Search Results - "Rothbart, Scott B"

Interpreting the language of histone and DNA modifications by Rothbart, Scott B., Strahl, Brian D.

“…A major mechanism regulating the accessibility and function of eukaryotic genomes are the covalent modifications to DNA and histone proteins that dependably…”
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Chromatin Regulation through Ubiquitin and Ubiquitin-like Histone Modifications by Vaughan, Robert M., Kupai, Ariana, Rothbart, Scott B.

“…Chromatin functions are influenced by the addition, removal, and recognition of histone post-translational modifications (PTMs). Ubiquitin and ubiquitin-like…”
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Structural basis for DNMT3A-mediated de novo DNA methylation by Zhang, Zhi-Min, Lu, Rui, Wang, Pengcheng, Yu, Yang, Chen, Dongliang, Gao, Linfeng, Liu, Shuo, Ji, Debin, Rothbart, Scott B, Wang, Yinsheng, Wang, Gang Greg, Song, Jikui

“…A crystal structure of DNMT3A and its regulatory partner DNMT3L bound to DNA reveals the mechanistic basis for DNMT3A-mediated DNA methylation and establishes…”
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An H3K36 Methylation-Engaging Tudor Motif of Polycomb-like Proteins Mediates PRC2 Complex Targeting by Cai, Ling, Rothbart, Scott B., Lu, Rui, Xu, Bowen, Chen, Wei-Yi, Tripathy, Ashutosh, Rockowitz, Shira, Zheng, Deyou, Patel, Dinshaw J., Allis, C. David, Strahl, Brian D., Song, Jikui, Wang, Gang Greg

“…Polycomb repressive complex 2 (PRC2) regulates pluripotency, differentiation, and tumorigenesis through catalysis of histone H3 lysine 27 trimethylation…”
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Lysine Methylation Regulators Moonlighting outside the Epigenome by Cornett, Evan M., Ferry, Laure, Defossez, Pierre-Antoine, Rothbart, Scott B.

“…Landmark discoveries made nearly two decades ago identified known transcriptional regulators as histone lysine methyltransferases. Since then, the field of…”
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An Interactive Database for the Assessment of Histone Antibody Specificity by Rothbart, Scott B., Dickson, Bradley M., Raab, Jesse R., Grzybowski, Adrian T., Krajewski, Krzysztof, Guo, Angela H., Shanle, Erin K., Josefowicz, Steven Z., Fuchs, Stephen M., Allis, C. David, Magnuson, Terry R., Ruthenburg, Alexander J., Strahl, Brian D.

“…Access to high-quality antibodies is a necessity for the study of histones and their posttranslational modifications (PTMs). Here we debut the Histone Antibody…”
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Neuronal Stress Pathway Mediating a Histone Methyl/Phospho Switch Is Required for Herpes Simplex Virus Reactivation by Cliffe, Anna R., Arbuckle, Jesse H., Vogel, Jodi L., Geden, Matthew J., Rothbart, Scott B., Cusack, Corey L., Strahl, Brian D., Kristie, Thomas M., Deshmukh, Mohanish

“…Herpes simplex virus (HSV) reactivation from latent neuronal infection requires stimulation of lytic gene expression from promoters associated with repressive…”
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Histone H3.3 phosphorylation amplifies stimulation-induced transcription by Armache, Anja, Yang, Shuang, Martínez de Paz, Alexia, Robbins, Lexi E., Durmaz, Ceyda, Cheong, Jin Q., Ravishankar, Arjun, Daman, Andrew W., Ahimovic, Dughan J., Klevorn, Thaís, Yue, Yuan, Arslan, Tanja, Lin, Shu, Panchenko, Tanya, Hrit, Joel, Wang, Miao, Thudium, Samuel, Garcia, Benjamin A., Korb, Erica, Armache, Karim-Jean, Rothbart, Scott B., Hake, Sandra B., Allis, C. David, Li, Haitao, Josefowicz, Steven Z.

“…Complex organisms can rapidly induce select genes in response to diverse environmental cues. This regulation occurs in the context of large genomes condensed…”
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AMP-activated Protein Kinase (AMPK) Control of mTORC1 Is p53- and TSC2-independent in Pemetrexed-treated Carcinoma Cells by Agarwal, Stuti, Bell, Catherine M., Rothbart, Scott B., Moran, Richard G.

“…The key sensor of energy status in mammalian cells, AMP-activated protein kinase (AMPK), can also be activated by the AMP analog aminoimidazolecarboxamide…”
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HDAC inhibition results in widespread alteration of the histone acetylation landscape and BRD4 targeting to gene bodies by Slaughter, Mariesa J., Shanle, Erin K., Khan, Abid, Chua, Katrin F., Hong, Tao, Boxer, Lisa D., Allis, C. David, Josefowicz, Steven Z., Garcia, Benjamin A., Rothbart, Scott B., Strahl, Brian D., Davis, Ian J.

