Search Results - "Rothstein, J L"

The RET/PTC3 oncogene activates classical NF-κB by stabilizing NIK by Neely, R J, Brose, M S, Gray, C M, McCorkell, K A, Leibowitz, J M, Ma, C, Rothstein, J L, May, M J

“…The oncogenic fusion protein RET/PTC3 (RP3) that is expressed in papillary thyroid carcinoma (PTC) and thyroid epithelia in Hashimoto's thyroiditis activates…”
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Thyroid targeting of the N-ras(Gln61Lys) oncogene in transgenic mice results in follicular tumors that progress to poorly differentiated carcinomas by VITAGLIANO, D, PORTELLA, G, PASQUINELLI, R, CHIAPPETTA, G, TERRACCIANO, D, MACCHIA, V, MELILLO, R. M, FUSCO, A, SANTORO, M, TRONCONE, G, FRANCIONE, A, ROSSI, C, BRUNO, A, GIORGINI, A, COLUZZI, S, NAPPI, T. C, ROTHSTEIN, J. L

“…Ras oncogenes are frequently mutated in thyroid carcinomas. To verify the role played by N-ras in thyroid carcinogenesis, we generated transgenic mice in which…”
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Cancer Mucosa Antigens as a Novel Immunotherapeutic Class of Tumor-associated Antigen by Snook, A E, Eisenlohr, L C, Rothstein, J L, Waldman, S A

“…Colorectal cancer is a leading cause of cancer‐related mortality worldwide. Surgery and chemoradiation exhibit incomplete efficacy and, ultimately, 50% of…”
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The RET/PTC3 oncogene : Metastatic solid-type papillary carcinomas in murine thyroids by POWELL, D. J, RUSSELL, J, ROTHSTEIN, J. L, NIBU, K.-I, GUOQI LI, RHEE, E, LIAO, M, GOLDSTEIN, M, KEANE, W. M, SANTORO, M, FUSCO, A

“…Our research goal is to better understand the mechanisms controlling the initiation and progression of thyroid diseases. One such disease, papillary thyroid…”
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Synergy between Tumor Necrosis Factor and Bacterial Products Causes Hemorrhagic Necrosis and Lethal Shock in Normal Mice by Rothstein, Jay L., Schreiber, Hans

“…We find a strong synergism between tumor necrosis factor (TNF) and bacteria or their products. Endotoxin-``free'' recombinant TNF, even at very high doses (160…”
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Expression of the RET/PTC Fusion Gene as a Marker for Papillary Carcinoma in Hashimoto's Thyroiditis by Wirtschafter, Ari, Schmidt, Richard, Rosen, David, Kundu, Nandita, Santoro, Massimo, Fusco, Alfredo, Multhaupt, Hinke, Atkins, Joseph P., Rosen, Marc R., Keane, William M., Rothstein, Jay L.

“…Hashimoto's thyroiditis is an inflammatory disease of the thyroid gland with autoimmune etiology.1 Patients afflicted with Hashimoto's have a higher risk of…”
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Gene expression during preimplantation mouse development by ROTHSTEIN, J. L, JOHNSON, D, DELOIA, J. A, SKOWRONSKI, J, SOLTER, D, KNOWLES, B

“…To develop a resource for the identification and isolation of genes expressed in the early mammalian embryo, large and representative cDNA libraries were…”
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Tumor Necrosis Factor: A Potent Effector Molecule for Tumor Cell Killing by Activated Macrophages by Urban, James L., Shepard, H. Michael, Rothstein, Jay L., Sugarman, Barry J., Schreiber, Hans

“…Activated macrophages (aMφ ) destroy more effectively cancer cells than normal cells. The mechanism by which macrophages destroy cancer cells is not known. We…”
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Depressed serum high density lipoprotein cholesterol levels in veterans with spinal cord injury by BAUMAN, W. A, SPUNGEN, A. M, YOU-GONG ZHONG, ROTHSTEIN, J. L, PETRY, C, GORDON, S. K

“…Cardiovascular diseases are the most frequent cause of death among persons with spinal cord injury (SCI), and these diseases are reported to occur prematurely…”
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The RET/PTC3 oncogene activates classical NF-[kappa]B by stabilizing NIK by Neely, R J, Brose, M S, Gray, C M, Mccorkell, K A, Leibowitz, J M, Ma, C, Rothstein, J L, May, M J

