Search Results - "Rothwell, Patrick E"

Dopamine-Evoked Synaptic Regulation in the Nucleus Accumbens Requires Astrocyte Activity by Corkrum, Michelle, Covelo, Ana, Lines, Justin, Bellocchio, Luigi, Pisansky, Marc, Loke, Kelvin, Quintana, Ruth, Rothwell, Patrick E., Lujan, Rafael, Marsicano, Giovanni, Martin, Eduardo D., Thomas, Mark J., Kofuji, Paulo, Araque, Alfonso

“…Dopamine is involved in physiological processes like learning and memory, motor control and reward, and pathological conditions such as Parkinson’s disease and…”
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Autism-Associated Neuroligin-3 Mutations Commonly Impair Striatal Circuits to Boost Repetitive Behaviors by Rothwell, Patrick E., Fuccillo, Marc V., Maxeiner, Stephan, Hayton, Scott J., Gokce, Ozgun, Lim, Byung Kook, Fowler, Stephen C., Malenka, Robert C., Südhof, Thomas C.

“…In humans, neuroligin-3 mutations are associated with autism, whereas in mice, the corresponding mutations produce robust synaptic and behavioral changes…”
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Cellular Taxonomy of the Mouse Striatum as Revealed by Single-Cell RNA-Seq by Gokce, Ozgun, Stanley, Geoffrey M., Treutlein, Barbara, Neff, Norma F., Camp, J. Gray, Malenka, Robert C., Rothwell, Patrick E., Fuccillo, Marc V., Südhof, Thomas C., Quake, Stephen R.

“…The striatum contributes to many cognitive processes and disorders, but its cell types are incompletely characterized. We show that microfluidic and FACS-based…”
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Single-Cell mRNA Profiling Reveals Cell-Type-Specific Expression of Neurexin Isoforms by Fuccillo, Marc V., Földy, Csaba, Gökce, Özgün, Rothwell, Patrick E., Sun, Gordon L., Malenka, Robert C., Südhof, Thomas C.

“…Neurexins are considered central organizers of synapse architecture that are implicated in neuropsychiatric disorders. Expression of neurexins in hundreds of…”
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Autism Spectrum Disorders and Drug Addiction: Common Pathways, Common Molecules, Distinct Disorders? by Rothwell, Patrick E

“…Autism spectrum disorders (ASDs) and drug addiction do not share substantial comorbidity or obvious similarities in etiology or symptomatology. It is thus…”
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Integrating synaptic plasticity and striatal circuit function in addiction by Grueter, Brad A, Rothwell, Patrick E, Malenka, Robert C

“…Highlights ► Modifications in MSN excitatory synapses occur in response to drugs of abuse. ► MSN modifications depend on amount of drug experience and time…”
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Input- and Output-Specific Regulation of Serial Order Performance by Corticostriatal Circuits by Rothwell, Patrick E., Hayton, Scott J., Sun, Gordon L., Fuccillo, Marc V., Lim, Byung Kook, Malenka, Robert C.

“…The serial ordering of individual movements into sequential patterns is thought to require synaptic plasticity within corticostriatal circuits that route…”
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Cocaine Experience Controls Bidirectional Synaptic Plasticity in the Nucleus Accumbens by Kourrich, Said, Rothwell, Patrick E, Klug, Jason R, Thomas, Mark J

“…Plasticity of glutamatergic synapses is a fundamental mechanism through which experience changes neural function to impact future behavior. In animal models of…”
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Opioid-Mediated Astrocyte-Neuron Signaling in the Nucleus Accumbens by Corkrum, Michelle, Rothwell, Patrick E, Thomas, Mark J, Kofuji, Paulo, Araque, Alfonso

“…Major hallmarks of astrocyte physiology are the elevation of intracellular calcium in response to neurotransmitters and the release of neuroactive substances…”
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Effect of Aggressive Experience in Female Syrian Hamsters on Glutamate Receptor Expression in the Nucleus Accumbens by Borland, Johnathan M, Kim, Ellen, Swanson, Samuel P, Rothwell, Patrick E, Mermelstein, Paul G, Meisel, Robert L

“…Our social relationships determine our health and well-being. In rodent models, there is now strong support for the rewarding properties of aggressive or…”
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Characterization and mu opioid receptor sensitivity of neuropeptide Y interneurons in the mouse nucleus accumbens by Retzlaff, Cassandra L., Rothwell, Patrick E.

