Search Results - "Rothman, Alex M"

Diagnostic accuracy of CT pulmonary angiography in suspected pulmonary hypertension by Swift, Andrew J., Dwivedi, Krit, Johns, Chris, Garg, Pankaj, Chin, Matthew, Currie, Ben J, Rothman, Alex MK, Capener, Dave, Shahin, Yousef, Elliot, Charlie A, Charalampopolous, Thanos, Sabroe, Ian, Rajaram, Smitha, Hill, Catherine, Wild, Jim M., Condliffe, Robin, Kiely, David G.

“…Objectives Computed tomography (CT) pulmonary angiography is widely used in patients with suspected pulmonary hypertension (PH). However, the diagnostic and…”
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Quantitative CT Evaluation of Small Pulmonary Vessels Has Functional and Prognostic Value in Pulmonary Hypertension by Shahin, Yousef, Alabed, Samer, Alkhanfar, Dheyaa, Tschirren, Juerg, Rothman, Alex M K, Condliffe, Robin, Wild, James M, Kiely, David G, Swift, Andrew J

“…Background The in vivo relationship between peel pulmonary vessels, small pulmonary vessels, and pulmonary hypertension (PH) is not fully understood. Purpose…”
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Establishing minimally important differences for cardiac MRI end-points in pulmonary arterial hypertension by Alabed, Samer, Garg, Pankaj, Alandejani, Faisal, Dwivedi, Krit, Maiter, Ahmed, Karunasaagarar, Kavita, Rajaram, Smitha, Hill, Catherine, Thomas, Steven, Gossling, Rebecca, Sharkey, Michael J, Salehi, Mahan, Wild, Jim M, Watson, Lisa, Hameed, Abdul, Charalampopoulos, Athanasios, Lu, Haiping, Rothman, Alex M K, Thompson, A A Roger, Elliot, Charlie A, Hamilton, Neil, Johns, Christopher S, Armstrong, Iain, Condliffe, Robin, van der Geest, Rob J, Swift, Andrew J, Kiely, David G

“…Cardiac magnetic resonance (CMR) is the gold standard technique to assess biventricular volumes and function, and is increasingly being considered as an…”
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Intracellular retention of mutant retinoschisin is the pathological mechanism underlying X-linked retinoschisis by Wang, Tao, Waters, Caroline T., Rothman, Alex M.K., Jakins, Tracy J., Römisch, Karin, Trump, Dorothy

“…X-linked retinoschisis results in visual loss in early life with splitting within the inner retinal layers. Many missense and protein truncating mutations of…”
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MicroRNA in Pulmonary Vascular Disease by Rothman, Alex M.K., Chico, Timothy J.A., Lawrie, Allan

“…MicroRNA (miRNA) are short noncoding RNA that regulate gene expression by inhibiting translation or promoting degradation of target mRNA. miRNA are key…”
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Abstract 12811: Incidence and Phenotypic Predictors of Arrhythmias in Idiopathic Pulmonary Arterial Hypertension by Reddy, Ashwin, Middleton, Jennifer, Nethercott, Sarah, Polwarth, Gary, Pepke-Zaba, Joanna, Martin, Claire, Rothman, Alex M, Toshner, Mark

“…Abstract only Introduction: Arrhythmias are common in patients with idiopathic pulmonary arterial hypertension (IPAH). However prospective analysis of…”
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Abstract 13527: The Development of a Remote Pulmonary Arterial Hypertension Risk Score Utilising Remote Monitoring Technology to Monitor Parameters Associated With Mortality in Pulmonary Arterial Hypertension by Middleton, Jennifer T, Binmahfooz, Sarah, Zafar, Hamza, Patel, Junaid, Neelam Naganathan, Dharshan Giri, Battersby, Christian, Toshner, Mark, Reddy, Ashwin, Lewis, Robert, Swift, Andrew J, Condliffe, Robin, Elliot, Charlie, Hameed, Abdul, Charalampopoulos, Athanasios, Thompson, Alfred, Kiely, David G, Rothman, Alex M

“…BackgroundIn patients with pulmonary arterial hypertension (PAH) risk stratification is used to aid clinical decision making and guide treatment categorising…”
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Abstract 13553: Remote Monitoring of the Haemodynamic Response to Clinically Indicated Therapeutic Escalation and Clinical Worsening Events in Patients With Pulmonary Arterial Hypertension by Middleton, Jennifer T, Binmahfooz, Sarah, Zafar, Hamza, Patel, Junaid, Giri, Dharshan, Battersby, Christian, Toshner, Mark, Reddy, Ashwin, Lewis, Robert, Condliffe, Robin, Elliot, Charlie, Hameed, Abdul, Charalampopoulos, Athanasios, Thompson, Alfred, Kiely, David G, Rothman, Alex M

“…Background Hospital-based assessment of haemodynamics, exercise capacity and right heart function/strain are used for risk-stratification to aid clinical…”
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Abstract 14275: Allosteric Inhibition Restricts Motion of the SMURF1 Glycine Hinge and Reverses Experimental Pulmonary Arterial Hypertension by Rothman, Alex M, Florentin, Amir, Quigley, Catherine, Zink, Florence, Bonneau, Olivier, Hemming, Rene, Hachey, Amanda, Rejtar, Tomas, Thaker, Maulik, Jain, Rishi, Zhang, Ji-Hu, Cotesta, Simona, Ottl, Johannes, Kordinsky, Alina, Avishid, Reut, Troxler, Thomas, Binmahfooz, Sarah K, Morrell, Nicholas W, Humbert, Marc, Cobb, Jennifer, Osterman, Nils, Tallerico, John, Shaw, Duncan, Guth-Gundel, Sabine, Prag, Gali, Rowlands, David J

