Search Results - "Rothman, Alexander M.K"

Pulmonary Artery Denervation Reduces Pulmonary Artery Pressure and Induces Histological Changes in an Acute Porcine Model of Pulmonary Hypertension by Rothman, Alexander M.K, Arnold, Nadine D, Chang, William, Watson, Oliver, Swift, Andrew J, Condliffe, Robin, Elliot, Charlie A, Kiely, David G, Suvarna, S Kim, Gunn, Julian, Lawrie, Allan

“…BACKGROUND—Pulmonary arterial hypertension is a devastating disease with high morbidity and mortality and limited treatment options. Recent studies have shown…”
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Ambulatory haemodynamic‐guided management reduces heart failure hospitalizations in a multicentre European heart failure cohort by Dauw, Jeroen, Sokolski, Mateusz, Middleton, Jennifer T., Nijst, Petra, Dupont, Matthias, Forouzan, Omid, Rothman, Alexander M.K., Ruschitzka, Frank, Flammer, Andreas J., Mullens, Wilfried

“…Aims To investigate the outcomes and associated costs of haemodynamic‐guided heart failure (HF) management with a pulmonary artery pressure (PAP) sensor in a…”
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MicroRNA-140-5p and SMURF1 regulate pulmonary arterial hypertension by Rothman, Alexander M K, Arnold, Nadine D, Pickworth, Josephine A, Iremonger, James, Ciuclan, Loredana, Allen, Robert M H, Guth-Gundel, Sabine, Southwood, Mark, Morrell, Nicholas W, Thomas, Matthew, Francis, Sheila E, Rowlands, David J, Lawrie, Allan

“…Loss of the growth-suppressive effects of bone morphogenetic protein (BMP) signaling has been demonstrated to promote pulmonary arterial endothelial cell…”
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Hemodynamic, Functional, and Clinical Responses to Pulmonary Artery Denervation in Patients With Pulmonary Arterial Hypertension of Different Causes: Phase II Results From the Pulmonary Artery Denervation-1 Study by Chen, Shao-Liang, Zhang, Hang, Xie, Du-Jiang, Zhang, Juan, Zhou, Ling, Rothman, Alexander M.K, Stone, Gregg W

“…BACKGROUND—The mechanisms underlying pulmonary arterial hypertension (PAH) are multifactorial. The efficacy of pulmonary artery denervation (PADN) for…”
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Pulmonary Artery Denervation Attenuates Pulmonary Arterial Remodeling in Dogs With Pulmonary Arterial Hypertension Induced by Dehydrogenized Monocrotaline by Zhou, Ling, MD, Zhang, Juan, MD, Jiang, Xiao-Min, MD, Xie, Du-Jiang, MD, Wang, Jin-Song, MD, Li, Li, MD, Li, Bin, PhD, Wang, Zhi-Mei, MD, Rothman, Alexander M.K., MD, Lawrie, Allan, PhD, Chen, Shao-Liang, MD

“…Abstract Objectives This study aimed to investigate sympathetic nerve (SN) ultrastructural changes and hemodynamic and pulmonary artery (PA) pathological…”
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Prolonged enoxaparin therapy compared with standard-of-care antithrombotic therapy in opiate-treated patients undergoing primary percutaneous coronary intervention by Sumaya, Wael, Parker, William A.E., Judge, Heather M., Hall, Ian R., Orme, Rachel C., Adam, Zulfiquar, Richardson, James D., Rothman, Alexander M.K., Morgan, Kenneth P., Gunn, Julian P., Storey, Robert F.

“…A novel enoxaparin regimen consisting of intra-arterial bolus (0.75 mg/kg) followed by intravenous infusion (0.75 mg/kg/6 hours) has been developed as a…”
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Severe pulmonary hypertension associated with lung disease is characterised by a loss of small pulmonary vessels on quantitative computed tomography by Alkhanfar, Dheyaa, Shahin, Yousef, Alandejani, Faisal, Dwivedi, Krit, Alabed, Samer, Johns, Chris, Lawrie, Allan, Thompson, A A Roger, Rothman, Alexander M K, Tschirren, Juerg, Uthoff, Johanna M, Hoffman, Eric, Condliffe, Robin, Wild, Jim M, Kiely, David G, Swift, Andrew J

“…Pulmonary hypertension (PH) in patients with chronic lung disease (CLD) predicts reduced functional status, clinical worsening and increased mortality, with…”
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Role of biomarkers in evaluation, treatment and clinical studies of pulmonary arterial hypertension by Hemnes, Anna, Rothman, Alexander M.K., Swift, Andrew J., Zisman, Lawrence S.

“…Pulmonary arterial hypertension is a complex disease resulting from the interplay of myriad biological and environmental processes that lead to remodeling of…”
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Response to Letter Regarding Article, “Hemodynamic, Functional, and Clinical Responses to Pulmonary Artery Denervation in Patients With Pulmonary Arterial Hypertension of Different Causes: Phase II Results From the Pulmonary Artery Denervation-1 Study” by Chen, Shao-Liang, Zhang, Hang, Xie, Du-Jiang, Zhang, Juan, Zhou, Ling, Rothman, Alexander M.K, Stone, Gregg W

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Balloon Pulmonary Angioplasty: State of the Art by Coghlan, John G, Rothman, Alexander M.K, Hoole, Stephen P

“…Balloon pulmonary angioplasty (BPA) is a novel technique for the treatment of chronic thromboembolic pulmonary hypertension. While cardiologists need no…”
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Digital health care solution for proactive heart failure management with the Cordella Heart Failure System: results of the SIRONA first‐in‐human study by Mullens, Wilfried, Sharif, Faisal, Dupont, Matthias, Rothman, Alexander M.K., Wijns, William

“…Aims Incorporation of remote monitoring of pulmonary artery pressure and vital signs has been demonstrated to reduce heart failure (HF) hospitalization and…”
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IL-6 in pulmonary hypertension: why novel is not always best by Toshner, Mark, Rothman, Alex

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Effects of Interleukin-1β Inhibition on Blood Pressure, Incident Hypertension, and Residual Inflammatory Risk: A Secondary Analysis of CANTOS by Rothman, Alexander MK, MacFadyen, Jean, Thuren, Tom, Webb, Alastair, Harrison, David G, Guzik, Tomasz J., Libby, Peter, Glynn, Robert J., Ridker, Paul M.

