Search Results - "Rothberg, Jonathan M"

Progress in Ion Torrent semiconductor chip based sequencing by Merriman, Barry, R&D Team, Ion Torrent, Rothberg, Jonathan M.

“…In order for next‐generation sequencing to become widely used as a diagnostic in the healthcare industry, sequencing instrumentation will need to be mass…”
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Prospective genomic characterization of the German enterohemorrhagic Escherichia coli O104:H4 outbreak by rapid next generation sequencing technology by Mellmann, Alexander, Harmsen, Dag, Cummings, Craig A, Zentz, Emily B, Leopold, Shana R, Rico, Alain, Prior, Karola, Szczepanowski, Rafael, Ji, Yongmei, Zhang, Wenlan, McLaughlin, Stephen F, Henkhaus, John K, Leopold, Benjamin, Bielaszewska, Martina, Prager, Rita, Brzoska, Pius M, Moore, Richard L, Guenther, Simone, Rothberg, Jonathan M, Karch, Helge

“…An ongoing outbreak of exceptionally virulent Shiga toxin (Stx)-producing Escherichia coli O104:H4 centered in Germany, has caused over 830 cases of hemolytic…”
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Droplet microfluidic technology for single-cell high-throughput screening by Brouzes, Eric, Medkova, Martina, Savenelli, Neal, Marran, Dave, Twardowski, Mariusz, Hutchison, J. Brian, Rothberg, Jonathan M, Link, Darren R, Perrimon, Norbert, Samuels, Michael L

“…We present a droplet-based microfluidic technology that enables high-throughput screening of single mammalian cells. This integrated platform allows for the…”
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Impaired Mitochondrial Dynamics and Mitophagy in Neuronal Models of Tuberous Sclerosis Complex by Ebrahimi-Fakhari, Darius, Saffari, Afshin, Wahlster, Lara, Di Nardo, Alessia, Turner, Daria, Lewis, Tommy L., Conrad, Christopher, Rothberg, Jonathan M., Lipton, Jonathan O., Kölker, Stefan, Hoffmann, Georg F., Han, Min-Joon, Polleux, Franck, Sahin, Mustafa

“…Tuberous sclerosis complex (TSC) is a neurodevelopmental disease caused by TSC1 or TSC2 mutations and subsequent activation of the mTORC1 kinase. Upon mTORC1…”
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Ultrasound-on-chip platform for medical imaging, analysis, and collective intelligence by Rothberg, Jonathan M., Ralston, Tyler S., Rothberg, Alex G., Martin, John, Zahorian, Jaime S., Alie, Susan A., Sanchez, Nevada J., Chen, Kailiang, Chen, Chao, Thiele, Karl, Grosjean, David, Yang, Jungwook, Bao, Liewei, Schneider, Rob, Schaetz, Sebastian, Meyer, Christophe, Neben, Abraham, Ryan, Bob, Petrus, J. R., Lutsky, Joe, McMahill, Dan, Corteville, Gregory, Hageman, Matthew R., Miller, Larry, Fife, Keith G.

“…Over the past half-century, ultrasound imaging has become a key technology for assessing an ever-widening range of medical conditions at all stages of life…”
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The complete genome of an individual by massively parallel DNA sequencing by Lupski, James R, Rothberg, Jonathan M, Shen, Yufeng, Chen, Yi-Ju, Turcotte, Cynthia L, Tartaro, Karrie, Irzyk, Gerard P, Wheeler, David A, Gomes, Xavier, Yuan, Ye, Qin, Xiang, Chinault, Craig, Weinstock, George M, Song, Xing-zhi, Chen, Lei, Srinivasan, Maithreyan, He, Wen, Liu, Yue, Muzny, Donna M, Gibbs, Richard A, Niazi, Faheem, Margulies, Marcel, Roth, G. Thomas, Makhijani, Vinod, Nazareth, Lynne, McGuire, Amy, Egholm, Michael