“…Abstract only Background: Reduced expression of bone morphogenetic protein receptor 2 (BMPR2) predisposes to pulmonary vascular remodelling and the development…”
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Abstract 13581: Heart Rhythm versus Heart Rate Control Strategy in Patients With Pre-Capillary Pulmonary Hypertension and Atrial Arrhythmias by Sammut, Mark Anthony, Condliffe, Robin, Hameed, Abdul, Rothman, Alex M, Kyriacou, Andreas, Lewis, Robert A, Durrington, Charlotte, Elliot, Charlie A, Thompson, Alfred A, Sabroe, Ian, Kiely, David G, Charalampopoulos, Athanasios

“…IntroductionAtrial tachyarrhythmias in patients with pre-capillary pulmonary hypertension are often poorly tolerated leading to increased morbidity and…”
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Abstract 15636: Effect of COVID-19 Public Health Measures on Activity and Quality of Life in Patients With Pulmonary Arterial Hypertension by Middleton, Jennifer T, Konganige, Shiran, Dahaghin, Payman, Zafar, Hamza, Reddy, Ashwin, Martin, Claire, Thompson, A.A.R, Swift, Andy J, Morris, Paul, Condliffe, Robin, Morrell, Nicholas W, Kiely, David G, Toshner, Mark, ROTHMAN, Alex M

“…BackgroundLimitation of physical activity has been widely enforced to reduce COVID-19 transmission, however it is a critical measure in the prevention of…”
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Biological heterogeneity in idiopathic pulmonary arterial hypertension identified through unsupervised transcriptomic profiling of whole blood by Kariotis, Sokratis, Jammeh, Emmanuel, Swietlik, Emilia M., Pickworth, Josephine A., Rhodes, Christopher J., Otero, Pablo, Wharton, John, Iremonger, James, Dunning, Mark J., Pandya, Divya, Mascarenhas, Thomas S., Errington, Niamh, Thompson, A. A. Roger, Romanoski, Casey E., Rischard, Franz, Garcia, Joe G. N., Yuan, Jason X.-J., An, Tae-Hwi Schwantes, Desai, Ankit A., Coghlan, Gerry, Lordan, Jim, Corris, Paul A., Howard, Luke S., Condliffe, Robin, Kiely, David G., Church, Colin, Pepke-Zaba, Joanna, Toshner, Mark, Wort, Stephen, Gräf, Stefan, Morrell, Nicholas W., Wilkins, Martin R., Lawrie, Allan, Wang, Dennis

“…Idiopathic pulmonary arterial hypertension (IPAH) is a rare but fatal disease diagnosed by right heart catheterisation and the exclusion of other forms of…”
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Author Correction: Biological heterogeneity in idiopathic pulmonary arterial hypertension identified through unsupervised transcriptomic profiling of whole blood by Kariotis, Sokratis, Jammeh, Emmanuel, Swietlik, Emilia M., Pickworth, Josephine A., Rhodes, Christopher J., Otero, Pablo, Wharton, John, Iremonger, James, Dunning, Mark J., Pandya, Divya, Mascarenhas, Thomas S., Errington, Niamh, Thompson, A. A. Roger, Romanoski, Casey E., Rischard, Franz, Garcia, Joe G. N., Yuan, Jason X.-J., An, Tae-Hwi Schwantes, Desai, Ankit A., Coghlan, Gerry, Lordan, Jim, Corris, Paul A., Howard, Luke S., Condliffe, Robin, Kiely, David G., Church, Colin, Pepke-Zaba, Joanna, Toshner, Mark, Wort, Stephen, Gräf, Stefan, Morrell, Nicholas W., Wilkins, Martin R., Lawrie, Allan, Wang, Dennis

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Abstract 13921: Dysfunctional Bone Morphogenetic Protein Signaling Interlinks With Interleukin-1ß Mediated Inflammation in Pulmonary Arterial Hypertension by Pickworth, Josephine A, Shay, Sheila, Gladson, Santhi, Iremonger, James, Rothman, Alex M, Francis, Sheila, West, James, Lawrie, Allan

“…RationaleBone morphogenetic protein receptor type 2 (BMPR2) mutations are found in heritable and idiopathic pulmonary arterial hypertension but disease…”
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Abstract 14742: Expression of SMURF1 is Increased in Patients With Pulmonary Arterial Hypertension and SiRNA Inhibition of SMURF1 Reduces Pulmonary Artery Smooth Muscle Cell Proliferation by Rothman, Alex M, West, Laura, Srivastava, Salil, Quigley, Catherine, Southwood, Mark, Lawrie, Allan, Francis, Sheila, Morrell, Nick, Rowlands, David

“…RationaleMutation of Bone Morphogenetic Protein (BMP) Receptor II, and reduced downstream signaling, predisposes to pulmonary vascular remodeling and the…”
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Abstract 10426: Prolonged Enoxaparin Infusion in Patients Undergoing Primary Percutaneous Coronary Intervention Compared to Standard-of-care: A Single-centre Clinical Trial by Sumaya, Wael, Parker, William, Judge, Heather M, Hall, Ian R, Orme, Rachel C, Adam, Zulfiquar, Richardson, James D, Rothman, Alex M, Morgan, Kenneth P, Gunn, Julian P, Storey, Robert F

“…IntroductionStrategies are needed to circumvent the delayed absorption of oral P2Y12 inhibitors in opiate-treated patients undergoing primary percutaneous…”
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