Search Results - "Rothblat, G H"

Expression of Scavenger Receptor BI in COS-7 Cells Alters Cholesterol Content and Distribution by Kellner-Weibel, G, de la Llera-Moya, M, Connelly, M. A, Stoudt, G, Christian, A. E, Haynes, M. P, Williams, D. L, Rothblat, G. H

“…Previous studies have shown that scavenger receptor BI (SR-BI) stimulates the bidirectional flux of free cholesterol (FC) between HDL and SR-BI-expressing…”
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Crystallization of Free Cholesterol in Model Macrophage Foam Cells by Kellner-Weibel, G, Yancey, P G, Jerome, W G, Walser, T, Mason, R P, Phillips, M C, Rothblat, G H

“…The present study examined free cholesterol (FC) crystallization in macrophage foam cells. Model foam cells (J774 or mouse peritoneal macrophages [MPMs]) were…”
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Use of cyclodextrins for manipulating cellular cholesterol content by Christian, A E, Haynes, M P, Phillips, M C, Rothblat, G H

“…Previous studies from this laboratory have demonstrated that exposure of tissue culture cells to cyclodextrins results in rapid cholesterol depletion. In the…”
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Cellular cholesterol flux studies: methodological considerations by Rothblat, G.H, de la Llera-Moya, M, Favari, E, Yancey, P.G, Kellner-Weibel, G

“…Reverse cholesterol transport (RCT) is the process in which peripheral cells release cholesterol to an extracellular acceptor such as high-density lipoprotein…”
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Effects of Intracellular Free Cholesterol Accumulation on Macrophage Viability: A Model for Foam Cell Death by Kellner-Weibel, G, Jerome, W.G, Small, NA, Warner, G.J, Stoltenborg, J.K, Kearney, NA, Corjay, M.H, Phillips, NA, Rothblat, G.H

“…This study was designed to identify cellular responses associated with free cholesterol (FC) accumulation in model macrophage foam cells. Mouse peritoneal…”
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Scavenger Receptor Class B Type I as a Mediator of Cellular Cholesterol Efflux to Lipoproteins and Phospholipid Acceptors by Jian, Bo, de la Llera-Moya, Margarita, Ji, Yong, Wang, Nan, Phillips, Michael C., Swaney, John B., Tall, Alan R., Rothblat, George H.

“…We recently reported that the rate of efflux of cholesterol from cells to high density lipoprotein (HDL) was related to the expression level of scavenger…”
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Apolipoproteins, membrane cholesterol domains, and the regulation of cholesterol efflux by Rothblat, GH, Mahlberg, FH, Johnson, WJ, Phillips, MC

“…Published data related to both cell membrane biology and apolipoprotein structure are reviewed and used to formulate a new model describing the mechanisms of…”
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Cytotoxic cholesterol is generated by the hydrolysis of cytoplasmic cholesteryl ester and transported to the plasma membrane by Kellner-Weibel, G, Geng, Y.J, Rothblat, G.H

“…The present study examines the fate and effects of free cholesterol (FC) generated by the hydrolysis of cytoplasmic cholesteryl esters (CE) in model macrophage…”
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Cholesterol Metabolism and Efflux in Human THP-1 Macrophages by Kritharides, Leonard, Christian, Aimee, Stoudt, Genevieve, Morel, Dianne, Rothblat, George H

“…This study has investigated in detail factors regulating accumulation, esterification, and mobilization of cholesterol in human THP-1 macrophages. Human THP-1…”
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Cyclodextrins as catalysts for the removal of cholesterol from macrophage foam cells by Atger, V M, de la Llera Moya, M, Stoudt, G W, Rodrigueza, W V, Phillips, M C, Rothblat, G H

“…Low concentrations of cyclodextrins (< 1.0 mM) added to serum act catalytically, accelerating the exchange of cholesterol between cells and lipoproteins. J774…”
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Analysis of Chimeric Receptors Shows That Multiple Distinct Functional Activities of Scavenger Receptor, Class B, Type I (SR-BI), Are Localized to the Extracellular Receptor Domain by Connelly, Margery A, de la Llera-Moya, Margarita, Monzo, Pascale, Yancey, Patricia G, Drazul, Denise, Stoudt, Genevieve, Fournier, Natalie, Klein, Seth M, Rothblat, George H, Williams, David L