“…The association of genetic variation with disease and drug response, and improvements in nucleic acid technologies, have given great optimism for the impact of…”
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Low-Abundance Drug-Resistant Viral Variants in Chronically HIV-Infected, Antiretroviral Treatment–Naive Patients Significantly Impact Treatment Outcomes by Simen, Birgitte B., Simons, Jan Fredrik, Hullsiek, Katherine Huppler, Novak, Richard M., MacArthur, Rodger D., Baxter, John D., Huang, Chunli, Lubeski, Christine, Turenchalk, Gregory S., Braverman, Michael S., Desany, Brian, Rothberg, Jonathan M., Egholm, Michael

“…BackgroundMinor (i.e., <20% prevalence) drug-resistant human immunodeficiency virus (HIV) variants may go undetected, yet be clinically important ObjectivesTo…”
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Analysis of one million base pairs of Neanderthal DNA by Ronan, Michael T, Egholm, Michael, Paunovic, Maja, Pääbo, Svante, Green, Richard E, Ptak, Susan E, Rothberg, Jonathan M, Briggs, Adrian W, Simons, Jan F, Krause, Johannes, Du, Lei

“…Neanderthals are the extinct hominid group most closely related to contemporary humans, so their genome offers a unique opportunity to identify genetic changes…”
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A Complete Neandertal Mitochondrial Genome Sequence Determined by High-Throughput Sequencing by Green, Richard E., Malaspinas, Anna-Sapfo, Krause, Johannes, Briggs, Adrian W., Johnson, Philip L.F., Uhler, Caroline, Meyer, Matthias, Good, Jeffrey M., Maricic, Tomislav, Stenzel, Udo, Prüfer, Kay, Siebauer, Michael, Burbano, Hernán A., Ronan, Michael, Rothberg, Jonathan M., Egholm, Michael, Rudan, Pavao, Brajković, Dejana, Kućan, Željko, Gušić, Ivan, Wikström, Mårten, Laakkonen, Liisa, Kelso, Janet, Slatkin, Montgomery, Pääbo, Svante

“…A complete mitochondrial (mt) genome sequence was reconstructed from a 38,000 year-old Neandertal individual with 8341 mtDNA sequences identified among 4.8 Gb…”
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Assessment of whole genome amplification-induced bias through high-throughput, massively parallel whole genome sequencing by Pinard, Robert, de Winter, Alex, Sarkis, Gary J, Gerstein, Mark B, Tartaro, Karrie R, Plant, Ramona N, Egholm, Michael, Rothberg, Jonathan M, Leamon, John H

“…Whole genome amplification is an increasingly common technique through which minute amounts of DNA can be multiplied to generate quantities suitable for…”
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Gaining confidence in high-throughput protein interaction networks by Bader, Joel S, Chaudhuri, Amitabha, Rothberg, Jonathan M, Chant, John

“…Although genome-scale technologies have benefited from statistical measures of data quality, extracting biologically relevant pathways from high-throughput…”
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A comprehensive analysis of protein-protein interactions in Saccharomyces cerevisiae by Fields, Stanley, Uetz, Peter, Giot, Loic, Cagney, Gerard, Mansfield, Traci A, Judson, Richard S, Knight, James R, Lockshon, Daniel, Narayan, Vaibhav, Srinivasan, Maithreyan, Pochart, Pascale, Qureshi-Emili, Alia, Li, Ying, Godwin, Brian, Conover, Diana, Kalbfleisch, Theodore, Vijayadamodar, Govindan, Yang, Meijia, Johnston, Mark, Rothberg, Jonathan M

“…Two large-scale yeast two-hybrid screens were undertaken to identify protein-protein interactions between full-length open reading frames predicted from the…”
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Impaired Mitochondrial Dynamics And Mitophagy In Neuronal Models Of Tuberous Sclerosis Complex by Ebrahimi-Fakhari, Darius, Saffari, Afshin, Wahlster, Lara, DiNardo, Alessia, Turner, Daria, Lewis, Tommy L., Conrad, Christopher, Rothberg, Jonathan M., Lipton, Jonathan O., Kölker, Stefan, Hoffmann, Georg F., Han, Min-Joon, Polleux, Franck, Sahin, Mustafa

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The development and impact of 454 sequencing by Rothberg, Jonathan M, Leamon, John H

“…The 454 Sequencer has dramatically increased the volume of sequencing conducted by the scientific community and expanded the range of problems that can be…”
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Overview: methods and applications for droplet compartmentalization of biology by Leamon, John H, Link, Darren R, Egholm, Michael, Rothberg, Jonathan M

