Search Results - "Rothman, Vicki L."

Thrombospondin-1 (TSP-1) up-regulates tissue inhibitor of metalloproteinase-1 (TIMP-1) production in human tumor cells: Exploring the functional significance in tumor cell invasion by John, Anitha S., Hu, Xioulong, Rothman, Vicki L., Tuszynski, George P.

“…Thrombospondin-1 (TSP-1), a matrix-bound adhesive glycoprotein, has been shown to modulate tumor progression. We previously demonstrated that TSP-1…”
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G-Protein-Coupled Receptor-Associated Sorting Protein 1 Overexpression Is Involved in the Progression of Benign Prostatic Hyperplasia, Early-Stage Prostatic Malignant Diseases, and Prostate Cancer by Torres-Luna, Cesar, Wei, Shuanzeng, Bhattiprolu, Sreenivas, Tuszynski, George, Rothman, Vicki L, McNulty, Declan, Yang, Jeff, Chang, Frank N

“…Background/Objectives: Prostate cancer (PCa) is a prevalent malignancy, necessitating accurate diagnostic methods to distinguish it from benign conditions such…”
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Angiostatin Binds to Tyrosine Kinase Substrate Annexin II through the Lysine-Binding Domain in Endothelial Cells by Tuszynski, George P., Sharma, Meena R., Rothman, Vicki L., Sharma, Mahesh C.

“…Angiostatin(AS), an internal fragment of plasminogen, is one of the most potent specific inhibitors of angiogenesis. Angiostatin treatment has resulted in the…”
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Interaction of α9β1 Integrin With Thrombospondin-1 Promotes Angiogenesis by Staniszewska, Izabela, Zaveri, Shachi, Valle, Luis Del, Oliva, Isabela, Rothman, Vicki L, Croul, Sidney E, Roberts, David D, Mosher, Deane F, Tuszynski, George P, Marcinkiewicz, Cezary

“…Thrombospondin-1 is a multifunctional protein interacting with several cell surface receptors including integrins. We found that it is a ligand for α9β1…”
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Effect of VP12 and viperistatin on inhibition of collagen receptors: dependent melanoma metastasis by Staniszewska, Izabela, Walsh, Erin M., Rothman, Vicki L., Gaathon, Ariel, Tuszynski, George P., Calvete, Juan J., Lazarovici, Philip, Marcinkiewicz, Cezary

“…Viperistatin and VP12 isolated from Vipera paleastinae venom showed a potent inhibitory activity against collagen receptors, α1β1 and α2β1 integrins,…”
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Angiocidin induces differentiation of acute myeloid leukemia cells by Tuszynski, George P., Rothman, Vicki L.

“…Acute myeloid leukemia (AML) is a malignant proliferative disorder in which leukemic cells fail to terminally differentiate and accumulate in the blood and…”
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The novel angiogenic inhibitor, angiocidin, induces differentiation of monocytes to macrophages by Gaurnier-Hausser, Anita, Rothman, Vicki L, Dimitrov, Svetoslav, Tuszynski, George P

“…We previously showed that angiocidin, a tumor and vascular associated protein, is a potent inhibitor of angiogenesis and tumor growth. Angiocidin is a…”
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Expression of thrombospondin-1 in human pancreatic adenocarcinomas: role in matrix metalloproteinase-9 production by Qian, X, Rothman, V L, Nicosia, R F, Tuszynski, G P

“…Human pancreatic adenocarcinoma, an aggressive malignant disease, shows a strong desmoplastic reaction characterized by a remarkable proliferation of…”
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G-protein coupled receptor-associated sorting protein 1 (GASP-1), a ubiquitous tumor marker by Zheng, Xiaoyi, Chang, Frank, Zhang, Xinmin, Rothman, Vicki L., Tuszynski, George P.