“…The oncogenic fusion protein RET/PTC3 (RP3) that is expressed in papillary thyroid carcinoma (PTC) and thyroid epithelia in Hashimoto's thyroiditis activates…”
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Expression patterns of novel genes during mouse preimplantation embryogenesis by Temeles, G L, Ram, P T, Rothstein, J L, Schultz, R M

“…Little is known about the repertoire of genes expressed following zygotic gene activation, which occurs during the two-cell stage in the mouse. As an initial…”
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Spontaneous production of tumor necrosis factor α by Kupffer cells of MRL/lpr mice by MAGILAVY, D. B, ROTHSTEIN, J. L

“…We report that freshly isolated, unstimulated Kupffer cells (KC) from MRL/lpr female mice in short-term culture spontaneously produce high levels of TNF-alpha…”
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Induction of differentiation of human olfactory neuroblastoma cells into odorant-responsive cells by Gomez, G, Restrepo, D, Rawson, N, Lowry, L.D, Keane, W.M, Rothstein, J.L

“…Olfactory neuroblastoma is a rare malignancy of the olfactory mucosa that may be derived from the olfactory epithelium. To characterize this tumor, we cultured…”
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Functional expression of the CXCR4 chemokine receptor is induced by RET PTC oncogenes and is a common event in human papillary thyroid carcinomas by CASTELLONE, Maria D, GUARINO, Valentina, FUSCO, Alfredo, SANTORO, Massimo, MELILLO, Rosa Marina, DE FALCO, Valentina, CARLOMAGNO, Francesca, BASOLO, Fulvio, FAVIANA, Pinuccia, KRUHOFFER, Mogens, ORNTOFT, Torben, RUSSELL, John P, ROTHSTEIN, Jay L

“…To identify genes involved in the transformation of thyroid follicular cells, we explored, using DNA oligonucleotide microarrays, the transcriptional response…”
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The murine Tcl1 oncogene : embryonic and lymphoid cell expression by NARDUCCI, M. G, VIRGILIO, L, ENGILES, J. B, BUCHBERG, A. M, BILLIPS, L, FACCHIANO, A, CROCE, C. M, RUSSO, G, ROTHSTEIN, J. L

“…In human leukemias and lymphomas nonrandom chromosomal rearrangements cause changes in cell growth and/or survival in such a way as to promote malignancy. The…”
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Phenotypically diverse mouse thymic stromal cell lines which induce proliferation and differentiation of hematopoietic cells by Faas, S J, Rothstein, J L, Kreider, B L, Rovera, G, Knowles, B B

“…The heterogeneity of the thymic stroma has made careful characterization of particular thymic stromal cell types difficult. To this end, we have derived a…”
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Human N-ras, TRK-T1, and RET/PTC3 oncogenes, driven by a thyroglobulin promoter, differently affect the expression of differentiation markers and the proliferation of thyroid epithelial cells by Portella, G, Vitagliano, D, Borselli, C, Melillo, R M, Salvatore, D, Rothstein, J L, Vecchio, G, Fusco, A, Santoro, M

“…The ras family members and the tyrosine kinases RET and TRK are frequently activated in human tumors of the thyroid gland. To ascertain the effects of these…”
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Proinflammatory Mediators and Genetic Background in Oncogene Mediated Tumor Progression by Russell, John P, Engiles, Julie B, Rothstein, Jay L

“…RET/PTC3 (RP3) is an oncogenic fusion protein which is frequently expressed in papillary thyroid carcinomas and has been detected in thyroid tissue from…”
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Interleukin 24 is induced by the RET PTC3 oncoprotein and is an autocrine growth factor for epithelial cells by SHINOHARA, Shogo, ROTHSTEIN, Jay L

“…Thyroid cancers, like hematological malignancies, are commonly associated with chromosomal translocations leading to the formation of fusion proteins. Through…”
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Expression of the human achaete-scute 1 gene in olfactory neuroblastoma (esthesioneuroblastoma) by CARNEY, M. E, O'REILLY, R. C, SHOLEVAR, B, BUIAKOVA, O. I, LOWRY, L. D, KEANE, W. M, MARGOLIS, F. L, ROTHSTEIN, J. L

“…Olfactory neuroblastoma (ONB) is a rare neuronal malignancy of the olfactory mucosal. Markers used in the diagnosis of ONB do not distinguish ONB from other…”
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