Search Results - "Rothman, Alexander M"

Anatomical characterization of pulmonary artery and implications to pulmonary artery pressure monitor implantation by Zafar, Hamza, Neelam-Naganathan, Dharshan, Middleton, Jennifer T., Binmahfooz, Sarah K., Battersby, Christian, Rogers, Dominic, Swift, Andrew J., Rothman, Alexander M. K.

“…In patients with heart failure, guideline directed medical therapy improves outcomes and requires close patient monitoring. Pulmonary artery pressure monitors…”
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The impact of patient choice on survival in chronic thromboembolic pulmonary hypertension by Quadery, Syed Rehan, Swift, Andrew J, Billings, Catherine G, Thompson, Alfred A R, Elliot, Charles A, Hurdman, Judith, Charalampopoulos, Athanasios, Sabroe, Ian, Armstrong, Iain J, Hamilton, Neil, Sephton, Paul, Garrad, Sian, Pepke-Zaba, Joanna, Jenkins, David P, Screaton, Nicholas, Rothman, Alexander M, Lawrie, Allan, Cleveland, Trevor, Thomas, Steven, Rajaram, Smitha, Hill, Catherine, Davies, Christine, Johns, Christopher S, Wild, Jim M, Condliffe, Robin, Kiely, David G

“…Pulmonary endarterectomy (PEA) is the gold standard treatment for operable chronic thromboembolic pulmonary hypertension (CTEPH). However, a proportion of…”
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The effect of interleukin-1 receptor antagonist therapy on markers of inflammation in non-ST elevation acute coronary syndromes: the MRC-ILA Heart Study by Morton, Allison C, Rothman, Alexander M K, Greenwood, John P, Gunn, Julian, Chase, Alex, Clarke, Bernard, Hall, Alistair S, Fox, Keith, Foley, Claire, Banya, Winston, Wang, Duolao, Flather, Marcus D, Crossman, David C

“…Acute coronary syndromes (ACSs) are driven by inflammation within coronary plaque. Interleukin-1 (IL-1) has an established role in atherogenesis and the…”
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A therapeutic antibody targeting osteoprotegerin attenuates severe experimental pulmonary arterial hypertension by Arnold, Nadine D., Pickworth, Josephine A., West, Laura E., Dawson, Sarah, Carvalho, Joana A., Casbolt, Helen, Braithwaite, Adam T., Iremonger, James, Renshall, Lewis, Germaschewski, Volker, McCourt, Matthew, Bland-Ward, Philip, Kowash, Hager, Hameed, Abdul G., Rothman, Alexander M. K., Frid, Maria G., Roger Thompson, A. A., Evans, Holly R., Southwood, Mark, Morrell, Nicholas W., Crossman, David C., Whyte, Moira K. B., Stenmark, Kurt R., Newman, Christopher M., Kiely, David G., Francis, Sheila E., Lawrie, Allan

“…Pulmonary arterial hypertension (PAH) is a rare but fatal disease. Current treatments increase life expectancy but have limited impact on the progressive…”
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Maximal Exercise Testing Using the Incremental Shuttle Walking Test Can Be Used to Risk-Stratify Patients with Pulmonary Arterial Hypertension by Lewis, Robert A, Billings, Catherine G, Hurdman, Judith A, Smith, Ian A, Austin, Matthew, Armstrong, Iain J, Middleton, Jennifer, Rothman, Alexander M K, Harrington, John, Hamilton, Neil, Hameed, Abdul G, Thompson, A A Roger, Charalampopoulos, Athanasios, Elliot, Charlie A, Lawrie, Allan, Sabroe, Ian, Wild, Jim M, Swift, Andrew J, Condliffe, Robin, Kiely, David G

“…Exercise capacity predicts mortality in pulmonary arterial hypertension (PAH), but limited data exist on the routine use of maximal exercise testing. This…”
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Pulmonary Artery Denervation Attenuates Pulmonary Arterial Remodeling in Dogs With Pulmonary Arterial Hypertension Induced by Dehydrogenized Monocrotaline by Zhou, Ling, MD, Zhang, Juan, MD, Jiang, Xiao-Min, MD, Xie, Du-Jiang, MD, Wang, Jin-Song, MD, Li, Li, MD, Li, Bin, PhD, Wang, Zhi-Mei, MD, Rothman, Alexander M.K., MD, Lawrie, Allan, PhD, Chen, Shao-Liang, MD