“…Using an innovative “2-D high performance liquid electrophoresis” (2-D HPLE) technology we identified that a specific fragment of G-protein coupled…”
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G-protein coupled receptor-associated sorting protein 1 (GASP-1), a potential biomarker in breast cancer by Tuszynski, George P., Rothman, Vicki L., Zheng, Xiaoyi, Gutu, Mohammed, Zhang, Xinmin, Chang, Frank

“…An innovative “2-D high performance liquid electrophoresis” (2-D HPLE) technology was used to identify serum biomarkers associated with the early stage of…”
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Angiocidin inhibits breast cancer proliferation through activation of epidermal growth factor receptor and nuclear factor kappa (NF-ĸB) by Godek, Jessica, Sargiannidou, Irene, Patel, Sneha, Hurd, Lauren, Rothman, Vicki L., Tuszynski, George P.

“…Angiocidin, a tumor-associated peptide, has been previously shown to inhibit tumor progression by blocking angiogenesis. We now show that angiocidin has a…”
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The interaction of angiocidin with tissue transglutaminase by L’Heureux, Darryl Z., Rothman, Vicki L., Tuszynski, George P.

“…Angiocidin, a matrix bound and tumor associated protein, has been shown to inhibit tumor progression and angiogenesis. We previously demonstrated that…”
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Clinical significance of serum angiocidin levels in hepatocellular carcinoma by Sabherwal, Yamini, Rothman, Vicki L, Poon, Ronnie T.P, Tuszynski, George P

“…Abstract Angiocidin, a tumor-secreted protein, was measured in serum of 27 healthy volunteers and 33 hepatocellular carcinoma (HCC) patients. Healthy controls…”
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Cloning and characterization of angiocidin, a tumor cell binding protein for thrombospondin-1 by Zhou, Jing, Rothman, Vicki L., Sargiannidou, Irene, Dimitrov, Svetoslav, Qiu, Cuie, Smith, Elana, Sheffield, Joel, Sharma, Mahesh, Tuszynski, George P.

“…Thrombospondin‐1 (TSP‐1) is a matrix protein that has been implicated in mechanisms of tumor progression. Our laboratory previously showed that the CSVTCG…”
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Reduction of angiocidin expression in human umbilical vein endothelial cells via siRNA silencing inhibits angiogenesis by Yang, Xiao, Rothman, Vicki L., L'Heureux, Darryl Z., Tuszynski, George

“…Angiocidin, a protein over-expressed in many different solid tumors and tumor capillary endothelial cells inhibits angiogenesis and tumor growth [Zhou, J., et…”
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Thrombospondin-1 Promotes Proliferative Healing through Stabilization of PDGF by Krishnaswami, Sanjay, Ly, Quan P., Rothman, Vicki L., Tuszynski, George P.

“…Purpose. Thrombospondin-1 (TSP-1) mediates chemotaxis, cell proliferation, angiogenesis, and protease regulation in healing. TSP-1 also binds platelet-derived…”
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Thrombospondin-1 (TSP-1) Promotes the Invasive Properties of Human Breast Cancer by Wang, Thomas N., Qian, Xiao-hua, Granick, Mark S., Solomon, Mark P., Rothman, Vicki L., Berger, David H., Tuszynski, George P.

“…TSP-1 is a matrix-bound adhesive glycoprotein, which plays a role in tumor cell proliferation and tumor angiogenesis. The purpose of this study was to…”
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Thrombospondin and transforming growth factor-beta 1 increase expression of urokinase-type plasminogen activator and plasminogen activator inhibitor-1 in human MDA-MB-231 breast cancer cells by Arnoletti, J P, Albo, D, Granick, M S, Solomon, M P, Castiglioni, A, Rothman, V L, Tuszynski, G P

“…Thrombospondin is a high molecular weight adhesive glycoprotein that has been shown to function in mechanisms of tumor progression. The authors' previous…”
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Thrombospondin-1 may modulate keloid formation through up-regulation of the matrix-associated plasminogen/plasmin system by Centeno, Robert F, Albo, Daniel, Rothman, Vicki L, Granick, Mark S, Tuszynski, George P

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Identification and Characterization of a Tumor Cell Receptor for CSVTCG, a Thrombospondin Adhesive Domain by Tuszynski, George P., Rothman, Vicki L., Papale, Maria, Hamilton, Bruce K., Eyal, Jacob

“…We have previously shown that peptides derived from the thrombospondin sequence, CSVTCG, promoted tumor cell adhesion. To further investigate this observation,…”
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