Search Results - "Roth, Willy"

The pharmacokinetics, pharmacodynamics and tolerability of dabigatran etexilate, a new oral direct thrombin inhibitor, in healthy male subjects by Stangier, Joachim, Rathgen, Karin, Stähle, Hildegard, Gansser, Dietmar, Roth, Willy

“…Aims The novel direct thrombin inhibitor (DTI), dabigatran etexilate (Boehringer Ingelheim Pharma GmbH & Co. KG), shows potential as an oral antithrombotic…”
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The Metabolism and Disposition of the Oral Direct Thrombin Inhibitor, Dabigatran, in Humans by BLECH, Stefan, EBNER, Thomas, LUDWIG-SCHWELLINGER, Eva, STANGIER, Joachim, ROTH, Willy

“…The pharmacokinetics and metabolism of the direct thrombin inhibitor dabigatran (BIBR 953 ZW, β-alanine, N…”
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PREDOMINANT CONTRIBUTION OF OATP1B3 TO THE HEPATIC UPTAKE OF TELMISARTAN, AN ANGIOTENSIN II RECEPTOR ANTAGONIST, IN HUMANS by ISHIGURO, Naoki, MAEDA, Kazuya, KISHIMOTO, Wataru, SAITO, Asami, HARADA, Akiko, EBNER, Thomas, ROTH, Willy, IGARASHI, Takashi, SUGIYAMA, Yuichi

“…Telmisartan, a nonpeptide angiotensin II receptor antagonist, is selectively distributed to liver. In the present study, we have characterized the contribution…”
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Concentration-dependent plasma protein binding of the novel dipeptidyl peptidase 4 inhibitor BI 1356 due to saturable binding to its target in plasma of mice, rats and humans by Fuchs, Holger, Tillement, Jean-Paul, Urien, Saik, Greischel, Andreas, Roth, Willy

“…Objectives The purpose of this study was to characterise the plasma protein binding of BI 1356. Methods BI 1356 (proposed trade name ONDERO) is a novel…”
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The impact of pharmacogenetics of metabolic enzymes and transporters on the pharmacokinetics of telmisartan in healthy volunteers by Yamada, Akihiro, Maeda, Kazuya, Ishiguro, Naoki, Tsuda, Yasuhiro, Igarashi, Takashi, Ebner, Thomas, Roth, Willy, Ikushiro, Shinichi, Sugiyama, Yuichi

“…OBJECTIVETelmisartan is mainly taken up into the liver by organic anion transporting polypeptide (OATP) 1B3, conjugated with glucuronate, and excreted into the…”
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Establishment of a Set of Double Transfectants Coexpressing Organic Anion Transporting Polypeptide 1B3 and Hepatic Efflux Transporters for the Characterization of the Hepatobiliary Transport of Telmisartan Acylglucuronide by ISHIGURO, Naoki, MAEDA, Kazuya, SAITO, Asami, KISHIMOTO, Wataru, MATSUSHIMA, Soichiro, EBNER, Thomas, ROTH, Willy, IGARASHI, Takashi, SUGIYAMA, Yuichi

“…In the hepatic uptake of organic anions, organic anion transporting polypeptide (OATP) 1B1 is believed to be mainly involved. We have constructed a set of…”
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Pharmacokinetics of Meloxicam in Animals and The Relevance to Humans by BUSCH, U, SCHMID, J, HEINZEL, G, SCHMAUS, H, BAIERL, J, HUBER, C, ROTH, W

“…The pharmacokinetic profile of the new nonsteroidal anti-inflammatory drug meloxicam was investigated in a number of animal species, including mice, rats,…”
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Pharmacokinetics and Pharmacodynamics of Dabigatran Etexilate, an Oral Direct Thrombin Inhibitor, Are Not Affected by Moderate Hepatic Impairment by Stangier, Joachim, Stähle, Hildegard, Rathgen, Karin, Roth, Willy, Shakeri-Nejad, Kasra

“…The impact of moderate hepatic impairment on the pharmacokinetics (PK) and pharmacodynamics (PD) of dabigatran etexilate was evaluated in an open,…”
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Concentration-dependent plasma protein binding of the novel dipeptidyl peptidase 4 inhibitor BI 1356 due to saturable binding to its target in plasma of mice, rats and humans by Fuchs, Holger, Tillement, Jean-Paul, Urien, Saik, Greischel, Andreas, Roth, Willy