“…Inhibitory interneurons represent less than 5% of neurons within the nucleus accumbens, but are critical for proper microcircuit function within this brain…”
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Differential Patterns of Synaptic Plasticity in the Nucleus Accumbens Caused by Continuous and Interrupted Morphine Exposure by Lefevre, Emilia M, Gauthier, Elysia A, Bystrom, Lauren L, Scheunemann, Jordan, Rothwell, Patrick E

“…Opioid exposure and withdrawal both cause adaptations in brain circuits that may contribute to abuse liability. These adaptations vary in magnitude and…”
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Sex differences in morphine sensitivity of neuroligin-3 knockout mice by Brandner, Dieter D., Mashal, Mohammed A., Grissom, Nicola M., Rothwell, Patrick E.

“…Sex has a strong influence on the prevalence and course of brain conditions, including autism spectrum disorders. The mechanistic basis for these sex…”
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μ-Opioid Receptor (Oprm1) Copy Number Influences Nucleus Accumbens Microcircuitry and Reciprocal Social Behaviors by Toddes, Carlee, Lefevre, Emilia M, Brandner, Dieter D, Zugschwert, Lauryn, Rothwell, Patrick E

“…The μ-opioid receptor regulates reward derived from both drug use and natural experiences, including social interaction, through actions in the nucleus…”
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Current understanding of the link between angiotensin-converting enzyme and pain perception by Bhilare, Kiran D., Dobariya, Prakashkumar, Hanak, Filip, Rothwell, Patrick E., More, Swati S.

“…•Angiotensin-converting enzyme (ACE) modulates a variety of bioactive peptides in the renin–angiotensin system and endogenous opioid system.•There is an…”
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Nucleus Accumbens Fast-Spiking Interneurons Constrain Impulsive Action by Pisansky, Marc T, Lefevre, Emilia M, Retzlaff, Cassandra L, Trieu, Brian H, Leipold, David W, Rothwell, Patrick E

“…AbstractBackgroundThe nucleus accumbens (NAc) controls multiple facets of impulsivity but is a heterogeneous brain region with diverse microcircuitry. Prior…”
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Modulation of endogenous opioid signaling by inhibitors of puromycin-sensitive aminopeptidase by Singh, Rohit, Jiang, Rongrong, Williams, Jessica, Dobariya, Prakashkumar, Hanak, Filip, Xie, Jiashu, Rothwell, Patrick E., Vince, Robert, More, Swati S.

“…The endogenous opioid system regulates pain through local release of neuropeptides and modulation of their action on opioid receptors. However, the effect of…”
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Interruption of continuous opioid exposure exacerbates drug-evoked adaptations in the mesolimbic dopamine system by Lefevre, Emilia M, Pisansky, Marc T, Toddes, Carlee, Baruffaldi, Federico, Pravetoni, Marco, Tian, Lin, Kono, Thomas J Y, Rothwell, Patrick E

“…Drug-evoked adaptations in the mesolimbic dopamine system are postulated to drive opioid abuse and addiction. These adaptations vary in magnitude and direction…”
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Angiotensin-converting enzyme gates brain circuit-specific plasticity via an endogenous opioid by Trieu, Brian H, Remmers, Bailey C, Toddes, Carlee, Brandner, Dieter D, Lefevre, Emilia M, Kocharian, Adrina, Retzlaff, Cassandra L, Dick, Rachel M, Mashal, Mohammed A, Gauthier, Elysia A, Xie, Wei, Zhang, Ying, More, Swati S, Rothwell, Patrick E

“…Angiotensin-converting enzyme (ACE) regulates blood pressure by cleaving angiotensin I to produce angiotensin II. In the brain, ACE is especially abundant in…”
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Neuroligin‐3 in dopaminergic circuits promotes behavioural and neurobiological adaptations to chronic morphine exposure by Brandner, Dieter D., Retzlaff, Cassandra L., Kocharian, Adrina, Stieve, Bethany J., Mashal, Mohammed A., Mermelstein, Paul G., Rothwell, Patrick E.

“…Chronic opioid exposure causes structural and functional changes in brain circuits, which may contribute to opioid use disorders. Synaptic cell‐adhesion…”
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