Search Results - "Rothman, J H"

Caenorhabditis elegans p53: Role in Apoptosis, Meiosis, and Stress Resistance by Derry, W. Brent, Putzke, Aaron P., Rothman, Joel H.

“…We have identified a homolog of the mammalian p53 tumor suppressor protein in the nematode Caenorhabditis elegans that is expressed ubiquitously in embryos…”
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ELT-5 and ELT-6 are required continuously to regulate epidermal seam cell differentiation and cell fusion in C. elegans by Koh, K, Rothman, J H

“…The C. elegans epidermis is a simple epithelium comprised of three major cell types, the seam, syncytial and P cells. While specification of all major…”
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Obstruction of BRAF V600E transcription by complementary PNA oligomers as a means to inhibit BRAF-mutant melanoma growth by Rothman, J H, Surriga, O, de Stanchina, E, Vasudeva, S D, Schwartz, G K

“…Peptide nucleic acid (PNA) oligomers are DNA mimics, which are capable of binding gene sequences 1000-fold more avidly than complementary native DNA by strand…”
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Baculovirus p35 prevents developmentally programmed cell death and rescues a ced‐9 mutant in the nematode Caenorhabditis elegans by Sugimoto, A., Friesen, P.D., Rothman, J.H.

“…Programmed cell death, or apoptosis, occurs throughout the course of normal development in most animals and can also be elicited by a number of stimuli such as…”
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Characterization of genes required for protein sorting and vacuolar function in the yeast Saccharomyces cerevisiae by Rothman, J. H., Howald, I., Stevens, T. H.

“…To further our studies of protein sorting and biogenesis of the lysosome‐like vacuole in yeast, we have isolated spontaneous mutations in 11 new VPL…”
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A Deficiency Screen for Zygotic Loci Required for Establishment and Patterning of the Epidermis in Caenorhabditis elegans by Terns, R. M, Kroll-Conner, P, Zhu, J, Chung, S, Rothman, J. H

“…To identify genomic regions required for establishment and patterning of the epidermis, we screened 58 deficiencies that collectively delete at least…”
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PEP4 gene of Saccharomyces cerevisiae encodes proteinase A, a vacuolar enzyme required for processing of vacuolar precursors by AMMERER, G, HUNTER, C. P, ROTHMAN, J. H, SAARI, G. C, VALLS, L. A, STEVENS, T. H

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Regulation of developmental rate and germ cell proliferation in Caenorhabditis elegans by the p53 gene network by Derry, W B, Bierings, R, van Iersel, M, Satkunendran, T, Reinke, V, Rothman, J H

“…Caenorhabditis elegans CEP-1 activates germline apoptosis in response to genotoxic stress, similar to its mammalian counterpart, tumor suppressor p53. In…”
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dad‐1, an endogenous programmed cell death suppressor in Caenorhabditis elegans and vertebrates by Sugimoto, A., Hozak, R. R., Nakashima, T., Nishimoto, T., Rothman, J. H.

“…Programmed cell death (apoptosis) is a normally occurring process used to eliminate unnecessary or potentially harmful cells in multicellular organisms. Recent…”
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Protein sorting in yeast: mutants defective in vacuole biogenesis mislocalize vacuolar proteins into the late secretory pathway by Rothman, J H, Stevens, T H

“…We have devised a genetic selection for mutant yeast cells that fail to properly deliver the vacuolar glycoprotein CPY to the lysosome-like vacuole. This has…”
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Structure, biosynthesis, and localization of dipeptidyl aminopeptidase B, an integral membrane glycoprotein of the yeast vacuole by Roberts, C.J, Pohlig, G, Rothman, J.H, Stevens, T.H

“…We have characterized the structure, biogenesis, and localization of dipeptidyl aminopeptidase B (DPAP B), a membrane protein of the yeast vacuole. An antibody…”
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Gene dosage-dependent secretion of yeast vacuolar carboxypeptidase Y by Stevens, T.H, Rothman, J.H, Payne, G.S, Schekman, R

“…The structural gene for yeast vacuolar carboxypeptidase Y (PRC1) has been cloned by complementation of the prc1-1 mutation. As much as an eightfold elevation…”
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A new generation of fluorescent chemosensors demonstrate improved analyte detection sensitivity and photobleaching resistance by Rothman, Jeffrey H., Still, W.Clark

“…Molecular chemosensors have found increased utility in the development of precise and sensitive detection devices. However, chemosensors that report binding…”
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Making Worm Guts: The Gene Regulatory Network of the Caenorhabditis elegans Endoderm by Maduro, Morris F., Rothman, Joel H.

“…The nematode Caenorhabditis elegans is a triploblastic ecdysozoan, which, although it contains too few cells during embryogenesis to create discernible germ…”
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Overproduction-Induced Mislocalization of a Yeast Vacuolar Protein Allows Isolation of Its Structural Gene by Rothman, Joel H., Hunter, Craig P., Valls, Luis A., Stevens, Tom H.

“…Using an immunological screening procedure that allows the detection of yeast cells aberrantly secreting vacuolar proteins, we have isolated a cloned DNA…”
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Protein sorting in yeast: the localization determinant of yeast vacuolar carboxypeptidase Y resides in the propeptide by Valls, L A, Hunter, C P, Rothman, J H, Stevens, T H

“…We have isolated cis-acting mutations in the gene encoding the yeast vacuolar protein carboxypeptidase Y (CPY) that result in missorting and aberrant secretion…”
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Suppression of CED-3-independent apoptosis by mitochondrial βNAC in Caenorhabditis elegans by Rothman, Joel H, Bloss, Tim A, Witze, Eric S

“…To ensure cell survival, it is essential that the ubiquitous pro-apoptotic machinery is kept quiescent. As death is irreversible, cells must continually…”
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Restriction of Mesendoderm to a Single Blastomere by the Combined Action of SKN-1 and a GSK-3β Homolog Is Mediated by MED-1 and -2 in C. elegans by Maduro, Morris F, Meneghini, Marc D, Bowerman, Bruce, Broitman-Maduro, Gina, Rothman, Joel H

“…The endoderm and much of the mesoderm arise from the EMS cell in the four-cell C. elegans embryo. We report that the MED-1 and -2 GATA factors specify the…”
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Cytokinesis and midzone microtubule organization in Caenorhabditis elegans require the kinesin-like protein ZEN-4 by Raich, W B, Moran, A N, Rothman, J H, Hardin, J

“…Members of the MKLP1 subfamily of kinesin motor proteins localize to the equatorial region of the spindle midzone and are capable of bundling antiparallel…”
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The Noncanonical Binding Site of the MED-1 GATA Factor Defines Differentially Regulated Target Genes in the C. elegans Mesendoderm by Broitman-Maduro, Gina, Maduro, Morris F., Rothman, Joel H.

“…Mesoderm and endoderm in C. elegans arise from sister cells called MS and E, respectively. The identities of both of these mesendodermal progenitors are…”
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