“…Three protocols in this issue highlight applications of emulsification procedures, which deliver high-throughput potential to the molecular biology laboratory,…”
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PDGF-D, a new protease-activated growth factor by LaRochelle, William J, Jeffers, Michael, McDonald, William F, Chillakuru, Rajeev A, Giese, Neill A, Lokker, Nathalie A, Sullivan, Carol, Boldog, Ferenc L, Yang, Meijia, Vernet, Corine, Burgess, Catherine E, Fernandes, Elma, Deegler, Lisa L, Rittman, Beth, Shimkets, Juliette, Shimkets, Richard A, Rothberg, Jonathan M, Lichenstein, Henri S

“…Platelet-derived growth factor (PDGF) has been directly implicated in developmental and physiological processes, as well as in human cancer, fibrotic diseases…”
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An integrated semiconductor device enabling non-optical genome sequencing by Rothberg, Jonathan M., Hinz, Wolfgang, Rearick, Todd M., Schultz, Jonathan, Mileski, William, Davey, Mel, Leamon, John H., Johnson, Kim, Milgrew, Mark J., Edwards, Matthew, Hoon, Jeremy, Simons, Jan F., Marran, David, Myers, Jason W., Davidson, John F., Branting, Annika, Nobile, John R., Puc, Bernard P., Light, David, Clark, Travis A., Huber, Martin, Branciforte, Jeffrey T., Stoner, Isaac B., Cawley, Simon E., Lyons, Michael, Fu, Yutao, Homer, Nils, Sedova, Marina, Miao, Xin, Reed, Brian, Sabina, Jeffrey, Feierstein, Erika, Schorn, Michelle, Alanjary, Mohammad, Dimalanta, Eileen, Dressman, Devin, Kasinskas, Rachel, Sokolsky, Tanya, Fidanza, Jacqueline A., Namsaraev, Eugeni, McKernan, Kevin J., Williams, Alan, Roth, G. Thomas, Bustillo, James

“…The seminal importance of DNA sequencing to the life sciences, biotechnology and medicine has driven the search for more scalable and lower-cost solutions…”
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Massively parallel ("next-generation") DNA sequencing by Gould Rothberg, Bonnie E, Rothberg, Jonathan M

“…[...]metagenomics, the study of genetic material from communities of microorganisms extracted from environmental samples, is borne of NGS. [...]implementation…”
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Sensitive mutation detection in heterogeneous cancer specimens by massively parallel picoliter reactor sequencing by Meyerson, Matthew, Thomas, Roman K, Nickerson, Elizabeth, Simons, Jan F, Jänne, Pasi A, Tengs, Torstein, Yuza, Yuki, Garraway, Levi A, LaFramboise, Thomas, Lee, Jeffrey C, Shah, Kinjal, O'Neill, Keith, Sasaki, Hidefumi, Lindeman, Neal, Wong, Kwok-Kin, Borras, Ana M, Gutmann, Edward J, Dragnev, Konstantin H, DeBiasi, Ralph, Chen, Tzu-Hsiu, Glatt, Karen A, Greulich, Heidi, Desany, Brian, Lubeski, Christine K, Brockman, William, Alvarez, Pablo, Hutchison, Stephen K, Leamon, J H, Ronan, Michael T, Turenchalk, Gregory S, Egholm, Michael, Sellers, William R, Rothberg, Jonathan M

“…The sensitivity of conventional DNA sequencing in tumor biopsies is limited by stromal contamination and by genetic heterogeneity within the cancer. Here, we…”
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34.1 An 8960-Element Ultrasound-on-Chip for Point-of-Care Ultrasound by Sanchez, Nevada, Chen, Kailiang, Chen, Chao, McMahill, Dan, Hwang, Sewook, Lutsky, Joseph, Yang, Jungwook, Bao, Liewei, Chiu, Leung Kin, Peyton, Graham, Soleimani, Hamid, Ryan, Bob, Petrus, J. R., Kook, Youn-Jae, Ralston, Tyler S., Fife, Keith G., Rothberg, Jonathan M.

“…Point-of-care ultrasound (POCUS) is transforming healthcare worldwide as a diagnostic tool with the potential to significantly reduce the delay between symptom…”
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