.J.L, Eisel, U.L.M, Schoemaker, R.G

“…Highlights • We review the complex link between cardiovascular disease and depression. • We introduce NGAL as a possible mediator between these pathologies. •…”
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Epigenetic Editing: targeted rewriting of epigenetic marks to modulate expression of selected target genes by de Groote, Marloes L, Verschure, Pernette J, Rots, Marianne G

“…Despite significant advances made in epigenetic research in recent decades, many questions remain unresolved, especially concerning cause and consequence of…”
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Gadolinium Enhancement of the Aneurysm Wall in Extracranial Carotid Artery Aneurysms by van Laarhoven, C J H C M, Rots, M L, Pourier, V E C, Jorritsma, N K N, Leiner, T, Hendrikse, J, Vergouwen, M D I, de Borst, G J

“…The natural history and optimal treatment of extracranial carotid artery aneurysms are unknown. Gadolinium enhancement of the aneurysm wall may reflect…”
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Addressing medical absenteeism in pre-vocational secondary students: effectiveness of a public health intervention, using a quasi-experimental design by Vanneste, Yvonne T M, Mathijssen, Jolanda J P, van de Goor, Ien A M, Rots-de Vries, Carin M C, Feron, Frans J M

“…Students' health and school absenteeism affect educational level, with adverse effects on their future health. This interdependence is reflected in medical…”
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Aberrant DNA methylation and expression of SPDEF and FOXA2 in airway epithelium of patients with COPD by Song, J, Heijink, I H, Kistemaker, L E M, Reinders-Luinge, M, Kooistra, W, Noordhoek, J A, Gosens, R, Brandsma, C A, Timens, W, Hiemstra, P S, Rots, M G, Hylkema, M N

“…Goblet cell metaplasia, a common feature of chronic obstructive pulmonary disease (COPD), is associated with mucus hypersecretion which contributes to the…”
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Bidirectional modulation of endogenous EpCAM expression to unravel its function in ovarian cancer by van der Gun, B T F, Huisman, C, Stolzenburg, S, Kazemier, H G, Ruiters, M H J, Blancafort, P, Rots, M G

“…Background: The epithelial cell adhesion molecule (EpCAM) is overexpressed on most carcinomas. Dependent on the tumour type, its overexpression is either…”
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Transcription factors and molecular epigenetic marks underlying EpCAM overexpression in ovarian cancer by van der Gun, B T F, de Groote, M L, Kazemier, H G, Arendzen, A J, Terpstra, P, Ruiters, M H J, McLaughlin, P M J, Rots, M G

“…Background: The epithelial cell adhesion molecule (EpCAM) is overexpressed on carcinomas, and its downregulation inhibits the oncogenic potential of multiple…”
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Targeted cancer gene therapy: the flexibility of adenoviral gene therapy vectors by Rots, M.G., Curiel, D.T., Gerritsen, W.R., Haisma, H.J.

“…Recombinant adenoviral vectors are promising reagents for therapeutic interventions in humans, including gene therapy for biologically complex diseases like…”
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A comparative study on the immunotherapeutic efficacy of recombinant Semliki Forest virus and adenovirus vector systems in a murine model for cervical cancer by RIEZEBOS-BRILMAN, A, WALCZAK, M, REGTS, J, ROTS, M. G, KAMPS, G, DONTJE, B, HAISMA, H. Y, WILSCHUT, J, DAEMEN, T

“…Currently, various therapeutic strategies are being explored as a potential means to immunize against metastatic malignant cells or even primary tumours. Using…”
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First-principles calculation of the electric field gradient and magnetic hyperfine field in rare-earth metals (Gd to Lu) and dilute alloys with Cd by Mohanta, S.K., Mishra, S.N., Srivastava, S.K., Rots, M.

“…We present detailed ab initio calculations of the magnetic hyperfine field ( B h f ) and electric field gradient (EFG) of a dilute Cd impurity in heavy…”
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Targeted adenovirus mediated inhibition of NF-κB-dependent inflammatory gene expression in endothelial cells in vitro and in vivo by Kułdo, J.M., Ásgeirsdóttir, S.A., Zwiers, P.J., Bellu, A.R., Rots, M.G., Schalk, J.A.C., Ogawara, K.I., Trautwein, C., Banas, B., Haisma, H.J., Molema, G., Kamps, J.A.A.M.

“…In chronic inflammatory diseases the endothelium expresses mediators responsible for harmful leukocyte infiltration. We investigated whether targeted delivery…”
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Protein transduction domains and their utility in gene therapy by Beerens, A M J, Al Hadithy, A F Y, Rots, M G, Haisma, H J

“…Protein transduction domains (PTDs, sometimes termed cell permeable proteins (CPP) or membrane translocating sequences (MTS)) are small peptides that are able…”
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Coordination dependence of hyperfine interactions at impurities on fcc metal surfaces. I. Electric-field gradient by COTTENIER, S, BELLINI, V, CAKMAK, M, MANGHI, F, ROTS, M

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mRNA expression levels of methotrexate resistance-related proteins in childhood leukemia as determined by a standardized competitive template-based RT-PCR method by ROTS, M. G, WILLEY, J. C, JANSEN, G, VAN ZANTWIJK, C. H, NOORDHUIS, P, DEMUTH, J. P, KUIPER, E, VEERMAN, A. J. P, PIETERS, R, PETERS, G. I

“…Drug resistance of leukemic blasts is correlated to event-free survival and might be predicted by mRNA expression of drug resistance-related proteins…”
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Nuclear imaging of hormonal receptor status in breast cancer: a tool for guiding endocrine treatment and drug development by de Vries, E F J, Rots, M G, Hospers, G A P

“…Breast cancer is a commonly occurring disease in women and a major cause of morbidity and mortality. In the past decades, the development of medical endocrine…”
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Expression of deoxycytidine kinase in leukaemic cells compared with solid tumour cell lines, liver metastases and normal liver by van der Wilt, C.L, Kroep, J.R, Loves, W.J.P, Rots, M.G, Van Groeningen, C.J, Kaspers, G.J, Peters, G.J

“…Deoxycytidine kinase (dCK) is required for the phosphorylation of several deoxyribonucleoside analogues that are widely employed as chemotherapeutic agents…”
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Suppressors of interictal discharges in idiopathic childhood occipital epilepsy of Gastaut by Rots, M.L, De Vos, C.C, Smeets-Schouten, J.S, Portier, R, van Putten, M.J.A.M

“…Abstract Idiopathic childhood occipital epilepsy of Gastaut (ICOE-G) is a rare form of epilepsy, characterized by visual hallucinations, periods of blindness,…”
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