Search Results - "Rothberg, Brad S."

Molecular mechanism of a potassium channel gating through activation gate-selectivity filter coupling by Kopec, Wojciech, Rothberg, Brad S., de Groot, Bert L.

“…Potassium channels are presumed to have two allosterically coupled gates, the activation gate and the selectivity filter gate, that control channel opening,…”
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MICU1 Is an Essential Gatekeeper for MCU-Mediated Mitochondrial Ca2+ Uptake that Regulates Cell Survival by Mallilankaraman, Karthik, Doonan, Patrick, Cárdenas, César, Chandramoorthy, Harish C., Müller, Marioly, Miller, Russell, Hoffman, Nicholas E., Gandhirajan, Rajesh Kumar, Molgó, Jordi, Birnbaum, Morris J., Rothberg, Brad S., Mak, Don-On Daniel, Foskett, J. Kevin, Madesh, Muniswamy

“…Mitochondrial Ca2+ (Ca2+m) uptake is mediated by an inner membrane Ca2+ channel called the uniporter. Ca2+ uptake is driven by the considerable voltage present…”
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Distinct Orai-coupling domains in STIM1 and STIM2 define the Orai-activating site by Wang, Xizhuo, Wang, Youjun, Zhou, Yandong, Hendron, Eunan, Mancarella, Salvatore, Andrake, Mark D, Rothberg, Brad S, Soboloff, Jonathan, Gill, Donald L

“…STIM1 and STIM2 are widely expressed endoplasmic reticulum (ER) Ca 2+ sensor proteins able to translocate within the ER membrane to physically couple with and…”
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The STIM1-binding site nexus remotely controls Orai1 channel gating by Zhou, Yandong, Cai, Xiangyu, Loktionova, Natalia A., Wang, Xianming, Nwokonko, Robert M., Wang, Xizhuo, Wang, Youjun, Rothberg, Brad S., Trebak, Mohamed, Gill, Donald L.

“…The ubiquitously expressed Orai Ca 2+ channels are gated through a unique process of intermembrane coupling with the Ca 2+ -sensing STIM proteins. Despite the…”
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STIM1 dimers undergo unimolecular coupling to activate Orai1 channels by Zhou, Yandong, Wang, Xizhuo, Wang, Xianming, Loktionova, Natalia A., Cai, Xiangyu, Nwokonko, Robert M., Vrana, Erin, Wang, Youjun, Rothberg, Brad S., Gill, Donald L.

“…The endoplasmic reticulum (ER) Ca 2+ sensor, STIM1, becomes activated when ER-stored Ca 2+ is depleted and translocates into ER–plasma membrane junctions where…”
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Orai channel pore properties and gating by STIM: implications from the Orai crystal structure by Rothberg, Brad S, Wang, Youjun, Gill, Donald L

“…The Orai channels are unusual, yet prominent, calcium (Ca2+) signal mediators in most cell types. Orai proteins are structurally unique, having little sequence…”
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Permeating disciplines: Overcoming barriers between molecular simulations and classical structure-function approaches in biological ion transport by Howard, Rebecca J., Carnevale, Vincenzo, Delemotte, Lucie, Hellmich, Ute A., Rothberg, Brad S.

“…Ion translocation across biological barriers is a fundamental requirement for life. In many cases, controlling this process—for example with neuroactive…”
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Neuronal STIMulation at rest by Hooper, Robert, Rothberg, Brad S, Soboloff, Jonathan

“…Almost a decade has passed since first STIM, and later Orai, proteins were identified as the molecular constituents of store-operated calcium entry (SOCE)…”
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STIM proteins: dynamic calcium signal transducers by Soboloff, Jonathan, Rothberg, Brad S., Madesh, Muniswamy, Gill, Donald L.

“…Key Points Stromal interaction molecule (STIM) proteins are dynamic sensors of Ca 2+ stored within the endoplasmic reticulum (ER) and are triggered by Ca 2+…”
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Knockdown of lncRNA TP53TG1 Enhances the Efficacy of Sorafenib in Human Hepatocellular Carcinoma Cells by Lu, Qingchun, Xin, Mingyang, Guo, Qian, Rothberg, Brad S., Gamero, Ana M., Yang, Ling

“…The multikinase inhibitor, sorafenib, is a first-line treatment for hepatocellular carcinoma (HCC), but its limited efficacy, drug resistance and toxicity are…”
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Interrogating the gating motions of the NaK channel by Rothberg, Brad S

“…Previous crystallographic studies depicted a physical gate of the NaK channel localized at a bundle crossing of pore-lining helices, but solution NMR studies…”
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Initial steps of inactivation at the K⁺ channel selectivity filter by Thomson, Andrew S, Heer, Florian T, Smith, Frank J, Hendron, Eunan, Bernèche, Simon, Rothberg, Brad S

“…K ⁺ efflux through K ⁺ channels can be controlled by C-type inactivation, which is thought to arise from a conformational change near the channel’s selectivity…”
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Bimane Fluorescence Scanning Suggests Secondary Structure near the S3-S4 Linker of BK Channels by Semenova, Nina P., Abarca-Heidemann, Karin, Loranc, Eva, Rothberg, Brad S.

“…Gating of large conductance Ca2+-activated K+ channels (BK or maxi-K channels) is controlled by a Ca2+-sensor, formed by the channel cytoplasmic C-terminal…”
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Structure and function of multiple Ca²⁺ -binding sites in a K⁺ channel regulator of K⁺ conductance (RCK) domain by Pau, Victor P. T., Smith, Frank J., Taylor, Alexander B., Parfenova, Liubov V., Samakai, Elsie, Callaghan, Matthew M., Abarca-Heidemann, Karin, Hart, P. John, Rothberg, Brad S.

“…Regulator of K⁺ conductance (RCK) domains control the activity of a variety of K⁺ transporters and channels, including the human large conductance Ca²⁺…”
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Crystal Structure of a Ba2+-Bound Gating Ring Reveals Elementary Steps in RCK Domain Activation by Smith, Frank J., Pau, Victor P.T., Cingolani, Gino, Rothberg, Brad S.

“…RCK domains control activity of a variety of K+ channels and transporters through binding of cytoplasmic ligands. To gain insight toward mechanisms of RCK…”
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Charge of the Proton Channel by Rothberg, Brad S.

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Role of lipids in hydrophobic gating and blocker affinity in BK channels by Coronel, Lucia, Vouga, Alexandre G., Rothberg, Brad S., Carnevale, Vincenzo

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MICU1 is an essential gatekeeper for MCU-mediated mitochondrial Ca(2+) uptake that regulates cell survival by Mallilankaraman, Karthik, Doonan, Patrick, Cárdenas, César, Chandramoorthy, Harish C, Müller, Marioly, Miller, Russell, Hoffman, Nicholas E, Gandhirajan, Rajesh Kumar, Molgó, Jordi, Birnbaum, Morris J, Rothberg, Brad S, Mak, Don-On Daniel, Foskett, J Kevin, Madesh, Muniswamy

“…Mitochondrial Ca(2+) (Ca(2+)(m)) uptake is mediated by an inner membrane Ca(2+) channel called the uniporter. Ca(2+) uptake is driven by the considerable…”
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A slick, slack pathway through the pore by Rothberg, Brad S.

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Understanding the conformational motions of RCK gating rings by Giraldez, Teresa, Rothberg, Brad S

“…Regulator of conduction of K (RCK) domains are ubiquitous regulators of channel and transporter activity in prokaryotes and eukaryotes. In humans, RCK domains…”
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