“…Histone acetylation levels are regulated by histone acetyltransferases (HATs) and histone deacetylases (HDACs) that antagonistically control the overall…”
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A histone methylation network regulates transgenerational epigenetic memory in C. elegans by Greer, Eric L, Beese-Sims, Sara E, Brookes, Emily, Spadafora, Ruggero, Zhu, Yun, Rothbart, Scott B, Aristizábal-Corrales, David, Chen, Shuzhen, Badeaux, Aimee I, Jin, Qiuye, Wang, Wei, Strahl, Brian D, Colaiácovo, Monica P, Shi, Yang

“…How epigenetic information is transmitted from generation to generation remains largely unknown. Deletion of the C. elegans histone H3 lysine 4 dimethyl…”
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Streamlined quantitative analysis of histone modification abundance at nucleosome-scale resolution with siQ-ChIP version 2.0 by Dickson, Bradley M., Kupai, Ariana, Vaughan, Robert M., Rothbart, Scott B.

“…We recently introduced an absolute and physical quantitative scale for chromatin immunoprecipitation followed by sequencing (ChIP-seq). The scale itself was…”
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An Allosteric Interaction Links USP7 to Deubiquitination and Chromatin Targeting of UHRF1 by Zhang, Zhi-Min, Rothbart, Scott B., Allison, David F., Cai, Qian, Harrison, Joseph S., Li, Lin, Wang, Yinsheng, Strahl, Brian D., Wang, Gang Greg, Song, Jikui

“…The protein stability and chromatin functions of UHRF1 (ubiquitin-like, containing PHD and RING finger domains, 1) are regulated in a cell-cycle-dependent…”
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The Histone-H3K4-Specific Demethylase KDM5B Binds to Its Substrate and Product through Distinct PHD Fingers by Klein, Brianna J., Piao, Lianhua, Xi, Yuanxin, Rincon-Arano, Hector, Rothbart, Scott B., Peng, Danni, Wen, Hong, Larson, Connie, Zhang, Xi, Zheng, Xia, Cortazar, Michael A., Peña, Pedro V., Mangan, Anthony, Bentley, David L., Strahl, Brian D., Groudine, Mark, Li, Wei, Shi, Xiaobing, Kutateladze, Tatiana G.

“…The histone lysine demethylase KDM5B regulates gene transcription and cell differentiation and is implicated in carcinogenesis. It contains multiple conserved…”
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The Arginine Methyltransferase PRMT6 Regulates DNA Methylation and Contributes to Global DNA Hypomethylation in Cancer by Veland, Nicolas, Hardikar, Swanand, Zhong, Yi, Gayatri, Sitaram, Dan, Jiameng, Strahl, Brian D., Rothbart, Scott B., Bedford, Mark T., Chen, Taiping

“…DNA methylation plays crucial roles in chromatin structure and gene expression. Aberrant DNA methylation patterns, including global hypomethylation and…”
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Study of mitotic chromatin supports a model of bookmarking by histone modifications and reveals nucleosome deposition patterns by Javasky, Elisheva, Shamir, Inbal, Gandhi, Shashi, Egri, Shawn, Sandler, Oded, Rothbart, Scott B, Kaplan, Noam, Jaffe, Jacob D, Goren, Alon, Simon, Itamar

“…Mitosis encompasses key molecular changes including chromatin condensation, nuclear envelope breakdown, and reduced transcription levels. Immediately after…”
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Multivalent histone engagement by the linked tandem Tudor and PHD domains of UHRF1 is required for the epigenetic inheritance of DNA methylation by Rothbart, Scott B, Dickson, Bradley M, Ong, Michelle S, Krajewski, Krzysztof, Houliston, Scott, Kireev, Dmitri B, Arrowsmith, Cheryl H, Strahl, Brian D

“…Histone post-translational modifications regulate chromatin structure and function largely through interactions with effector proteins that often contain…”
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Pemetrexed indirectly activates the metabolic kinase AMPK in human carcinomas by Rothbart, Scott B, Racanelli, Alexandra C, Moran, Richard G

“…The chemotherapeutic drug pemetrexed, an inhibitor of thymidylate synthase, has an important secondary target in human leukemic cells,…”
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Trabectedin Inhibits EWS-FLI1 and Evicts SWI/SNF from Chromatin in a Schedule-dependent Manner by Harlow, Matt L, Chasse, Maggie H, Boguslawski, Elissa A, Sorensen, Katie M, Gedminas, Jenna M, Kitchen-Goosen, Susan M, Rothbart, Scott B, Taslim, Cenny, Lessnick, Stephen L, Peck, Anderson S, Madaj, Zachary B, Bowman, Megan J, Grohar, Patrick J

“…The successful clinical translation of compounds that target specific oncogenic transcription factors will require an understanding of the mechanism of target…”
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Therapeutics by Cytotoxic Metabolite Accumulation: Pemetrexed Causes ZMP Accumulation, AMPK Activation, and Mammalian Target of Rapamycin Inhibition by RACANELLI, Alexandra C, ROTHBART, Scott B, HEYER, Cortney L, MORAN, Richard G

“…Pemetrexed represents the first antifolate cancer drug to be approved by the Food and Drug Administration in 20 years; it is currently in widespread use for…”
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