“…While hypertension and inflammation are physiologically inter-related, the effect of therapies that specifically target inflammation on blood pressure is…”
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Identification of Cardiac Magnetic Resonance Imaging Thresholds for Risk Stratification in Pulmonary Arterial Hypertension by Lewis, Robert A, Johns, Christopher S, Cogliano, Marcella, Capener, David, Tubman, Euan, Elliot, Charlie A, Charalampopoulos, Athanasios, Sabroe, Ian, Thompson, A A Roger, Billings, Catherine G, Hamilton, Neil, Baster, Kathleen, Laud, Peter J, Hickey, Peter M, Middleton, Jennifer, Armstrong, Iain J, Hurdman, Judith A, Lawrie, Allan, Rothman, Alexander M K, Wild, Jim M, Condliffe, Robin, Swift, Andrew J, Kiely, David G

“…Pulmonary arterial hypertension (PAH) is a life-shortening condition. The European Society of Cardiology and European Respiratory Society and the REVEAL (North…”
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The effect of interleukin-1 receptor antagonist therapy on markers of inflammation in non-ST elevation acute coronary syndromes: the MRC-ILA Heart Study by Morton, Allison C, Rothman, Alexander M K, Greenwood, John P, Gunn, Julian, Chase, Alex, Clarke, Bernard, Hall, Alistair S, Fox, Keith, Foley, Claire, Banya, Winston, Wang, Duolao, Flather, Marcus D, Crossman, David C

“…Acute coronary syndromes (ACSs) are driven by inflammation within coronary plaque. Interleukin-1 (IL-1) has an established role in atherogenesis and the…”
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A current and future outlook on upcoming technologies in remote monitoring of patients with heart failure by Bekfani, Tarek, Fudim, Marat, Cleland, John G.F., Jorbenadze, Ana, Haehling, Stephan, Lorber, Avraham, Rothman, Alexander M.K., Stein, Kenneth, Abraham, William T., Sievert, Horst, Anker, Stefan D.

“…Heart failure is a major health and economic challenge in both developing and developed countries. Despite advances in pharmacological and device therapies for…”
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Intravascular Ultrasound Pulmonary Artery Denervation to Treat Pulmonary Arterial Hypertension (TROPHY1) by Rothman, Alexander M.K., Vachiery, Jean-Luc, Howard, Luke S., Mikhail, Ghada W., Lang, Irene M., Jonas, Michael, Kiely, David G., Shav, Dalit, Shabtay, Or, Avriel, Avital, Lewis, Gregory D., Rosenzweig, Erika B., Kirtane, Ajay J., Kim, Nick H., Mahmud, Ehtisham, McLaughlain, Vallerie V., Chetcuti, Stanley, Leon, Martin B., Ben-Yehuda, Ori, Rubin, Lewis J.

“…The aim of this study was to investigate whether therapeutic intravascular ultrasound pulmonary artery denervation (PDN) is safe and reduces pulmonary vascular…”
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Cerebrovascular Effects of Sildenafil in Small Vessel Disease: The OxHARP Trial by Webb, Alastair J S, Birks, Jacqueline, Feakins, Karolina A, Lawson, Amy, Dawson, Jesse, Rothman, Alexander M K, Werring, David J, Llwyd, Osian, Stewart, Catriona, Thomas, James

“…Vascular cognitive impairment due to cerebral small vessel disease is associated with cerebral pulsatility, white matter hypoperfusion, and reduced…”
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Validation of Artificial Intelligence Cardiac MRI Measurements: Relationship to Heart Catheterization and Mortality Prediction by Alabed, Samer, Alandejani, Faisal, Dwivedi, Krit, Karunasaagarar, Kavita, Sharkey, Michael, Garg, Pankaj, de Koning, Patrick J H, Tóth, Attila, Shahin, Yousef, Johns, Christopher, Mamalakis, Michail, Stott, Sarah, Capener, David, Wood, Steven, Metherall, Peter, Rothman, Alexander M K, Condliffe, Robin, Hamilton, Neil, Wild, James M, O'Regan, Declan P, Lu, Haiping, Kiely, David G, van der Geest, Rob J, Swift, Andrew J

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Intravascular Ultrasound Pulmonary Artery Denervation to Treat Pulmonary Arterial Hypertension (TROPHY1): Multicenter, Early Feasibility Study by Rothman, Alexander M K, Vachiery, Jean-Luc, Howard, Luke S, Mikhail, Ghada W, Lang, Irene M, Jonas, Michael, Kiely, David G, Shav, Dalit, Shabtay, Or, Avriel, Avital, Lewis, Gregory D, Rosenzweig, Erika B, Kirtane, Ajay J, Kim, Nick H, Mahmud, Ehtisham, McLaughlain, Vallerie V, Chetcuti, Stanley, Leon, Martin B, Ben-Yehuda, Ori, Rubin, Lewis J

“…The aim of this study was to investigate whether therapeutic intravascular ultrasound pulmonary artery denervation (PDN) is safe and reduces pulmonary vascular…”
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