Search Results - "Rothwell, N.J."

Inflammation and brain injury: Acute cerebral ischaemia, peripheral and central inflammation by Denes, A, Thornton, P, Rothwell, N.J, Allan, S.M

“…Abstract Inflammation is a classical host defence response to infection and injury that has many beneficial effects. However, inappropriate (in time, place and…”
Get full text

Systemic infection, inflammation and acute ischemic stroke by McColl, B.W, Allan, S.M, Rothwell, N.J

“…Abstract Extensive evidence implicates inflammation in multiple phases of stroke etiology and pathology. In particular, there is growing awareness that…”
Get full text

Interleukin-1 and inflammatory neurodegeneration by Simi, A, Tsakiri, N, Wang, P, Rothwell, N J

“…Inflammation occurs rapidly in response to acute brain insults such as stroke, haemorrhage or trauma, and can be sustained for long periods of time, for…”
Get more information

Cytokines in neurodegeneration and repair by Rothwell, N J, Strijbos, P J

“…Cytokines have diverse actions in the brain, some of which may facilitate either neurodegeneration or neuroprotection. The expression of cytokines,…”
Get more information

Involvement of corticotrophin releasing factor (CRF) in the thermogenic and anorexic actions of serotonin (5-HT) and related compounds by Le Feuvre, R A, Aisenthal, L, Rothwell, N J

“…The present study investigated the involvement of corticotrophin-releasing factor (CRF) in the thermogenic and anorexic actions of serotonin (5-HT) in the rat…”
Get more information

Eicosanoids, thermogenesis and thermoregulation by Rothwell, N J

Get more information

Lipocortin-1 inhibits NMDA receptor-mediated neuronal damage in the striatum of the rat by Black, M D, Carey, F, Crossman, A R, Relton, J K, Rothwell, N J

“…Lipocortin-1 (annexin-1), an endogenous phospholipid and calcium binding protein, has been shown to significantly attenuate the damage produced by focal…”
Get more information

Localization of immunoreactive lipocortin-1 in the brain and pituitary gland of the rat. Effects of adrenalectomy, dexamethasone and colchicine treatment by Strijbos, P J, Tilders, F J, Carey, F, Forder, R, Rothwell, N J

“…The presence and localization of endogenous lipocortin-1 (LC-1, a protein which has been proposed to mediate the anti-inflammatory actions of the…”
Get more information

Systemic inflammation and stroke: aetiology, pathology and targets for therapy by McColl, B W, Allan, S M, Rothwell, N J

“…There is growing evidence that systemic inflammation is involved in multiple aspects of stroke aetiology and pathology. In the present review, we provide an…”
Get more information

Energy balance, diet-induced thermogenesis and brown adipose tissue in lean and obese (fa/fa) Zucker rats after adrenalectomy by Marchington, D, Rothwell, N J, Stock, M J, York, D A

“…Five-week-old male, lean (+/?) and genetically obese (fa/fa) Zucker rats received either bilateral adrenalectomy or sham operations, and energy balance was…”
Get more information

Contribution of Interleukin-1 Receptor Accessory Protein b to Interleukin-1 Actions in Neuronal Cells by Nguyen, L., Rothwell, N.J., Pinteaux, E., Boutin, H.

“…Interleukin (IL)-1 is an important neuroimmunomodulator and a key mediator of inflammation during brain disorders. It acts on neuronal and glial cells via…”
Get full text

Interleukin-1 receptor antagonist inhibits neuronal damage caused by fluid percussion injury in the rat by Toulmond, S., Rothwell, N.J.

“…Increased expression of the cytokine interleukin-1 (IL-1) has been observed in rodent and human brain after injury, and IL-1 has been implicated in ischaemic…”
Get full text

CNS injury: the role of the cytokine IL-1 by Gibson, Rosemary M., Rothwell, Nancy J., Le Feuvre, Ros A.

“…Injury to the central nervous system (CNS) and the resulting neuronal loss contribute significantly to morbidity and mortality in human and domestic animal…”
Get full text

Changes in body composition, brown adipose tissue activity and thermogenic capacity in BN/BiRij rats undergoing senescence by Horan, M A, Little, R A, Rothwell, N J, Stock, M J

“…Metabolic rate, thermogenesis, brown adipose tissue (BAT) activity, and body composition were followed in ageing rats (female BN/BiRij) at 3 to 35.5 months of…”
Get more information

Dose-dependent effects of an anabolic steroid, nandrolone phenylpropionate (Durabolin), on body composition and muscle protein metabolism in female rats by Choo, J J, Emery, P W, Rothwell, N J

“…The effects of three doses (1, 4 and 10 mg/kg body weight) of an anabolic steroid, nandrolone phenylpropionate (NPP), on body weight and composition, and…”
Get more information

Neurodegenerative actions of interleukin-1 in the rat brain are mediated through increases in seizure activity by Patel, H.C., Ross, F.M., Heenan, L.E., Davies, R.E., Rothwell, N.J., Allan, S.M.

“…The cytokine interleukin‐1 (IL‐1) is an established and important mediator of diverse forms of neuronal injury in experimental animals. However, its mechanisms…”
Get full text

Central administration of rat IL-6 induces HPA activation and fever but not sickness behavior in rats by Lenczowski, M J, Bluthé, R M, Roth, J, Rees, G S, Rushforth, D A, van Dam, A M, Tilders, F J, Dantzer, R, Rothwell, N J, Luheshi, G N

“…Interleukin (IL)-6 has been proposed to mediate several sickness responses, including brain-mediated neuroendocrine, temperature, and behavioral changes…”
Get full text

Different Receptor Mechanisms Mediate the Pyrogenic and Behavioral Effects of Interleukin 1 by Kent, Stephen, Bluthe, Rose-Marie, Dantzer, Robert, Hardwick, Anthea J., Kelley, Keith W., Rothwell, Nancy J., Vannice, James L.

“…Interleukin 1 (IL-1) is a cytokine released during immune activation that mediates the host's response to infection and inflammation. Peripheral and central…”
Get full text

Anandamide suppresses nitric oxide production in response to LPS in primary astrocytes mouse cultures by a mechanism mediated by the central cannabinoid receptor (CB1) by Molina-Holgado, F., Moore, J., Rothwell, N.J.

Get full text

Changes in metabolic rate and brown adipose tissue composition during nutritional rehabilitation of postnatally undernourished rats by Rothwell, N J, Stephens, D N, Stock, M J

“…Rats previously undernourished (PU) during the first 3 postnatal weeks gained less weight than controls during the subsequent rehabilitation period, in spite…”
Get more information