“…Abstract Objectives This study aimed to investigate sympathetic nerve (SN) ultrastructural changes and hemodynamic and pulmonary artery (PA) pathological…”
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Digital health care solution for proactive heart failure management with the Cordella Heart Failure System: results of the SIRONA first‐in‐human study by Mullens, Wilfried, Sharif, Faisal, Dupont, Matthias, Rothman, Alexander M.K., Wijns, William

“…Aims Incorporation of remote monitoring of pulmonary artery pressure and vital signs has been demonstrated to reduce heart failure (HF) hospitalization and…”
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Role of biomarkers in evaluation, treatment and clinical studies of pulmonary arterial hypertension by Hemnes, Anna, Rothman, Alexander M.K., Swift, Andrew J., Zisman, Lawrence S.

“…Pulmonary arterial hypertension is a complex disease resulting from the interplay of myriad biological and environmental processes that lead to remodeling of…”
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Non-invasive detection of severe PH in lung disease using magnetic resonance imaging by Alkhanfar, Dheyaa, Dwivedi, Krit, Alandejani, Faisal, Shahin, Yousef, Alabed, Samer, Johns, Chris, Garg, Pankaj, Thompson, A A Roger, Rothman, Alexander M K, Hameed, Abdul, Charalampopoulos, Athanasios, Wild, Jim M, Condliffe, Robin, Kiely, David G, Swift, Andrew J

“…Severe pulmonary hypertension (mean pulmonary artery pressure ≥35 mmHg) in chronic lung disease (PH-CLD) is associated with high mortality and morbidity. Data…”
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klf2ash317 Mutant Zebrafish Do Not Recapitulate Morpholino-Induced Vascular and Haematopoietic Phenotypes by Novodvorsky, Peter, Watson, Oliver, Gray, Caroline, Wilkinson, Robert N, Reeve, Scott, Smythe, Carl, Beniston, Richard, Plant, Karen, Maguire, Richard, M K Rothman, Alexander, Elworthy, Stone, van Eeden, Fredericus J M, Chico, Timothy J A

“…The zinc-finger transcription factor Krϋppel-like factor 2 (KLF2) transduces blood flow into molecular signals responsible for a wide range of responses within…”
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Imaging and Risk Stratification in Pulmonary Arterial Hypertension: Time to Include Right Ventricular Assessment by Alandejani, Faisal, Hameed, Abdul, Tubman, Euan, Alabed, Samer, Shahin, Yousef, Lewis, Robert A, Dwivedi, Krit, Mahmood, Aqeeb, Middleton, Jennifer, Watson, Lisa, Alkhanfar, Dheyaa, Johns, Christopher S, Rajaram, Smitha, Garg, Pankaj, Condliffe, Robin, Elliot, Charlie A, Thompson, A A Roger, Rothman, Alexander M K, Charalampopoulos, Athanasios, Lawrie, Allan, Wild, Jim M, Swift, Andrew J, Kiely, David G

“…Current European Society of Cardiology and European Respiratory Society guidelines recommend regular risk stratification with an aim of treating patients with…”
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The incremental shuttle walk test predicts mortality in non-group 1 pulmonary hypertension: results from the ASPIRE Registry by Billings, Catherine G., Lewis, Robert, Hurdman, Judith A., Condliffe, Robin, Elliot, Charlie A., Thompson, A.A. Roger, Smith, Ian A., Austin, Matthew, Armstrong, Iain J., Hamilton, Neil, Charalampopoulos, Athanasios, Sabroe, Ian, Swift, Andrew J., Rothman, Alexander M., Wild, Jim M., Lawrie, Allan, Waterhouse, Judith C., Kiely, David G.

