Search Results - "Rothenberg, P. L."

Pharmacokinetics, Pharmacodynamics, Safety, and Tolerability of JNJ-38431055, a Novel GPR119 Receptor Agonist and Potential Antidiabetes Agent, in Healthy Male Subjects by Katz, L B, Gambale, J J, Rothenberg, P L, Vanapalli, S R, Vaccaro, N, Xi, L, Polidori, D C, Vets, E, Sarich, T C, Stein, P P

“…The incidence of type 2 diabetes mellitus is increasing worldwide. Several G–protein–coupled receptor agonists are being studied for their efficacy as…”
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Regulation of insulin receptor substrate-1 in liver and muscle of animal models of insulin resistance by SAAD, M. J. A, ARAKI, E, MIRALPEIX, M, ROTHENBERG, P. L, WHITE, M. F, KAHN, C. R

“…Insulin rapidly stimulates tyrosine phosphorylation of a protein of approximately 185 kD in most cell types. This protein, termed insulin receptor substrate-1…”
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Insulin receptor signaling in the beta-cell influences insulin gene expression and insulin content: evidence for autocrine beta-cell regulation by Xu, G. G., Rothenberg, P. L.

“…Insulin receptor signaling in the beta-cell influences insulin gene expression and insulin content: evidence for autocrine beta-cell regulation. G G Xu and P L…”
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Effects of JNJ-38431055, a novel GPR119 receptor agonist, in randomized, double-blind, placebo-controlled studies in subjects with type 2 diabetes by Katz, L. B., Gambale, J. J., Rothenberg, P. L., Vanapalli, S. R., Vaccaro, N., Xi, L., Sarich, T. C., Stein, P. P.

“…Aim: G‐protein coupled receptor agonists are currently under investigation for their potential utility in patients with type 2 diabetes mellitus (T2DM). The…”
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Purification and partial sequence analysis of pp185, the major cellular substrate of the insulin receptor tyrosine kinase by ROTHENBERG, P. L, LANE, W. S, KARASIK, A, BACKER, J, WHITE, M, KAHN, C. R

“…Insulin stimulates the tyrosine phosphorylation of a 185-kDa putative cytosolic substrate protein (pp185) in diverse cell types. After intravenous insulin…”
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Insulin inhibits pertussis toxin-catalyzed ADP-ribosylation of G-proteins. Evidence for a novel interaction between insulin receptors and G-proteins by Rothenberg, P L, Kahn, C R

“…Insulin modifies cellular responsiveness to some hormones which operate via guanine nucleotide binding proteins (G-proteins); also, G-proteins have been…”
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Expression of insulin receptor mRNA and insulin receptor substrate 1 in pancreatic islet beta-cells by Harbeck, M. C., Louie, D. C., Howland, J., Wolf, B. A., Rothenberg, P. L.

“…Expression of insulin receptor mRNA and insulin receptor substrate 1 in pancreatic islet beta-cells. M C Harbeck , D C Louie , J Howland , B A Wolf and P L…”
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Glucose-induced insulin receptor tyrosine phosphorylation in insulin-secreting beta-cells by Rothenberg, P. L., Willison, L. D., Simon, J., Wolf, B. A.

“…Glucose-induced insulin receptor tyrosine phosphorylation in insulin-secreting beta-cells. P L Rothenberg , L D Willison , J Simon and B A Wolf Department of…”
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Genistein differentially inhibits postreceptor effects of insulin in rat adipocytes without inhibiting the insulin receptor kinase by ABLER, A, SMITH, J. A, RANDAZZO, P. A, ROTHENBERG, P. L, JARETT, L

“…Genistein, an isoflavone putative tyrosine kinase inhibitor, was used to investigate the coupling of insulin receptor tyrosine kinase activation to four…”
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Wortmannin inhibits insulin secretion in pancreatic islets and β-TC3 cells independent of its inhibition of phosphatidylinositol 3-kinase by GAO, Z.-Y, KONRAD, R. J, COLLINS, H, MATSCHINSKY, F. M, ROTHENBERG, P. L, WOLF, B. A

