Search Results - "Roth, Shoshannah L."

HIV-1 capsid-cyclophilin interactions determine nuclear import pathway, integration targeting and replication efficiency by Schaller, Torsten, Ocwieja, Karen E, Rasaiyaah, Jane, Price, Amanda J, Brady, Troy L, Roth, Shoshannah L, Hué, Stéphane, Fletcher, Adam J, Lee, KyeongEun, KewalRamani, Vineet N, Noursadeghi, Mahdad, Jenner, Richard G, James, Leo C, Bushman, Frederic D, Towers, Greg J

“…Lentiviruses such as HIV-1 traverse nuclear pore complexes (NPC) and infect terminally differentiated non-dividing cells, but how they do this is unclear. The…”
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Characterization of a Highly Conserved Domain within the Severe Acute Respiratory Syndrome Coronavirus Spike Protein S2 Domain with Characteristics of a Viral Fusion Peptide by MADU, Ikenna G, ROTH, Shoshannah L, BELOUZARD, Sandrine, WHITTAKER, Gary R

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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HIV integration targeting: a pathway involving Transportin-3 and the nuclear pore protein RanBP2 by Ocwieja, Karen E, Brady, Troy L, Ronen, Keshet, Huegel, Alyssa, Roth, Shoshannah L, Schaller, Torsten, James, Leo C, Towers, Greg J, Young, John A T, Chanda, Sumit K, König, Renate, Malani, Nirav, Berry, Charles C, Bushman, Frederic D

“…Genome-wide siRNA screens have identified host cell factors important for efficient HIV infection, among which are nuclear pore proteins such as RanBP2/Nup358…”
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Gammaretroviral Integration into Nucleosomal Target DNA In Vivo by ROTH, Shoshannah L, MALANI, Nirav, BUSHMAN, Frederic D

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A method to sequence and quantify DNA integration for monitoring outcome in gene therapy by Brady, Troy, Roth, Shoshannah L., Malani, Nirav, Wang, Gary P., Berry, Charles C., Leboulch, Philippe, Hacein-Bey-Abina, Salima, Cavazzana-Calvo, Marina, Papapetrou, Eirini P., Sadelain, Michel, Savilahti, Harri, Bushman, Frederic D.

“…Human genetic diseases have been successfully corrected by integration of functional copies of the defective genes into human cells, but in some cases…”
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One-pot multi-step synthesis: a challenge spawning innovation by Broadwater, Steven J, Roth, Shoshannah L, Price, Kristin E, Kobaslija, Muris, McQuade, D Tyler

“…Creating one-pot synthetic routes is a challenge that is already spawning new chemistry, enzymes, materials, and mechanistic insight. Through one-pot…”
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Global landscape of HIV–human protein complexes by Jäger, Stefanie, Cimermancic, Peter, Gulbahce, Natali, Johnson, Jeffrey R., McGovern, Kathryn E., Clarke, Starlynn C., Shales, Michael, Mercenne, Gaelle, Pache, Lars, Li, Kathy, Hernandez, Hilda, Jang, Gwendolyn M., Roth, Shoshannah L., Akiva, Eyal, Marlett, John, Stephens, Melanie, D’Orso, Iván, Fernandes, Jason, Fahey, Marie, Mahon, Cathal, O’Donoghue, Anthony J., Todorovic, Aleksandar, Morris, John H., Maltby, David A., Alber, Tom, Cagney, Gerard, Bushman, Frederic D., Young, John A., Chanda, Sumit K., Sundquist, Wesley I., Kortemme, Tanja, Hernandez, Ryan D., Craik, Charles S., Burlingame, Alma, Sali, Andrej, Frankel, Alan D., Krogan, Nevan J.

“…Affinity tagging, mass spectroscopy and a tailor-made scoring system are used to identify 497 high-confidence interactions between human proteins and human…”
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Genomic safe harbors permit high β-globin transgene expression in thalassemia induced pluripotent stem cells by Sadelain, Michel, Papapetrou, Eirini P, Lee, Gabsang, Malani, Nirav, Setty, Manu, Riviere, Isabelle, Tirunagari, Laxmi M S, Kadota, Kyuichi, Roth, Shoshannah L, Giardina, Patricia, Viale, Agnes, Leslie, Christina, Bushman, Frederic D, Studer, Lorenz

“…Realizing the therapeutic potential of human induced pluripotent stem (iPS) cells will require robust, precise and safe strategies for genetic modification, as…”
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Promotion of vesicular stomatitis virus fusion by the endosome-specific phospholipid bis(monoacylglycero)phosphate (BMP) by Roth, Shoshannah L., Whittaker, Gary R.

“…Vesicular stomatitis virus (VSV) is a prototypic virus commonly used in studies of endocytosis and membrane trafficking. One proposed mechanism for VSV entry…”
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2′ Substituted sergeants influencing the deoxy soldiers in folded oligonucleotides by Park, Jeong-il, Roth, Shoshannah L., Price, Kristin E., McQuade, D. Tyler

“…We demonstrate that conformational‐biased monomers can alter neighboring monomer conformation leading to globe changes in polymer topology. This work is…”
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Genomic safe harbors permit high -globin transgene expression in thalassemia induced pluripotent stem cells by Papapetrou, Eirini P, Lee, Gabsang, Malani, Nirav, Setty, Manu, Riviere, Isabelle, Tirunagari, Laxmi M S, Kadota, Kyuichi

“…If transgenes are to be introduced into the genome for cell therapies, the integration events should permit high transgene expression without altering the…”
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Genomic safe harbors permit high #946;-globin transgene expression in thalassemia induced pluripotent stem cells by Papapetrou, Eirini P, Lee, Gabsang, Malani, Nirav, Setty, Manu, Riviere, Isabelle, Tirunagari, Laxmi M.S, Kadota, Kyuichi, Roth, Shoshannah L, Giardina, Patricia, Viale, Agnes, Leslie, Christina, Bushman, Frederic D, Studer, Lorenz, Sadelain, Michel

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Therapeutic Transgene Expression From Genomic Safe Harbors In Patient-Specific Induced Pluripotent Stem Cells by Papapetrou, Eirini P, Lee, Gabsang, Malani, Nirav, Setty, Manu, Riviere, Isabelle, Tirunagari, Laxmi MS, Kadota, Kyuichi, Roth, Shoshannah L, Giardina, Patricia, Viale, Agnes, Leslie, Christina, Bushman, Frederic, Studer, Lorenz, Sadelain, Michel

“…Abstract 564 Insertional oncogenesis poses a severe hurdle to current gene therapy for blood disorders. The semi-random insertion of retroviral vectors…”
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