“…Pulmonary hypertension (PH) is classified into five groups based on disease etiology but there is only limited information on the prognostic value of exercise…”
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Identification of Cardiac Magnetic Resonance Imaging Thresholds for Risk Stratification in Pulmonary Arterial Hypertension by Lewis, Robert A, Johns, Christopher S, Cogliano, Marcella, Capener, David, Tubman, Euan, Elliot, Charlie A, Charalampopoulos, Athanasios, Sabroe, Ian, Thompson, A A Roger, Billings, Catherine G, Hamilton, Neil, Baster, Kathleen, Laud, Peter J, Hickey, Peter M, Middleton, Jennifer, Armstrong, Iain J, Hurdman, Judith A, Lawrie, Allan, Rothman, Alexander M K, Wild, Jim M, Condliffe, Robin, Swift, Andrew J, Kiely, David G

“…Pulmonary arterial hypertension (PAH) is a life-shortening condition. The European Society of Cardiology and European Respiratory Society and the REVEAL (North…”
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MicroRNA-140-5p and SMURF1 regulate pulmonary arterial hypertension by Rothman, Alexander M K, Arnold, Nadine D, Pickworth, Josephine A, Iremonger, James, Ciuclan, Loredana, Allen, Robert M H, Guth-Gundel, Sabine, Southwood, Mark, Morrell, Nicholas W, Thomas, Matthew, Francis, Sheila E, Rowlands, David J, Lawrie, Allan

“…Loss of the growth-suppressive effects of bone morphogenetic protein (BMP) signaling has been demonstrated to promote pulmonary arterial endothelial cell…”
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Hemodynamic, Functional, and Clinical Responses to Pulmonary Artery Denervation in Patients With Pulmonary Arterial Hypertension of Different Causes: Phase II Results From the Pulmonary Artery Denervation-1 Study by Chen, Shao-Liang, Zhang, Hang, Xie, Du-Jiang, Zhang, Juan, Zhou, Ling, Rothman, Alexander M.K, Stone, Gregg W

“…BACKGROUND—The mechanisms underlying pulmonary arterial hypertension (PAH) are multifactorial. The efficacy of pulmonary artery denervation (PADN) for…”
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A current and future outlook on upcoming technologies in remote monitoring of patients with heart failure by Bekfani, Tarek, Fudim, Marat, Cleland, John G.F., Jorbenadze, Ana, Haehling, Stephan, Lorber, Avraham, Rothman, Alexander M.K., Stein, Kenneth, Abraham, William T., Sievert, Horst, Anker, Stefan D.

“…Heart failure is a major health and economic challenge in both developing and developed countries. Despite advances in pharmacological and device therapies for…”
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Cerebrovascular Effects of Sildenafil in Small Vessel Disease: The OxHARP Trial by Webb, Alastair J S, Birks, Jacqueline, Feakins, Karolina A, Lawson, Amy, Dawson, Jesse, Rothman, Alexander M K, Werring, David J, Llwyd, Osian, Stewart, Catriona, Thomas, James

“…Vascular cognitive impairment due to cerebral small vessel disease is associated with cerebral pulsatility, white matter hypoperfusion, and reduced…”
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Right ventricular remodelling in pulmonary arterial hypertension predicts treatment response by Goh, Ze Ming, Balasubramanian, Nithin, Alabed, Samer, Dwivedi, Krit, Shahin, Yousef, Rothman, Alexander M K, Garg, Pankaj, Lawrie, Allan, Capener, David, Thompson, A A Roger, Alandejani, Faisal, Wild, Jim M, Johns, Christopher S, Lewis, Robert A, Gosling, Rebecca, Sharkey, Michael, Condliffe, Robin, Kiely, David G, Swift, Andrew J

“…To determine the prognostic value of patterns of right ventricular adaptation in patients with pulmonary arterial hypertension (PAH), assessed using cardiac…”
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Canakinumab for Atherosclerotic Disease by Rothman, Alexander M, Morton, Allison C, Crossman, David C

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Validation of Artificial Intelligence Cardiac MRI Measurements: Relationship to Heart Catheterization and Mortality Prediction by Alabed, Samer, Alandejani, Faisal, Dwivedi, Krit, Karunasaagarar, Kavita, Sharkey, Michael, Garg, Pankaj, de Koning, Patrick J H, Tóth, Attila, Shahin, Yousef, Johns, Christopher, Mamalakis, Michail, Stott, Sarah, Capener, David, Wood, Steven, Metherall, Peter, Rothman, Alexander M K, Condliffe, Robin, Hamilton, Neil, Wild, James M, O'Regan, Declan P, Lu, Haiping, Kiely, David G, van der Geest, Rob J, Swift, Andrew J

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