“…OBJECTIVESThe purpose of this study was to characterise the plasma protein binding of BI 1356.METHODSBI 1356 (proposed trade name ONDERO) is a novel dipeptidyl…”
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Pharmacokinetics and Pharmacodynamics of Dabigatran Etexilate, an Oral Direct Thrombin Inhibitor, With Coadministration of Digoxin by Stangier, Joachim, Stähle, Hildegard, Rathgen, Karin, Roth, Willy, Reseski, Kathrin, Körnicke, Thomas

“…This study evaluated the potential impact of concomitant digoxin on the pharmacokinetics and pharmacodynamics of dabigatran etexilate, a novel oral direct…”
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Coadministration of Dabigatran Etexilate and Atorvastatin: Assessment of Potential Impact on Pharmacokinetics and Pharmacodynamics by Stangier, Joachim, Rathgen, Karin, Stähle, Hildegard, Reseski, Kathrin, Körnicke, Thomas, Roth, Willy

“…Background Dabigatran etexilate, a novel oral direct thrombin inhibitor, has been approved for prophylaxis of thromboembolism in patients undergoing total knee…”
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The impact of pharmacogenetics of metabolic enzymes and transporters on the pharmacokinetics of telmisartan in healthy volunteers by Yamada, Akihiro, Maeda, Kazuya, Ishiguro, Naoki, Tsuda, Yasuhiro, Igarashi, Takashi, Ebner, Thomas, Roth, Willy, Ikushiro, Shinichi, Sugiyama, Yuichi

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The pharmacokinetics, pharmacodynamics and tolerability of dabigatran etexilate, a new oral direct thrombin inhibitor, in healthy male subjects. Commentary by QING MA, STANGIER, Joachim, RATHGEN, Karin, STÄHLE, Hildegard, GANSSER, Dietmar, ROTH, Willy

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Modelling the anti-migraine effects of BIBN 4096 BS : A new calcitonin gene-related peptide receptor antagonist by TROCONIZ, Inaki F, WOLTERS, Jan-Markus, TILLMANN, Christiane, SCHAEFER, Hans G, ROTH, Willy

“…Migraine attacks are associated with release of the calcitonin gene-related peptide (CGRP) from trigeminal nerves. BIBN 4096 BS is the first CGRP receptor…”
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Population pharmacokinetic modelling of BIBN 4096 BS, the first compound of the new class of calcitonin gene-related peptide receptor antagonists by Trocóniz, Iñaki F, Wolters, Jan-Markus, Schaefer, Hans Guenter, Roth, Willy

“…Pharmacokinetics (PK) of the calcitonin gene-related (CGRP) peptide receptor antagonist BIBN 4096 BS, the first compound of this new class tested in humans,…”
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Altered drug disposition of the platelet activating factor antagonist apafant in mdr1a knockout mice by Leusch, Andreas, Volz, Astrid, Müller, Gabriele, Wagner, Andrea, Sauer, Achim, Greischel, Andreas, Roth, Willy

“…The aim of the present study was to determine a potential impact of P-glycoprotein (P-gp) on the tissue distribution and disposition of apafant (WEB 2086, CAS…”
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Pharmacokinetics and Safety of Intravenous and Oral Telmisartan 20 mg and 120 mg in Subjects with Hepatic Impairment Compared with Healthy Volunteers by Stangier, Joachim, Su, Chung-An P. F., Schöndorfer, G., Roth, Willy

“…The pharmacokinetics and safety of telmisartan were assessed in subjects with hepatic impairment in a single‐center, open‐label study. Single oral doses of…”
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Altered drug disposition of the platelet activating factor antagonist apafant in mdrla knockout mice by LEUSCH, Andreas, VOLZ, Astrid, MÜLLER, Gabriele, WAGNER, Andrea, SAUER, Achim, GREISCHEL, Andreas, ROTH, Willy

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Pharmacokinetics and safety of intravenous and oral telmisartan 20 mg and 120 mg in subjects with hepatic impairment compared with healthy volunteers: Clinical Pharmacology of Telmisartan by STANGIER, Joachim, SU, Chung-An P. F, SCHÖNDORFER, G, ROTH, Willy

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Kaposi's sarcoma: a review of gene expression and ultrastructure of KS spindle cells in vivo by Stürzl, M, Brandstetter, H, Roth, W K

“…The ultrastructural features and the gene expression pattern of Kaposi's sarcoma (KS) spindle cells in vivo suggest that KS is a tumor of the mixed cell type…”
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