“…Scavenger receptor BI (SR-BI) mediates the selective uptake of high-density lipoprotein (HDL) cholesteryl ester (CE), a process by which HDL CE is taken into…”
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Efflux of lipid from fibroblasts to apolipoproteins: dependence on elevated levels of cellular unesterified cholesterol by Bielicki, JK, Johnson, WJ, Weinberg, RB, Glick, JM, Rothblat, GH

“…Earlier work from this laboratory showed that enrichment of cells with free cholesterol enhanced the efflux of phospholipid to lipoprotein acceptors,…”
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Human ApoA-IV Overexpression in Transgenic Mice Induces cAMP-Stimulated Cholesterol Efflux From J774 Macrophages to Whole Serum by Fournier, Natalie, Atger, Véronique, Paul, Jean-Louis, Sturm, Marie, Duverger, Nicolas, Rothblat, George H, Moatti, Nicole

“…The role of apolipoprotein A-IV (apoA-IV) in lipoprotein metabolism has not been established. The aim of the present study was to investigate the role of…”
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Formation of cholesterol monohydrate crystals in macrophage-derived foam cells by Tangirala, R.K, Jerome, W.G, Jones, N.L, Small, D.M, Johnson, W.J, Glick, J.M, Mahlberg, F.H, Rothblat, G.H

“…In a previous study using the J774 macrophage foam cells, we quantitated the accumulation of unesterified (free) cholesterol derived from cholesteryl ester…”
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Mechanisms of high density lipoprotein-mediated efflux of cholesterol from cell plasma membranes by Phillips, Michael C, Gillotte, Kristin L, Haynes, M.Page, Johnson, William J, Lund-Katz, Sissel, Rothblat, George H

“…The participation of HDL in the reverse cholesterol transport (RCT) from peripheral cells to the liver is critical for the antiatherogenic properties of this…”
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Importance of Different Pathways of Cellular Cholesterol Efflux by Yancey, Patricia G, Bortnick, Anna E, Kellner-Weibel, Ginny, de la Llera-Moya, Margarita, Phillips, Michael C, Rothblat, George H, Tall, Alan R

“…ABSTRACT—The removal of excess free cholesterol from cells by HDL or its apolipoproteins is important for maintaining cellular cholesterol homeostasis. This…”
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Overexpression of apolipoprotein A-I promotes reverse transport of cholesterol from macrophages to feces in vivo by Zhang, YuZhen, Zanotti, Ilaria, Reilly, Muredach P, Glick, Jane M, Rothblat, George H, Rader, Daniel J

“…Abundant data indicate that overexpression of apolipoprotein A-I (apoA-I) in mice inhibits atherosclerosis. One mechanism is believed to be promotion of…”
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Cellular cholesterol efflux. Role of cell membrane kinetic pools and interaction with apolipoproteins AI, AII, and Cs by MAHLBERG, F. H, ROTHBLAT, G. H

“…Efflux of [14C]cholesterol from various cells was monitored in the presence of discoidal complexes of egg phosphatidylcholine and purified apolipoproteins,…”
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Cholesterol efflux from cells to immunopurified subfractions of human high density lipoprotein: LP-AI and LP-AI/AII by Johnson, WJ, Kilsdonk, EP, van Tol, A, Phillips, MC, Rothblat, GH

“…Using immunoaffinity chromatography, we separated human high density lipoprotein (HDL) into two subfractions: LP-AI, in which all particles contain…”
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Role of HDL phospholipid in efflux of cell cholesterol to whole serum: studies with human apoA-I transgenic rats by Fournier, N, de la Llera Moya, M, Burkey, B F, Swaney, J B, Paterniti, Jr, J, Moatti, N, Atger, V, Rothblat, G H

“…Sera of transgenic rats expressing human apoA-I were tested for their ability to stimulate efflux of radiolabeled cholesterol from Fu5AH rat hepatoma cells…”
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