“…Glucose is the primary stimulus for insulin secretion by pancreatic beta-cells, and it triggers membrane depolarization and influx of extracellular Ca2+…”
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Increased protein kinase C activity is linked to reduced insulin receptor autophosphorylation in liver of starved rats by KARASIK, A, ROTHENBERG, P. L, YAMADA, K, WHITE, M. F, KAHN, C. R

“…Phosphorylation of the insulin receptor beta-subunit on serine/threonine residues by protein kinase C reduces both receptor kinase activity and insulin action…”
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Wortmannin inhibits insulin secretion in pancreatic islets and beta-TC3 cells independent of its inhibition of phosphatidylinositol 3-kinase by Gao, Z., Konrad, R. J., Collins, H., Matschinsky, F. M., Rothenberg, P. L., Wolf, B. A.

“…Wortmannin inhibits insulin secretion in pancreatic islets and beta-TC3 cells independent of its inhibition of phosphatidylinositol 3-kinase. Z Gao , R J…”
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Expression of insulin receptor mRNA and insulin receptor substrate 1 in pancreatic islet β-cells by HARBECK, M. C, LOUIE, D. C, HOWLAND, J, WOLF, B. A, ROTHENBERG, P. L

“…The expression of insulin receptor mRNA was examined in rat pancreatic islet cells by single-cell reverse transcriptase (RT)-polymerase chain reaction (PCR)…”
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Glucose-induced insulin receptor tyrosine phosphorylation in insulin-secreting β-cells by ROTHENBERG, P. L, WILLISON, L. D, SIMON, J, WOLF, B. A

“…In the beta TC3 insulin-secreting beta-cell line, glucose rapidly induces the tyrosine phosphorylation of the 97-kDa insulin receptor beta-subunit…”
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Insulin receptor signaling in the β-cell influences insulin gene expression and insulin content : Evidence for autocrine β-cell regulation by XU, G. G, ROTHENBERG, P. L

“…The insulin receptor (IR) is expressed by insulin-secreting beta-cells, but its cellular function is unknown. We transfected betaTC6-F7 beta-cells with cDNAs…”
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Infected acute myocardial infarct with rupture in systemic lupus erythematosus by Cunningham, Michael J., Rothenberg, Paul L., Schatten, Sam, Schur, Peter H., Schoen, Frederick J.

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Insulin and secretagogues differentially regulate fluid-phase pinocytosis in insulin-secreting beta-cells by Xu, G, Howland, J, Rothenberg, P L

“…The physiological role of the beta-cell insulin receptor is unknown. To evaluate a candidate function, the insulin regulation of fluid-phase pinocytosis was…”
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A Technique for Isolating Single Cells for Analysis by Reverse Transcription Polymerase Chain Reaction by Harbeck, M.C., Rothenberg, P.L.

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Pharmacokinetics of Aprepitant After Single and Multiple Oral Doses in Healthy Volunteers by Majumdar, Anup K., Howard, Laura, Goldberg, Michael R., Hickey, Lisa, Constanzer, Marvin, Rothenberg, Paul L., Crumley, Tami M., Panebianco, Deborah, Bradstreet, Thomas E., Bergman, Arthur J., Waldman, Scott A., Greenberg, Howard E., Butler, Kathleen, Knops, A., De Lepeleire, Inge, Michiels, Nicole, Petty, Kevin J.

“…Aprepitant is the first NK1 receptor antagonist approved for use with corticosteroids and 5HT3 receptor antagonists to prevent chemotherapy‐induced nausea and…”
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Increased protein kinase C activity is linked to reduced insulin receptor autophosphorylation in livers of starved rats by Karasik, A, Rothenberg, P L, Yamada, K, White, M F, Kahn, C R

“…Phosphorylation of the insulin receptor beta -subunit on serine/threonine residues by protein kinase C reduces both receptor kinase activity and insulin action…”
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